PALOZAC 0.50MG TABLET

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Prescription Medicine

PALOZAC 0.50MG TABLET is used to prevent nausea and vomiting during chemotherapy. It contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre. In some cases, this medicine may cause side effects such as diarrhoea, constipation, dizziness or headache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

PALONOSETRON-0.50MG

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About PALOZAC 0.50MG TABLET

PALOZAC 0.50MG TABLET belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

PALOZAC 0.50MG TABLET contains Palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone—CTZ) in the brain. Thus, it prevents nausea and vomiting.

Take PALOZAC 0.50MG TABLET as prescribed by your doctor. You are advised to take PALOZAC 0.50MG TABLET for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience diarrhoea, constipation, dizziness or headache. Most of these side effects of PALOZAC 0.50MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to PALOZAC 0.50MG TABLET or any other medicines, please tell your doctor. PALOZAC 0.50MG TABLET is not recommended for children. If you are pregnant or breastfeeding, please inform your doctor before taking PALOZAC 0.50MG TABLET. Drive only if you are alert as PALOZAC 0.50MG TABLET may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Uses of PALOZAC 0.50MG TABLET

PALOZAC 0.50MG TABLET is used to prevent nausea and vomiting during chemotherapy. The detailed use of PALOZAC 0.50MG TABLET is as follows:

Chemotherapy-Induced Nausea and Vomiting (CINV): PALOZAC 0.50MG TABLET prevents acute and delayed CINV, providing long-lasting relief and improving patient quality of life during chemotherapy.

Have a query?

Directions for Use

PALOZAC 0.50MG TABLET can be taken with or without food as recommended by the doctor.
Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
Swallow PALOZAC 0.50MG TABLET as a whole with a glass of water.
Do not chew, crush, or break it.

Key Benefits

PALOZAC 0.50MG TABLET contains Palonosetron, which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone—CTZ) in the brain. Thus, it prevents nausea and vomiting during chemotherapy.

How PALOZAC 0.50MG TABLET Works

PALOZAC 0.50MG TABLET contains Palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zoneâ€”CTZ) in the brain. Thus, it prevents nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of PALOZAC 0.50MG TABLET

Take PALOZAC 0.50MG TABLET only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to PALOZAC 0.50MG TABLET or any other medicines, please tell your doctor. The oral form is not recommended for children. However, the injection may be given to children above one month as advised by a doctor. If you are pregnant or breastfeeding, please inform your doctor before taking PALOZAC 0.50MG TABLET. Drive only if you are alert, as PALOZAC 0.50MG TABLET may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Drug-Drug Interactions

PalonosetronZiprasidone

Critical

PalonosetronFentanyl

Severe

Drug-Drug Interactions

PalonosetronZiprasidone

Critical

How does the drug interact with Palozac 0.50mg Tablet:
Combining Palozac 0.50mg Tablet with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Palozac 0.50mg Tablet is not recommended, please consult your doctor before taking it.

PalonosetronFentanyl

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Taking fentanyl with Palozac 0.50mg Tablet may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Fentanyl with Palozac 0.50mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.

PalonosetronAmiodarone

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Coadministration of Amiodarone with Palozac 0.50mg Tablet can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Palozac 0.50mg Tablet together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

PalonosetronAmitriptyline

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Combining Palozac 0.50mg Tablet with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Palozac 0.50mg Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.

PalonosetronBuspirone

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Using Buspirone together with Fenfluramine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Co- administration of buspirone along with Palozac 0.50mg Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

PalonosetronLinezolid

Severe

How does the drug interact with Palozac 0.50mg Tablet:
When linezolid is taken with Palozac 0.50mg Tablet it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of linezolid along with Palozac 0.50mg Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

PalonosetronPentazocine

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Taking Palozac 0.50mg Tablet with Pentazocine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Palozac 0.50mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

PalonosetronVenlafaxine

Severe

How does the drug interact with Palozac 0.50mg Tablet:
When venlafaxine is taken with Palozac 0.50mg Tablet, it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Palozac 0.50mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.

PalonosetronChloroquine

Severe

How does the drug interact with Palozac 0.50mg Tablet:
Using chloroquine together with Palozac 0.50mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Palozac 0.50mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

PalonosetronHydroxychloroquine

Severe

How does the drug interact with Palozac 0.50mg Tablet:
The combined use of Palozac 0.50mg Tablet and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of palponosetron and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Eat a healthy and low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over sweet food and include more salty food, especially if you have been vomiting.
Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
Drink any other liquid at least 30 minutes after eating food.
If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do cooking or use prepared food from the freezer.

Habit Forming

Therapeutic Class

[ANTIEMETICS]

Alcohol

Consult your doctor

The interaction of alcohol with PALOZAC 0.50MG TABLET is unknown. Please consult a doctor before consuming alcohol with PALOZAC 0.50MG TABLET.

Pregnancy

Consult your doctor

PALOZAC 0.50MG TABLET is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.

Breast Feeding

Consult your doctor

Please consult a doctor before taking PALOZAC 0.50MG TABLET if you are breastfeeding. PALOZAC 0.50MG TABLET is given to breastfeeding women only if the doctor thinks benefits are greater than risks.

Driving

Caution

PALOZAC 0.50MG TABLET may cause tiredness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking PALOZAC 0.50MG TABLET.

Liver

Safe if prescribed

PALOZAC 0.50MG TABLET may be safe to use in patients with liver problems if prescribed by a doctor.

Kidney

Safe if prescribed

PALOZAC 0.50MG TABLET may be safe to use in patients with kidney problems if prescribed by a doctor.

Children

Unsafe

PALOZAC 0.50MG TABLET is not recommended for children.

Heart

Please inform your doctor if you have a history of heart disease before taking PALOZAC 0.50MG TABLET. Your doctor will prescribe it only if the potential benefits outweigh the possible risks.

Geriatrics

Consult your doctor

PALOZAC 0.50MG TABLET should be used in elderly patients only when prescribed by a doctor. If you have any concerns about using PALOZAC 0.50MG TABLET for geriatrics, please consult a doctor.

FAQs

How does PALOZAC 0.50MG TABLET work?

PALOZAC 0.50MG TABLET contains Palonosetron that works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Can I take erythromycin with PALOZAC 0.50MG TABLET?

You are not recommended to take erythromycin with PALOZAC 0.50MG TABLET as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with PALOZAC 0.50MG TABLET.

Does PALOZAC 0.50MG TABLET cause constipation?

PALOZAC 0.50MG TABLET may cause constipation as a side effect. It is not necessary for everyone taking PALOZAC 0.50MG TABLET to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

Is PALOZAC 0.50MG TABLET safe for patients suffering from heart problems?

PALOZAC 0.50MG TABLET should be used with caution in patients suffering from heart problems as it may worsen the condition. Therefore, inform your doctor if you have any heart problems before taking have PALOZAC 0.50MG TABLET so that the dose may be adjusted appropriately.

Can I stop taking PALOZAC 0.50MG TABLET on my own?

You are not recommended to stop taking PALOZAC 0.50MG TABLET without consulting your doctor as it may increase the risk of nausea and vomiting during chemotherapy. Therefore, take PALOZAC 0.50MG TABLET for as long as your doctor has prescribed it and if you experience any difficulty while taking PALOZAC 0.50MG TABLET, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India

Other Info - PAL0072

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Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 18, 2025 | 7:29 AM IST

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