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compositionComposition:OXETACAINE-10MG+SUCRALFATE-1000MG
prescription
Prescription Medicine
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Pepshield Suspension 200 ml is used to treat acidity, heartburn, and gastrointestinal ulcers. It contains Sucralfate and Oxetacaine, which work by forming a protective barrier and exerting a numbing effect. This medicine may sometimes cause side effects such as constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

OXETACAINE-10MG+SUCRALFATE-1000MG

Manufacturer/Marketer :

Avis Life Care Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Pepshield Suspension 200 ml

Pepshield Suspension 200 ml is an oral liquid medicine primarily used to treat and prevent stomach ulcers, acidity, and irritation of the oesophagus (food pipe). It works by creating a physical barrier over raw, irritated areas in your digestive tract while simultaneously numbing the site to provide rapid relief. This dual approach helps the stomach lining heal while shielding it from further damage caused by stomach acid.

For the best results, you must take Pepshield Suspension 200 ml consistently and exactly as directed. It is typically taken on an empty stomach, usually one hour before your meals and at bedtime, which allows the liquid to coat your stomach lining effectively. Making key dietary changes, such as eating smaller portions and avoiding late-night snacks, can also significantly improve your treatment results.

While taking Pepshield Suspension 200 ml, you may experience mild and temporary side effects, with constipation and a dry mouth being the most common. These symptoms usually resolve on their own as your body adapts to the medicine. However, if you experience severe, ongoing stomach pain or signs of an allergic reaction, stop taking the medicine and consult your doctor immediately.

Before starting this medicine, it is important to discuss your medical history with your doctor. Do not take this if you have severe kidney disease, as your body may struggle to clear some of the minerals contained in the liquid. You should also talk to your doctor if you have a history of swallowing difficulties or bowel blockages.

Pepshield Suspension 200 ml can interfere with the absorption of other medications, meaning you must carefully space out your doses. Additionally, you should avoid drinking alcohol and smoking while taking this medicine, as both can irritate your stomach lining and delay healing. If you are pregnant, breastfeeding, or caring for an elderly patient, consult your doctor or pharmacist before starting treatment.

Uses of Pepshield Suspension 200 ml

Pepshield Suspension 200 ml is used in the treatment of stomach ulcers, acid reflux, and gastritis. The detailed uses of Pepshield Suspension 200 ml are as follows:

  • Stomach ulcers: Pepshield Suspension 200 ml forms a protective barrier over the raw surface of the ulcer, shielding it from harmful stomach acid and digestive enzymes so it can heal.
  • Acid reflux/Gastroesophageal Reflux Disease (GERD): It helps soothe the food pipe by forming a protective coating over irritated tissues while the local anaesthetic temporarily relieves the burning pain caused by acid reflux.
  • Gastritis (Stomach inflammation): Pepshield Suspension 200 ml protects and calms the inflamed lining of the stomach, reducing pain and discomfort.

Key Benefits

Pepshield Suspension 200 ml provides quick relief from pain and discomfort caused by stomach ulcers and food pipe irritation while protecting damaged tissues to support natural healing. The following are the benefits of this medication:

  • Provides fast-acting relief from burning sensations.
  • Temporarily numbs the surface of the stomach and the food pipe to ease pain and discomfort.
  • Forms a protective coating over ulcers and irritated tissues.
  • Acts like a liquid bandage, protecting damaged areas from further irritation.
  • Shields the affected tissue from stomach acid, pepsin, and bile salts.
  • Supports the body's natural healing process by allowing damaged tissues to repair themselves.
Side effects of Pepshield Suspension 200 ml
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Pepshield Suspension 200 ml should be taken 1 hour before or 2 hours after a meal.
  • It is usually taken 4 times daily or as advised by your doctor.
  • Shake the bottle well before each use.
  • Take the prescribed dose by mouth using the measuring cup provided with the pack.
  • Avoid using regular household spoons, as they may not measure the dose correctly.

How Pepshield Suspension 200 ml Works

Pepshield Suspension 200 ml is a combination of two active components that work together to treat and protect your digestive system. Sucralfate: It is a mucosal protective agent. When you swallow the liquid, this ingredient reacts with the acid in your stomach to form a thick, paste-like gel. This gel selectively binds to the surface of stomach ulcers and irritated tissues, creating a physical barrier. This shield protects the raw area from stomach acid, pepsin, and bile salts, giving the tissue a chance to heal. Oxetacaine: It is a fast-acting local anaesthetic. It works directly on the surface of the lining of your stomach and food pipe to temporarily block pain signals. This provides rapid, localised relief from the sharp, burning pain associated with ulcers and acid irritation. Its numbing effect is temporary and limited to the treated mucosal surface while the protective gel continues to support healing.
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Alcohol

Unsafe

Drinking alcohol with Pepshield Suspension 200 ml may cause dehydration and elevate the level of stomach acid thereby decreasing Pepshield Suspension 200 ml efficacy.

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Pregnancy

Consult your doctor

Pepshield Suspension 200 ml is a pregnancy category B drug. It should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Consult your doctor

There is limited data on how Pepshield Suspension 200 ml affects breastfeeding. Please consult your doctor, before taking Pepshield Suspension 200 ml. your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Driving

Unsafe

Pepshield Suspension 200 ml decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Pepshield Suspension 200 ml to be taken with caution if you had or have a history of liver disease/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Consult your doctor before taking Pepshield Suspension 200 ml if you have kidney impairment or any concerns regarding this. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Sucralfate in Pepshield Suspension 200 ml contains aluminum, which is normally excreted by your kidney. Therefore, people who have kidney problems may be at greater risk for developing high aluminum toxicity in the body. The dose adjustment is necessary for patients with kidney disease.

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Children

Unsafe

The safety and effectiveness of Pepshield Suspension 200 ml in children has not been established. Please consult your doctor before giving Pepshield Suspension 200 ml to children.

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Heart

Safe if prescribed

Pepshield Suspension 200 ml can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Pepshield Suspension 200 ml can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of Pepshield Suspension 200 ml

If you take more than the prescribed amount of Pepshield Suspension 200 ml, you may experience severe constipation or stomach pain. Seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Eat smaller, more frequent meals: Large meals can put pressure on your stomach and trigger acid reflux.
  • Avoid trigger foods: Limit your intake of spicy, fatty, acidic (like citrus and tomatoes), and caffeinated foods and beverages, which can irritate your stomach.
  • Do not lie down right after eating: Wait at least 2 to 3 hours after a meal before lying down or going to bed to prevent acid from travelling up your oesophagus (food pipe).
  • Elevate your head while sleeping: Use a wedge pillow or raise the head of your bed by 6 inches to help keep stomach acid where it belongs.
  • Avoid tight clothing: Clothes that fit tightly around your abdomen can squeeze your stomach and worsen acid reflux.
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How Soon It Starts Working

  • The time required for Pepshield Suspension 200 ml to start to work: Pepshield Suspension 200 ml ideally shows its action within 1 to 2 hours after administration.
  • The time for which the effects of Pepshield Suspension 200 ml last: The effect of Pepshield Suspension 200 ml lasts for 6 hours.

What if you forget to take Pepshield Suspension 200 ml

If you miss a dose, take it as soon as you remember on an empty stomach. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Pepshield Suspension 200 ml at room temperature, ideally between 15°C and 30°C. •Do not freeze this medicine, as freezing can break down the suspension.

Drug Warnings

  • Shake well before use: Shake the bottle vigorously before each dose. This helps ensure the medicine is mixed properly and you receive the correct amount.
  • Avoid food and drinks after taking it: Do not eat or drink anything for at least 30 minutes after taking Pepshield Suspension 200 ml. This allows the medicine to form a protective coating over your stomach lining.
  • Take other medicines at a different time: Take other medicines at least 2 hours before or 2 hours after Pepshield Suspension 200 ml. This helps prevent it from reducing the absorption of other medicines.
  • Be careful with activities requiring alertness: This medicine may occasionally cause mild drowsiness. Avoid driving or operating machinery until you know how it affects you.
  • Check the medicine before use: Do not use the liquid if it has unusual clumps, has changed colour, or if the bottle is damaged. If you notice any of these changes, consult your pharmacist before using it.

Drug-Drug Interactions

verifiedApollotooltip
  • Thyroid medications (e.g., Levothyroxine): Pepshield Suspension 200 ml can block the absorption of thyroid hormones. Take your thyroid medicine at least 2 hours before or after taking Pepshield Suspension 200 ml.
  • Antibiotics (e.g., Ciprofloxacin, Tetracycline): This medicine can significantly lower the effectiveness of these antibiotics. Space these medications at least 2 hours apart.
  • Blood thinners (e.g., Warfarin): Pepshield Suspension 200 ml may reduce the absorption of blood thinners, making them less effective. Close monitoring by your doctor is advised.
  • Heart medications (e.g., Digoxin): The absorption of digoxin may be reduced when taken together with Pepshield Suspension 200 ml.
Sucralfate + OxetacaineColecalciferol
Severe
Sucralfate + OxetacaineDolutegravir
Severe

Drug-Drug Interactions

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Sucralfate + OxetacaineColecalciferol
Severe
How does the drug interact with Pepshield Suspension 200 ml:
Taking Cholecalciferol together with Sucralfate and Oxetacaine may increase the blood levels of Sucralfate and Oxetacaine.

How to manage the interaction:
There may be a possibility of interaction when Cholecalciferol is taken with Sucralfate and Oxetacaine, but it can be taken if prescribed by a doctor. In case you experience any symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, nausea, vomiting, yellowing of the skin or eyes, weakness, confusion, tingling sensation in hands or feet, heaviness in legs, or slow or rapid heart rate. Do not discontinue any medications without consulting a doctor.
Sucralfate + OxetacaineDolutegravir
Severe
How does the drug interact with Pepshield Suspension 200 ml:
Co-administration of Dolutegravir with Sucralfate and Oxetacaine can decrease the blood levels of Dolutegravir.

How to manage the interaction:
Although taking Dolutegravir with Sucralfate and Oxetacaine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sucralfate + OxetacaineDoxercalciferol
Severe
How does the drug interact with Pepshield Suspension 200 ml:
Taking Doxercalciferol together with Sucralfate and Oxetacaine may increase the blood levels of Sucralfate and Oxetacaine.

How to manage the interaction:
There may be a possibility of interaction between Doxercalciferol and Sucralfate, but it can be taken if prescribed by a doctor. In case you experience any symptoms like like as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, yellowing of the skin or the whites of your eyes, weakness, confusion, tingling sensation in hands or feet, heaviness in legs, or slow or rapid heartrate. Do not discontinue any medications without consulting a doctor.
Sucralfate + OxetacaineParicalcitol
Severe
How does the drug interact with Pepshield Suspension 200 ml:
Taking Paricalcitol together with Sucralfate and Oxetacaine may increase the blood levels of Sucralfate and Oxetacaine.

How to manage the interaction:
There may be a possibility of interaction between Paricalcitol and Sucralfate, but it can be taken if prescribed by a doctor. In case you experience any symptoms like like as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, yellowing of the skin or the whites of your eyes, weakness, confusion, tingling sensation in hands or feet, heaviness in legs, or slow or rapid heartrate. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Acidic beverages (fruit juices, sodas): Drinking highly acidic beverages close to your dose can interfere with how the medicine coats your stomach.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIULCERANTS]

FAQs

Pepshield Suspension 200 ml is used to treat peptic ulcers or gastrointestinal ulcers. It also treats hyperacidity, heartburn, indigestion, and gastritis (inflammation of the stomach).
Pepshield Suspension 200 ml is a combination of two medicines: Sucralfate and Oxetacaine. Sucralfate is an antiulcers covers the damaged ulcer tissue in the stomach and protects it from acid or injury to facilitate healing. Oxetacaine is a local anesthetic that shows numbing effect provides fast relief from pain caused due to ulcers or acidic injury in the stomach.
If you miss a dose of Pepshield Suspension 200 ml, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not take Pepshield Suspension 200 ml for longer durations unless prescribed by the doctor. Talk to your doctor if you do not feel better even after taking Pepshield Suspension 200 ml for a few days.
Do not stop taking Pepshield Suspension 200 ml without consulting your doctor. The stomach ulcer and duodenal ulcer tends to be recurrent disease. If you stop taking Pepshield Suspension 200 ml, it will not influence the frequency or severity of future ulceration.
Do not take aspirin and ibuprofen as a pain killer while taking Pepshield Suspension 200 ml unless your doctor says it to take. These pain killers increase the secretion of stomach acid and exaggerate gastrointestinal bleeding. Besides this, avoid acid-containing food/drinks, coffee, tea, carbonated drinks and vegetables like lemon, tomato etc.
Pepshield Suspension 200 ml is prescribed to treat gastrointestinal issues such as peptic ulcers, hyperacidity, heartburn, indigestion, and gastritis. It provides a protective barrier for the stomach lining and helps alleviate pain.
Take the prescribed dose one hour before a meal or as your doctor directs. Before using, shake the bottle well and administer the dose orally using the provided measuring cup. Afterwards, refrain from drinking anything to ensure the medication works optimally.
No, it is recommended that you avoid drinking water or any other liquid immediately after taking Pepshield Suspension 200 ml. This helps ensure the medication works effectively.
Yes, the use of Pepshield Suspension 200 ml can cause constipation in some individuals, which typically resolves on its own over time. To manage this side effect, try increasing your fluid intake, eating a fibre-rich diet, and engaging in regular physical activity. If the constipation persists or worsens, consult your doctor for further guidance.
Common side effects of Pepshield Suspension 200 ml including constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhea. These side effects usually resolve on their own. If they persist or worsen, consult your doctor.
No, Pepshield Suspension 200 ml can interfere with how your body absorbs many other medicines, making them less effective. You should always space other oral medications at least 2 hours before or 2 hours after taking Pepshield Suspension 200 ml. Talk to your doctor or pharmacist to help plan your medication schedule.
The safety of Pepshield Suspension 200 ml during pregnancy has not been fully established. It should only be used during pregnancy if your doctor determines that the benefits outweigh the potential risks. Talk to your doctor before using this medicine if you are pregnant or planning to become pregnant.
No, Pepshield Suspension 200 ml provides rapid relief from the symptoms of acidity and helps heal stomach ulcers, but it does not cure the underlying cause of chronic acid reflux permanently. Maintaining healthy dietary and lifestyle habits is essential for long-term management. Talk to your doctor for a long-term treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Sucralfate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 018333S034,019183S016Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Antacid And Oxetacaine Oral Suspension Sth Unlicensed Medicines Information Leaflet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Pujitha Kudaravalli; Savio John. Sucralfate. StatPearls [Internet]. NIH. National Library of Medicine. National Center for Biotechnology Information. [Revised in February 2022]. [Accessed on 15th October 2022]Check here
  5. Oxetacaine. [Accessed on 02 Jun. 2026]Check here
  6. Avinash S, Amresh S, Anuradha S Sucralfate - Oxetacain Suspension in Management of Persistent Gastroenteritis of Varied OriginCheck here
  7. Leeford Leeford. [Accessed on 14 Aug. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

No.R-9, 1st Main Road, 1st Block,Muthamizh Nagar, Chennai - 600118
Other Info - PEP0446

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