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Olkem Trio 12.5 Tablet is used to treat hypertension (high blood pressure). It effectively lowers elevated blood pressure, improves overall blood circulation, and supports better heart function. By controlling blood pressure, it reduces the risk of serious complications such as heart attack, stroke, and other cardiovascular problems, thereby promoting long-term heart health.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN MEDOXOMIL-20MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Olkem Trio 12.5 Tablet

Olkem Trio 12.5 Tablet is a tablet primarily used to treat high blood pressure (hypertension) when standard single or dual-medicine treatments are not enough. By controlling blood pressure, this medication helps protect your organs and reduces the risk of serious complications such as heart attacks, strokes, and kidney problems.

For the best results, you should take this medication consistently once a day, preferably at the same time each morning. It can be taken with or without food. Combining this daily treatment with healthy lifestyle choices, such as eating a low-salt diet and staying physically active, will help you manage your blood pressure more effectively.

While taking Olkem Trio 12.5 Tablet , some people may experience mild side effects like lightheadedness, mild headaches, or an increased need to urinate. However, if you notice severe symptoms such as swelling in your ankles or feet, chest pain, or rapid weight gain, you should consult your doctor immediately.

Talk to your doctor before starting this medicine if you have a history of kidney issues, liver damage, or heart failure. Do not take this medicine if you are pregnant, unable to produce urine (anuria), or have a history of severe allergic reactions to any of its ingredients. Patients with diabetes who are taking aliskiren-containing medicines should also discuss alternative treatment options with their doctor.

This medicine can interact with other blood pressure pills, potassium supplements, and common pain relievers, which may alter its effectiveness. Avoid drinking alcohol while taking this medicine because it can cause your blood pressure to drop too low, leading to fainting. Pregnant and breastfeeding women must not take this medication, and elderly individuals should consult their doctor for careful monitoring.

Uses of Olkem Trio 12.5 Tablet

Olkem Trio 12.5 Tablet is used to treat high blood pressure and help reduce the risk of cardiovascular complications associated with uncontrolled hypertension. The detailed uses of Olkem Trio 12.5 Tablet are as follows: 

  • Hypertension (High Blood Pressure): Olkem Trio 12.5 Tablet helps lower blood pressure when other medicines have not worked well enough on their own. By relaxing the blood vessels and removing excess fluid, it brings your blood pressure back into a safer, controlled range.
  • Prevention of Heart Attacks and Strokes: By maintaining healthy blood pressure levels, this medication reduces the overall workload on your heart, helping to prevent long-term damage to your cardiovascular system.
     

Key Benefits

Olkem Trio 12.5 Tablet combines three blood pressure-lowering medicines in a single tablet to provide comprehensive blood pressure control. This combination helps simplify treatment while supporting long-term cardiovascular and kidney health.

  • Comprehensive and Convenient Blood Pressure Control: By combining three complementary medicines into one tablet, this medication helps manage blood pressure effectively while reducing the complexity of taking multiple separate prescriptions.
  • Protection Against Long-Term Organ Damage: Regular use helps prevent the silent damage caused by uncontrolled high blood pressure, protecting the heart, blood vessels, and kidneys while reducing the risk of future cardiovascular complications.
     

Directions for Use

To get the safest and most effective results from your medication, follow these simple steps:

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can interfere with how the medicine is absorbed into your body.
  • Take your dose at the same time every day, preferably in the morning to prevent having to wake up during the night to urinate.
  • You may take this medication with or without food.

Always follow your doctor's exact instructions regarding your treatment. Do not stop taking this medicine suddenly, even if you feel completely healthy, as your blood pressure can rise quickly if treatment is interrupted.
 

How Olkem Trio 12.5 Tablet Works

Olkem Trio 12.5 Tablet contains olmesartan, cilnidipine, and chlorthalidone, which work together to help lower blood pressure through complementary mechanisms. Olmesartan is an angiotensin II receptor blocker (ARB) that prevents the action of angiotensin II, a natural substance that causes blood vessels to narrow. By blocking its effects, olmesartan helps blood vessels relax and widen, allowing blood to flow more easily. Cilnidipine is a calcium channel blocker that acts on both L-type and N-type calcium channels. It helps relax the muscles in blood vessel walls, leading to widening of the blood vessels and improved blood flow. Its action on N-type calcium channels may also help reduce excessive sympathetic nervous system activity, which can contribute to better blood pressure control. Chlorthalidone is a thiazide-like diuretic that helps the kidneys remove excess salt and water from the body through urine. This reduces the volume of fluid circulating in the bloodstream, helping to lower blood pressure. Together, these actions help improve blood flow, reduce strain on the heart and blood vessels, and provide effective control of high blood pressure.
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Alcohol

Unsafe

Olkem Trio 12.5 Tablet can lower your blood pressure, causing dizziness and drowsiness. It can also cause orthostatic hypotension (a sudden fall in blood pressure while standing). So try to avoid taking Olkem Trio 12.5 Tablet with alcoholic beverages.

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Pregnancy

Unsafe

Olkem Trio 12.5 Tablet is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Olkem Trio 12.5 Tablet as soon as possible and consult the doctor.

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Breast Feeding

Caution

Olkem Trio 12.5 Tablet passes into the breast milk, but its effect on the baby is not clear. Therefore, it is advisable to contact the doctor before intake of Olkem Trio 12.5 Tablet .

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Driving

Unsafe

Olkem Trio 12.5 Tablet may cause side effects, which could affect your ability to drive. Taking Olkem Trio 12.5 Tablet may lower your blood pressure.

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Liver

Caution

Olkem Trio 12.5 Tablet to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Not recommended in patients with chronic kidney disease (severe renal impairment). Safety and effectiveness in patients with severe renal impairment have not been established.

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Children

Unsafe

Olkem Trio 12.5 Tablet is not recommended in children. The safety and efficacy of Olkem Trio 12.5 Tablet in children have not yet been established.

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Heart

Caution

Olkem Trio 12.5 Tablet is often prescribed to patients with heart problems to treat hypertension. However, it must be taken strictly under medical supervision, as it can affect liver and kidney function and may interact with other heart medications.

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Geriatrics

Caution

Olkem Trio 12.5 Tablet should be taken with caution in geriatric patients. Please inform your doctor before using Olkem Trio 12.5 Tablet .

What if I have taken an overdose of Olkem Trio 12.5 Tablet

An overdose of Olkem Trio 12.5 Tablet may cause unpleasant effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Limit your sodium intake: Avoid adding extra salt to your meals and stay away from highly processed or canned foods, as sodium directly raises blood pressure.
  • Eat a heart-healthy diet: Incorporate more fresh fruits, vegetables, whole grains, and lean proteins into your meals to support your blood vessels.
  • Stay properly hydrated: Drink moderate amounts of water throughout the day. Because this medicine contains a diuretic, it is important to maintain a healthy balance of fluids.
  • Incorporate gentle exercise: Engage in moderate physical activities like brisk walking, cycling, or swimming for at least 30 minutes most days of the week, after consulting your doctor.
  • Avoid tobacco and limit alcohol: Smoking damages your blood vessels, and excessive alcohol can interfere with your medication, causing your blood pressure to fluctuate dangerously.
     
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How Soon It Starts Working

The time required for Olkem Trio 12.5 Tablet to start to work: The time required for Olkem Trio 12.5 Tablet to show its action is unknown.

The time for which the effects of Olkem Trio 12.5 Tablet last: The duration of action for Olkem Trio 12.5 Tablet is unknown.

What if you forget to take Olkem Trio 12.5 Tablet

If you miss a dose of Olkem Trio 12.5 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Olkem Trio 12.5 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the tablets in their original blister packaging to protect them from direct light, heat, and moisture. Avoid storing your medication in humid

Drug Warnings

  • Stand up slowly: This medication can make you dizzy when rising from a lying or sitting position. Take your time when standing up to prevent falls.
  • Keep a home blood pressure log: Check and record your blood pressure regularly at home so you can share these readings with your doctor during your checkups.
  • Watch for heavy sweating or dehydration: If you experience severe diarrhoea, vomiting, or excessive sweating, notify your doctor, as this can lead to dehydration and cause your blood pressure to drop too low.
  • Do not take potassium supplements: Avoid taking potassium supplements or using salt substitutes that contain potassium unless specifically advised by your doctor, as this medicine can affect your potassium levels.
  • Avoid driving if you feel dizzy: Do not drive, ride a bicycle, or operate machinery if you feel dizzy, sleepy, or less alert after taking your tablet.
  • Monitor Electrolytes: Keep all appointments for blood tests so your doctor can check your kidney health and monitor sodium, potassium, and uric acid levels. The chlorthalidone component may lower sodium and potassium levels and increase uric acid levels, which may trigger gout attacks in susceptible individuals.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Olkem Trio 12.5 Tablet :

  • Other blood pressure treatments: Combining Olkem Trio 12.5 Tablet with other blood pressure drugs, such as ACE inhibitors, can increase the risk of extremely low blood pressure and kidney strain.
  • NSAIDs (Pain relievers): Taking regular pain relievers like ibuprofen or naproxen can reduce the blood pressure-lowering effectiveness of this medicine and increase the risk of kidney damage.
  • Lithium: This medication can cause lithium levels in your blood to rise, which may lead to lithium toxicity.
  • Potassium supplements or sparing diuretics: Combining these can cause your blood potassium levels to become dangerously high.
  • Aliskiren: Combining Olkem Trio 12.5 Tablet with aliskiren is generally not recommended, particularly in patients with diabetes, as it may increase the risk of low blood pressure, kidney problems, and abnormal potassium levels. 

Drug-Food Interactions

The following foods and beverages may interact with Olkem Trio 12.5 Tablet and affect its safety or effectiveness:

  • Alcohol: Drinking alcohol while taking this medicine can cause severe dizziness, lightheadedness, and increase the risk of your blood pressure dropping too low.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Olkem Trio 12.5 Tablet , as it may worsen your condition or cause complications:

  • Kidney Disease: If you have severe kidney problems, this medicine should be used with extreme caution, as the diuretic component may not work well and can affect kidney function.
  • Liver Damage: Patients with impaired liver function require careful monitoring, as the liver helps process the active components of this medicine.
  • Anuria (Inability to urinate): Do not take this medication if you are unable to pass urine, as the diuretic component will be ineffective and can cause harm.
     
Olmesartan medoxomil + Cilnidipine + chlorthalidoneCisapride
Critical
Olmesartan medoxomil + Cilnidipine + chlorthalidoneAliskiren
Critical

Drug-Drug Interactions

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Olmesartan medoxomil + Cilnidipine + chlorthalidoneCisapride
Critical
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet and cisapride may increase the risk or severity of an irregular heart rhythm.

How to manage the interaction:
Taking chlorthalidone with Cisapride is not recommended as it can cause an interaction, they can be taken if advised by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult a doctor. Do not discontinue the medication without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneAliskiren
Critical
How does the drug interact with Olkem Trio 12.5 Tablet:
Using Olkem Trio 12.5 Tablet together with aliskiren may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Olkem Trio 12.5 Tablet with Aliskiren is not recommended as it can cause an interaction, they can be taken if advised by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat.It is crucial that you continue to consume enough fluids while taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneArsenic trioxide
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with arsenic trioxide may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet with arsenic trioxide may cause an interaction, it can be taken if a doctor has prescribed it. Consult a doctor, if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat. Do not stop taking any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidonePotassium citrate
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with potassium citrate may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet together with potassium citrate may result in an interaction, they can be taken together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneBenazepril
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with benazepril may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet with benazepril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneCaptopril
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
When Olkem Trio 12.5 Tablet is taken with captopril, it may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet with captopril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintaining an appropriate fluid intake is crucial when taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneAminolevulinic acid
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with Aminolevulinic acid may increase the risk of severe sunburn.

How to manage the interaction:
Taking Olkem Trio 12.5 Tablet together with Aminolevulinic acid can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a really bad sunburn, it's important to contact your doctor right away.It is recommended that you shield your eyes and skin from bright indoor lights or sunlight for 48 hours after treatment. Do not discontinue any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneDroperidol
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with droperidol may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet with droperidol may cause an interaction, it can be taken if a doctor has prescribed it. Consult a doctor, if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, tiredness, drowsiness, muscle pain, cramps, nausea, or vomiting. Do not stop taking any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidonepotassium phosphate
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Coadministration of Olkem Trio 12.5 Tablet with potassium phosphate may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet together with potassium phosphate can cause an interaction, it can be taken if a doctor has suggested it. However if you experience symptoms such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, consult a doctor. It is crucial that you continue to consume enough fluids while taking these medications. Do not discontinue any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneAmiodarone
Severe
How does the drug interact with Olkem Trio 12.5 Tablet:
Co-administration of Olkem Trio 12.5 Tablet with amiodarone may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Olkem Trio 12.5 Tablet with amiodarone may cause an interaction, it can be taken if a doctor has prescribed it. Consult a doctor, if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN MEDOXOMIL-20MGPotassium rich foods
Moderate

Drug-Food Interactions

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CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN MEDOXOMIL-20MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
When Olkem Trio 12.5 Tablet is taken along with potassium-containing salt substitutes or over-the-counter potassium supplements it may lead to high potassium levels in blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements with Olkem Trio 12.5 Tablet as this can lead to high potassium levels in the blood. However, consult a doctor if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Olkem Trio 12.5 Tablet is used to treat high blood pressure. It works by relaxing blood vessels, reducing the heart's workload and making the heart more efficient at pumping blood throughout the body. It also removes extra water and certain electrolytes from the body and efficiently reduces blood pressure.
Olkem Trio 12.5 Tablet is a combination of three medicines, namely Olmesartan medoxomil, Cilnidipine, and Chlorthalidone, which help lower raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the heart's blood vessels. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water and certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.
Yes, Olkem Trio 12.5 Tablet is contraindicated in people with known allergy to any of this medicine's components. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.
Yes, Olkem Trio 12.5 Tablet can cause dry mouth. Therefore, it is always advised to increase fluid intake while taking Olkem Trio 12.5 Tablet . If you still feel excessively thirsty, please consult your doctor and follow their advice for the best results.
Yes, Olkem Trio 12.5 Tablet is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists, consult your doctor and do what is advised.
Yes, Olkem Trio 12.5 Tablet can cause an upset stomach. So, it is preferred to take Olkem Trio 12.5 Tablet with food to avoid it.
High blood pressure during pregnancy may cause eclampsia, which can be harmful to both the baby and the mother. Therefore, during pregnancy, you should have regular blood pressure monitoring.
Olkem Trio 12.5 Tablet and Cilacar 10 are medications used to treat high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Olkem Trio 12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Cilacar 10 contains Cilnidipine.
Olkem Trio 12.5 Tablet and Benlong 4 mg are medications used to treat high blood pressure (hypertension). Still, they differ in their active ingredients and mechanism of action. Olkem Trio 12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Benlong 4 mg contains Benidipine.
Olkem Trio 12.5 Tablet and Telma 40 are medications for treating high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Olkem Trio 12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Telma 40 contains Telmisartan.
Olkem Trio 12.5 Tablet and Ciplar tablet differ in their composition and mechanism of action. Olkem Trio 12.5 Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone, while the Ciplar tablet contains Propranolol.
Common side effects of Olkem Trio 12.5 Tablet may include headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Olkem Trio 12.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Olkem Trio 12.5 Tablet can start showing its effect within one hour of its oral intake. However, it may take a few days to show its full effect, and this may vary from person to person.
Yes, Olkem Trio 12.5 Tablet can generally be taken on an empty stomach. However, it's always best to follow your doctor's instructions or as mentioned on the medication label.
No, you should not take Olkem Trio 12.5 Tablet or any other prescription medication on your own. Olkem Trio 12.5 Tablet is a prescription medication used to treat high blood pressure. Consult with a healthcare professional before starting any new medication, including Olkem Trio 12.5 Tablet , is essential. They can diagnose your condition accurately and prescribe the correct dosage.
No, you should not drink alcohol while taking this medication. Alcohol can increase the risk of side effects, such as dizziness and lightheadedness.
No, you should not drink grapefruit juice while taking this medication. Grapefruit juice can interact with this medication and increase the risk of side effects.
Olkem Trio 12.5 Tablet may interact with certain medications. So, you should talk to your doctor before taking any over-the-counter medications, such as pain relievers or cold medications, while taking this medication.
Your doctor will monitor your blood pressure to evaluate if this medicine is effective. You may also experience less symptoms, such as headaches or dizziness.
The long-term effects of taking this medicine remain unclear. However, the majority of people who use this drug do not encounter any serious long-term negative effects.
Olkem Trio 12.5 Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.
Olkem Trio 12.5 Tablet is not recommended in children. The safety and efficacy of Olkem Trio 12.5 Tablet in children have not yet been established.
No, you must not take Olkem Trio 12.5 Tablet if you are pregnant or planning to become pregnant. The ingredients in this medicine can cause serious injury or death to an unborn baby, particularly if taken during the second and third trimesters. If you discover you are pregnant, stop taking this medicine immediately and talk to your doctor.
Blood pressure may begin to respond within the first few days of treatment, but it typically takes 2 to 4 weeks of regular use to achieve a stable blood-pressure-lowering effect. Continue taking the medicine exactly as prescribed, even if you do not notice immediate changes. Talk to your doctor if you have questions about your progress.
This medicine contains a diuretic component, which helps your body get rid of excess water and salt. This naturally increases the frequency of your urination, especially when you first start the treatment. To avoid waking up during the night, try taking your tablet in the morning, and talk to your doctor if this becomes a concern.
Many salt substitutes contain high levels of potassium instead of sodium. Because Olkem Trio 12.5 Tablet can alter the way your kidneys manage potassium, using these substitutes can cause a dangerous buildup of potassium in your blood. Talk to your doctor or pharmacist before using any salt alternatives.
Dizziness is a common side effect when starting this medication or when your doctor is gradually increasing your dose. If you feel dizzy, sit or lie down immediately until the feeling passes. Avoid standing up too quickly. Talk to your doctor if the dizziness persists or makes you feel unsafe.
No, you should not stop taking this medicine without consulting your healthcare provider. High blood pressure is a chronic condition that is managed, not cured, by medication. Stopping your medicine suddenly can cause your blood pressure to rise rapidly, increasing your risk of a stroke or heart attack. Talk to your doctor about long-term management.
This medicine can make some people feel dizzy, tired, or lightheaded, especially during the first few days of treatment or after a dose change. Do not drive or operate machinery until you are certain of how this medication affects you. Talk to your doctor if you experience persistent sleepiness or dizziness.
Take your missed tablet as soon as you remember on that day. However, if it is almost time for your next scheduled dose, skip the missed one entirely and continue with your regular schedule. Do not take two doses at once to make up for a missed tablet. Talk to your doctor or pharmacist if you have trouble remembering your doses.
Breastfeeding is generally not recommended while taking Olkem Trio 12.5 Tablet because some components may pass into breast milk or affect the nursing infant. If you are breastfeeding or planning to breastfeed, talk to your doctor about safer treatment options that may be appropriate for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8787 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 019574S016Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 202331Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Pmc3905258 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Olmesartan Medoxomil Amlodipine And Hydrochlorothiazide Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Olmesartan medoxomil. 2009. [Accessed on 11 Apr. 2019]Check here
  7. PubChem PubChem. [Accessed on 11 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - OLK0010
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