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compositionComposition:ONDANSETRON-2MG
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Prescription Medicine
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Ondamac Injection 2 ml is an antiemetic medication used in the treatment and prevention of nausea and vomiting during chemotherapy. This medication contains ondansetron which functions by inhibiting the activity of serotonin, a neurotransmitter that activates the brain's vomiting center (chemoreceptor trigger zone, or CTZ).

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ONDANSETRON-2MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Ondamac Injection 2 ml

Ondamac Injection 2 ml is an injection used to prevent and treat severe nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It works by blocking the natural chemical pathways in your body that trigger the urge to throw up. By controlling these symptoms, it helps you undergo your medical treatments with much greater physical ease.

This medicine is injected either before your treatment begins or during your recovery, with the frequency determined by your medical team. Since it is given as an injection, it bypasses your stomach entirely, making it highly reliable even if you are currently unable to keep food or liquids down. To support your recovery, it is also helpful to make simple changes such as resting in a quiet, cool room and avoiding strong odours.

While this medicine is highly effective, some people may experience mild side effects, such as headaches or constipation. If you develop serious symptoms, such as a fast or irregular heartbeat, severe dizziness, or fainting, you must contact your doctor immediately.

Do not take this if you are currently using apomorphine, as this can lead to a dangerous drop in blood pressure. Before starting therapy, make sure to tell your healthcare provider if you have a history of liver damage, heart rhythm problems, or low levels of potassium or magnesium in your blood.

This medicine can interact with other prescription drugs, especially those that affect your heart rhythm or serotonin levels. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits for your specific situation.

Uses of Ondamac Injection 2 ml

Ondamac Injection 2 ml helps prevent and control nausea and vomiting caused by cancer treatment, radiotherapy, and surgery. Your doctor may recommend it for the following conditions:

  • Chemotherapy-induced nausea and vomiting: Ondamac Injection 2 ml helps by blocking the signals in the brain and gut that trigger vomiting during cancer treatments.
  • Radiotherapy-induced nausea and vomiting: Ondamac Injection 2 ml prevents stomach upset and retching caused by radiation therapies.
  • Postoperative nausea and vomiting: Ondamac Injection 2 ml is injected before or after surgery to stop sickness as anaesthesia wears off.

Key Benefits

Ondamac Injection 2 ml helps provide fast and effective relief from nausea and vomiting, improving comfort during medical treatment. Key benefits include:

  • Provides rapid relief: As an injection, it works quickly to prevent and control nausea and vomiting.
  • Supports hydration and nutrition: Helps you keep down fluids and food, reducing the risk of dehydration and weakness.
  • Improves comfort during treatment: Helps make chemotherapy, radiotherapy, and recovery after surgery more comfortable.
  • Supports smoother recovery: Reduces the physical strain of repeated vomiting, promoting a more comfortable recovery after surgery or medical treatment.
Side effects of Ondamac Injection 2 ml
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink plenty of fluids to stay hydrated and replace the lost electrolytes.
  • Eat small, frequent meals of bland foods like crackers, toast, or plain rice.
  • Avoid heavy or fatty foods that can worsen nausea.
  • Use relaxation techniques like deep breathing or meditation to manage stress and anxiety.
  • Minimize exposure to strong smells or odors that can trigger nausea.
  • Ensure good airflow in the room by keeping it well-ventilated and maintaining a comfortable temperature.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Ondamac Injection 2 ml will be administered by the doctor.
  • Do not self-administer.

How Ondamac Injection 2 ml Works

Ondamac Injection 2 ml contains ondansetron, which works by targeting specific nerve pathways in your body. During chemotherapy, radiation, or surgery, your body releases a natural chemical called serotonin in your gut and brain. This chemical binds to specific sensors (receptors) that tell your brain it is time to vomit. ondansetron blocks these serotonin sensors. By stopping serotonin from binding to these receptors, Ondamac Injection 2 ml prevents the nerve signals from reaching the vomiting centre of your brain, successfully cutting off the nausea reflex before it can start.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Ondamac Injection 2 ml as this medicine can interact with alcohol and may worsen the side effects.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before taking Ondamac Injection 2 ml. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

If you are a nursing mother, inform your doctor before taking Ondamac Injection 2 ml. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Driving

Caution

Ondamac Injection 2 ml usually does not affect your driving ability. However, do not drive if you feel any discomfort.

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Liver

Caution

Take Ondamac Injection 2 ml with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Safe if prescribed

Ondamac Injection 2 ml may be safe to use in patients with kidney problems if prescribed by a doctor.

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Children

Consult your doctor

Ondamac Injection 2 ml should be used in children only in doses advised by the doctor based on child’s body weight or body surface area.

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Heart

Caution

Ondamac Injection 2 ml may be used in heart patients but requires caution due to risk of QT prolongation. ECG monitoring is advised to prevent serious arrhythmias, especially in those with existing cardiac conditions.

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Geriatrics

Caution

Ondamac Injection 2 ml can be used in geriatric patients, but with caution. Older adults may be more sensitive to side effects like QT prolongation, so ECG monitoring is often recommended during treatment.

What if I have taken an overdose of Ondamac Injection 2 ml

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include sudden vision loss, severe constipation, extreme lightheadedness, or a fainting spell.

Diet & Lifestyle Advise

  • Eat small, frequent meals: Eat small, frequent meals rather than three large ones to keep your stomach from feeling overly full.
  • Stay hydrated: Sip clear, cool fluids like water or clear broths slowly throughout the day to stay hydrated.
  • Avoid trigger foods: Avoid greasy, fatty, highly spiced, or extremely sweet foods, as these are more likely to trigger nausea.
  • Stay upright after meals: Sit upright for at least 30 to 60 minutes after eating or drinking to assist your digestion.
  • Avoid strong odours: Keep your living spaces well-ventilated and free from strong odours, such as cooking smells, perfumes, or tobacco smoke.
health query

Have a query?

How Soon It Starts Working

  • The time required for Ondamac Injection 2 ml to start to work: Ondamac Injection 2 ml ideally shows its action within 30 minutes after administration.
  • The time for which the effects of Ondamac Injection 2 ml last: The duration of action for Ondamac Injection 2 ml is unknown.

What if you forget to take Ondamac Injection 2 ml

Because this injection is usually given by a healthcare professional before a medical procedure, it is unlikely that you will miss a dose. If you are using this medicine at home and miss a scheduled injection, contact your doctor or pharmacist right away for advice. Do not inject a double dose to make up for a missed one.

Storage

• Store Ondamac Injection 2 ml at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect before use: Always inspect the injection liquid before use. If it is cloudy, discoloured, or contains any floating particles, do not inject it.
  • Do not self-inject without training: Do not attempt to self-inject this medicine unless you have received formal training from a healthcare professional.
  • Rotate injection sites: If you are injecting this medicine at home, rotate your injection sites each time to help prevent skin irritation or tissue damage.
  • Be cautious with activities: This medicine may cause dizziness or drowsiness. Do not drive, operate machinery, or perform tasks requiring alertness until you know how it affects you.
  • Seek immediate medical help if needed: Contact your healthcare team immediately if you experience chest tightness, sudden shortness of breath, or a racing pulse during or shortly after the injection.

Drug-Drug Interactions

verifiedApollotooltip
  • Apomorphine: Do not take this if you are using apomorphine, as the combination can cause a severe, life-threatening drop in blood pressure and loss of consciousness.
  • Heart rhythm medicines: Combining Ondamac Injection 2 ml with other medicines that affect your heart rhythm can increase the risk of serious, irregular heartbeats.
  • Serotonergic medicines (like SSRI or SNRI antidepressants): Combining these can lead to a rare but severe condition called serotonin syndrome, causing high fever, agitation, and muscle stiffness.
OndansetronZiprasidone
Critical
OndansetronOsimertinib
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Ondamac Injection 2 ml:
Taking Ondamac Injection 2 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ondamac Injection 2 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronOsimertinib
Severe
How does the drug interact with Ondamac Injection 2 ml:
Taking Ondamac Injection 2 ml with Osimertinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with Osimertinib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronMirtazapine
Severe
How does the drug interact with Ondamac Injection 2 ml:
Using Ondamac Injection 2 ml with mirtazapine might raise serotonin hormone levels in the body, affects the brain and nerve cells.

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronPanobinostat
Severe
How does the drug interact with Ondamac Injection 2 ml:
Taking Ondamac Injection 2 ml with Panobinostat increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with Panobinostat can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronAlmotriptan
Severe
How does the drug interact with Ondamac Injection 2 ml:
When Ondamac Injection 2 ml, is taken with almotriptan it can cause serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with almotriptan can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronFluvoxamine
Severe
How does the drug interact with Ondamac Injection 2 ml:
When Ondamac Injection 2 ml is taken with fluvoxamine, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with fluvoxamine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronFentanyl
Severe
How does the drug interact with Ondamac Injection 2 ml:
Taking fentanyl with Ondamac Injection 2 ml may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking fentanyl with Ondamac Injection 2 ml can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.
OndansetronIvabradine
Severe
How does the drug interact with Ondamac Injection 2 ml:
Coadministration of Ondamac Injection 2 ml with ivabradine can increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with ivabradine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronEfavirenz
Severe
How does the drug interact with Ondamac Injection 2 ml:
Taking Ondamac Injection 2 ml with efavirenz increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondamac Injection 2 ml along with efavirenz can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronDoxepin
Severe
How does the drug interact with Ondamac Injection 2 ml:
When Ondamac Injection 2 ml is taken with doxepin, it can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Ondamac Injection 2 ml along with doxepin can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Ondamac Injection 2 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Yes. Constipation is a recognised side effect of Ondamac Injection 2 ml, although not everyone experiences it. Drinking plenty of fluids, eating a fibre-rich diet, and staying physically active may help. Contact your doctor if constipation is severe, persistent, or accompanied by severe abdominal pain.
Yes, but only if you have been thoroughly trained by a healthcare professional on how to prepare, inject, and safely dispose of the medicine. Otherwise, it should always be given by a doctor or nurse. Talk to your doctor if you have questions about home administration.
You should only use this medicine during pregnancy if your doctor decides that the benefits outweigh the potential risks to the developing baby. Talk to your doctor to discuss safer alternatives.
It is highly recommended to avoid alcohol, as it can worsen side effects like dizziness and drowsiness, and can also irritate your stomach, making your nausea worse. Talk to your doctor for personalised advice.
Mild, temporary pain or redness at the injection site is common. However, if you notice severe pain, swelling, warmth, or pus, contact your healthcare provider right away, as these could be signs of an infection. Talk to your doctor if the pain persists.
Yes, it is widely used in older adults, but they may be more sensitive to certain side effects, especially changes in heart rhythm. Talk to your doctor to ensure the dose is tailored safely for you.
No, this medicine is not effective for motion sickness, as it targets different pathways in the body than those involved in inner-ear balance. Talk to your doctor or pharmacist to find an appropriate motion sickness treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - OND0010

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