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compositionComposition:CYCLOSPORINE-100MG
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Panimun Bioral 100 mg Solution is used to prevent organ transplant rejection. It is also used to treat inflammation and pain associated with psoriasis and rheumatoid arthritis. This medicine contains cyclosporine, which works by suppressing the immune system. It also helps reduce rapid skin cell growth, pain, and inflammation. It may sometimes cause common side effects such as headaches, vomiting, nausea, loss of appetite, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOSPORINE-100MG

Manufacturer/Marketer :

Panacea Biotec Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Panimun Bioral 100 mg Solution

Panimun Bioral 100 mg Solution is a solution or suspension prescribed to prevent organ rejection after a kidney, liver, or heart transplant. It is also used to treat severe cases of rheumatoid arthritis and psoriasis when other treatments have not worked. By calming the body's natural defence system, it helps protect new organs or reduce painful joint swelling and skin irritation.

To get the best results, you must take Panimun Bioral 100 mg Solution consistently every day at the same times. Taking it on a regular schedule keeps a steady level of the medicine in your blood. You can take it with or without food, but you must choose one way and do it the exact same way with every dose. Making simple lifestyle choices, such as wearing sun protection and practising thorough dental care, can also help manage the therapy safely.

While taking Panimun Bioral 100 mg Solution, you may experience some common side effects like shaking hands, increased hair growth, or mild stomach upset. However, it is vital to contact your doctor immediately if you experience signs of kidney problems, liver damage, or unusual infections.

Talk to your doctor before starting this medicine if you have high blood pressure, kidney disease, cancer, or a current infection. Do not take this if you are allergic to any of its ingredients or if you have severe kidney issues not related to your transplant, psoriasis, or arthritis.

Panimun Bioral 100 mg Solution can interact with many other medicines, which can increase the risk of side effects or reduce how well it works. Avoid drinking alcohol or smoking while using this medicine, as they can alter its effectiveness and increase strain on your body. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits before starting.

Uses of Panimun Bioral 100 mg Solution

Your doctor may prescribe Panimun Bioral 100 mg Solution for the following conditions: 

  • Preventing transplant rejection: Helps the body accept a new kidney, liver, or heart by preventing the immune system from attacking the donor organ.
  • Severe rheumatoid arthritis: Relieves painful joint swelling and stiffness when standard arthritis medications fail to provide relief.
  • Severe psoriasis: Clears up widespread, red, scaly skin patches by controlling the overactive immune response, causing rapid skin cell buildup.
     

Key Benefits

Panimun Bioral 100 mg Solution suppresses the immune system to help prevent organ rejection after transplantation and to manage certain autoimmune diseases. It helps protect transplanted organs while reducing inflammation in conditions caused by an overactive immune system.

  • Helps Prevent Organ Rejection: Reduces the risk of the immune system attacking a transplanted kidney, liver, heart, or other transplanted organ.
  • Controls Autoimmune Diseases: Helps reduce inflammation and immune system activity in conditions such as rheumatoid arthritis, psoriasis, and certain eye disorders.
  • Relieves Symptoms: Helps reduce joint pain, swelling, stiffness, and skin inflammation, improving comfort and mobility.
  • Supports Long-Term Disease Control: Regular use helps maintain stable disease control and reduces the frequency of disease flare-ups.
  • Improves Quality of Life: By protecting transplanted organs and controlling autoimmune conditions, it supports better daily functioning and overall well-being.
     
Side effects of Panimun Bioral 100 mg Solution 50 ml
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

Directions for Use

  • Panimun Bioral 100 mg Solution can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Check the label for directions and use as advised by your doctor.
  • Measure the prescribed dose of Panimun Bioral 100 mg Solution using the dosing syringe. Mix it with apple or orange juice, stir well, and drink immediately.
  • Do not store the prepared mixture for later use.

How Panimun Bioral 100 mg Solution Works

Panimun Bioral 100 mg Solution contains cyclosporine, an immunosuppressant that helps regulate the body's immune response. It works by selectively reducing the activity of T-lymphocytes (T-cells), a type of white blood cell involved in immune reactions. By suppressing these cells, cyclosporine helps prevent the immune system from attacking a transplanted organ or healthy body tissues in autoimmune conditions. Through this action, cyclosporine helps prevent organ rejection after transplantation and reduces inflammation associated with conditions such as psoriasis and rheumatoid arthritis, while preserving much of the body's normal immune function.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Panimun Bioral 100 mg Solution. It could lead to increased dizziness.

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Pregnancy

Caution

Panimun Bioral 100 mg Solution belongs to pregnancy category C. Consult your doctor before taking Panimun Bioral 100 mg Solution if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Panimun Bioral 100 mg Solution passes into breast milk. Avoid breastfeeding while taking Panimun Bioral 100 mg Solution.

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Driving

Caution

Panimun Bioral 100 mg Solution may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Panimun Bioral 100 mg Solution is not recommended for children as efficacy and safety have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

Panimun Bioral 100 mg Solution should be given to elderly patients only if prescribed by a doctor. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Panimun Bioral 100 mg Solution

If you accidentally take too much of this medicine, seek emergency medical care or call a poison control centre immediately. Symptoms of taking too much may include severe dizziness, vomiting, or signs of kidney problems.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit contains natural chemicals that can dangerously increase the amount of this medicine in your bloodstream, raising your risk of serious side effects.
  • Practice good oral hygiene: Brush your teeth at least twice a day and floss regularly to prevent gum swelling and tenderness, which are common with this medication.
  • Protect yourself from infections: Wash your hands frequently, avoid close contact with people who are sick, and consult your doctor before getting any vaccines.
  • Limit sun exposure: This medicine can make your skin more sensitive to sunlight and increase the risk of skin cancer. Wear protective clothing and apply a high-SPF sunscreen when outdoors.
  • Monitor your blood pressure: Check your blood pressure regularly at home as this medication can cause it to rise, and share these readings with your healthcare provider.
     
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How Soon It Starts Working

The time required for Panimun Bioral 100 mg Solution to start to work: The time required for Panimun Bioral 100 mg Solution to show its action is unknown. The time for which the effects of Panimun Bioral 100 mg Solution last: The duration of action for Panimun Bioral 100 mg Solution is unknown.

What if you forget to take Panimun Bioral 100 mg Solution

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store the liquid medicine at room temperature, ideally between 68°F and 77°F (20°C to 25°C). Do not store it in the refrigerator, as cold temperatures can cause the solution to thicken or gel. •Keep the bottle tightly closed and store it in its ori

Drug Warnings

  • Inspect the Medicine Before Use: If using the oral solution, a slight cloudiness or small particles may be normal. Do not use it if you notice unusual colour changes, heavy clumping, or signs of contamination.
  • Handle the Dosing Device Correctly: Do not wash the dosing syringe with water unless instructed in the product directions, as moisture may affect the medicine. Follow the manufacturer's cleaning instructions.
  • Attend Regular Monitoring Appointments: Keep all scheduled blood tests so your doctor can monitor your kidney function, liver function, blood pressure, and cyclosporine levels.
  • Do Not Switch Brands Without Medical Advice: Different brands and formulations may not be absorbed in the same way. Only switch if advised by your doctor.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Panimun Bioral 100 mg Solution:

  • NSAIDs and Certain Blood Pressure Medicines: Medicines such as ibuprofen and some ACE inhibitors or ARBs may increase the risk of kidney damage.
  • Certain Antibiotics, Antifungals, and Antiseizure Medicines: These medicines can increase or decrease cyclosporine levels, affecting its safety and effectiveness.
     
CiclosporinSimvastatin
Critical
CiclosporinBosentan
Critical

Drug-Drug Interactions

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CiclosporinSimvastatin
Critical
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Combining Panimun Bioral 100 mg Solution 50 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Panimun Bioral 100 mg Solution 50 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBosentan
Critical
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Panimun Bioral 100 mg Solution 50 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinCidofovir
Critical
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Panimun Bioral 100 mg Solution 50 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinPitavastatin
Critical
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Coadministration of pitavastatin with Panimun Bioral 100 mg Solution 50 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Panimun Bioral 100 mg Solution 50 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinBaricitinib
Critical
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Panimun Bioral 100 mg Solution 50 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinZalcitabine
Severe
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Co-administration of zalcitabine with Panimun Bioral 100 mg Solution 50 ml may significantly decrease the effect of zalcitabine.

How to manage the interaction:
Although there is a possible interaction between Zalcitabine and Panimun Bioral 100 mg Solution 50 ml, you can take these medicines together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
CiclosporinDocetaxel
Severe
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Coadministration of docetaxel with Panimun Bioral 100 mg Solution 50 ml may significantly increase the blood levels of docetaxel.

How to manage the interaction:
Although there is a possible interaction between deferasirox and Panimun Bioral 100 mg Solution 50 ml, they can be taken together if your doctor has prescribed them. Contact your doctor immediately if experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
CiclosporinFingolimod
Severe
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
When fingolimod is taken with cyclosporine, it can increase the risk of infection.

How to manage the interaction:
Although taking fingolimod and Panimun Bioral 100 mg Solution 50 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CiclosporinOrlistat
Severe
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Coadministration of Panimun Bioral 100 mg Solution 50 ml with Orlistat can reduce the levels and effects of Panimun Bioral 100 mg Solution 50 ml.

How to manage the interaction:
Although there is a possible interaction between Orlistat and Panimun Bioral 100 mg Solution 50 ml, you can take these medicines together when prescribed by your doctor. Do not stop using any medications without talking to a doctor.
CiclosporinTacrolimus
Severe
How does the drug interact with Panimun Bioral 100 mg Solution 50 ml:
Taking tacrolimus with Panimun Bioral 100 mg Solution 50 ml may cause serious side effects on the kidneys.

How to manage the interaction:
Although taking tacrolimus and Panimun Bioral 100 mg Solution 50 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, body aches, and severe pain in your upper stomach spreading to your back. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Inform your doctor about your dietary habits and follow these precautions while taking this medicine:

  • Grapefruit and St. John's Wort: Avoid grapefruit, grapefruit juice, and St. John's Wort, as they can significantly alter cyclosporine levels in your body.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Panimun Bioral 100 mg Solution is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis.
Panimun Bioral 100 mg Solution acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.
If you miss a dose of Panimun Bioral 100 mg Solution, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose instead.
Diarrhoea might be a side effect of Panimun Bioral 100 mg Solution. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Yes, the use of Panimun Bioral 100 mg Solution may cause abnormal facial and body hair growth as a common side effect. Please consult your doctor if you have any concerns.
Panimun Bioral 100 mg Solution is known to suppress the immune system. As a result, it increases the risk of infections and developing cancers, especially of the skin. Therefore, avoid prolonged exposure to sunlight by wearing suitable protective clothing and using sunscreen regularly.
Panimun Bioral 100 mg Solution may cause high blood pressure. Therefore, consult the doctor before taking Panimun Bioral 100 mg Solution if you have high blood pressure.
No, Panimun Bioral 100 mg Solution is not a steroid. It is an immunosuppressant.
Panimun Bioral 100 mg Solution may cause weight gain. Follow a healthy diet and exercise regularly to maintain proper weight. Consult your doctor if you have any concerns.
Panimun Bioral 100 mg Solution may cause fatigue. Eat a healthy diet, get regular exercise, manage stress, improve sleep habits, and quit smoking. Doing these may help cope with fatigue.
Yes, your doctor will recommend certain tests to check your body’s response to Panimun Bioral 100 mg Solution.
Panimun Bioral 100 mg Solution may cause side effects like headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Talk to your doctor if you experience these side effects persistently.
Use the measuring cup/dosing syringe provided with the pack to measure the prescribed dose of Panimun Bioral 100 mg Solution. Mix the solution/suspension in a glass of milk or orange juice, stir well, and consume immediately. Do not store the prepared mixture for later use.
You can mix the solution with apple juice, orange juice, or chocolate milk, but never use grapefruit juice, as it can dangerously increase the medicine's level in your body. Talk to your doctor or pharmacist if you have questions about mixing.
This medicine should only be used during pregnancy if the potential benefit justifies the potential risk to the baby. Talk to your doctor or pharmacist to discuss your specific situation.
The liquid can thicken or form light crystals if it gets cold. Keep it at room temperature, and it should return to normal; never microwave or expose it to high heat. Talk to your doctor or pharmacist if the liquid looks unusual.
You should avoid live vaccines while taking this medicine, as your weakened immune system may not be able to handle them safely. Talk to your doctor or pharmacist before scheduling any vaccinations.
This medicine can cause your gums to swell, grow, or bleed more easily. Practising excellent oral hygiene and seeing a dentist regularly can help manage this. Talk to your doctor or pharmacist if gum changes become painful.
It is best to avoid alcohol, as it can interact with this medication and increase the risk of liver irritation or side effects. Talk to your doctor or pharmacist for personalised guidance.
Do not take another dose immediately to make up for it, as you might take too much. Talk to your doctor or pharmacist right away for instructions on what to do.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 050715S035,050716S038Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Cyclosporine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.5300 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.1034 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  6. RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% [Internet]. [Accessed on 27 Feb 2025]Check here
  7. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 27 Feb 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Ambala- Chandigarh Highway, Lalru ? 140501, Punjab
Other Info - PAN0075
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