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compositionComposition:CLOBAZAM-10MG
prescription
Prescription Medicine
info
ORESTA 10MG TABLET
ORESTA 10MG TABLET

ORESTA 10MG TABLET is used to treat epilepsy (fits) and severe anxiety over a short period. Also, it is used in combination with other medicines to treat schizophrenia (a mental illness). It prevents fits by stabilizing the electrical activity of nerve cells in the brain. Also, it calms nerve cells and helps in reducing anxiety and induces sleep. Some people may experience side effects such as restlessness, irritability, drowsiness, constipation, aggressive behaviour, tiredness or breathing problems. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLOBAZAM-10MG

Manufacturer/Marketer :

Canvas Biotech

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About ORESTA 10MG TABLET

ORESTA 10MG TABLET is a prescription medicine used alongside other treatments to manage severe seizures, particularly those associated with a rare form of epilepsy called Lennox-Gastaut syndrome. It belongs to a group of medicines that help calm excessive electrical activity in the brain to prevent sudden seizure episodes.

To ensure this medicine works effectively, you must take it consistently at the same times every day as directed by your healthcare professional. You can take ORESTA 10MG TABLET with or without food, but keeping your routine consistent is essential. Making practical adjustments, such as maintaining a regular sleep schedule and avoiding sensory seizure triggers, can also help support your overall seizure management.

While taking ORESTA 10MG TABLET, some individuals may experience mild side effects like drowsiness or dizziness. If you notice any serious side effects, such as breathing difficulties, extreme sleepiness, or unusual changes in your mood, you must contact your doctor immediately.

Do not take this if you have a known allergy to similar medications or severe liver problems. It is crucial to talk to your doctor before starting this medicine if you have a history of depression, kidney issues, muscle weakness, or breathing difficulties.

This medicine can interact with other drugs that cause drowsiness, as well as alcohol, which can significantly increase the risk of severe breathing issues. Speak to your doctor or pharmacist if you are pregnant, breastfeeding, planning a pregnancy, or if you are an older adult, as special precautions may be needed.

Uses of ORESTA 10MG TABLET

Your doctor may prescribe ORESTA 10MG TABLET to treat several conditions, including:

  • Severe seizures (Lennox-Gastaut syndrome): ORESTA 10MG TABLET is used as an add-on treatment to help decrease the frequency and severity of seizures in adults and children.
  • Severe anxiety: In specific, short-term situations, doctors may prescribe this medicine to help manage severe, disabling anxiety that has not responded to other treatments.

Key Benefits

When taken as prescribed, ORESTA 10MG TABLET offers several important benefits, including::

  • Helps reduce seizure frequency: As an add-on treatment, ORESTA 10MG TABLET helps improve seizure control in people with severe epilepsy, including Lennox-Gastaut syndrome.
  • Supports safer daily activities: Better seizure control may reduce disruptions caused by sudden seizure episodes and improve confidence during everyday activities.
  • Provides calming effects in specific situations: When prescribed for severe anxiety, ORESTA 10MG TABLET may help reduce overwhelming feelings of fear, tension, and restlessness under careful medical supervision.
  • Improves overall quality of life: By helping manage seizures or severe anxiety symptoms, this medicine may support better daily functioning and emotional well-being.
Side effects of Oresta 10mg Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Stay hydrated by drinking plenty of water to make swallowing easier.
  • Maintaining dental health and minimizing irritation that could cause drooling can be achieved with regular brushing and flossing.
  • Eat smaller, more frequent meals to reduce saliva production and manage drooling.
  • Good posture can help you stop drooling. Hold your head up straight and raise your chin a little.
  • Avoid spicy foods like chili peppers, wasabi, and horseradish, as they can increase saliva production and worsen drooling.
  • Try natural products like papaya juice, dark grape juice, or sage tea.
  • Contact your doctor for alternative options if these strategies and exercises don't improve saliva management.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.

Directions for Use

Always take this medicine exactly as your doctor has instructed. Follow these general guidelines for taking this medicine by mouth:

  • If you are taking tablets, swallow them whole with a glass of water. If your doctor has approved it, some tablets may be crushed and mixed with a small amount of applesauce, but always check with your pharmacist first.
  • If you are using the liquid form, shake the bottle thoroughly before each dose. Always use the special dose-measuring device or syringe provided with the medicine to measure your dose accurately; do not use a regular household spoon.
  • You may take this medicine with or without food, but try to take it the same way each time.

Your doctor will determine the right schedule for you. Never change your dose or stop taking this medication without consulting your healthcare provider first.

How ORESTA 10MG TABLET Works

ORESTA 10MG TABLET contains clobazam. It works directly on your central nervous system to calm down overactive electrical activity in the brain. It does this by boosting the effects of a natural chemical messenger in your body called gamma-aminobutyric acid (GABA). GABA acts as a natural brake system for the brain, sending signals that tell hyperactive nerve cells to slow down. By enhancing this calming chemical, ORESTA 10MG TABLET stabilises the brain’s electrical signals, helping to prevent the sudden, rapid nerve firing that leads to seizures or intense anxiety.
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Alcohol

Unsafe

Avoid consumption of alcohol with ORESTA 10MG TABLET as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

ORESTA 10MG TABLET is a Category C pregnancy drug. It is not recommended for use during pregnancy, especially in the second and third trimesters as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking ORESTA 10MG TABLET as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

ORESTA 10MG TABLET may cause dizziness, double vision or drowsiness in some people. It is an offence to drive if ORESTA 10MG TABLET affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking ORESTA 10MG TABLET.

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Liver

Caution

Take ORESTA 10MG TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take ORESTA 10MG TABLET with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

ORESTA 10MG TABLET is not recommended for children below 6 years. However, ORESTA 10MG TABLET may be used in children above 6 years in dose and duration as prescribed by a doctor.

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Heart

Consult your doctor

Please consult your doctor before using ORESTA 10MG TABLET if you have pre-existing heart problems. Your doctor will prescribe ORESTA 10MG TABLET if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering ORESTA 10MG TABLET to geriatric patients. Your doctor will prescribe ORESTA 10MG TABLET if the benefits outweigh the risks.

What if I have taken an overdose of ORESTA 10MG TABLET

Do not take more than the prescribed dose of ORESTA 10MG TABLET as it may cause overdose. Clobazam overdose can be fatal if it is taken with opiod medicine, alcohol, or other drugs that cause slow breathing or drowsiness. The symptoms of overdose include confusion, extreme drowsiness or weakness, loss of consciousness or slow breathing. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Alcohol interacts dangerously with this medication, increasing the risk of extreme drowsiness, severe breathing difficulties, and loss of consciousness.
  • Prioritise consistent sleep: Lack of sleep is a well-known trigger for seizures. Aim for a regular sleeping schedule by going to bed and waking up at the same time daily.
  • Keep a detailed seizure log: Track when your seizures occur, how long they last, and any potential triggers. Share this information with your healthcare team to assess how well the medicine is working.
  • Do not stop taking the medicine suddenly: Stopping this medication abruptly can cause your seizures to return or become worse. Always follow your doctor’s plan for gradually decreasing the dose when stopping.

Have a query?

How Soon It Starts Working

The time required for ORESTA 10MG TABLET to start to work: ORESTA 10MG TABLET ideally shows its action within 0.5 to 4 hours after administration. The time for which the effects of ORESTA 10MG TABLET last: The effect of ORESTA 10MG TABLET lasts for 3 to 4 days.

What if you forget to take ORESTA 10MG TABLET

If you miss a dose of ORESTA 10MG TABLET, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store ORESTA 10MG TABLET tablets or oral suspension at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from moisture and direct light. Do not store this medicine in damp

Drug Warnings

  • Check the oral suspension: If you are using the liquid form, inspect the bottle before use. Ensure it is well-shaken, has no unusual particles, and use only the oral syringe provided for measuring.
  • Avoid driving and operating machinery: This medicine can make you feel sleepy and slow your reaction times. Do not drive, ride a bicycle, or operate machinery until you know how this medicine affects you.
  • Watch for mood changes: Pay close attention to any sudden changes in your mood, thoughts, or behavior. Tell your doctor immediately if you experience new or worsening feelings of sadness, anxiety, or self-harm.
  • Plan your refills early: Because stopping this medication suddenly can trigger severe, continuous seizures, make sure you never run out of your medicine. Request your refills well in advance.
  • Carry medical identification: It is highly recommended to wear a medical alert bracelet or carry a card stating that you are taking this medicine for seizure management.

Drug-Drug Interactions

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact with ORESTA 10MG TABLET:

  • Opioid pain or cough medicines: May increase the risk of severe sleepiness, slow breathing, coma, or life-threatening breathing problems.
  • Other medicines that cause drowsiness: Sleeping pills, muscle relaxants, and other anxiety medicines may increase sedation and affect coordination.
  • Certain medicines that affect liver processing: Some medicines that slow the breakdown of ORESTA 10MG TABLET may increase its levels in the body and raise the risk of side effects.

Drug-Food Interactions:

  • Alcohol: Avoid alcohol while taking ORESTA 10MG TABLET, as it can greatly increase drowsiness, poor coordination, and breathing problems.

Drug-Disease Interactions:

Inform your doctor if you have any of the following conditions before taking ORESTA 10MG TABLET:

  • Severe breathing problems: Conditions such as sleep apnea or chronic obstructive pulmonary disease (COPD) may increase the risk of breathing difficulties.
  • Liver or kidney problems: These conditions may affect how your body processes the medicine and may require careful dose adjustment.
  • Myasthenia gravis: ORESTA 10MG TABLET may worsen muscle weakness in people with this condition.
ClobazamThioridazine
Critical
ClobazamSodium oxybate
Critical

Drug-Drug Interactions

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ClobazamThioridazine
Critical
How does the drug interact with Oresta 10mg Tablet:
When Thioridazine is taken with Oresta 10mg Tablet, may increase the blood levels of thioridazine and cause an irregular heart rhythm.

How to manage the interaction:
Co-administration of Oresta 10mg Tablet and Thioridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClobazamSodium oxybate
Critical
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet can enhance the sedative effects of Sodium oxybate on the central nervous system.

How to manage the interaction:
Co-administration of Clarithromycin and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like respiratory depression, low blood pressure, fainting, coma, and even death, a doctor immediately. Do not stop using any medications without a doctor's advice.
ClobazamKetamine
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Ketamine can increase the risk of sedation, drowsiness, and depression of the central nervous system.

How to manage the interaction:
Co-administration of Ketamine with Oresta 10mg Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. If you are feeling dizzy, sleepy, confused, or having trouble focusing, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
ClobazamCodeine
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Codeine may lead to serious side effects like respiratory distress.

How to manage the interaction:
Consult the doctor if you are taking Oresta 10mg Tablet with Codeine. Avoid driving or operating hazardous machinery. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination, consult a doctor. Do not exceed the doses and duration prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
ClobazamModafinil
Severe
How does the drug interact with Oresta 10mg Tablet:
Modafinil may increase the blood levels of Oresta 10mg Tablet. This may increase the risk and/or severity of side effects.

How to manage the interaction:
Although there is a possible interaction, Oresta 10mg Tablet can be taken with modafinil if prescribed by the doctor. Consult the prescriber if you experience side effects such as tiredness, drowsiness, constipation, drooling, and breathing difficulties. Use caution when getting up from a sitting or lying position.
ClobazamHydromorphone
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Hydromorphone may cause serious side effects like respiratory depression or coma.

How to manage the interaction:
Consult the doctor if you are taking Oresta 10mg Tablet with Hydromorphone. Avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the doses and duration prescribed by your doctor.
ClobazamTapentadol
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Tapentadol together with Oresta 10mg Tablet can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Oresta 10mg Tablet with Tapentadol can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
ClobazamRemifentanil
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Remifentanil can increase the risk of breathing problems.

How to manage the interaction:
Taking Oresta 10mg Tablet with Remifentanil together can possibly result in an interaction, but it can be taken if your doctor has advised it. When used together, these effects can be worsened, increasing the risk of respiratory depression. If you experience symptoms such as difficulty breathing, dizziness, or drowsiness, it is important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
ClobazamClozapine
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Clozapine may increase the effects of both medications.

How to manage the interaction:
Although there is a possible interaction, Oresta 10mg Tablet can be taken with Clozapine if prescribed by the doctor. Consult the prescriber if you experience side effects such as extreme drowsiness, shallow breathing, confusion, low blood pressure, weak pulse, and incoordination. Do not discontinue any medications without consulting a doctor.
ClobazamOxycodone
Severe
How does the drug interact with Oresta 10mg Tablet:
Co-administration of Oresta 10mg Tablet with Oxycodone may cause serious side effects like respiratory depression.

How to manage the interaction:
Consult the doctor if you are taking Oresta 10mg Tablet with Oxycodone. Avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the doses and duration prescribed by your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANXIOLYTICS]

FAQs

ORESTA 10MG TABLET is used to treat epilepsy (fits) and severe anxiety over a short period. It works by increasing the release of GABA (a chemical messenger that acts as a nerve-calming agent) in the brain and calming nerve cells.
No, you are not recommended to take ORESTA 10MG TABLET with opioids as co-administration of these medicines may cause breathing problems, drowsiness, coma and even death. However, before using ORESTA 10MG TABLET with any other medicines, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.
No, ORESTA 10MG TABLET does not cure epilepsy. ORESTA 10MG TABLET only helps in controlling seizures (fits). There is no cure for epilepsy but treatment at an early stage can make a huge difference as prolonged or uncontrolled fits may result in brain damage.
No. You should never stop taking ORESTA 10MG TABLET suddenly or without consulting your doctor. Abrupt discontinuation may cause withdrawal symptoms such as anxiety, irritability, confusion, insomnia, depression, and, in some cases, worsening or recurrent seizures. If treatment needs to be stopped, your doctor will gradually reduce the dose to minimize withdrawal effects.
Yes, drowsiness and sleepiness are common side effects of this medication, especially when you first start taking it or when your dose is increased. Avoid driving or operating machinery until you know how it affects you. Talk to your doctor if sleepiness becomes severe.
No, you must avoid alcohol while taking this medicine. Alcohol can cause dangerous interactions, leading to extreme sleepiness, coordination issues, and life-threatening breathing difficulties. Talk to your doctor or pharmacist.
ORESTA 10MG TABLET is generally not recommended during pregnancy unless your doctor determines that the benefits outweigh the risks. It may affect the unborn baby, especially when used during the later stages of pregnancy. However, uncontrolled seizures can also be dangerous for both the mother and baby. Consult your doctor before starting, stopping, or changing treatment during pregnancy.
Yes. ORESTA 10MG TABLET may be habit-forming and can lead to physical or psychological dependence, especially when used for long periods or at higher doses. Always take it exactly as prescribed and do not increase or stop the dose without medical advice.
Yes, you can take this medication with or without food. The most important thing is to be consistent with how you take it each day. Talk to your doctor or pharmacist.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your regular schedule. Do not double the dose.
In certain cases, healthcare providers may prescribe this medicine for short-term relief of severe, disabling anxiety, although its primary clinical use is for specific seizure disorders.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1574 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Pil.7618 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. U.S. Food and Drug Administration (FDA). 203993S005Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Clobazam Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Clobazam Clobazam. 2011. [Accessed on 19 Jun. 2019] Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020] Check here
  7. Pubchem.ncbi.nlm.nih.gov. n.d. Clobazam. [online] Available at:Check here

Country of origin

INDIA

Manufacturer/Marketer address

Arya Arcade,409/4th Floor, Station Road, Vikhroli West, Mumbai-400083
Other Info - ORE0041

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