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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure). It contains Amlodipine and Perindopril, which relaxes and widens the blood vessels, so that blood passes through them easily, thereby lowering the blood pressure and makes it easier for your heart to pump blood around your body. Thus, it lowers high blood pressure, reducing the risk of heart attack or stroke. It may cause side effects such as ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, the increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), taste change, decreased blood pressure, and upset stomach. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against blood vessel's walls. This condition makes the heart work harder in pumping the blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing heart attack or stroke chances. 

Take Perindosyl-Am 4/5Mg Tablet as prescribed by your doctor. You may experience ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with Aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, and high potassium levels in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Uses of Perindosyl-Am 4/5Mg Tablet

Treatment of Hypertension (high blood pressure).

Directions for Use

• Take Perindosyl-Am 4/5Mg Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Perindosyl-Am 4/5Mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It also treats chest pain by improving the blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. On the other hand, Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. However, Perindosyl-Am 4/5Mg Tablet does not cure high blood pressure (hypertension) but does help control it. In addition to this, Perindosyl-Am 4/5Mg Tablet also reduces the physical effects of anxiety.

How Perindosyl-Am 4/5Mg Tablet Works

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing heart attack or stroke chances.

Storage

Keep this medicine out of the sight and reach of children.

What if I have taken an overdose of Perindosyl-Am 4/5Mg Tablet

Do not take more than the prescribed dose of Perindosyl-Am 4/5Mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food.  Avoid potassium, containing food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Combining Aliskiren with Perindosyl-Am 4/5Mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Taking simvastatin with Perindosyl-Am 4/5Mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineFosphenytoin
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
When Perindosyl-Am 4/5Mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Perindosyl-Am 4/5Mg Tablet, which may make Perindosyl-Am 4/5Mg Tablet less effective.

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet and phenytoin together may drastically lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Perindosyl-Am 4/5Mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Ceritinib together with Perindosyl-Am 4/5Mg Tablet can slow heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet with Ceritinib, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, or an irregular heartbeat, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and rifampicin together may lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet and rifabutin together may lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of lemborexant and Perindosyl-Am 4/5Mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Perindosyl-Am 4/5Mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet with itraconazole may significantly raise the blood levels and effects of Perindosyl-Am 4/5Mg Tablet.

How to manage the interaction:
Perindosyl-Am 4/5Mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Perindosyl-Am 4/5Mg Tablet.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.

  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.

  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

  • If you are taking alcohol, use only one serving for women and two servings for men.

  • Quit smoking to lower the risk of heart diseases.

  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.

  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.

  • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Perindosyl-Am 4/5Mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Perindosyl-Am 4/5Mg Tablet interacts with alcohol. Therefore alcohol is not safe.

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Pregnancy

Unsafe

The use of Perindosyl-Am 4/5Mg Tablet is usually contraindicated during the second and third trimester of pregnancy. It may cause harm to the unborn baby. Hence, you should always consult your doctor before using Perindosyl-Am 4/5Mg Tablet .

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Breast Feeding

Caution

Use of Perindosyl-Am 4/5Mg Tablet is not recommended during the breastfeeding stage unless recommended by your doctor.

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Driving

Caution

Perindosyl-Am 4/5Mg Tablet may cause dizziness and sleepiness. Therefore, drive with caution while using Perindosyl-Am 4/5Mg Tablet .

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Liver

Caution

Let your doctor know if you have any history of liver diseases before using Perindosyl-Am 4/5Mg Tablet . Perindosyl-Am 4/5Mg Tablet is to be administered with caution in patients with severe hepatic impairment.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before using Perindosyl-Am 4/5Mg Tablet . Perindosyl-Am 4/5Mg Tablet is primarily eliminated by the kidney and can be accumulated in patients with renal impairment.

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Children

Unsafe

Perindosyl-Am 4/5Mg Tablet is not recommended for use in children.

Have a query?

FAQs

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure).

Perindosyl-Am 4/5Mg Tablet relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

Perindosyl-Am 4/5Mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Perindosyl-Am 4/5Mg Tablet on your own as it may lead to a sudden rise in blood pressure increases the risk of heart attack and stroke.

Perindosyl-Am 4/5Mg Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

Perindosyl-Am 4/5Mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Perindosyl-Am 4/5Mg Tablet if you have diabetes.

Even though your blood pressure becomes normal after using Perindosyl-Am 4/5Mg Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Yes, you can take Perindosyl-Am 4/5Mg Tablet with or without food. However, it is recommended that you take it at the same time each day to maintain consistent blood levels.

Common side effects of Perindosyl-Am 4/5Mg Tablet may include ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.

Perindosyl-Am 4/5Mg Tablet should be avoided during pregnancy as it can harm the unborn baby. It's generally advised to avoid Perindosyl-Am 4/5Mg Tablet while breastfeeding. Consult your doctor for personalized advice.

If you have kidney or liver problems, allergies, or diabetes, inform your doctor before taking Perindosyl-Am 4/5Mg Tablet . Regular monitoring of potassium and blood sugar levels may be necessary.

Store Perindosyl-Am 4/5Mg Tablet in a cool, dry place, away from light and moisture. Keep it out of the reach of children and pets.

It may take a few weeks for the whole blood pressure-lowering effect of Perindosyl-Am 4/5Mg Tablet to be felt. However, some people may notice a difference in blood pressure within a few days.

Yes, Perindosyl-Am 4/5Mg Tablet can cause a dry cough. This is a common side effect, especially in the early stages of treatment. If the cough becomes bothersome, talk to your doctor.

No, you should not stop taking Perindosyl-Am 4/5Mg Tablet suddenly. Doing so can cause a sudden spike in blood pressure. If you must stop taking it, your doctor will gradually reduce your dosage.

Inform your doctor about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Some medicines may interact with Perindosyl-Am 4/5Mg Tablet .

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and take the scheduled dose. Do not double the dose.

Yes, Perindosyl-Am 4/5Mg Tablet can cause dizziness or lightheadedness, especially when you first start taking it. To minimize this risk, get up slowly from a sitting or lying position.

Yes, Perindosyl-Am 4/5Mg Tablet can cause swelling in the ankles or feet. This is a common side effect that usually goes away on its own. If the swelling is severe or bothersome, talk to your doctor.

Excessive alcohol consumption can lower blood pressure and interact with Perindosyl-Am 4/5Mg Tablet . It's best to avoid or limit your alcohol intake while taking Perindosyl-Am 4/5Mg Tablet .

While Perindosyl-Am 4/5Mg Tablet itself doesn't directly cause weight gain, it can contribute to weight gain by causing swelling or affecting appetite. If you're concerned about weight gain, talk to your doctor.

While rare, Perindosyl-Am 4/5Mg Tablet can cause a rash or skin irritation in some people. Stop taking the medication and contact your doctor immediately if you develop a rash or skin reaction.

In rare cases, Perindosyl-Am 4/5Mg Tablet can cause blurred vision or other eye-light changes. If you experience any vision problems, contact your doctor.

Yes, grapefruit and grapefruit juice can interact with Perindosyl-Am 4/5Mg Tablet , potentially increasing blood levels and leading to side effects. Avoid consuming grapefruit or grapefruit juice while taking this medication.

It's generally safe to take Perindosyl-Am 4/5Mg Tablet with over-the-counter pain relievers like paracetamol or ibuprofen. However, if you have concerns or are taking other medications, do not take them unless prescribed by the doctor.

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor).

Perindosyl-Am 4/5Mg Tablet may cause dizziness and drowsiness. Therefore, drive only if you are alerted after taking the Perindosyl-Am 4/5Mg Tablet .

Country of origin

India

Manufacturer/Marketer address

“Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Other Info - PER0453

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