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compositionComposition:METHOXSALEN-10MG
prescription
Prescription Medicine
info
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Octrin 10 Tablet is used to treat psoriasis (scaly, itchy, and red patches on the skin), or vitiligo (discoloured patches in different areas of the body, including the skin, hair). It contains Methoxsalen, which is used alongside ultraviolet-A radiation. It works by reducing the number of cells the skin makes. It may cause side effects such as erythema (skin redness), oedema (swelling), blisters on the skin, and itching. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METHOXSALEN-10MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Octrin 10 Tablet

Octrin 10 Tablet is an oral prescription medication used to treat severe, stubborn skin conditions like disabling psoriasis, vitiligo, and certain skin-related cancers such as cutaneous T-cell lymphoma. It belongs to a group of medicines that make the skin highly sensitive to light, and it must always be used in combination with supervised ultraviolet light therapy. This combined approach helps to clear up abnormal skin cell growth and restore a healthier skin appearance.

You will only take this medicine on the specific days you are scheduled to receive light therapy, rather than as a daily treatment. It is best to take your prescribed dose with food or a glass of milk to prevent stomach upset. Because this medicine makes your skin and eyes extremely sensitive to light, you will need to make immediate lifestyle changes, such as wearing specialised protective eyewear and keeping your skin covered when outdoors.

While taking Octrin 10 Tablet, some people may experience mild, temporary side effects such as nausea, dizziness, headache, or skin itching. However, you must contact your doctor immediately if you notice serious signs, including severe skin burning, blistering, extreme redness, or changes in your vision. Monitoring your skin closely during treatment is a key part of staying safe.

Before starting this medication, tell your doctor if you have a history of liver disease, kidney problems, cataracts, or skin cancer. Do not take this if you are highly sensitive to sunlight, have medical conditions like lupus, or if you do not have the natural lens in your eye. Your doctor will help determine if this treatment is safe for your specific health history.

This medicine can interact with alcohol, tobacco, and other drugs that increase light sensitivity, which can raise your risk of severe burns. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, consult your healthcare provider before starting treatment. They will carefully weigh the benefits and risks for your specific group.

Uses of Octrin 10 Tablet

Octrin 10 Tablet is used together with ultraviolet (UV) light therapy to treat certain skin conditions and disorders that affect skin pigmentation or cause abnormal skin cell growth. Common uses include:

  • Severe Psoriasis: Helps control and clear thick, scaly, and painful plaques on the skin when other standard treatments have failed to work.
  • Vitiligo: Works with ultraviolet light to help restore natural pigment or color to patches of skin that have lost their colour.
  • Cutaneous T-cell Lymphoma: Helps manage and reduce skin lesions and plaques associated with this specific type of white blood cell cancer.
     

Key Benefits

By enhancing the effects of ultraviolet light therapy and helping normalise skin cell activity, Octrin 10 Tablet provides several important benefits, including:

  • Reduces Psoriasis Symptoms: Helps decrease scaling, redness, itching, and discomfort associated with severe psoriasis.
  • Promotes Skin Pigmentation: Encourages pigment-producing cells to restore colour to depigmented areas of skin in people with vitiligo.
  • Improves Skin Appearance: Supports clearer, healthier-looking skin by reducing visible lesions and plaques.
  • Helps Manage Chronic Skin Conditions: Provides an additional treatment option for skin disorders that may not respond adequately to standard therapies.
  • Enhances Physical Comfort and Confidence: Improvement in skin symptoms and appearance can contribute to greater comfort, self-confidence, and overall quality of life.
     
Side effects of Octrin 10 Tablet
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Octrin 10 Tablet can be taken with food or milk, or as advised by your doctor. Taking it with food helps to increase absorption of the medication and also decreases nausea.
  • It is usually taken 2 to 4 hours before your UVA light treatment. However, follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Octrin 10 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Octrin 10 Tablet Works

Octrin 10 Tablet is a photosensitising agent, which means it is completely inactive in your body until it is exposed to ultraviolet A (UVA) light. Once you take the capsule, the medicine travels through your bloodstream to your skin cells. When the specialist applies the UVA light to your skin, the light activates the medicine. Once activated, the medicine binds directly to the DNA of the overactive skin cells. This action slows down the rapid, uncontrolled division and growth of these cells. By normalising the rate at which your skin cells multiply, the treatment allows your skin to heal and reduces the buildup of scaly plaques and lesions.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Octrin 10 Tablet to avoid unpleasant side effects. Alcohol can make you dizzier.

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Pregnancy

Caution

It is not known whether Octrin 10 Tablet taken orally will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Caution

It is not safe to use Octrin 10 Tablet for breastfeeding mothers. Always ask your doctor because it causes risks to the baby.

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Driving

Unsafe

Octrin 10 Tablet usually causes dizziness and affects driving ability. Do not drive, use machinery, or do anything that requires alertness until you can do it safely.

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Liver

Caution

Octrin 10 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Octrin 10 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

This Octrin 10 Tablet is not recommended for children below 12 years. Therefore, it is not safe for children.

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Heart

Caution

Octrin 10 Tablet should be administered with caution in patients with heart problems.

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Geriatrics

Caution

Octrin 10 Tablet should be given with extreme caution in elderly patients as it can lead to age-related side effects.

What if I have taken an overdose of Octrin 10 Tablet

If you take more than your prescribed dose, or if you take it and do not receive light therapy, you must immediately protect yourself from all sunlight and artificial UV light. Seek emergency medical attention right away. You must stay in a dark or heavily shaded room for at least 24 hours to prevent severe skin burns and eye damage.

Diet & Lifestyle Advise

  • Protect your eyes: Wear specialized, UVA-absorbing wrap-around sunglasses for at least 24 hours after taking your medicine, even when you are indoors near windows. This protects your eyes from developing cataracts.
  • Cover your skin: Wear protective clothing, including long sleeves, long pants, a wide-brimmed hat, and gloves, for 24 hours after taking your dose to prevent accidental severe sunburn from regular sunlight.
  • Avoid light-sensitising foods: Do not eat foods that can naturally increase your skin's sensitivity to light, such as limes, figs, parsley, parsnips, mustard, carrots, and celery.
  • Moisturise your skin: Apply gentle, fragrance-free moisturising creams regularly to help soothe dry, itchy skin resulting from the treatment.
     
health query

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How Soon It Starts Working

The time required for Octrin 10 Tablet to start to work: The time required for Octrin 10 Tablet to start to work is 1 to 3 hours of administration. The time for which the effects of Octrin 10 Tablet last: The duration of action for Octrin 10 Tablet is unknown.

What if you forget to take Octrin 10 Tablet

Because this medicine must be taken at a very precise time before your scheduled light therapy session, missing a dose means you cannot undergo the light treatment. If you forget to take your dose at the correct time, do not take a double dose to make up for it. Contact your light therapy clinic or doctor immediately to reschedule your session and get instructions on your next dose.

Storage

•Store Octrin 10 Tablet capsules at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the bottle tightly closed and protect it from direct light, heat, and moisture.

Drug Warnings

  • Wear Protective Eyewear: Always wear your protective eyewear for the full 24 hours post-dose to prevent cataract formation.
  • Follow the Treatment Schedule Carefully: Strictly adhere to the specific time gap (usually 1.5 to 2 hours) between taking the pill and receiving light therapy.
  • Monitor Your Skin Regularly: Check your skin regularly for any new or changing moles, growths, or sores, and report them to your dermatologist immediately.
  • Avoid Additional UV Exposure: Avoid artificial tanning beds, sunbathing, or unnecessary outdoor activities for 24 hours after each dose.
  • Do Not Share Your Medication: Do not share this medicine with anyone else, even if they have similar skin symptoms.
     

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions

Octrin 10 Tablet can interact with medicines that increase sensitivity to ultraviolet light or alter the way the body processes the medication, including:

  • Other light-sensitising medicines: Taking Octrin 10 Tablet with tetracycline antibiotics, sulfa drugs, certain water pills (thiazide diuretics), or coal tar treatments can dangerously increase your risk of severe skin burns.
  • Phenytoin: May reduce the effectiveness of Octrin 10 Tablet by altering how your body processes the medicine.

Drug-Food Interactions

Certain foods contain natural compounds that can increase the skin's sensitivity to ultraviolet light and may raise the risk of treatment-related skin reactions, including:

  • Furanocoumarin-containing foods: Eating celery, carrots, parsnips, figs, parsley, or limes while taking this medicine can greatly increase your sensitivity to UV light and cause severe skin reactions.

Drug-Disease Interactions

Octrin 10 Tablet may not be suitable for people with conditions associated with light sensitivity, eye disorders, or impaired liver function, including:

  • Lupus and Porphyria: Do not take this if you have these conditions, as they naturally cause extreme sensitivity to light, which can lead to severe complications.
  • Aphakia: Do not take this if you lack a natural lens in your eye, as your risk of severe retina damage from light is highly increased.
  • Liver Damage: If you have liver issues, your body may struggle to clear this medicine, increasing the risk of side effects.
     
MethoxsalenAminolevulinic acid
Severe
MethoxsalenTizanidine
Severe

Drug-Drug Interactions

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MethoxsalenAminolevulinic acid
Severe
How does the drug interact with Octrin 10 Tablet:
Co-administration of Aminolevulinic acid and Octrin 10 Tablet together can increase the risk of sunburn.

How to manage the interaction:
Co-administration of Octrin 10 Tablet with Aminolevulinic acid can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a really bad sunburn, it's important to contact a doctor right away. Following treatment, you should avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours. Do not stop using any medications without talking to a doctor.
MethoxsalenTizanidine
Severe
How does the drug interact with Octrin 10 Tablet:
Taking Tizanidine with Octrin 10 Tablet may increase the risk of severe side effects.

How to manage the interaction:
Co-administration of Tizanidine with Octrin 10 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as drowsiness, dizziness, lightheadedness, fainting, and irregular heart rhythm. Do not stop using any medications without a doctor's advice.
MethoxsalenRasagiline
Severe
How does the drug interact with Octrin 10 Tablet:
Taking rasagiline with Octrin 10 Tablet may increases the blood levels of rasagiline.

How to manage the interaction:
Although there is an interaction between Octrin 10 Tablet and rasagiline, it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, blood pressure changes, nausea, vomiting, or hallucinations (seeing or hearing things that do not exist) contact a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSORIATICS]

FAQs

Octrin 10 Tablet is used to treat psoriasis (scaly, itchy, and red patches on the skin) and vitiligo (discoloured patches in different areas of the body, including the skin, hair).
Octrin 10 Tablet works by altering the way by which cells of the skin receive the ultraviolet light A (UVA) radiation, thus clearing up the disease.
Immediately contact your doctor if you did not takeOctrin 10 Tablet at the correct time. You may need to reschedule.
Avoid contact with artificial UV rays or sunlight other than your scheduled light treatment.
The common side effects of Octrin 10 Tablet include erythema (skin redness), oedema (swelling), blisters on the skin, and itching. If these side effects are persistent, please inform your doctor.
No. This medicine is inactive on its own and will not treat your skin condition unless it is activated by professional UVA light therapy. Always follow your doctor's treatment plan.
This medicine makes your eyes highly sensitive to ultraviolet light, which can cause cataracts to form. Wearing wrap-around, UVA-blocking sunglasses for 24 hours post-dose protects your eyes from damage.
No, it is highly recommended to take this medicine with food or a glass of milk. This helps prevent nausea and stomach upset. Talk to your doctor or pharmacist if stomach issues continue.
This medicine is generally not recommended during pregnancy or breastfeeding due to potential risks to the baby. Talk to your doctor or pharmacist to discuss safer alternative treatments.
Long-term use of this medicine combined with UVA light therapy (PUVA) can increase your risk of developing skin cancers, including melanoma. Your doctor will monitor your skin regularly to ensure safety.
It is best to avoid alcohol, as it can increase the risk of side effects like nausea and dizziness, and may affect how your liver processes the medicine. Talk to your doctor or pharmacist for guidance.

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