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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Perigard D Tablet is used alone or with other drugs to treat Hypertension (High blood pressure). It contains Perindopril and Indapamide, which relaxes blood vessels and lowers increased blood pressure. Also, it increases the amount of urine passed out from the kidneys. It effectively reduces excess fluid overload in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient in pumping blood throughout the body. Sometimes, it may cause headaches, tiredness, slow heart rate, and nausea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Perigard D Tablet

Perigard D Tablet is prescribed alone or with other drugs to lower the raised blood pressure. Hypertension (High blood pressure) is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease.

Perigard D Tablet contains two medicines: Perindopril (blood pressure-lowering agent) and Indapamide (diuretics or water pills). Perindopril is an angiotensin-converting enzyme or ACE inhibitor that lowers increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and helps lower high blood pressure. On the other hand, Indapamide (diuretic) increases the amount of urine passed out from the kidneys. But unlike other water pills, it does not increase urine output. It effectively reduces excess fluid overload in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, both help lower high blood pressure, reducing heart attack or stroke chances.

Perigard D Tablet is taken with or without food in a dose and duration as advised by the doctor. The doctor will adjust your dose according to your condition and response to the medicine. Sometimes, you may experience headaches, tiredness, slow heart rate, and nausea. Most of these side effects of Perigard D Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Even if your blood pressure becomes normal, you should not stop using Perigard D Tablet . Doing so may worsen your condition. Tell your doctor if you have had or currently have liver, kidney, or heart problems. In pregnancy and lactation, Perigard D Tablet should only be taken after consulting your doctor. You should regularly monitor your blood pressure and heart rate. Please tell your doctor if you are taking any other medicines or are allergic to Perigard D Tablet . Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Perigard D Tablet

Treatment of Hypertension (high blood pressure)

Directions for Use

• Perigard D Tablet can be taken before a meal, preferably in the morning or as advised by your doctor.• It should be taken once a day or as directed by the doctor.• Swallow Perigard D Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Perigard D Tablet is primarily used to treat hypertension (high blood pressure), reduce the heart's workload, and reduce the risk of any future heart attack or stroke. It contains two medicines: Perindopril (blood pressure-lowering agent) and Indapamide (diuretics or water pills). Perindopril lowers the increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and helps lower high blood pressure. On the other hand, Indapamide (diuretic) increases the amount of urine passed out from the kidneys. But unlike other water pills, it does not increase urine output too much. Thus, both help lower high blood pressure, reducing heart attack or stroke chances.

How Perigard D Tablet Works

Perigard D Tablet contains two medicines: Perindopril(blood pressure-lowering agent) and Indapamide (diuretics or water pills). Perindopril is an angiotensin-converting enzyme or ACE inhibitor that lowers increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and helps lower high blood pressure. On the other hand, Indapamide (diuretic) increases the amount of urine passed out from the kidneys. But unlike other water pills, it does not increase urine output and effectively reduces excess fluid overload in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, both can lower high blood pressure, reducing heart attack or stroke chances.

Storage

Keep Perigard D Tablet out of the sight and reach of children.

What if I have taken an overdose of Perigard D Tablet

Do not take more than the prescribed dose of Perigard D Tablet as it may cause overdose. The symptoms of overdose include cramps, dizziness, nausea, vomiting, mental confusion, or change in the amount of urine. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Perigard D Tablet should not be given to people allergic to Perigard D Tablet , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Perigard D Tablet is not recommended in neonates and children with worse kidney functioning (glomerular filtration rate <30 mL/min). The raised bilirubin level has been reported in some cases, so patients with liver diseases (like cirrhosis, jaundice, yellowing of skin/eye, etc.) should take the Perigard D Tablet with caution. Perigard D Tablet contains perindopril, which is a category D pregnancy drug, it can cause harm to the baby, so it is not recommended to be taken during pregnancy. Do not take Perigard D Tablet with alcohol as it may cause low blood pressure (hypotension) with symptoms of dizziness, drowsiness, weariness, or sleepiness. Tell your doctor you are using Perigard D Tablet before undergoing dental or other surgery. Your doctor might stop this medicine before the surgery. Perigard D Tablet contains Indapamide, which positively reacts to drug tests, so if you are an athlete, be aware if you are taking Perigard D Tablet and are undergoing a drug test.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Perigard D Tablet:
Combining Aliskiren with Perigard D Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perigard D Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perigard D Tablet:
Taking Perigard D Tablet with Thioridazine can increase the risk of heart problems.

How to manage the interaction:
Taking Thioridazine with Perigard D Tablet is not recommended, but can be taken if prescribed by the doctor.
IndapamideDroperidol
Critical
How does the drug interact with Perigard D Tablet:
Taking Droperidol with Perigard D Tablet can lead to severe heart problems.

How to manage the interaction:
Taking Droperidol with Perigard D Tablet is not recommended, but can be taken if prescribed by the doctor.
IndapamideProtriptyline
Critical
How does the drug interact with Perigard D Tablet:
Taking Protriptyline along with Perigard D Tablet can lead to serious heart problems.

How to manage the interaction:
Taking Protriptyline with Perigard D Tablet is not recommended, but can be taken if prescribed by the doctor.
How does the drug interact with Perigard D Tablet:
Taking Irbesartan with Perigard D Tablet may cause low blood pressure and kidney problems.

How to manage the interaction:
Although taking Irbesartan with Perigard D Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in the legs, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perigard D Tablet:
Taking Perigard D Tablet with telmisartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and high blood potassium.

How to manage the interaction:
Although there is a possible interaction, telmisartan can be taken with Perigard D Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Maintain adequate fluid intake during treatment with these medications. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Perigard D Tablet:
Coadministration of Losartan with Perigard D Tablet can increase of kidney problems and irregular heart rhythm.

How to manage the interaction:
Taking Losartan with Perigard D Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perigard D Tablet:
Taking Perigard D Tablet with candesartan can increase the risk of kidney failure, low blood pressure, and high potassium levels.

How to manage the interaction:
Although taking Perigard D Tablet and Candesartan together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perigard D Tablet:
Coadministration of Olmesartan medoxomil with Perigard D Tablet may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking olmesartan medoxomil together with Perigard D Tablet may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perigard D Tablet:
Taking Azilsartan medoxomil with Perigard D Tablet can cause low blood pressure, kidney function impairment, or increased potassium levels.

How to manage the interaction:
Although taking Azilsartan medoxomil with Perigard D Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience vomiting, weakness, tingling in your hands and feet, or palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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INDAPAMIDE-1.25MG+PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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INDAPAMIDE-1.25MG+PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Tomatoes, Sweet Potatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming Potassium containing food with Perindopril and Indapamide can increase the risk of high levels of potassium in your blood. Avoid consuming Potassium-containing food with Perindopril and Indapamide.

Diet & Lifestyle Advise

  • Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

  • Keep your weight under control with a BMI of 19.5-24.9.

  • Avoid chronic stress, as it can raise your blood pressure.

  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.

  • Be mindful of salt; consume no more than 2,300 mg each day.

  • Limit or avoid alcohol consumption.

  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Perigard D Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Limit or cut down alcohol consumption; alcohol consumption may enhance this drug's hypotensive (low blood pressure) effect

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Pregnancy

Caution

The use of Perigard D Tablet or any ACE inhibitors (pregnancy category D) is usually contraindicated during the second and third trimesters of pregnancy. It may cause harm to the developing fetus. Hence, you should always consult your doctor before using the Perigard D Tablet .

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Breast Feeding

Caution

Use of Perigard D Tablet is not recommended during the breastfeeding stage.

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Driving

Caution

Drive with caution, Perigard D Tablet may cause blurry vision, and dizziness or weariness may occur.

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Liver

Caution

Perigard D Tablet to be taken with caution, especially in case of severe liver disease. The dose may have to be adjusted by your doctor. Perigard D Tablet should be given with precaution in hemodialysis conditions.

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Kidney

Caution

Perigard D Tablet to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. Perigard D Tablet should be given with precaution in hemodialysis conditions.

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Children

Caution

Perigard D Tablet is not recommended for children. The safety and effectiveness of Perigard D Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Perigard D Tablet or not.

Have a query?

FAQs

Perigard D Tablet is used to treat hypertension (high blood pressure), a condition in which the blood exerts increased pressure on the walls of blood vessels.

Perigard D Tablet contains two medicines: Perindopril (blood pressure-lowering agent) and Indapamide (diuretics or water pills). Perindopril is an angiotensin-converting enzyme or ACE inhibitor that lower increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). Indapamide (diuretic) increases the amount of urine passed out from the kidneys. Thus, both help lower high blood pressure, reducing heart attack or stroke chances.

It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.

Usually, Perigard D Tablet is prescribed for a long-term treatment ranging from months to years for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor&amp;#039;s consent can be fatal. Hence, only take it as long as your doctor prescribes it.

Before surgery, you should inform your doctor that you are taking Perigard D Tablet to reduce your blood pressure when used along with anaesthesia, which is given before a major operation.

Perigard D Tablet contains Indapamide, which gives a positive reaction to drug tests. If you are an athlete, be aware if you are taking Perigard D Tablet and are undergoing a drug test.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - PER0013

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