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compositionComposition:BORTEZOMIB-2MG
prescription
Prescription Medicine
info
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Onbort 2 mg Injection is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BORTEZOMIB-2MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Onbort 2 mg Injection

Onbort 2 mg Injection is a prescribed injection used to treat certain types of cancers, specifically multiple myeloma and mantle cell lymphoma. It works by targeting and slowing the growth of abnormal cells in the body, helping to manage these serious conditions. This medicine is a key component of cancer therapy and is carefully managed by medical specialists.

This medicine is injected in a healthcare setting by a trained professional, usually in weekly or multi-week cycles. Consistent scheduling is essential for the treatment to work effectively, and keeping all your clinic appointments is critical. While you do not need to avoid food before your injection, staying highly hydrated throughout your treatment cycle is highly recommended to protect your kidneys.

Some people may experience common side effects like nausea, tiredness, diarrhoea, and a temporary drop in blood cell counts. It is vital to consult your doctor immediately if you experience severe symptoms, such as sudden shortness of breath, severe nerve pain, or swelling in your hands or feet. Your healthcare team will monitor you closely during each cycle to manage these issues.

Do not take this if you are allergic to any of its components or boron. Before starting treatment, tell your doctor if you have a history of liver damage, kidney disease, heart problems, diabetes, or nerve pain. This medicine may not be suitable for individuals with certain pre-existing nerve conditions.

This medicine can interact with other substances, including alcohol, which can worsen dizziness and dehydration. You should also tell your doctor about all other medicines you take, as some can increase the risk of nerve damage or change how Onbort 2 mg Injection works in your body. Pregnant or breastfeeding women should not receive this medicine, and elderly individuals may require closer monitoring for side effects.

Uses of Onbort 2 mg Injection

Your doctor may prescribe this medicine to treat several conditions, including:

  • Multiple myeloma: Onbort 2 mg Injection helps slow the growth and spread of multiple myeloma cells, helping control the disease and reduce related complications.
  • Mantle cell lymphoma: This medicine helps destroy lymphoma cells and slows disease progression in people with mantle cell lymphoma.

Key Benefits

Onbort 2 mg Injection helps treat certain blood cancers by blocking the growth and survival of cancer cells. It helps control disease progression, reduce cancer-related symptoms, and improve treatment outcomes when used alone or in combination with other anticancer medicines.

  • Helps Control Cancer Growth: It slows the multiplication of cancer cells, helping manage multiple myeloma and mantle cell lymphoma.
  • Reduces Cancer-Related Symptoms: By controlling the disease, it may help reduce bone pain, fatigue, and other symptoms associated with these cancers.
  • Supports Long-Term Disease Management: When used as prescribed, it helps improve treatment response and prolong periods of disease control.
Side effects of Onbort 2 mg Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Onbort 2 mg Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Onbort 2 mg Injection Works

Onbort 2 mg Injection contains bortezomib, which belongs to a group of medicines called proteasome inhibitors. Proteasomes are structures inside cells that break down damaged or unnecessary proteins. Cancer cells depend heavily on proteasomes to survive and multiply. Onbort 2 mg Injection blocks the activity of proteasomes, causing unwanted proteins to accumulate inside cancer cells. This buildup disrupts normal cell function, leading to cancer cell death while helping slow the progression of the disease.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Onbort 2 mg Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Onbort 2 mg Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Onbort 2 mg Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Onbort 2 mg Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Onbort 2 mg Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Onbort 2 mg Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Onbort 2 mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Onbort 2 mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Onbort 2 mg Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

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Heart

Caution

Onbort 2 mg Injection should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Onbort 2 mg Injection.

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Geriatrics

Caution

Onbort 2 mg Injection should be administered with caution in elderly patients due to an increased risk of side effects. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Onbort 2 mg Injection

Since this medicine is administered under medical supervision, overdose is uncommon. If an overdose is suspected, you will receive immediate medical monitoring and supportive treatment.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink plenty of fluids before and after treatment unless your doctor advises otherwise.
  • Prevent infections: Wash your hands frequently, avoid close contact with people who are ill, and promptly report fever or signs of infection.
  • Protect your hands and feet: Wear comfortable footwear and avoid activities that may worsen numbness or tingling if you develop peripheral neuropathy.
  • Eat a balanced diet: Consume nutritious meals and small, frequent meals if nausea or loss of appetite occurs.
health query

Have a query?

How Soon It Starts Working

The time required for Onbort 2 mg Injection to start to work: Onbort 2 mg Injection ideally shows its action within 1 hour after administration. The time for which the effects of Onbort 2 mg Injection last: The duration of action for Onbort 2 mg Injection is clinically unknown.

What if you forget to take Onbort 2 mg Injection

Because this medicine is administered by a healthcare professional, a missed dose usually means a missed appointment. Contact your healthcare provider as soon as possible to arrange another appointment. Do not attempt to receive a double dose.

Storage

• Onbort 2 mg Injection is usually stored, prepared, and administered by healthcare professionals.

Drug Warnings

  • Attend all follow-up appointments: Regular blood tests and medical check-ups help your doctor monitor your response to treatment and detect side effects early.
  • Report nerve-related symptoms promptly: Tell your doctor immediately if you experience numbness, tingling, burning pain, or weakness in your hands or feet.
  • Rise slowly from sitting or lying down: This medicine may cause dizziness or low blood pressure, especially when you first start treatment.
  • Watch for signs of infection or bleeding: Contact your doctor immediately if you develop fever, sore throat, unusual bruising, bleeding, or any signs of infection.
  • Inform your healthcare provider about all medicines: Tell your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking before starting or during treatment.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all medicines you are taking before starting this medicine.

  • Strong CYP3A4 inhibitors (such as ketoconazole) may increase Onbort 2 mg Injection exposure and the risk of side effects.
  • Strong CYP3A4 inducers (such as rifampicin, carbamazepine, phenytoin, or St. John's wort) may reduce the effectiveness of Onbort 2 mg Injection.
  • Medicines that may cause peripheral neuropathy (such as certain chemotherapy medicines) may increase the risk of nerve damage.
  • Antidiabetic medicines: Blood glucose levels may fluctuate during treatment, requiring closer monitoring and possible dose adjustments.
BortezomibNatalizumab
Severe
BortezomibGolimumab
Severe

Drug-Drug Interactions

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BortezomibNatalizumab
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of Onbort 2 mg Injection and natalizumab can increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and natalizumab together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibGolimumab
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of golimumab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Golimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibPhenobarbital
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of Onbort 2 mg Injection and phenobarbital may reduce the blood levels of Onbort 2 mg Injection, which may make the medication less effective in treating a condition.

How to manage the interaction:
Although using Onbort 2 mg Injection and Phenobarbital together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
BortezomibRifabutin
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of Onbort 2 mg Injection and rifabutin may reduce the blood levels of Onbort 2 mg Injection.

How to manage the interaction:
Although using Onbort 2 mg Injection and Rifabutin together can possibly result in an interaction, they can be taken together if prescribed by a doctor. Do not stop taking any medications without consulting a doctor.
BortezomibCertolizumab
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of certolizumab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibInfliximab
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of infliximab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Infliximab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibVoclosporin
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of voclosporin and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibTofacitinib
Severe
How does the drug interact with Onbort 2 mg Injection:
Taking tofacitinib and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Tofacitinib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibSamarium (153sm) lexidronam
Severe
How does the drug interact with Onbort 2 mg Injection:
Using samarium (153sm) lexidronam together with Onbort 2 mg Injection may increase the risk of side effects

How to manage the interaction:
Co-administration of Onbort 2 mg Injection with Samarium (153sm) lexidronam can possibly result in an interaction; they can be taken if your doctor has advised it. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
BortezomibDeferiprone
Severe
How does the drug interact with Onbort 2 mg Injection:
Coadministration of deferiprone and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Deferiprone together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, body sores, or burning during urination. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no clinically significant food interactions established for Onbort 2 mg Injection.
  • Follow your doctor's advice regarding diet and hydration during treatment.
BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Onbort 2 mg Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Onbort 2 mg Injection is used to treat multiple myeloma (a cancer of plasma cells) and mantle cell lymphoma (blood cancer).
Onbort 2 mg Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.
Onbort 2 mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Onbort 2 mg Injection must not be administered into your spinal fluid (intrathecally).
Yes, Onbort 2 mg Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Avoid taking Onbort 2 mg Injection if you are pregnant because Onbort 2 mg Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Onbort 2 mg Injection.
Before you receive treatment with Onbort 2 mg Injection, tell your doctor about all of your medical conditions. You should not receive Onbort 2 mg Injection if you are allergic to bortezomib or any contents in Onbort 2 mg Injection.
If not given an inappropriate dose, Onbort 2 mg Injection can cause toxic effects, although not everyone gets it. So, Onbort 2 mg Injection is prescribed by a doctor experienced in using medications to treat cancer only.
Onbort 2 mg Injection contains bortezomib as its active substance. It belongs to a group of anti-cancer medicines.
No, Onbort 2 mg Injection does not have any habit-forming potential.
Your doctor decides the dose of Onbort 2 mg Injection based on your medical condition. Taking a double dose can lead to potential side effects.
You should call your doctor right away if you experience side effects like wheezing, chest tightness, swelling of the face or throat, difficulty breathing, seizures, or any unusual skin reactions. Also, seek immediate medical help if you have a sudden change in vision, numbness or tingling, severe stomach issues, unexplained bruising or bleeding, or if your symptoms worsen. Always contact your doctor if you notice any concerning changes in your condition.
You will know if Onbort 2 mg Injection is working by noticing improvements in your condition. Regular scans will show if your tumor is reacting to the treatment. Your doctor will decide when these scans should be done. Always follow the doctor's advice as they will monitor your progress to assess its effectiveness.
To minimize the risk of infection while using Onbort 2 mg Injection, maintain good hygiene, wash your hands frequently, and avoid contact with sick people. Protect any open wounds and be cautious with food handling. Take care not to harm yourself when using sharp objects like razor or nail cutters. Use a toothbrush with soft bristles to stop gum bleeding.
Onbort 2 mg Injection may affect your lungs. However, it might cause allergies with symptoms like trouble breathing or chest tightness. If this happens, stop using Onbort 2 mg Injection and get medical attention immediately
Yes, Onbort 2 mg Injection may cause hair loss. If you experience unexpected hair thinning or loss, consult your doctor to avoid potential causes or talk if you have any concerns.
Avoid putting prolonged pressure on your limbs, maintain proper posture, be cautious when moving around and follow your doctor's recommendations for managing the symptoms. If you experience tingling or numbness in your arms or legs, inform your doctor immediately, as these could indicate nerve-related issues.
It is important to avoid prolonged sun exposure and UV light, as Onbort 2 mg Injection can make your skin more sensitive. Wear protective clothing, sunglasses, and sunscreen to shield your skin. Keep track of your symptoms and consult your doctor to determine if Onbort 2 mg Injection is the cause. Your doctor may adjust your treatment or suggest ways to manage the skin changes. Always follow their advice to ensure the treatment remains safe and effective.
To relieve constipation during treatment, focus on eating more fibre, staying hydrated, and staying active with light exercise. You can also consider using stool softeners after consulting your doctor. Establishing a routine for bowel movements and avoiding strain can also help. Always talk to your healthcare provider before trying new remedies.
You may experience nausea and extreme tiredness due to Onbort 2 mg Injection, as these are among the side effects.These do not require any medical treatment as they will gradually reduce over time. However, please contact a doctor if these persist longer.
If you are experiencing a change in taste while using Onbort 2 mg Injection, try staying hydrated, by using sugar-free gum or mint. Practicing good oral hygiene by brushing your teeth and tongue can also help. If the issue persists, consult your doctor for further advice on managing the side effect.
It is given as an injection by a healthcare professional, either into a vein (intravenously) or under the skin (subcutaneously), usually in a clinic or hospital.
No, you should avoid high-dose Vitamin C supplements, as they can interfere with how the medicine works. Talk to your doctor before taking any supplements.
Inform your doctor immediately. Numbness or tingling can be a sign of nerve damage, and your healthcare team may need to adjust your dose. Talk to your doctor about any nerve changes.
It is a targeted therapy known as a proteasome inhibitor. While it acts on cancer cells to destroy them, it works differently than traditional chemotherapy.
It is best to avoid or limit alcohol, as it can increase the risk of severe dehydration, dizziness, and strain on your liver. Talk to your doctor for personal advice.
Significant hair loss is uncommon with this specific medicine, though some mild thinning can happen in some cases. Talk to your doctor if you are concerned about this.
Cycles typically last between 21 and 35 days, with the injection given on specific days followed by rest days. Your doctor will determine the exact schedule for your condition.
No, this medicine can harm an unborn baby. You must use effective birth control during treatment and for a period after your last dose. Talk to your doctor immediately if you suspect you are pregnant.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - ONB0018
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