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  3. Pioneer-M-15 Tablet 10's

Pioneer-M-15 Tablet 10's, Pack of 10 TABLETS
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Composition :

METFORMIN-500MG + PIOGLITAZONE-15MG

Manufacturer/Marketer :

Olcare Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pioneer-M-15 Tablet 10's

Pioneer-M-15 Tablet 10's belongs to the group of medicines called anti-diabetic drugs used to treat type 2 diabetes. Type 2 diabetes mellitus used to be known as 'non-insulin-dependent diabetes mellitus (NIDDM)' or 'maturity-onset diabetes'. Type 2 diabetes develops if the body does not produce enough insulin or when the insulin that your body makes does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

Pioneer-M-15 Tablet 10's contains Pioglitazone (thiazolidinediones) & Metformin (biguanides). Pioglitazone decreases blood sugar and reverses the effects of Type II diabetes by activating switches (PPAR) inside cells to take up free glucose from the blood and decrease its levels in the blood. Metformin, on the other hand, decreases blood sugar by decreasing its formation and increasing its consumption by cells, thereby decreasing high blood sugar levels. Pioneer-M-15 Tablet 10's is used in adults to treat type 2 (non-insulin-dependent) diabetes mellitus when treatment with metformin alone is not sufficient.

Pioneer-M-15 Tablet 10's should be taken with food to avoid an upset stomach. Pioneer-M-15 Tablet 10's should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, and it can change timely depending upon your condition. Some people may have stomach aches, feeling sick (Nausea), vomiting, diarrhoea, loss of appetite, localized swelling (oedema), weight gain, headache, respiratory infection, numbness, taste disturbance, etc. Most of these side effects of Pioneer-M-15 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Pioneer-M-15 Tablet 10's should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Pioneer-M-15 Tablet 10's abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Pioneer-M-15 Tablet 10's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease, are or are planning to get pregnant or are breastfeeding.

Uses of Pioneer-M-15 Tablet 10's

Treatment of Type II diabetes (Non insulin-dependent diabetes).

Directions for Use

• Pioneer-M-15 Tablet 10's should be taken with food to avoid an upset stomach. • It should be taken at the same time of the day each time for best results.• Swallow it as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Pioneer-M-15 Tablet 10's lowers blood sugar in type II diabetic patients (Non-insulin dependent ) & prevents diseases of the heart, kidneys, eyes & blood vessels in feet, which happens due to persistently high levels of blood sugar in diabetic patients. Pioneer-M-15 Tablet 10's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing. Pioneer-M-15 Tablet 10's lowers blood sugar due to the activation of cell switches (PPAR) to take up free glucose from blood & use it for energy production  & decrease the production of glucose inside the liver.

How Pioneer-M-15 Tablet 10's Works

Pioneer-M-15 Tablet 10's contains Pioglitazone (thiazolidinediones) & Metformin (biguanides). Pioglitazone decreases blood sugar and reverses the effects of Type II diabetes by activating switches (PPAR) inside cells to take up free glucose from the blood and decrease its levels in the blood. Metformin, on the other hand, decreases blood sugar by decreasing its formation and increasing its consumption by cells, thereby decreasing high blood sugar levels. Pioneer-M-15 Tablet 10's is used in adults to treat type 2 (non-insulin-dependent) diabetes mellitus when treatment with metformin alone is not sufficient.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Pioneer-M-15 Tablet 10's

Do not take more than the prescribed dose of Pioneer-M-15 Tablet 10's as it may cause overdose resulting in lactic acidosis. The symptoms of overdose include severe voiting/nausea/diarrhoea, severe drowsiness, slow/irregular heartbeat and rapid breathing. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Pioneer-M-15 Tablet 10's should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Pioneer-M-15 Tablet 10's, might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid accumulates in the blood, which can damage the workings of the liver and kidneys required for the elimination of excess lactic acid from the blood. Before you start taking Pioneer-M-15 Tablet 10's, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Pioneer-M-15 Tablet 10's, when used with insulin, may extremely lower the blood sugar level, leading to hypoglycemia condition, which can be fatal. In this case, your doctor may adjust the dose by lowering the dose of insulin or Pioneer-M-15 Tablet 10's. Prolonged intake of Pioneer-M-15 Tablet 10's may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Pioneer-M-15 Tablet 10's should be stopped for a short time before having an X-ray procedure.

Drug-Drug Interactions

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MetforminMetrizamide
Critical
MetforminIopanoic acid
Critical

Drug-Drug Interactions

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MetforminMetrizamide
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Pioneer-M-15 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Iopanoic acid with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Iodixanol with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoversol
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Ioversol with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Iopentol with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Pioneer-M-15 Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Pioneer-M-15 Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Iotroxic acid with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Ioglycamic acid with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Pioneer-M-15 Tablet:
Co-administration of Iohexol with Pioneer-M-15 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pioneer-M-15 Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grains.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are lots of fluctuations.
  • Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates-containing foods with whole grain foods and increase your intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce your intake of saturated fat (or hidden fats) in foods like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

Pioneer-M-15 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Not recommended with alcohol as it may result in a harmful decrease or increase in levels of blood sugar depending on how much alcohol a patient has consumed.

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Pregnancy

Caution

Not recommended in pregnancy. Pioneer-M-15 Tablet 10's treatment should be stopped and replaced with any other alternative drug from other blood sugar-lowering agents on the recommendation of a doctor. You must tell your doctor if you are pregnant, think you may be pregnant or are planning to have a baby.

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Breast Feeding

Caution

Not recommended in breastfeeding mothers. Do not use Pioneer-M-15 Tablet 10's if you are breastfeeding or are planning to breastfeed, as a doctor's consultation is required.

bannner image

Driving

Safe if prescribed

It is safe to use while driving or operating heavy machinery. This medicine will not affect your ability to drive or use machines, but care should be taken if you experience abnormal vision or anything that affects your ability to drive.

bannner image

Liver

Caution

Pioneer-M-15 Tablet 10's should be used with caution in patients with liver disease as Pioneer-M-15 Tablet 10's has been found to cause harmful interactions in them. Doctors' recommendation is required before taking this drug.

bannner image

Kidney

Caution

Pioneer-M-15 Tablet 10's should be taken with caution in patients with kidney disease. In rare cases, serious interactions have been found in kidney patients, called lactic acidosis; thus, a doctor's consultation is required before taking this drug.

bannner image

Children

Unsafe

Not recommended in children below 12 years of age. Use in children and adolescents under 18 years is not recommended. Consult a doctor for better alternative blood sugar-lowering agents in diabetic children.

Have a query?

FAQs

Pioneer-M-15 Tablet 10's is used to treat Type II diabetes (non-insulin-dependent diabetes). It lowers blood sugar by activating cell switches (PPAR) to take up free glucose from the blood and use it for energy production. It also decreases the production of glucose in the liver.

Pioneer-M-15 Tablet 10's can cause fluid retention, which causes heart failure. The doctor usually recommends starting from a lower dose and increasing the dose slowly while treating patients who are at risk of heart failure. Heart failure is reported mainly in patients taking insulin & Pioneer-M-15 Tablet 10's simultaneously.

There have been rare cases of liver damage in patients taking Pioneer-M-15 Tablet 10's. The doctor usually screens the patient continuously during the course of treatment with Pioneer-M-15 Tablet 10's. A patient is advised to visit a doctor strictly as per the doctor's advice.

Pioneer-M-15 Tablet 10's is contradictory when used in patients with high blood pressure. Doctors consultation is required before taking this drug in a patient with high blood pressure.

Pioneer-M-15 Tablet 10's is safe to take before driving a vehicle or operating machinery as long as blood sugar levels are stable. However, a patient is advised to take proper precautions and make sure that Pioneer-M-15 Tablet 10's is not taken with another blood sugar-lowering agent.

Not recommended to be taken with contraceptives. Pioneer-M-15 Tablet 10's decreases the activity of oral contraceptives like Ethinyl estradiol by almost 30% and leads to failure of contraception.

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work correctly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination, slow, increased hunger, fatigue, and blurred vision.

Pioneer-M-15 Tablet 10's should be swallowed as a whole with a glass of water. Avoid crushing, chewing, or breaking it.

Don't stop taking Pioneer-M-15 Tablet 10's without consulting your doctor, even if your blood sugar levels return to normal. Stopping the medication suddenly can cause your blood sugar levels to fluctuate, leading to potential complications. Your doctor prescribed Pioneer-M-15 Tablet 10's to help manage your type 2 diabetes, and they need to assess your condition before making any changes to your treatment plan. Consult your doctor before stopping or adjusting your medication, as they will provide personalized guidance to ensure your blood sugar levels remain stable and under control.

Avoid or limit alcohol consumption while taking Pioneer-M-15 Tablet 10's, as it can interact with the medication and increase the risk of low or high blood sugar levels, as well as a rare but serious condition called lactic acidosis. Additionally, alcohol can worsen certain health conditions, such as nerve damage or liver disease. If you do choose to drink alcohol, do so in moderation and closely monitor your blood sugar levels.

Common side effects of Pioneer-M-15 Tablet 10's may include stomach aches, feeling sick (Nausea), vomiting, diarrhoea, loss of appetite, localized swelling (oedema), weight gain, headache, respiratory infection, numbness, taste disturbance, etc. Most of these side effects of Pioneer-M-15 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Limited information is available. To make an informed decision, consult your healthcare professional, who can assess your individual situation and provide personalized guidance on using Pioneer-M-15 Tablet 10's while breastfeeding.

Pioneer-M-15 Tablet 10's should be taken with caution in patients with kidney disease. In rare cases, serious interactions have been found in kidney patients, called lactic acidosis; thus, a doctor's consultation is required before taking Pioneer-M-15 Tablet 10's.

Pioneer-M-15 Tablet 10's is recommended not to be used in children. Pioneer-M-15 Tablet 10's is a medication typically prescribed for adults over 18 years with type 2 diabetes.

Pioneer-M-15 Tablet 10's is not recommended during pregnancy as there is not much information about its safety during pregnancy. If you are pregnant or thinking of getting pregnant, talk to your doctor, as they will need to review your treatment. They can suggest a different medicine that is safer for you to take during pregnancy.

Store in a cool and dry place away from sunlight. Keep Pioneer-M-15 Tablet 10's out of reach and out of sight to children.

No, Pioneer-M-15 Tablet 10's is not indicated for treating type 1 diabetes. Pioneer-M-15 Tablet 10's is a medication specifically designed to treat type 2 diabetes, and it's not suitable for managing type 1 diabetes.

Pioneer-M-15 Tablet 10's can interact with various other drugs, including those used to manage diabetes, blood pressure, heart conditions, and thyroid disorders, as well as steroids and blood thinners. Always let your healthcare professional know about all the medications you are currently taking to reduce risks. They will help you navigate potential interactions and ensure safe treatment. Consulting your healthcare professional before combining Pioneer-M-15 Tablet 10's with any other medications is key.

Pioneer-M-15 Tablet 10's contains Pioglitazone (thiazolidinediones) & Metformin (biguanides).

Country of origin

India

Manufacturer/Marketer address

504/A, 505/A, G.I.D.C. Estate, Wadhwan 363 035., Dist. Surendranagar. Gujarat.
Other Info - PIO0326

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:40 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.236.pdf
  2. https://pubmed.ncbi.nlm.nih.gov/11192132/
  3. https://www.mims.co.uk/drugs/diabetes/oral-and-parenteral hypoglycaemics/pioglitazonemetformin

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