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compositionComposition:ORLISTAT-120MG
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Prescription Medicine
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Orlean 120 Capsule is used to treat obesity and help in weight loss. It is to be used along with a low-calorie diet and regular physical exercise. It contains Orlistat, which decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thus, it helps in weight loss.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ORLISTAT-120MG

Manufacturer/Marketer :

Eris Life Sciences Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Orlean 120 Capsule

Orlean 120 Capsule is a medication prescribed to help overweight and obese individuals lose weight and keep it off. For best results, it must be taken consistently with each main meal that contains fat, alongside a reduced-calorie, low-fat diet. Incorporating regular physical activity and mindful eating habits will significantly support your weight management goals.

Because of how this medicine works, you may experience changes in your bowel habits, such as oily stools or increased gas. While these common side effects are usually manageable, you should contact your doctor if you experience severe abdominal pain or signs of liver problems.

Do not take this if you have chronic malabsorption syndrome, gallbladder issues, or if you are pregnant. It is essential to discuss your complete medical history with your doctor before starting this treatment to ensure it is safe for you.

This medication can interact with other drugs, including blood thinners, thyroid medications, and certain immune-suppressing medicines, potentially altering their effectiveness. Talk to your doctor or pharmacist if you are elderly, breastfeeding, or taking daily vitamin supplements to plan a safe dosing routine
 

Uses of Orlean 120 Capsule

Orlean 120 Capsule is a weight management medicine that works by reducing the absorption of dietary fat from the food you eat. It is used alongside a reduced-calorie, low-fat diet and regular physical activity to support healthy weight management.

  • Weight Management: Orlean 120 Capsule helps obese or overweight individuals lose weight when combined with a calorie-controlled, low-fat diet.
  • Weight Maintenance: This medicine helps prevent patients from regaining the weight they have already lost.
     

Key Benefits

When used together with healthy eating habits and regular physical activity, Orlean 120 Capsule can support sustainable weight management and improve overall health. The following benefits contribute to long-term treatment success:

  • Supports Gradual Weight Loss: Orlean 120 Capsule helps promote steady, healthy weight reduction by decreasing the amount of fat your body absorbs from food.
  • Helps Maintain Weight Loss: Continued use, alongside lifestyle changes, helps reduce the risk of regaining weight after it has been lost.
  • Improves Overall Health: Losing excess weight can help reduce health risks associated with obesity, including high blood pressure, high cholesterol, and increased strain on the joints.
  • Encourages Healthy Lifestyle Habits: Orlean 120 Capsule works best when combined with a balanced, low-fat diet and regular exercise, helping reinforce healthy long-term lifestyle changes.
     
Side effects of Orlean 120 Capsule
  • If you notice your stools are bulky, frothy, greasy, floating, or foul-smelling, and have weight loss or cramps, consult your doctor right away.
  • Try to limit or avoid foods or drinks like whole nuts, butter, coconut and palm oils, red meat, coffee creamers, and alcohol.
  • Increase your intake of healthy fats in your diet, such as those from oily fish (like salmon and tuna), olive oil, and avocados.
  • Fatty stools can cause a lack of fat-soluble vitamins, so consider adding foods rich in vitamin A (fish oil, butter), vitamin D (fatty fish, mushrooms), vitamin E (sunflower seeds, almonds), and vitamin K (kale, spinach) to your meals.
  • If left untreated, fatty stools may lead to significant weight loss, malnutrition, and electrolyte imbalances, so have regular check-ups with your doctor, including nutritional assessments.
  • Tell your doctor about your gas symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage gas symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for gas symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Defecation urgency can bother you, and if this happens without a specific reason, consult your doctor.
  • Avoid infections that may frequently occur by maintaining good hygiene if you have an issue of frequent bowel movements.
  • Avoid eating fibre-containing foods, nuts and caffeine that make you feel like defecating.
  • Stay calm and do not smoke or drink alcohol, as it can worsen your condition.
  • Contract specific muscles near the anus that help to stop releasing the stool.
  • Try to stand or lie down instead of sitting for long hours if you have defecation urgency.
  • If you notice your stools are bulky, frothy, greasy, floating, or foul-smelling, and have weight loss or cramps, consult your doctor right away.
  • Try to limit or avoid foods or drinks like whole nuts, butter, coconut and palm oils, red meat, coffee creamers, and alcohol.
  • Increase your intake of healthy fats in your diet, such as those from oily fish (like salmon and tuna), olive oil, and avocados.
  • Fatty stools can cause a lack of fat-soluble vitamins, so consider adding foods rich in vitamin A (fish oil, butter), vitamin D (fatty fish, mushrooms), vitamin E (sunflower seeds, almonds), and vitamin K (kale, spinach) to your meals.
  • If left untreated, fatty stools may lead to significant weight loss, malnutrition, and electrolyte imbalances, so have regular check-ups with your doctor, including nutritional assessments.
  • If you notice your stools are bulky, frothy, greasy, floating, or foul-smelling, and have weight loss or cramps, consult your doctor right away.
  • Try to limit or avoid foods or drinks like whole nuts, butter, coconut and palm oils, red meat, coffee creamers, and alcohol.
  • Increase your intake of healthy fats in your diet, such as those from oily fish (like salmon and tuna), olive oil, and avocados.
  • Fatty stools can cause a lack of fat-soluble vitamins, so consider adding foods rich in vitamin A (fish oil, butter), vitamin D (fatty fish, mushrooms), vitamin E (sunflower seeds, almonds), and vitamin K (kale, spinach) to your meals.
  • If left untreated, fatty stools may lead to significant weight loss, malnutrition, and electrolyte imbalances, so have regular check-ups with your doctor, including nutritional assessments.
  • Increased defectaion can bother you, and if this happens without a specific reason, consult your doctor.
  • Avoid infections that may frequently occur by maintaining good hygiene if you have an issue of frequent bowel movements.
  • Do not eat fibre-containing foods, nuts and caffeine that make you feel like defecating.
  • Stay calm and do not smoke or drink alcohol, as it can worsen your condition.
  • Contract specific muscles near the anus that help to stop releasing the stool.
  • Try to stand or lie down instead of sitting for long hours if you have defecation urgency.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Orlean 120 Capsule can be taken during, or up to 1 hour after meals, as advised by your doctor.
  • Take Orlean 120 Capsule daily at the same time for effective results or as your doctor advises.
  • Swallow Orlean 120 Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Orlean 120 Capsule Works

Orlean 120 Capsule contains orlistat, a lipase inhibitor that helps with weight management by reducing the amount of fat your body absorbs from food. Orlean 120 Capsule works locally inside the stomach and small intestine by blocking the action of lipases, the enzymes responsible for breaking down dietary fat. As a result, about one-third of the fat you eat is not digested or absorbed. Instead, the undigested fat passes through your digestive system and is naturally eliminated from the body through bowel movements. Together, these actions help reduce calorie intake, support gradual weight loss, and help prevent weight regain when used alongside a calorie-controlled, low-fat diet.
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Alcohol

Caution

Alcohol should be limited or avoided while taking Orlistat to support weight loss goals and overall health.

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Pregnancy

Unsafe

Orlean 120 Capsule is a Category X pregnancy drug and is considered unsafe for pregnant women as it may cause harm to the unborn baby. So, if you are pregnant or planning for pregnancy, please inform your doctor before taking Orlean 120 Capsule .

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Breast Feeding

Caution

It is unknown whether Orlean 120 Capsule is excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits outweigh the risks.

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Driving

Safe if prescribed

Orlean 120 Capsule usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Orlean 120 Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Orlean 120 Capsule with caution, especially if you have a history of Kidney diseases/conditions. Orlean 120 Capsule may cause kidney stones in patients suffering from chronic kidney disease. Please consult a doctor if you have kidney problems so that the dose may be adjusted by your doctor as required.

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Children

Unsafe

Orlean 120 Capsule is not recommended for children below 18 years of age, as the safety and effectiveness have not been established.

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Heart

Safe if prescribed

Orlean 120 Capsule is safe for use in heart patients if prescribed by the physician. However, caution should be exercised.

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Geriatrics

Safe if prescribed

Orlean 120 Capsule is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Orlean 120 Capsule

If you suspect an overdose, seek immediate medical attention or call your local poison control center. Bring the medication container with you to show the healthcare providers.

Diet & Lifestyle Advise

  • Limit your fat intake: Ensure that your daily fat intake does not exceed 30% of your total calories. Eating meals too high in fat significantly increases the risk of unpleasant bowel side effects.
  • Distribute fat evenly: Spread your daily fat, carbohydrate, and protein intake evenly across your three main meals.
  • Take a daily multivitamin: Since this medication can reduce the absorption of fat-soluble vitamins (A, D, E, and K), take a daily multivitamin at least two hours before or after taking your medication, such as at bedtime.
  • Keep active: Combine your medication with regular physical activity, like walking or cycling, as recommended by your doctor, to optimise weight loss.
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Have a query?

How Soon It Starts Working

The time required for Orlean 120 Capsule to start to work: The time required for Orlean 120 Capsule to show its action is unknown. The time for which the effects of Orlean 120 Capsule last: The duration of action for Orlean 120 Capsule is unknown.

What if you forget to take Orlean 120 Capsule

If you miss a dose and it is within one hour of a fat-containing meal, take it as soon as you remember. If more than an hour has passed since your meal, skip the missed dose and resume your regular schedule with your next meal. Do not take a double dose to make up for a missed one.

Storage

• Store Orlean 120 Capsule at room temperature, ideally between 15°C and 30°C (59°F to 86°F)

Drug Warnings

  • Take It Only with Fat-Containing Meals: Only take your dose when eating a meal that contains some fat; if the meal is completely fat-free, skip that dose.
  • Watch for Liver-Related Symptoms: Watch for early signs of liver problems, such as unusual fatigue, itching, or yellowing of the skin, and report them to your doctor immediately.
  • Separate Vitamin Supplements: Ensure you are consistently taking your fat-soluble vitamin supplement at a completely different time of day than your medication.
  • Do Not Share Your Medication: Do not share this medication with anyone else, even if they have similar weight management goals.
  • Monitor Your Progress: Monitor your weight progress regularly and discuss the results with your doctor to evaluate the medication's effectiveness over time

Drug-Drug Interactions

verifiedApollotooltip

Orlean 120 Capsule may interact with certain medicines, affecting their absorption or increasing the risk of side effects. Tell your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking, including:

  • Cyclosporine: May lower cyclosporine levels in your blood, reducing its effectiveness. If prescribed both, take them at least three hours apart.
  • Levothyroxine: May reduce the absorption of thyroid hormone. Take these medications at least four hours apart and monitor your thyroid function closely.
  • Blood Thinners (such as Warfarin): May alter clotting times, increasing the risk of bleeding. Regular monitoring is required.
  • Anti-seizure Medications: May decrease the absorption of these medicines, potentially leading to seizures.
OrlistatLomitapide
Severe
OrlistatTeriflunomide
Severe

Drug-Drug Interactions

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OrlistatLomitapide
Severe
How does the drug interact with Orlean 120 Capsule:
Co-administration of Lomitapide and Orlean 120 Capsule can increase the risk of developing liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Orlean 120 Capsule can lead to an interaction, it can be taken when advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
OrlistatTeriflunomide
Severe
How does the drug interact with Orlean 120 Capsule:
Co-administration of Teriflunomide and nintedanib can increase the risk of developing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Nintedanib can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, fatigue, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
OrlistatKetoconazole
Severe
How does the drug interact with Orlean 120 Capsule:
Coadministration of Ketoconazole and Orlean 120 Capsule can increase the risk of developing liver damage.

How to manage the interaction:
Although taking Ketoconazole and Orlean 120 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, joint pain, unusual bleeding, skin rash, lack of appetite, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
OrlistatCalcitriol
Severe
How does the drug interact with Orlean 120 Capsule:
Co-administration of Orlean 120 Capsule with Calcitriol may reduce the levels of Calcitriol which can lead to low treatment outcomes.

How to manage the interaction:
Although there is an interaction, Calcitriol can be taken with Orlean 120 Capsule when prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
OrlistatCiclosporin
Severe
How does the drug interact with Orlean 120 Capsule:
Coadministration of Ciclosporin with Orlean 120 Capsule can reduce the levels and effects of Ciclosporin.

How to manage the interaction:
Although there is a possible interaction between Orlean 120 Capsule and Ciclosporin, you can take these medicines together when prescribed by your doctor. Do not stop using any medications without talking to a doctor.
OrlistatMipomersen
Severe
How does the drug interact with Orlean 120 Capsule:
Co-administration of Mipomersen and Orlean 120 Capsule can increase the risk of developing liver problems.

How to manage the interaction:
Co-administration of Mipomersen and Orlean 120 Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, fatigue, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
OrlistatLeflunomide
Severe
How does the drug interact with Orlean 120 Capsule:
Co-administration of leflunomide and Orlean 120 Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Orlean 120 Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain dietary habits can influence how well Orlean 120 Capsule works and may affect the likelihood of side effects. Keep the following in mind during treatment:

  • High-Fat Meals: Eating meals with a fat content higher than 30% significantly increases the severity of digestive side effects like oily stools and gas.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIOBESITY DRUG]

FAQs

Orlean 120 Capsule is used to treat obesity and help in weight loss. It is to be used along with a low-calorie diet and regular physical exercise.
Orlean 120 Capsule contains Orlistat, which works in the small intestine and stomach and inhibits the action of enzymes that break down fat, which is absorbed by the body. Orlean 120 Capsule decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thereby, Orlean 120 Capsule helps in weight loss.
You are not recommended to take Orlean 120 Capsule with ciclosporin (used for organ transplant rejections, severe rheumatoid arthritis) as it may reduce the effectiveness of ciclosporin. However, if you are supposed to take both medicines, you are advised to take ciclosporin after 3 hours of taking Orlean 120 Capsule . However, please consult a doctor before taking Orlean 120 Capsule with any other medicines.
Orlean 120 Capsule may cause kidney stones in patients suffering from chronic kidney disease. Therefore, if you have any kidney problems, please inform your doctor before taking Orlean 120 Capsule .
Orlean 120 Capsule should be used with caution in diabetic patients as it may increase the risk of low blood sugar levels. Therefore, inform your doctor if you have diabetes before taking Orlean 120 Capsule so that the dose of antidiabetic medicine may be adjusted accordingly.
You are recommended to avoid high-fat meals that include butter, meat, dark chocolate, olive oil, nuts and seeds (brazil nuts) with Orlean 120 Capsule as it may increase the risk of adverse effects on the stomach or intestines.
You are recommended to use Orlean 120 Capsule for as long as your doctor has prescribed it. However, avoid taking Orlean 120 Capsule for more than 6 months. If you do not notice weight loss after taking Orlean 120 Capsule for 12 weeks, please consult a doctor.
You are recommended to take a multivitamin containing fat-soluble vitamins such as A, D, E and K at bedtime or at least 2 hours after taking Orlean 120 Capsule . Generally, Orlean 120 Capsule may reduce the absorption of certain vitamins in the body. Therefore, your doctor may advise you to take multivitamins.
Do not take Orlean 120 Capsule if you are allergic to any of its components or if you have cholestasis (bile flow from the liver is blocked) or chronic malabsorption syndrome.
Follow a low-calorie diet and regular physical exercise. Include fruits, vegetables and whole grains in your diet.
Yes, it is important to do regular exercise and maintain a low-fat and low-calorie diet along with Orlean 120 Capsule for effective results.
Orlean 120 Capsule should be swallowed as a whole with water; do not crush or chew it. Take it during a meal or up to 1 hour after a meal.
Orlean 120 Capsule may cause side effects like soft stools, sudden bowel motions, flatulence (gas) with or without oily spotting, oily or fatty stools, stomach pain, stool incontinence (involuntary leakage of stools), and runny or liquid stools. If the side effects persist, please consult your doctor.
No. If you miss a meal or eat a meal that contains no fat, you should skip that dose. The medication works specifically by blocking the absorption of dietary fat, so it will not have any effect if there is no fat in your meal. Talk to your doctor or pharmacist if you have questions about your meal plan.
While alcohol does not directly interact with Orlean 120 Capsule , alcoholic beverages are often high in empty calories, which can slow down your weight loss progress. It is best to limit alcohol consumption while on a weight management programme. Talk to your doctor for personalised advice.
No, you should not take Orlean 120 Capsule if you are pregnant or breastfeeding. Weight loss is not recommended during pregnancy and can harm the developing baby. If you become pregnant while taking this medication, stop taking it immediately. Talk to your doctor for guidance.
These digestive changes are common and indicate that the medication is working by preventing fat absorption. You can minimise these effects by reducing the amount of fat in your meals to no more than 30% of your total calories. If these symptoms are severe or do not improve, talk to your doctor.
You should avoid taking other weight loss medications or dietary supplements without consulting a healthcare professional first, as they may interact or cause adverse effects. Talk to your doctor or pharmacist before combining any treatments.
The duration of your treatment depends on how well the medication works for you and whether you experience any side effects. Your doctor will monitor your progress and decide how long you should continue taking it. Talk to your doctor for a long-term treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

8th Floor, Commerce House IV, Prahladnagar, Ahmedabad – 380015 Gujarat, India
Other Info - ORL0018

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