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compositionComposition:S ADENOSYL L METHIONINE-400MG
prescription
Prescription Medicine
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Nusig 400 mg Tablet is used to help manage mild to moderate alcoholic liver disease, osteoarthritis, and depression. Nusig 400 mg Tablet plays a crucial role in supporting cellular functions, regulating key physiological activities, increasing glutathione (a vital antioxidant for liver health), and enhancing overall liver metabolism. Some common side effects may include nausea, diarrhoea, stomach discomfort, and gas (flatulence).

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

S ADENOSYL L METHIONINE-400MG

Manufacturer/Marketer :

Vanguard Therapeutics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nusig 400 mg Tablet

Nusig 400 mg Tablet is a medication used to support emotional well-being, promote joint comfort, and maintain healthy liver function. It is commonly suggested to help manage symptoms of mood disorders and to ease the physical discomfort associated with wear-and-tear on the joints.

To experience the full benefits of this medicine, you must take it consistently every day as directed by your healthcare provider. For the best absorption, you should take this medicine on an empty stomach, typically 30 to 60 minutes before a meal. Incorporating regular, low-impact exercise and a nutrient-rich diet can also help maximise your results.

While taking this medicine, you may experience mild side effects such as nausea or a slight upset stomach. However, if you develop severe mood swings, intense anxiety, or signs of an allergic reaction like a skin rash, you should contact your doctor immediately.

Talk to your doctor before starting this medicine if you have any pre-existing health conditions, especially nerve-related disorders or a history of mental health challenges. Specifically, individuals diagnosed with bipolar disorder should not take this medicine, as it can cause serious mood shifts.

This medicine can interact with other substances, such as certain suggested antidepressants and over-the-counter cough medicines, potentially causing a dangerous buildup of brain chemicals. If you are pregnant, breastfeeding, or an elderly individual, you should consult your healthcare provider to discuss whether this medicine is safe for you.

Uses of Nusig 400 mg Tablet

Nusig 400 mg Tablet is used to support joint health, liver function, and emotional well-being. It helps protect joint tissues, supports healthy bile flow, and promotes balanced brain function. 

  • Osteoarthritis: Helps protect joint tissue, reduces chronic joint pain, and improves overall physical mobility.
  • Depression and Mood Support: Works in the brain to balance essential chemicals, helping to ease symptoms of low mood and emotional distress.
  • Intrahepatic Cholestasis and Liver Health: Supports liver cell function and promotes the healthy flow of bile to prevent liver damage.

Key Benefits

Nusig 400 mg Tablet supports joint health, emotional well-being, and liver function by targeting the underlying causes of discomfort. It helps improve mobility, supports a balanced mood, and promotes healthy liver function. Key benefits include:

  • Supports joint health: Helps reduce joint stiffness and discomfort, improving mobility and making daily activities easier.
  • Promotes emotional well-being: Helps stabilise mood and supports emotional balance by maintaining healthy brain function.
  • Supports liver health: Helps maintain healthy liver function and promotes the natural flow of bile.
  • Provides antioxidant protection: Helps protect cells from oxidative stress, supporting overall metabolic health and energy levels.
Side effects of Nusig 400 mg Tablet
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Swelling of the throat can worsen if there is no proper rest for your throat.
  • Drink plenty of warm fluids and frequently gargle with salt water.
  • Humidify the surrounding air using a humidifier, as dry air may increase dryness and throat pain.
  • Talk to your doctor if the swelling bothers you while swallowing food.
  • Take enough rest and stay in warm places to reduce pain quickly.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Nusig 400 mg Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Nusig 400 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Nusig 400 mg Tablet Works

Nusig 400 mg Tablet contains s-adenosyl l-methionine (SAMe), a naturally occurring compound that delivers essential chemical groups to your cells. This transfer process is fundamental to many important biological functions. In the brain, it helps support the production of key neurotransmitters, such as serotonin and dopamine, which play an important role in regulating mood and emotional well-being. In the joints, SAMe helps maintain and repair cartilage, the protective tissue that cushions your bones, thereby reducing friction and supporting joint comfort. In the liver, it helps support the production of glutathione, a powerful antioxidant that protects liver cells from damage and assists in the body's natural detoxification processes.
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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Nusig 400 mg Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Nusig 400 mg Tablet should be used with caution in pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

The use of Nusig 400 mg Tablet should be exercised with caution in nursing mothers. Please consult a doctor.

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Driving

Caution

Nusig 400 mg Tablet may cause drowsiness and dizziness in rare cases. Exercise caution while driving in case of these side effects.

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Liver

Consult your doctor

Nusig 400 mg Tablet is possibly safe on the liver. Please consult your doctor if you have any concerns.

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Kidney

Consult your doctor

Nusig 400 mg Tablet is possibly safe on the kidney. Please consult your doctor in case of any concerns.

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Children

Caution

It is not established if Nusig 400 mg Tablet is safe to use in children. Please consult the treating doctor in case of any concerns.

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Heart

Safe if suggested

Nusig 400 mg Tablet is generally considered safe for individuals with heart conditions. However, it is advisable to consult your doctor before using Nusig 400 mg Tablet .

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Geriatrics

Consult your doctor

Nusig 400 mg Tablet should be given to elderly patients only when recommended by a doctor. If you have any concerns about using Nusig 400 mg Tablet for geriatrics, please consult a doctor.

What if I have taken an overdose of Nusig 400 mg Tablet

If you suspect an accidental overdose or experience severe physical symptoms, seek immediate medical attention or contact your local emergency services right away.

Diet & Lifestyle Advise

  • Boost your B-vitamins: Ensure your diet includes plenty of foods rich in vitamin B12 and folate, such as leafy greens, eggs, and fortified cereals, as your body needs these nutrients to process Nusig 400 mg Tablet properly.
  • Keep moving: Engage in low-impact activities like swimming or cycling to support joint lubrication and muscle strength without straining your cartilage.
  • Avoid alcohol: Limit your alcohol intake, as alcohol can compromise liver function and interfere with medications meant to support your mood.
  • Stay hydrated: Drink plenty of water throughout the day to support your body's natural detoxification processes and keep your joints hydrated.
health query

Have a query?

How Soon It Starts Working

The time required for Nusig 400 mg Tablet to start to work: The time required for Nusig 400 mg Tablet to show its action is unknown. The time for which the effects of Nusig 400 mg Tablet last: The duration of action for Nusig 400 mg Tablet is clinically unknown.

What if you forget to take Nusig 400 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your normal routine. Do not take a double dose to make up for a missed tablet.

Storage

• Store this medicine at controlled room temperature (20°C to 25°C / 68°F to 77°F).

Drug Warnings

  • Inspect the blister pack before use: Do not take the tablet if the foil is torn or broken, or if the tablet appears damp or discoloured.
  • Inform your surgeon or dentist: Tell them you are taking Nusig 400 mg Tablet well before any scheduled surgical or dental procedure.
  • Avoid taking it late in the evening: This may help prevent sleep disturbances or insomnia.
  • Keep an updated medicine list: Share a list of all your current medicines and supplements with your healthcare provider before starting Nusig 400 mg Tablet .

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants (such as SSRIs, SNRIs, or MAOIs): Combining these can cause a dangerous buildup of serotonin in your brain, leading to a serious condition called serotonin syndrome.
  • Cough suppressants containing dextromethorphan: Taking these together may increase the risk of severe neurological side effects.
  • Levodopa: This medicine may reduce the effectiveness of levodopa, which could worsen symptoms of Parkinson's disease.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Food in general: Taking this medicine with a meal significantly lowers how much of it your body can absorb, reducing its therapeutic effect.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Nusig 400 mg Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis‚ and depression.
Please see an orthopaedic doctor if you have had a fracture. Nusig 400 mg Tablet is used in the case of arthritis and has limited use in the treatment of fractures, as fractures are more often a surgical concern.
Yes, Nusig 400 mg Tablet finds a lot of benefit in treating depression. However, if you are on any antidepressants, keep your doctor informed to avoid any interactions.
In case you miss a dose of Nusig 400 mg Tablet , take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.
Nusig 400 mg Tablet is probably safe for the kidneys; however, in the case of CKD, it is best to consult your treating doctor before using Nusig 400 mg Tablet .
Nusig 400 mg Tablet works by synthesising methionine, an essential amino acid required for cellular energy.
Nusig 400 mg Tablet may cause side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.
Nusig 400 mg Tablet should not be used by people who are allergic to any of its components. It is also not recommended for people with bipolar disorder, HIV, pregnant and nursing women.
Nusig 400 mg Tablet contains S-Adenosylmethionine, a naturally occurring compound found in almost every tissue and fluid in the body. It is made in the body from methionine, an amino acid found in foods.
It is unknown whether Nusig 400 mg Tablet is safe for long-term use. Take Nusig 400 mg Tablet for the duration suggested by the doctor.
Yes, you should take this medicine on an empty stomach, ideally 30 to 60 minutes before a meal. Taking it with food can significantly reduce how much of the medicine your body absorbs. Talk to your doctor or pharmacist if you have a persistent stomach upset.
Weight gain is not a recognised side effect of this medicine. If you notice unexpected changes in your weight, discuss this with your healthcare provider to identify other potential causes. Talk to your doctor for guidance.
It is highly recommended to limit or avoid alcohol while taking this medicine, as alcohol can worsen mood symptoms and stress your liver. Talk to your doctor to see what is safe for you.
The safety of this medicine during pregnancy and breastfeeding has not been fully established. You should avoid taking it during these periods unless your healthcare provider explicitly advises you to do so. Talk to your doctor before starting.
Feeling overly anxious, restless, or hyperactive can happen when starting this medicine. If you experience these feelings, try taking your dose earlier in the day, and talk to your doctor to adjust your care plan.
These tablets are usually manufactured with a special enteric coating that prevents them from dissolving in your stomach acid, ensuring they reach your intestines intact for proper absorption. Chewing or crushing the tablet destroys this coating. Talk to your pharmacist if you have difficulty swallowing pills.
No, you should not take this medicine if you have bipolar disorder, as it can trigger severe manic episodes. Talk to your doctor to explore alternative treatment options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Flat No 102, Pancom Business Centre, Vinod Chambers, Ameerpet, Hyderabad - 500016
Other Info - NUS0074

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