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compositionComposition:PHENIRAMINE-22.75MG
prescription
Prescription Medicine
info
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Pheniramine Maleate Injection 2 ml is used to treat allergic symptoms. It contains Pheniramine that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It directly acts on the brain and relieves symptoms of allergies by preventing the release of histamine. It helps to provide relief from allergic symptoms. Common side effects of Pheniramine Maleate Injection 2 ml are a stinging or burning sensation at the injection site, rapid or irregular heartbeat, drowsiness, dizziness, nausea, vomiting, restlessness, dry mouth, weakness or headache.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PHENIRAMINE-22.75MG

Manufacturer/Marketer :

Hindustan Health Care

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pheniramine Maleate Injection 2 ml

Pheniramine Maleate Injection 2 ml is a prescription antihistamine injection used to treat severe allergic conditions such as acute hives, allergic swelling (angioedema), severe allergic rhinitis, and other allergic reactions. It works by blocking histamine, a natural chemical released during an allergic reaction that causes itching, swelling, redness, and watery eyes. Because it acts quickly, this medicine is mainly used in emergency or acute care settings.

Because Pheniramine Maleate Injection 2 ml is given as an injection, it is usually used for short-term treatment rather than long-term daily use. It is administered into a muscle or slowly into a vein by a trained healthcare professional, so food does not affect how it works. Avoiding known allergy triggers and following your allergy management plan can help reduce future reactions.

Common side effects include drowsiness, dry mouth, blurred vision, and dizziness. Contact your doctor immediately if you experience a very fast heartbeat, severe confusion, difficulty passing urine, trouble breathing, or worsening allergic symptoms after treatment.

Before receiving Pheniramine Maleate Injection 2 ml, tell your doctor if you have narrow-angle glaucoma, enlarged prostate, urinary bladder obstruction, severe liver disease, asthma, epilepsy, or other medical conditions. Do not receive this medicine if you have previously had a serious allergic reaction to Pheniramine Maleate Injection 2 ml or similar antihistamines. It is generally not recommended for newborn babies and should be used cautiously in very young children.

This medicine may interact with alcohol, sleeping medicines, opioid pain medicines, antidepressants, and other medicines that cause drowsiness. If you are pregnant, breastfeeding, an older adult, or if the patient is a young child, your doctor will carefully weigh the benefits and risks before treatment.

Uses of Pheniramine Maleate Injection 2 ml

Pheniramine Maleate Injection 2 ml is used in the treatment of Allergic conditions. The detailed uses of Pheniramine Maleate Injection 2 ml are as follows:

  • Severe allergic reactions: Helps quickly reduce symptoms like severe itching, skin rashes, and hives.
  • Anaphylactic reactions: Used alongside other emergency treatments like adrenaline to manage life-threatening, whole-body allergic reactions.
  • Allergic rhinitis: Controls severe nose congestion, sneezing, and watery eyes when oral medications cannot be used.

Key Benefits

Provides rapid allergy relief: Starts working quickly to reduce symptoms of severe allergic reactions.

  • Relieves itching and hives: Helps calm skin irritation, redness, and swelling caused by allergic reactions.
  • Reduces nasal allergy symptoms: Helps improve sneezing, runny nose, and watery eyes when oral medicines cannot be used.
  • Supports emergency allergy care: Used alongside other emergency treatments, such as adrenaline (epinephrine), during severe allergic reactions.
  • Improves comfort: Helps reduce discomfort and allows patients to recover more comfortably during acute allergic episodes.
Side effects of Pheniramine Maleate Injection 2 ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • The timing and frequency of Pheniramine Maleate Injection 2 ml will be determined by your doctor, based on your medical condition and response to treatment.
  • This medication should only be administered by a qualified healthcare provider.
  • Do not attempt self-administration of the injection.
  • Follow your healthcare provider’s instructions about the medication and any steps to track your progress or precautions during treatment.

How Pheniramine Maleate Injection 2 ml Works

During an allergic reaction, the body releases a chemical called histamine. Histamine binds to H1 receptors on cells, causing itching, redness, swelling, and increased mucus production. Pheniramine Maleate Injection 2 ml blocks these H1 receptors, preventing histamine from producing its effects. As a result, allergy symptoms begin to improve. Because the medicine is injected into a muscle or vein, it reaches the bloodstream quickly and provides faster relief than oral antihistamines in emergency situations.
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Alcohol

Unsafe

Avoid consumption of alcohol with Pheniramine Maleate Injection 2 ml as it may increase the adverse effects of Pheniramine. Please consult a doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Pheniramine Maleate Injection 2 ml is not recommended for pregnant women. In case of any concerns, please consult your doctor.

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Breast Feeding

Unsafe

Pheniramine Maleate Injection 2 ml is not recommended for use during breastfeeding. Please consult a doctor if you are a breastfeeding mother.

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Driving

Caution

Pheniramine Maleate Injection 2 ml may cause drowsiness in some people. Therefore, drive only if you are alert after taking Pheniramine Maleate Injection 2 ml.

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Liver

Caution

In patients with severe hepatic disease, dose adjustments should be taken into account because Pheniramine Maleate Injection 2 ml is metabolised in the liver.

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Kidney

Caution

Take Pheniramine Maleate Injection 2 ml with caution, as there is no specific information regarding the safety of Pheniramine Maleate Injection 2 ml in patients with kidney disease. The dose may be adjusted by your doctor as required.

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Children

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Pheniramine Maleate Injection 2 ml in children.

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Heart

Caution

Let your doctor know if you have heart disease before taking Pheniramine Maleate Injection 2 ml. Your doctor may adjust the dose if necessary based on your condition.

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Geriatrics

Caution

Elderly patients may require caution and dose adjustments, as Pheniramine Maleate Injection 2 ml may increase the risk of side effects like drowsiness.

What if I have taken an overdose of Pheniramine Maleate Injection 2 ml

If you suspect an overdose, seek emergency medical care immediately. Symptoms of an overdose can include extreme sleepiness, severe dizziness, a very rapid heart rate, dilated pupils, or loss of consciousness.

Diet & Lifestyle Advise

  • Identify your triggers: Keep a daily diary of your diet, activities, and environments to pinpoint what triggers your severe allergic reactions.
  • Stay hydrated: Drink plenty of water throughout the day to help ease the dry mouth and dry throat caused by the medication.
  • Avoid alcohol: Do not consume alcohol while being treated with this medicine, as it can dangerously increase sleepiness and affect your balance.
  • Keep air clean: Use allergen-proof covers on pillows and mattresses, and use an air purifier at home to reduce exposure to dust mites, pollen, and pet dander.

 

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How Soon It Starts Working

The time required for Pheniramine Maleate Injection 2 ml to start to work: The effect of Pheniramine Maleate Injection 2 ml is observed within 15 to 30 minutes of administration. The time for which the effects of Pheniramine Maleate Injection 2 ml last: Pheniramine Maleate Injection 2 ml effect lasts for a few hours.

What if you forget to take Pheniramine Maleate Injection 2 ml

Since this injection is usually given by a healthcare professional in a clinic or hospital as needed, a missed dose is unlikely. If you are on a scheduled injection plan and miss an appointment, call your doctor's office immediately to reschedule.

Storage

•Store Pheniramine Maleate Injection 2 ml injection at controlled room temperature, between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Check the solution: Before injecting, inspect the vial or ampoule to ensure the liquid is clear and free of particles.
  • Do not drive: Avoid driving, cycling, or operating machinery after receiving the injection, as it can cause severe drowsiness.
  • Practice needle safety: If injecting at home, always use a fresh, sterile needle and syringe for each injection, and throw them away immediately in a puncture-resistant sharps container.
  • Rotate injection sites: If you require multiple injections over time, change the injection spot each time to prevent muscle soreness and skin irritation.
  • Watch for dizziness: Sit or lie down for a short period after receiving the injection to prevent falls if you experience sudden dizziness.

Inform your healthcare provider if you have previously experienced severe reactions to antihistamines or if you take medicines that cause drowsiness.

Drug-Drug Interactions

verifiedApollotooltip
  • Sedatives and sleeping pills: May cause severe drowsiness and slow breathing when combined with Pheniramine Maleate Injection 2 ml.
  • MAO inhibitors (certain antidepressants): Can prolong and increase the side effects of this medicine, such as dry mouth and blurred vision.
  • Other antihistamines: May increase the risk of dry mouth, difficulty urinating, and drowsiness.
     
PheniramineLinezolid
Critical
PheniramineSelegiline
Critical

Drug-Drug Interactions

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PheniramineLinezolid
Critical
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using phenylephrine together with linezolid can increase your blood pressure.

How to manage the interaction:
Taking Pheniramine Maleate Injection 2 ml with Linezolid is not recommended but can be taken if prescribed by a doctor. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PheniramineSelegiline
Critical
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using Pheniramine Maleate Injection 2 ml with selageline can cause severe high blood pressure

How to manage the interaction:
Taking Pheniramine Maleate Injection 2 ml with Selegiline is not recommended, but it should be taken if prescribed by a doctor. However, if you experience headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PheniramineDihydroergotamine
Critical
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using dihydroergotamine together with phenylephrine may cause significant increases in blood pressure and the risk for complications may be increased.

How to manage the interaction:
Taking Pheniramine Maleate Injection 2 ml with Dihydroergotamine is not recommended but can be taken if prescribed by a doctor. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PheniramineFurazolidone
Critical
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using furazolidone together with phenylephrine can cause severe high blood pressure.

How to manage the interaction:
Taking Pheniramine Maleate Injection 2 ml with Furazolidone is not recommended, but can be taken together if prescribed by a doctor. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PheniramineNortriptyline
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Coadministration of Nortriptyline with Pheniramine Maleate Injection 2 ml can increase blood pressure.

How to manage the interaction:
Taking Nortriptyline with Pheniramine Maleate Injection 2 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PheniramineDesipramine
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Taking desipramine with Pheniramine Maleate Injection 2 ml can increase the risk of irregular heartbeats.

How to manage the interaction:
Co-administration of Pheniramine Maleate Injection 2 ml with Desipramine can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
PheniramineMethysergide
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using Pheniramine Maleate Injection 2 ml together with methysergide can cause severe high blood pressure.

How to manage the interaction:
Although taking Pheniramine Maleate Injection 2 ml and methysergide together can evidently cause an interaction, but can be taken if your doctor has suggested it. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PheniramineErgotamine
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Using ergotamine together with Pheniramine Maleate Injection 2 ml can cause significant increase in blood pressure.

How to manage the interaction:
Although there is a interaction between Pheniramine Maleate Injection 2 ml and Ergotamine, you can take these medicines together if prescribed by your doctor. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PheniraminePotassium chloride
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Taking Pheniramine Maleate Injection 2 ml and Potassium chloride together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Co-administration of Pheniramine Maleate Injection 2 ml with Potassium chloride can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
PheniramineTopiramate
Severe
How does the drug interact with Pheniramine Maleate Injection 2 ml Maleate Injection 2 ml:
Taking Pheniramine Maleate Injection 2 ml with Topiramate can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although there is a interaction between Pheniramine Maleate Injection 2 ml and Topiramate, but it can be taken if prescribed by a doctor. However, if you experience drowsiness, dizziness, or lightheadedness contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Strongly increases the sedative effects of this medicine, leading to extreme sleepiness and poor coordination.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIHISTAMINE]

FAQs

Pheniramine Maleate Injection 2 ml is used to treat Allergic conditions.
Pheniramine Maleate Injection 2 ml contains Pheniramine, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Thus, it helps provide relief from allergy symptoms such as sneezing/runny nose, red/itchy/watery eyes, throat swelling, itchy throat, and congestion or stiffness.
Pheniramine Maleate Injection 2 ml may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Pheniramine Maleate Injection 2 ml to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.
You are not recommended to take Pheniramine Maleate Injection 2 ml with phenytoin as co-administration of these two medicines may increase the effects of phenytoin. Therefore, please consult a doctor before taking Pheniramine Maleate Injection 2 ml with any other medicines.
Pheniramine Maleate Injection 2 ml injection is usually given by a doctor or nurse in a clinic, emergency department, or hospital. Home administration is uncommon and should only be done if your healthcare provider has specifically trained you and advised that it is appropriate.
Because it is given by injection, Pheniramine Maleate Injection 2 ml usually begins relieving allergy symptoms within minutes. The exact onset may vary depending on whether it is given into a muscle or directly into a vein.
Yes. Drowsiness is one of the most common side effects. Until you know how the medicine affects you, avoid driving, operating machinery, or performing activities that require full alertness.
Pheniramine Maleate Injection 2 ml should only be used during pregnancy if your healthcare provider determines that the expected benefit outweighs any potential risk to the baby. Emergency treatment decisions are based on both the mother's condition and fetal safety.
Mild soreness or redness at the injection site is usually temporary. However, if you develop increasing pain, swelling, warmth, pus, or fever, contact your healthcare provider promptly, as these may be signs of infection.
Pheniramine Maleate Injection 2 ml is generally not recommended for newborn babies and should be used cautiously in young children. The dose is carefully calculated according to the child's age and body weight and should only be given under medical supervision.
Older adults may be more sensitive to drowsiness, dizziness, confusion, blurred vision, and difficulty passing urine. Extra monitoring may be needed because these side effects can increase the risk of falls.
No. Epinephrine (adrenaline) is the first and most important treatment for anaphylaxis. Pheniramine Maleate Injection 2 ml may be given afterward as an additional medicine to help relieve skin symptoms such as itching and hives, but it should never replace epinephrine during a life-threatening allergic reaction.

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Country of origin

India

Manufacturer/Marketer address

No. 22, Guru Tej, Bahadur Nagar, Tej Bahadur Nagar, Nagpur-440026, Maharashtra, India
Other Info - PHE0124
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