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compositionComposition:DOMPERIDONE-5MG+SUCRALFATE-500MG
prescription
Prescription Medicine
info
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Pepsigard-P Oral Suspension 100 ml is used to treat duodenal ulcers, nausea, and vomiting. It contains Sucralfate and Domperidone which protect the ulcers from acid and facilitate their healing. Besides this, it blocks dopamine receptors that stimulate the vomiting centre. This medicine may sometimes cause side effects such as dry mouth, diarrhoea, constipation, drowsiness, dizziness, or headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOMPERIDONE-5MG+SUCRALFATE-500MG

Manufacturer/Marketer :

Saf Fermion Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Pepsigard-P Oral Suspension 100 ml

Pepsigard-P Oral Suspension 100 ml is a prescription medicine designed to treat and manage stomach ulcers, acid reflux, and stomach lining irritation. It helps relieve symptoms like heartburn, bloating, and upper abdominal pain by creating a protective layer in your digestive tract and improving gut movement. This dual action helps soothe your stomach and speeds up your path to recovery.

To get the best results, you must take Pepsigard-P Oral Suspension 100 ml consistently at the same times every day as directed by your doctor. It is typically taken on an empty stomach, either one hour before a meal or two hours after. Making simple dietary changes, such as eating smaller portions and avoiding heavy meals close to bedtime, will also greatly assist this medicine in doing its job.

Most people tolerate this medicine well when taken as prescribed, although some people may experience side effects such as constipation, dry mouth, or mild sleepiness. Contact your doctor immediately if you experience severe abdominal pain, persistent vomiting, signs of an allergic reaction, or symptoms such as a fast or irregular heartbeat, fainting, or severe dizziness.

Before you begin taking Pepsigard-P Oral Suspension 100 ml, tell your doctor if you have kidney disease, liver disease, digestive blockages or bleeding, a prolactinoma (a tumour of the pituitary gland), or a history of heart rhythm problems. You should also tell your doctor about all the medicines you are taking, especially certain antifungal medicines, macrolide antibiotics, or other medicines that may affect heart rhythm, as they may not be suitable to take with Pepsigard-P Oral Suspension 100 ml. Do not take this medicine if you are allergic to any of its ingredients.

This medicine can block the absorption of other drugs, so you should space it out from your other daily medicines. Avoid alcohol and smoking while using this product, as both can worsen stomach irritation and delay healing. If you are pregnant, breastfeeding, or elderly, please consult your healthcare provider to ensure this treatment is safe for you. The safety and suitability of this medicine for children depend on their age, body weight, and medical condition. It should only be used in children if prescribed and closely supervised by a doctor. 

Uses of Pepsigard-P Oral Suspension 100 ml

Pepsigard-P Oral Suspension 100 ml is used to treat acid-related digestive conditions. The detailed uses are as follows:

  • Stomach and intestinal ulcers: Pepsigard-P Oral Suspension 100 ml helps by coating raw, ulcerated areas in your digestive tract, shielding them from stomach acid so they can heal.
  • Acid reflux (GERD): It prevents stomach acid and food from travelling backwards into your food pipe, reducing heartburn and throat discomfort.
  • Gastritis: It soothes and protects an inflamed stomach lining, helping to relieve burning pain and nausea.

Key Benefits

Pepsigard-P Oral Suspension 100 ml helps relieve symptoms of acid-related digestive conditions by protecting the stomach lining and improving the movement of food through the digestive tract. By reducing irritation from stomach acid and promoting more efficient stomach emptying, it helps improve digestive comfort. This medicine offers several important benefits: 

  • Protects the Stomach Lining: Forms a protective barrier over ulcers and irritated areas, helping shield them from stomach acid and digestive enzymes while supporting the natural healing process.
  • Relieves Acid Reflux Symptoms: Helps reduce heartburn, acid regurgitation, and upper abdominal discomfort by improving stomach emptying and reducing the backflow of stomach contents into the food pipe.
  • Improves Digestive Comfort: Helps relieve symptoms such as bloating, nausea, and a feeling of fullness after meals, making everyday eating more comfortable.

Directions for Use

  • Pepsigard-P Oral Suspension 100 ml should be taken on an empty stomach, 1 hour before a meal, or as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.
  • Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

How Pepsigard-P Oral Suspension 100 ml Works

Pepsigard-P Oral Suspension 100 ml contains sucralfate and domperidone, which work together to relieve acid-related digestive conditions. Sucralfate forms a protective barrier over ulcers and damaged areas of the lining of the stomach and duodenum, helping protect them from stomach acid, pepsin, and bile salts to support healing. Domperidone increases the movement of the stomach and upper intestine, helping the stomach empty more quickly while relieving nausea and reducing the backflow of stomach contents into the food pipe. By combining these complementary actions, Pepsigard-P Oral Suspension 100 ml helps relieve symptoms such as heartburn, acid reflux, bloating, nausea, and upper abdominal discomfort while supporting ulcer healing.
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Alcohol

Unsafe

Avoid alcohol consumption as it may increase adverse effects such as irregular heartbeat, drowsiness or may irritate the stomach lining.

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Pregnancy

Caution

Pepsigard-P Oral Suspension 100 ml is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

Pepsigard-P Oral Suspension 100 ml may be excreted in human milk in small amounts and cause adverse effects in the baby. Therefore, Pepsigard-P Oral Suspension 100 ml is given to breastfeeding women only if the doctor thinks benefits are greater than risks. Please consult a doctor before taking Pepsigard-P Oral Suspension 100 ml if you are breastfeeding.

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Driving

Caution

Pepsigard-P Oral Suspension 100 ml may cause drowsiness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking Pepsigard-P Oral Suspension 100 ml.

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Liver

Caution

Take Pepsigard-P Oral Suspension 100 ml with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Pepsigard-P Oral Suspension 100 ml is not recommended for patients with moderate or severe liver disease.

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Kidney

Caution

Take Pepsigard-P Oral Suspension 100 ml with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Pepsigard-P Oral Suspension 100 ml is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established.

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Heart

Unsafe

Pepsigard-P Oral Suspension 100 ml is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Unsafe

Pepsigard-P Oral Suspension 100 ml is not safe for use in elderly patients due to its severe side effects.

What if I have taken an overdose of Pepsigard-P Oral Suspension 100 ml

If you take more than your prescribed dose and experience severe symptoms like extreme drowsiness, confusion, or muscle spasms, seek immediate emergency medical care or contact your local poison control centre right away.

Diet & Lifestyle Advise

  • Eat smaller, frequent meals: Large meals put pressure on the stomach valve, making acid reflux more likely. Spacing out your food helps digestion.
  • Identify and avoid food triggers: Limit foods that irritate the stomach, such as spicy dishes, fried or fatty foods, chocolate, citrus fruits, tomatoes, and caffeine.
  • Stay upright after eating: Avoid lying down, reclining, or bending over for at least 2 to 3 hours after a meal to let gravity keep stomach acid where it belongs.
  • Elevate the head of your bed: Raise the head of your bed by 6 to 9 inches using solid blocks or a specialised wedge pillow to prevent nighttime acid reflux.
  • Wear loose clothing: Avoid tight belts or waistbands that compress your stomach, which can force acid upward into your food pipe.

Health Queries

I have been experiencing abdominal pain for the past 15 days, which only occurs during dinner. Despite taking Pepsigard P and Rantac syrup, the pain remains the same. What alternative medications or treatments should I take for relief?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Since your pain has not responded to acid-reducers like ranitidine or mucosal protectants like sucralfate, the issue may not be simple acidity. Abdominal pain occurring specifically after dinner can sometimes point to gallbladder issues (like gallstones) or delayed digestion. Rather than trying alternative over-the-counter medications, it is best to consult a doctor. They may suggest an abdominal ultrasound to check your gallbladder or prescribe a different class of acid suppressants, like pantoprazole. For temporary relief, try eating smaller, low-fat dinners, avoid spicy foods, and do not lie down immediately after eating. Please seek a medical evaluation for an accurate diagnosis.
health query

Have a query?

How Soon It Starts Working

The time required for Pepsigard-P Oral Suspension 100 ml to start to work: The time required for Pepsigard-P Oral Suspension 100 ml to show its action is unknown. The time for which the effects of Pepsigard-P Oral Suspension 100 ml last: The duration of action for Pepsigard-P Oral Suspension 100 ml is clinically unknown.

What if you forget to take Pepsigard-P Oral Suspension 100 ml

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and resume your regular timing. Never take two doses at the same time to make up for a missed one.

Storage

• Store Pepsigard-P Oral Suspension 100 ml at room temperature, keeping it below 30°C (86°F). • Store this medicine safely out of reach of children and household pets.

Drug Warnings

  • Inspect the liquid: Always check the suspension before taking it; it should look uniform after shaking. Do not use it if you notice unusual clumping that does not mix back in or any discolouration.
  • Time your other drugs carefully: Because Pepsigard-P Oral Suspension 100 ml creates a strong barrier in your digestive tract, it can block your body from absorbing other medicines. Always take your other medicines at least 2 hours before or 2 hours after taking this product.
  • Avoid close antacid use: Do not take antacids within 30 minutes of your dose. One of the active parts of Pepsigard-P Oral Suspension 100 ml requires a certain level of stomach acidity to form its protective barrier properly.
  • Watch for dizziness: Since this medicine can cause mild sleepiness or dizziness, avoid driving or operating tools until you are certain of how it affects your alertness.
  • Check kidney warnings: Tell your doctor if you have kidney problems, as some of the mineral salts in this medicine can build up in the body if your kidneys are not filtering efficiently.

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Thyroid medicines (such as levothyroxine): Pepsigard-P Oral Suspension 100 ml may reduce the absorption of thyroid medicines. Take these medicines at least 2 hours apart, or as advised by your doctor.
  • Antibiotics (like tetracyclines and quinolones): Taking these along with Pepsigard-P Oral Suspension 100 ml can prevent the antibiotics from working effectively.
  • Blood thinners (like warfarin) and heart medicines (like digoxin): Pepsigard-P Oral Suspension 100 ml can lower their absorption, reducing their therapeutic effects.
  • Medicines that affect heart rhythm: Combining this medicine with certain heart or psychiatric drugs may increase the risk of irregular heartbeats.

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verifiedApollotooltip
  • High-fat meals: Eating heavy, fatty meals can delay the absorption and onset of this medicine.
  • Caffeine and carbonated drinks: These beverages can increase stomach acid production and weaken the stomach valve, countering the effects of this medicine.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

FAQs

Pepsigard-P Oral Suspension 100 ml is used to treat duodenal ulcers, nausea, and vomiting.
Pepsigard-P Oral Suspension 100 ml contains Sucralfate and Domperidone. Sucralfate is a protectant that works by forming a protective layer over the ulcer and protects the stomach from getting ulcer due to excess of the stomach acid. Thereby, it allows healing. Domperidone belongs to the class of dopamine antagonist that works by blocking dopamine receptors that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
You are not recommended to take antacids with Pepsigard-P Oral Suspension 100 ml such as sodium bicarbonate or cimetidine at the same time as it may affect the absorption of Pepsigard-P Oral Suspension 100 ml and reduce its effectiveness. However, if you are supposed to take these medicines together, you are recommended to maintain a time gap of 30 minutes between taking antacids and Pepsigard-P Oral Suspension 100 ml. Please consult your doctor before taking other medicines with Pepsigard-P Oral Suspension 100 ml.
Pepsigard-P Oral Suspension 100 ml should be used with caution in diabetic patients as it may increase the risk of change in blood sugar levels. However, inform your doctor if you have diabetes before taking have Pepsigard-P Oral Suspension 100 ml so that the dose may be adjusted appropriately and regular monitoring of blood sugar levels is recommended while taking Pepsigard-P Oral Suspension 100 ml.
Pepsigard-P Oral Suspension 100 ml may cause dry mouth as a temporary side effect. It is not necessary for everyone taking Pepsigard-P Oral Suspension 100 ml to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.
You are recommended to use Pepsigard-P Oral Suspension 100 ml for as long as your doctor has prescribed it. However, avoid taking Pepsigard-P Oral Suspension 100 ml for more than 1 week without consulting a doctor.
Pepsigard-P Oral Suspension 100 ml should be used with caution in patients suffering from kidney problems. However, inform your doctor if you have any kidney problems before taking have Pepsigard-P Oral Suspension 100 ml so that the dose may be adjusted appropriately.
You should take Pepsigard-P Oral Suspension 100 ml at the time and dosage prescribed by your doctor. It is typically taken on an empty stomach, either 1 hour before or 2 hours after a meal. For best results, it is important to take it at the same time every day to maintain a consistent level of the medication in your body.
Yes, you can take Pepsigard-P Oral Suspension 100 ml with other medications in most cases. However, you should inform your doctor first, especially if you are already taking certain medications, such as antifungals (e.g., fluconazole), antidepressants (e.g., citalopram), anti-allergic drugs (e.g., mizolastine), vitamins (e.g., ascorbic acid), and antibiotics (e.g., clarithromycin, erythromycin). This is not a complete list, and other drugs may interact with Pepsigard-P Oral Suspension 100 ml. Your doctor will evaluate your overall health, medication history, and any underlying conditions before recommending Pepsigard-P Oral Suspension 100 ml, to avoid possible interactions or side effects. Always follow your doctor's guidance and avoid self-medicating to ensure your safety and well-being.
Yes, Pepsigard-P Oral Suspension 100 ml may cause side effects in some individuals, although not everyone will experience them. Common side effects include dry mouth, diarrhoea, constipation, drowsiness, dizziness, and headache. These side effects are generally mild and tend to resolve over time or once the medication is discontinued. However, if any side effects persist or worsen, please consult your doctor for further guidance and management.
If you are pregnant or breastfeeding, it is important to consult your doctor. Pepsigard-P Oral Suspension 100 ml may be excreted in small amounts in human milk and could potentially cause adverse effects in the baby. Your doctor will prescribe Pepsigard-P Oral Suspension 100 ml only if the benefits outweigh the risks.
You should store Pepsigard-P Oral Suspension 100 ml in a cool, dry place, away from direct heat or sunlight. Make sure it is kept out of reach of children. Do not freeze the medication.
No, Pepsigard-P Oral Suspension 100 ml works best when taken on an empty stomach, either 1 hour before a meal or 2 hours after. Taking it with food can prevent the medicine from forming a protective coating over your ulcers. Talk to your doctor if you have questions about the timing of your doses.
Yes, mild sleepiness or drowsiness is a recognised side effect of Pepsigard-P Oral Suspension 100 ml for some individuals. It is best to avoid driving, riding a bicycle, or operating heavy machinery until you know how this medicine affects your alertness. Talk to your doctor if this sleepiness persists.
Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular timing. Do not double the dose to make up for a missed one. Talk to your doctor if you frequently miss doses.
No, you should not stop taking Pepsigard-P Oral Suspension 100 ml even if your pain goes away. Stomach ulcers and tissue irritation require a full course of treatment to heal completely. Stopping early may cause your symptoms to return. Talk to your doctor before changing your treatment routine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3188 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Sucralfate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Pepsigard P Suspension
  4. Make sure you eat regular meals and drink plenty of water
  5. Avoid spicy and fatty fried food

Country of origin

India

Manufacturer/Marketer address

Millennium City Information Technology Park, Tower-Ii, Plot No. 62, Block-Dn, Sector V, 8Th Floor, Salt Lake, Kolkata: 700 091
Other Info - PEP0509

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