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compositionComposition:ESOMEPRAZOLE-40MG+LEVOSULPIRIDE-75MG
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Prescription Medicine
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Ospride LS 75mg/40mg Tablet is used to treat gastro-oesophageal reflux disease (GERD). It contains Esomeprazole and Levosulpiride, which reduce acid production by increasing stomach and intestinal movement, and preventing the backflow of food and acid into the mouth. In some cases, you may experience certain common side effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ESOMEPRAZOLE-40MG+LEVOSULPIRIDE-75MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Ospride LS 75mg/40mg Tablet

Ospride LS 75mg/40mg Tablet is an oral medication used to manage conditions related to excess stomach acid and slow digestive movement. It is primarily prescribed for gastroesophageal reflux disease (GERD), persistent heartburn, and indigestion. This medication helps by controlling acid production and improving the movement of food through the digestive tract.

For the best results, it is important to take Ospride LS 75mg/40mg Tablet consistently at the same time every day, usually first thing in the morning. You should take this medicine on an empty stomach, at least 30 to 60 minutes before breakfast. Making simple lifestyle adjustments, such as eating smaller meals and avoiding fatty foods, can significantly improve how well this treatment works.

While taking this medicine, some patients may experience mild side effects like headache, diarrhoea, or a dry mouth. However, you should contact your doctor immediately if you notice muscle stiffness, breast swelling, or an irregular heartbeat. Early consultation with your physician can prevent these symptoms from becoming severe.

Before starting this medicine, inform your doctor if you have a history of osteoporosis (bone thinning), low magnesium levels, kidney disease, or liver problems. Certain conditions such as epilepsy, manic episodes, prolactin-dependent tumours, or bleeding, blockage, or perforation in the stomach or intestines are primarily related to the Levosulpiride component and may make this medicine unsuitable for some patients. Sharing your complete medical history helps your doctor determine whether this medicine is safe for you.

This medicine can interact with alcohol, smoking, and other medications like blood thinners or antifungals, which can decrease its effectiveness or increase side effects. Consult your doctor if you belong to special groups such as pregnant, breastfeeding, or elderly individuals, as your treatment may require careful monitoring.

Uses of Ospride LS 75mg/40mg Tablet

Ospride LS 75mg/40mg Tablet is used to treat acid-related stomach disorders. The detailed uses of Ospride LS 75mg/40mg Tablet are as follows:

  • Gastroesophageal Reflux Disease (GERD): Ospride LS 75mg/40mg Tablet helps treat severe acid reflux where stomach acid frequently flows back into the oesophagus, causing chronic heartburn and irritation.
  • Functional Dyspepsia: This medicine relieves persistent indigestion, early fullness during meals, bloating, and upper abdominal discomfort.
  • Peptic Ulcer Disease: The Esomeprazole component helps reduce stomach acid and supports the healing of ulcers in the stomach and upper small intestine. Levosulpiride may help improve associated digestive symptoms such as bloating and fullness.

Key Benefits

Ospride LS 75mg/40mg Tablet helps relieve symptoms of acid reflux and indigestion by reducing excess stomach acid and improving the movement of food through the digestive tract. It supports better digestion and helps protect the food pipe from irritation caused by stomach acid.

Benefits may include:

  • Relief from heartburn and burning sensations in the chest and throat.
  • Reduced acid reflux and regurgitation of stomach contents.
  • Improved digestion and faster movement of food from the stomach to the intestines.
  • Reduction in bloating, fullness, and stomach discomfort.
  • Better comfort while eating and sleeping.
  • Helps protect the food pipe from damage caused by long-term acid exposure.

Directions for Use

  • Take Ospride LS 75mg/40mg Tablet exactly as prescribed by your doctor.
  • Swallow the capsule or tablet whole with a glass of water. Do not crush, chew, or break it.
  • It is best to take this medicine on an empty stomach, ideally 30 to 60 minutes before your first meal of the day.
  • Always follow your doctor's exact instructions regarding how long you should continue taking this medication.

How Ospride LS 75mg/40mg Tablet Works

Ospride LS 75mg/40mg Tablet contains Esomeprazole and Levosulpiride. • Esomeprazole: It helps reduce the amount of acid produced in the stomach. This relieves symptoms such as heartburn and acid reflux and helps heal irritation in the food pipe and stomach. • Levosulpiride: It helps improve the movement of food through the stomach and intestines. This prevents food and acid from flowing back into the food pipe, reduces bloating, and supports better digestion.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ospride LS 75mg/40mg Tablet. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.

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Pregnancy

Unsafe

Ospride LS 75mg/40mg Tablet should not be taken if you are pregnant. Consult your doctor before taking Ospride LS 75mg/40mg Tablet if you are pregnant.

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Breast Feeding

Consult your doctor

Ospride LS 75mg/40mg Tablet may pass into breast milk. Consult your doctor before taking Ospride LS 75mg/40mg Tablet if you are breastfeeding.

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Driving

Caution

Ospride LS 75mg/40mg Tablet may cause dizziness, drowsiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Ospride LS 75mg/40mg Tablet should not be used in patients with hepatic impairment. Consult your doctor before taking Ospride LS 75mg/40mg Tablet if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Ospride LS 75mg/40mg Tablet if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Ospride LS 75mg/40mg Tablet should not be given to children as the safety and effectiveness were not established.

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Heart

Caution

Ospride LS 75mg/40mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Caution

Ospride LS 75mg/40mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Ospride LS 75mg/40mg Tablet.

What if I have taken an overdose of Ospride LS 75mg/40mg Tablet

If you accidentally take too much of this medicine, seek medical attention immediately or contact a poison control centre. Symptoms of taking too much may include severe drowsiness, shakiness, or confusion.

Diet & Lifestyle Advise

  • Eat smaller meals: Eat smaller, more frequent meals throughout the day rather than three large meals to reduce pressure on your stomach and help prevent acid reflux.
  • Avoid lying down after meals: Do not lie down for at least two to three hours after eating, as this can allow stomach acid to travel back into the oesophagus.
  • Limit trigger foods: Identify and avoid foods that worsen your symptoms, such as spicy, fatty, or highly acidic foods, citrus fruits, caffeine, chocolate, and mint.
  • Elevate your head while sleeping: Raise the head of your bed by 6 to 9 inches using blocks or a wedge pillow to help reduce nighttime heartburn and acid reflux.
  • Wear loose-fitting clothing: Avoid tight clothing around your waist, as it can increase pressure on your abdomen and worsen reflux symptoms.
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How Soon It Starts Working

  • The time required for Ospride LS 75mg/40mg Tablet to start to work: Ospride LS 75mg/40mg Tablet ideally shows its action within a few hours after administration.
  • The time for which the effects of Ospride LS 75mg/40mg Tablet last: The duration of action for Ospride LS 75mg/40mg Tablet is not clinically established.

What if you forget to take Ospride LS 75mg/40mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inspect the packaging before use: Do not take this medicine if the blister pack or bottle is broken, damaged, or shows signs of tampering.
  • Use caution during activities requiring alertness: This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating machinery until you know how it affects you.
  • Avoid prolonged self-medication: If your symptoms do not improve after a few weeks of treatment, consult your doctor for further evaluation and guidance.
  • Monitor your bone health during long-term treatment: Prolonged use of acid-reducing medicines may increase the risk of bone fractures. Discuss appropriate monitoring and preventive measures with your doctor if long-term treatment is required.

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Drug-Drug Interactions

  • Antifungal medicines (e.g., ketoconazole, itraconazole): Taking these medicines along with Ospride LS 75mg/40mg Tablet may reduce the absorption and effectiveness of certain antifungal treatments.
  • Blood thinners (e.g., warfarin): Combining Ospride LS 75mg/40mg Tablet with blood-thinning medicines may increase the risk of bleeding and require closer monitoring.
  • Prokinetic and anti-nausea medicines (e.g., metoclopramide): Taking these medicines together with the Levosulpiride component may increase the risk of involuntary movements, tremors, muscle stiffness, or other movement-related side effects because both medicines can affect dopamine activity in the brain.
  • Antidepressants: Some antidepressants may increase the risk of drowsiness or other nervous system-related side effects when taken with Ospride LS 75mg/40mg Tablet.
  • Medicines for Parkinson's disease (e.g., levodopa, pramipexole): The Levosulpiride component may reduce the effectiveness of these medicines because it can oppose their dopamine-related actions. Patients with Parkinson's disease should inform their doctor before using this medicine.

Drug-Food Interactions

  • High-fat meals: Taking Ospride LS 75mg/40mg Tablet with a high-fat meal may reduce the absorption of its active ingredients, making the medicine less effective.

Drug-Disease Interactions

  • Epilepsy or seizure disorders: Ospride LS 75mg/40mg Tablet may increase the risk of seizures or worsen existing seizure conditions in susceptible individuals.
  • Osteoporosis and other bone disorders: Long-term use of Ospride LS 75mg/40mg Tablet may affect bone health and could increase the risk of fractures in people with weakened bones.
  • Kidney disease: Patients with significant kidney impairment should use Ospride LS 75mg/40mg Tablet cautiously, as the medicine may accumulate in the body and increase the risk of side effects.
  • Liver disease: Ospride LS 75mg/40mg Tablet should be used with extreme caution in patients with severe liver damage, as reduced liver function may affect how the medicine is processed.

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Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

FAQs

Ospride LS 75mg/40mg Tablet is used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn.
Ospride LS 75mg/40mg Tablet is a combination of two drugs, namely: Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Ospride LS 75mg/40mg Tablet helps in preventing acid reflux, thereby providing relief from acidity.
Diarrhoea might be a side effect of Ospride LS 75mg/40mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Do not take Ospride LS 75mg/40mg Tablet with nelfinavir (a drug used to treat HIV infections). Consult your doctor before taking Ospride LS 75mg/40mg Tablet with other medications to avoid potential side effects.
Ospride LS 75mg/40mg Tablet contains esomeprazole, which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking Ospride LS 75mg/40mg Tablet for longer durations. Inform your doctor if you have osteoporosis or if you are taking corticosteroids; your doctor may prescribe calcium and vitamin D supplements.
Ospride LS 75mg/40mg Tablet may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Ospride LS 75mg/40mg Tablet.
Ospride LS 75mg/40mg Tablet works by relieving the symptoms such as heartburn, stomach pain, or irritation. It also neutralises the acid production in the stomach to prevent discomfort.
Ospride LS 75mg/40mg Tablet contains Esomeprazole and Levosulpiride.
The usual recommendation is to take it one hour before the meal, preferably in the morning.
Yes, it can help to ease stomach pain.
Store Ospride LS 75mg/40mg Tablet according to the instructions on the leaflet, away from sunlight, at a temperature not exceeding 25°C. Dispose of unused medicine. Keep it out of reach of pets and children.
Ospride LS 75mg/40mg Tablet is contraindicated for use if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. It is also contraindicated for use in pregnant and breastfeeding women.
Ospride LS 75mg/40mg Tablet might increase the risk of wrist, hip or spine fracture. This mainly occurs in individuals taking Ospride LS 75mg/40mg Tablet for extended periods.
Common side effects of Ospride LS 75mg/40mg Tablet may include headache, abdominal pain, constipation, diarrhea, flatulence, nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Ospride LS 75mg/40mg Tablet should not be given to children as safety and effectiveness have not been established.
Yes, Ospride LS 75mg/40mg Tablet is best taken on an empty stomach, ideally 30 to 60 minutes before breakfast. This helps the medicine absorb properly and work more effectively. Talk to your doctor if you have questions about your schedule.
Yes, some patients may experience mild drowsiness or sleepiness while taking this medicine. Avoid driving or operating heavy machinery until you know how this medication affects you. Talk to your doctor if this sleepiness persists.
It is highly recommended to avoid alcohol while taking Ospride LS 75mg/40mg Tablet. Alcohol can increase stomach acid production, irritate your digestive tract, and worsen drowsiness. Talk to your doctor for personalized advice.
You should not stop taking Ospride LS 75mg/40mg Tablet abruptly without consulting your physician. Stopping your treatment early may cause your acid reflux or indigestion symptoms to return. Talk to your doctor to determine the right course of action.
Many people begin to notice relief from symptoms such as heartburn, acid reflux, and bloating within a few days of starting treatment. However, healing of irritation or damage in the food pipe and stomach may take several weeks. In conditions such as erosive reflux disease, complete healing may require 4 to 8 weeks of treatment. Continue taking the medicine for the full duration prescribed by your doctor, even if your symptoms improve earlier.
Ospride LS 75mg/40mg Tablet is generally not recommended during pregnancy unless your doctor decides it is absolutely necessary. If you are pregnant or planning to become pregnant, talk to your doctor before starting this medicine.
Prolonged use of acid-reducing medicines may decrease the absorption of essential nutrients like Vitamin B12 and magnesium, and may slightly increase the risk of bone fractures. Talk to your doctor if you are prescribed this medication for an extended period.
Yes, dry mouth is a recognized mild side effect of Ospride LS 75mg/40mg Tablet. Sucking on sugarless lozenges or drinking plenty of water throughout the day can help manage this symptom. Talk to your doctor if the dryness becomes severe or uncomfortable.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. CiplaMed Clinical Compendium. Esomac L Capsules Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Esomeprazole Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. ScienceDirect ScienceDirect. [Accessed on 12 Apr. 2019]Check here
  4. Esomeprazole 40 mg Gastro-resistant Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 2 April 2025]Check here
  5. Esomac L Capsules [Internet]. CiplaMed. 2022 [Accessed on 2 April 2025]Check here
  6. Evangelos Kalaitzakis and Einar Bjornsson. A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). NCBI; PMC US National Library of Medicine, National Institute of Health. August 2007. [Accessed on 29th October 2022]Check here
  7. Caroline M den Hoed, Ernst J Kuipers. Esomeprazole for the treatment of peptic ulcer bleeding. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2010. [Accessed on 29th October 2022]Check here

Country of origin

India
Other Info - OS78927
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