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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Orio TZ Oral Suspension is used to treat various infections caused by bacteria and protozoans. It is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa, such as dysentery (inflammation of the colon) and malaria. It contains Ofloxacin and Tinidazole, which kill bacteria and parasites that cause infections and prevent the further spread of the infection. It may cause side effects such as nausea, vomiting, stomach pain, loss of appetite, headache, etc. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Samson Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Orio TZ Oral Suspension

Orio TZ Oral Suspension is a combination of medicines called 'antibiotics' primarily used to treat various infections caused by bacteria & protozoans. Orio TZ Oral Suspension is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria. 

Orio TZ Oral Suspension is a combination of two antibiotics: Ofloxacin and Tinidazole. Ofloxacin helps treat and prevent a wide range of bacterial infections. It is bactericidal in nature, which means it works by killing bacteria that cause infections. It inhibits the processes of bacterial cells, ultimately destroying the bacteria and thereby preventing the further spread of the infection. Orio TZ Oral Suspension is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen). On the other hand, Tinidazole kills parasites and anaerobic bacteria responsible for causing infections. It works by damaging their genetic material, called DNA. 

Orio TZ Oral Suspension should be taken in the dose and duration your doctor advises. It is recommended to take it with food and at a fixed time to achieve maximum effect. You may experience nausea, vomiting, stomach pain, loss of appetite, headache, and other symptoms. Most of these side effects of Orio TZ Oral Suspension do not require medical attention and typically resolve on their own over time. However, if the side effects are persistent, reach out to your doctor. Please consult your doctor immediately if you experience any allergic reaction symptoms such as rashes, itching, swelling, or shortness of breath.

Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), a sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease, or a problem with alcohol or other prescription or recreational drugs. Inform your doctor if you plan to get pregnant, are pregnant, or are breastfeeding. Use of Orio TZ Oral Suspension is associated with an increased risk of tendinitis and tendon (tough tissue that connects muscle to bone) rupture in all ages. People taking Orio TZ Oral Suspension who are over 60 years are at high risk, especially those taking anti-allergic medicines like corticosteroid drugs. Orio TZ Oral Suspension is contraindicated in people with kidney/heart diseases and those who have had lung transplants; its use is not recommended.

Uses of Orio TZ Oral Suspension

Orio TZ Oral Suspension is used in the treatment of bacterial and protozoal infections. The detailed uses of Orio TZ Oral Suspension are as follows:

  • Treatment of Bacterial Infections: Orio TZ Oral Suspension is an antibiotic used to treat various bacterial infections, including respiratory, urinary tract, sexually transmitted infections, and skin infections.
  • Management of Gastrointestinal Infections: Orio TZ Oral Suspension helps to treat gastrointestinal infections caused by bacteria, relieving symptoms and promoting recovery.
  • Urinary tract Infections (UTIs): Orio TZ Oral Suspension can be used to treat urinary tract infections (UTIs) caused by susceptible bacteria.
  • Preventing Infection: Orio TZ Oral Suspension can be prescribed to prevent infections in patients undergoing surgery or those with weakened immune systems.

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Directions for Use

  • Orio TZ Oral Suspension can be taken with or without food (excluding dairy products).
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Orio TZ Oral Suspension as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

Orio TZ Oral Suspension contains the antibiotics Ofloxacin and Tinidazole, which help treat and prevent a wide range of bacterial infections caused by Gram-negative bacteria, Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen). It is bactericidal and works by killing bacteria that cause infections by preventing the formation of their cell walls, which are required for living. It also inhibits the repair of bacterial cells. Altogether, it kills the bacteria. Orio TZ Oral Suspension has the advantage of good penetration in most deep tissues and body fluids. Hence, it is also suitable for treating deep tissue and bone bacterial infections. 

How Orio TZ Oral Suspension Works

Orio TZ Oral Suspension is a combination of two antibiotics: Ofloxacin and Tinidazole. Ofloxacin helps treat and prevent a wide range of bacterial infections. It is bactericidal, which means it works by killing bacteria that cause infections. It inhibits the processes of bacterial cells, ultimately destroying the bacteria and thereby preventing the further spread of the infection. Orio TZ Oral Suspension is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen). On the other hand, Tinidazole kills parasites and anaerobic bacteria responsible for causing infections. It works by damaging their genetic material, called DNA.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Orio TZ Oral Suspension

Do not take more than the prescribed dose of Orio TZ Oral Suspension as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Do not take Orio TZ Oral Suspension if you are allergic or have had a severe reaction to Ofloxacin or other quinolone or fluoroquinolone antibiotics such as Delafloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Ciprofloxacin. Taking Orio TZ Oral Suspension may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or having a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune condition of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Orio TZ Oral Suspension may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Orio TZ Oral Suspension. Additionally, exposure to sunlight should be avoided while taking Orio TZ Oral Suspension, as it may increase phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Orio TZ Oral Suspension.

Diet & Lifestyle Advise

  • Avoid consuming many caffeine-containing products, such as coffee, tea, energy drinks, cola, and chocolate. Orio TZ Oral Suspension may increase nervousness, sleeplessness and anxiety caused by caffeine.
  • Probiotics should be taken after taking the full course of Orio TZ Oral Suspension to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods, such as yoghurt, cheese, sauerkraut, kombucha, and kimchi, can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains, such as whole-grain bread and brown rice, should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Orio TZ Oral Suspension.
  • Avoid alcoholic consumption with Orio TZ Oral Suspension as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Orio TZ Oral Suspension in fighting off infections.

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

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Alcohol

Safe if prescribed

Alcohol is not known to cause any unpleasant side effects if taken along with Orio TZ Oral Suspension. But the intake of alcohol may damage your liver. So, consuming alcohol should be avoided with Orio TZ Oral Suspension.

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Pregnancy

Consult your doctor

Orio TZ Oral Suspension is a pregnancy Category C medicine. It is not known whether Orio TZ Oral Suspension will affect pregnancy. Hence, the intake of Orio TZ Oral Suspension should be avoided if you are pregnant or planning to become pregnant, as it may harm your foetus. Please consult your doctor.

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Breast Feeding

Consult your doctor

Orio TZ Oral Suspension is excreted in human milk. But the amount of Orio TZ Oral Suspension absorbed by the nursing infant is unknown. So, it may be unsafe to be used while breastfeeding. Please consult your doctor.

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Driving

Safe if prescribed

Orio TZ Oral Suspension can affect alertness and coordination. So, driving vehicles and operating machinery which requires concentration should be avoided.

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Liver

Consult your doctor

Orio TZ Oral Suspension to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may need to adjust the dose if you experience symptoms such as nausea, vomiting, loss of appetite, dark-coloured urine, or yellow discolouration of the skin or eyes.

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Kidney

Consult your doctor

Orio TZ Oral Suspension to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Orio TZ Oral Suspension is not recommended for use in children and adolescents below 18 years of age.

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Heart

This medicine is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Consult your doctor

Orio TZ Oral Suspension should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Orio TZ Oral Suspension.

FAQs

Orio TZ Oral Suspension is used to treat various infections caused by bacteria and protozoans. It is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria.

Not recommended. A patient with a transplanted kidney might be taking an immunosuppressive drug like cyclosporin, which is contraindicated with Orio TZ Oral Suspension failing to respond to the efficacy of the immunosuppressant drug. There are chances of rejection of the transplanted kidney in the patient, and, hence, it is not recommended to take Orio TZ Oral Suspension without a doctor's consultation.

Do not consume alcohol or alcohol-based products while taking Orio TZ Oral Suspension and for at least 3 days after your treatment commences. You may experience unpleasant side effects, such as a fast heartbeat, nausea, vomiting, sweating, and tingling under your skin.

Yes, after taking Orio TZ Oral Suspension, you may have diarrhoea. Orio TZ Oral Suspension is an antibiotic that kills or prevents bacterial growth, so some good intestinal bacteria that aid digestion might also get killed. Therefore, drink plenty of fluids and take probiotics to prevent excessive fluid loss from the body (dehydration).

It is advised not to take Orio TZ Oral Suspension with dairy products, as it may affect the absorption and efficacy of Orio TZ Oral Suspension. However, you can take it with a meal that includes these foods or drinks.

Orio TZ Oral Suspension can make your skin sensitive to sunlight, a condition known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In the event of an emergency, always wear sunscreen before going outdoors.

If you miss a dose of Orio TZ Oral Suspension, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Take Orio TZ Oral Suspension either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).

No, Orio TZ Oral Suspension should be taken as advised by the doctor in terms of dose and duration. If you take it in a dose greater than the recommended amount, it may cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor

Orio TZ Oral Suspension contains lactose, so tell your doctor if you are intolerant to some sugars.

It is advised to tell your doctor if you are already taking Warfarin before taking Orio TZ Oral Suspension as it can increase the time it takes for blood clotting.

Take Orio TZ Oral Suspension for as long as it is prescribed by your doctor. It is important to complete the full course of treatment for effective results.

Yes, Orio TZ Oral Suspension can cause dry mouth as a side effect. If you experience this, it's essential to stay hydrated by drinking plenty of water, taking regular sips throughout the day, and keeping a glass of water by your bedside at night.

You are recommended to take your doctor’s advice before taking Orio TZ Oral Suspension if you are breastfeeding, as Orio TZ Oral Suspension might enter breast milk and harm the unborn child.

Yes, a metallic taste may occur as a side effect of using Orio TZ Oral Suspension. This is usually temporary and can be managed by chewing sugar-free gum or mints, brushing your teeth after meals, and drinking plenty of water. If this side effect persists, consult your doctor.

The use of Orio TZ Oral Suspension is harmful for patients with a known allergy to ofloxacin or tinidazole. It should be avoided in patients with a history of tendinitis (inflammation of the tendons), or tendon rupture when using ofloxacin or any other medicine that belongs to the same group (quinolone group) of antimicrobial agents, and in patients with certain neurological disorders, kidney, or heart diseases.

Store the Orio TZ Oral Suspension in a cool, dry place at room temperature, away from direct light. Keep it out of reach of children.

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, please inform us if your symptoms are worsening while using this Orio TZ Oral Suspension.

No, you should not stop taking Orio TZ Oral Suspension even if you feel better. Complete the full course of treatment as prescribed by your doctor. If you stop using Orio TZ Oral Suspension too early, your infection may worsen.

Orio TZ Oral Suspension may affect alertness and coordination. Therefore, do not drive until you know how this medication affects you.

The common side effects of Orio TZ Oral Suspension are nausea, vomiting, stomach pain, loss of appetite, headache, and dry mouth. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

152 Sansiwala Barotiwala Solan Himachal Pradesh 174103, Baddi-174103, Himachal Pradesh, India
Other Info - ORIO473

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