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  3. Orthodex-MR Tablet 10's

Orthodex-MR Tablet 10's, Pack of 10 TABLETS
Orthodex-MR Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Orthodex-MR Tablet is used to reduce musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). It works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Also, it helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles. It may cause side effects such as drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

CHLORZOXAZONE-500MG + DICLOFENAC-50MG + PARACETAMOL-325MG

Manufacturer/Marketer :

Psychotropics India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Orthodex-MR Tablet

Orthodex-MR Tablet is used in the reduction of musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Pain can be temporary (acute) or long-term (chronic) in nature. Musculoskeletal pain can be caused due to soft tissue (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

Orthodex-MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Orthodex-MR Tablet can be taken with or after the meal. To avoid stomach upset Orthodex-MR Tablet can be taken with food or milk. It should be swallowed whole with a glass of water. Do not take Orthodex-MR Tablet if your pain lasts for more than ten days or if the fever lasts for more than three days. Do not take a double dose if you missed one dose. Like all medicines, Orthodex-MR Tablet may cause side effects, although not everybody gets them. Most of the side effects of Orthodex-MR Tablet are drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. In case of any discomfort, speak with your doctor. 

Do not take Orthodex-MR Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Orthodex-MR Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause even more side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation and fever do not disappear even after ten days.

Uses of Orthodex-MR Tablet

Orthodex-MR Tablet used in the treatment of Musculoskeletal pain. The detailed uses of Orthodex-MR Tablet are as follows:<br/>• Pain Relief: Orthodex-MR Tablet provides effective relief from various types of pain, including musculoskeletal pain, muscle pain, joint pain, body pain, toothache, headache, and rheumatic pain, helping to alleviate discomfort and improve daily activities.<br/>• Muscle Relaxation: Orthodex-MR Tablet helps to relieve muscle spasms, providing relaxation and comfort, especially in conditions like muscle strain and joint stiffness.<br/>• Fever Reduction: Orthodex-MR Tablet also helps to reduce fever associated with pain and discomfort.<br/>

Directions for Use

• Orthodex-MR Tablet should be taken with food.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Orthodex-MR Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Orthodex-MR Tablet is composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

How Orthodex-MR Tablet Works

Orthodex-MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Storage

Keep out of the sight and reach of children.
Side effects of Orthodex-MR Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.

What if I have taken an overdose of Orthodex-MR Tablet

Do not take more than the prescribed dose of Orthodex-MR Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Intake of Orthodex-MR Tablet should be avoided in liver disease (like jaundice) and cardiovascular disease (like coronary heart disease). Contact your doctor if you have signs of liver disease like feeling exhausted, dark urine, not feeling hungry, stomach pain or upset, light coloured stools or yellow skin/eyes. After taking if you have possible allergic symptoms like difficulty in breathing, difficulty in swallowing, lips/face/throat swelling, chest tightness, or skin rash, contact the doctor immediately. Ensure your doctor is aware if you are pregnant or planning to get pregnant, breastfeeding, allergic to Orthodex-MR Tablet or any other painkillers like aspirin, the problem of stomach ulcer or gastric bleeding, or taking any other OTC multivitamins, multi-minerals supplements.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
ParacetamolLeflunomide
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Orthodex-MR Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Orthodex-MR Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
ParacetamolLeflunomide
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Orthodex-MR Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Orthodex-MR Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Lomitapide and Orthodex-MR Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Orthodex-MR Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Orthodex-MR Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Orthodex-MR Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Mipomersen with Orthodex-MR Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Orthodex-MR Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Orthodex-MR Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Orthodex-MR Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Teriflunomide with Orthodex-MR Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Orthodex-MR Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of Orthodex-MR Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Orthodex-MR Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Orthodex-MR Tablet:
Co-administration of ketamine and Orthodex-MR Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Orthodex-MR Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ChlorzoxazoneMorphine
Severe
How does the drug interact with Orthodex-MR Tablet:
Using Morphine together with Orthodex-MR Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Orthodex-MR Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Orthodex-MR Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
  • Avoid driving while consuming Orthodex-MR Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
  • Avoid concomitant consumption of drugs containing the same chemicals as Orthodex-MR Tablet as it can lead to overdosage and unwanted side effects.
  • Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Orthodex-MR Tablet .
  • Avoid consuming alcohol while you are on Orthodex-MR Tablet .

Habit Forming

No

Therapeutic Class

ANALGESICS

Orthodex-MR Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol should not be consumed with Orthodex-MR Tablet as it leads to excessive drowsiness

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Pregnancy

Caution

Only consume Orthodex-MR Tablet , if you are prescribed by a doctor

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Breast Feeding

Caution

Orthodex-MR Tablet does not pass on to the child significantly via breast milk, consult your doctor before using Orthodex-MR Tablet .

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Driving

Caution

Orthodex-MR Tablet may affect driving ability as it causes dizziness.

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Liver

Caution

Orthodex-MR Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Orthodex-MR Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

bannner image

Children

Caution

Orthodex-MR Tablet is not recommended for children below 12 years of age without doctor's consent. For children above 12 years, dose to be adjusted and recommended by a child specialist only.

Have a query?

FAQs

Orthodex-MR Tablet is used to treat musculoskeletal pain due to tissue injury, post-surgery inflammation and oedema (swollen tissue with fluid).

No, Orthodex-MR Tablet should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Orthodex-MR Tablet , take it in doses and duration mentioned by your doctor.

No, it is not advisable to take Orthodex-MR Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Orthodex-MR Tablet .

Yes, Orthodex-MR Tablet is a short term medication and if you feel better you can stop taking Orthodex-MR Tablet , but only after consulting your doctor.

Orthodex-MR Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.

No, Orthodex-MR Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer or gastric bleeding. Do not take Orthodex-MR Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.

It depends on whether your cough and cold pills contains diclofenac, paracetamol and Chlorzoxazone or not. If it contains these three medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

No, do not take Orthodex-MR Tablet until prescribed by your doctor. For example, your shoulder pain may be due to lungs, spleen or gallbladder problem. Your back pain may be due to kidney stone, pancreas swelling, or in women, pelvic disorders. Your arm pain (especially left arm) may be due to heart attack (myocardial infarction).

Orthodex-MR Tablet is a combination of a muscle relaxant (Chlorzoxazone) and two pain relieving medicines (Diclofenac and Paracetamol).

Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.

Orthodex-MR Tablet is not intended to treat toothache. It is used to reduce musculoskeletal pain.

Avoid simultaneous consumption of other painkillers or cough and cold medicines with this Orthodex-MR Tablet , as it may lead to an overdose.

No, it is not indicated to treat gastritis. It may worsen your condition.

It may help ease pain associated with period pain. However, it should only be used if recommended by the doctor.

It may help ease headaches. However, it should be used only if recommended by the doctor.

Orthodex-MR Tablet usually takes effect within 30 minutes to an hour of intake.

No, it does not contain steroids. It combines one muscle relaxant medication and two pain relieving medicines.

Yes, in some cases, Orthodex-MR Tablet may cause acidity.

Yes, Orthodex-MR Tablet may cause drowsiness, although not everybody gets it. If you experience any discomfort, speak with your doctor.

No, Orthodex-MR Tablet is not intended to treat loose motion. It is meant to treat musculoskeletal pain.

Yes, it can be used to treat tissue or ligament injury. However, it should be used only if recommended by a doctor.

Orthodex-MR Tablet may cause constipation, although not everybody gets it. If you experience any discomfort, speak with your doctor.

Orthodex-MR Tablet is safe if used as advised by the doctor. Follow your doctor's instructions.

It may cause common side effects like nausea and vomiting in some patients, although not everybody gets them. If you experience any discomfort, speak with your doctor.

Yes, it may lead to dizziness, although not everybody gets it. If you experience any discomfort, consult your doctor.

Yes, long-term usage of Orthodex-MR Tablet may be harmful to the kidney.

Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children.

Yes, it should be taken with food or after food.

Orthodex-MR Tablet should not be used during pregnancy and by nursing mothers unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Orthodex-MR Tablet .

Orthodex-MR Tablet is not recommended for children below 12 years of age without a doctor's consent. For children above 12 years, the dose is to be adjusted and recommended by a child specialist only.

Alcohol should not be consumed with Orthodex-MR Tablet as it leads to excessive drowsiness.

Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Country of origin

India
Other Info - ORT0062

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.unitedpharmacies.md/Dicoliv-MR-Diclofenac-Potassium-Paracetamol-Chlorzoxazone.html
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.medicines.org.uk/emc/files/pil.10547.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/psg/PSG_011300.pdf
  5. https://www.sciencedirect.com/topics/neuroscience/chlorzoxazone
  6. https://www.nhs.uk/conditions/nsaids/

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