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  1. Home
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  3. Pregafur-M Tablet 10's

Pregafur-M Tablet 10's, Pack of 10 TABLETS
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Composition :

METHYLCOBALAMIN-1500MCG + PREGABALIN-75MG

Manufacturer/Marketer :

Hpur Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregafur-M Tablet 10's

Pregafur-M Tablet 10's belongs to the class of medications ‘anticonvulsants’ used in the treatment of neuropathic pain. Neuropathic pain is a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning. It is mostly seen in patients who had suffered a trauma or nerve injury, diabetes, vitamin deficiencies, cancer, multiple sclerosis (disease of the brain and spinal cord), shingles (a viral infection), and HIV.

Pregafur-M Tablet 10's is a combination of two medicines: Pregabalin and Methylcobalamin. Pregabalin acts by decreasing the pain signals sent by a damaged nerve in the body. On the other hand, Methylcobalamin helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cell - neuron).

You should take this medicine as prescribed by your doctor. The common side-effects of Pregafur-M Tablet 10's are dizziness, drowsiness, headache, anorexia (loss of appetite), nausea or vomiting, diarrhea, headache, hot sensation (burning pain), vision problems, and diaphoresis (sweating). Inform your doctor if any of these side effects persist.

Do not take Pregafur-M Tablet 10's if you are allergic to ‘Pregabalin’ and ‘Methylcobalamin’ or any contents before taking Pregafur-M Tablet 10's if you have a history of heart diseases, liver or kidney disease, alcoholism, or drug abuse.  It should not be used in children and adolescents below 18 years. Inform your doctor if you are pregnant and breastfeeding. Do not drive or operate heavy machinery as Pregafur-M Tablet 10's may cause dizziness or drowsiness. Pregafur-M Tablet 10's contains lactose, so inform your doctor if you have any intolerance to sugars. Do not discontinue treatment without telling your doctor. 

Uses of Pregafur-M Tablet 10's

Pregafur-M Tablet 10's is used in the treatment of Neuropathic pain. The detailed uses of Pregafur-M Tablet 10's are as follows:
•Anxiety Relief: Pregafur-M Tablet 10's known is to help reduce anxiety and tension, fostering a sense of calm and relaxation.
•Pain Management: Pregafur-M Tablet 10's may provide effective relief from various types of pain, including headaches and muscle discomfort.
•Sleep Aid: Pregafur-M Tablet 10's can be beneficial for individuals experiencing sleep disturbances, helping to enhance sleep quality and duration.
•Mood Stabilization: Pregafur-M Tablet 10's may assist in managing mood swings and supporting individuals with depressive symptoms, promoting emotional balance.
•Neuropathic Pain Relief: Pregafur-M Tablet 10's helps reduce nerve pain by calming overactive nerves and supports nerve repair and regeneration.

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Pregafur-M Tablet 10's is a combination of two drugs: Pregabalin and Methylcobalamin. Pregabalin is an anticonvulsant that affects the brain's chemicals that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels (responsible for excitatory response), thereby decreasing brain activity. This effect helps in relieving nerve pain and lowers the risk of seizures. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cells). Together, Pregafur-M Tablet 10's helps in providing relief from neuropathic pain and improved nerve signal conduction.  

 

How Pregafur-M Tablet 10's Works

Pregafur-M Tablet 10's is a combination of two medicines: Pregabalin and Methylcobalamin. Pregabalin acts by decreasing the pain signals sent by a damaged nerve in the body. On the other hand, Methylcobalamin helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cell - neuron).

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Pregafur-M Tablet 10's

Do not take more than the prescribed dose of Pregafur-M Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Pregafur-M Tablet 10's may increase the risk of heart failure in patients with heart diseases. It may cause dizziness and somnolence (sleepiness). So, it might increase the risk of accidental injury in elderly patients. Pregafur-M Tablet 10's may also cause temporary vision problems. However, if this condition is persistent, consult your doctor immediately. Patients with diabetes who gain weight with Pregafur-M Tablet 10's may need a change in diabetic medicines. If you notice decreased urination while taking Pregafur-M Tablet 10's, inform your doctor as Pregafur-M Tablet 10's may cause kidney failure in some cases. It may increase suicidal tendencies, though it is rare. You may experience convulsions after discontinuing Pregafur-M Tablet 10's. In such cases, inform your doctor immediately.  

Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.

  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

  • Exercising regularly helps in improving overall health and combating pain.

  • Rest well, get plenty of sleep.

  • Try taking a warm bath as it can be soothing.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

 

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Pregafur-M Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol may worsen the condition by increasing the risk of side-effects.

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Pregnancy

Unsafe

Pregafur-M Tablet 10's is a category C medicine. It is not recommended for use in pregnant women unless the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Pregafur-M Tablet 10's should be used with caution in breastfeeding mothers unless the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Pregafur-M Tablet 10's may cause dizziness and drowsiness. So, avoid driving or operating heavy machinery while using Pregafur-M Tablet 10's.

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Liver

Caution

Pregafur-M Tablet 10's should be used with caution in patients with liver diseases. Dose adjustments may be necessary.

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Kidney

Caution

Pregafur-M Tablet 10's should be used with caution in patients with kidney diseases. Dose adjustments may be necessary

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Children

Unsafe

Pregafur-M Tablet 10's is not recommended for anyone below the age of 18 years.

Have a query?

FAQs

Pregafur-M Tablet 10's is used in the treatment of neuropathic pain, a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning.

Pregafur-M Tablet 10's is a combination of two medicines: Pregabalin and Methylcobalamin. Pregafur-M Tablet 10's block the brain's pain signals and protect nerve cells from further damage, thereby improving nerve signal conduction to the whole body parts. These effects help to reduce pain in patients with neuropathic pain.

Pregafur-M Tablet 10's should not be given to children and adolescents under the age of 18 years as it may increase suicidal thoughts.

Pregafur-M Tablet 10's should not be stopped abruptly as it may cause withdrawal reactions such as trouble sleeping, headache, nausea, feeling anxious, diarrhea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating, and dizziness. Pregafur-M Tablet 10's should be stopped gradually over a minimum of 1 week.

Pregafur-M Tablet 10's can be used in patients with diabetes if they have neuropathic pain. However, inform your doctor if you notice any weight gain while using Pregafur-M Tablet 10's. Your doctor may change your diabetic medicines to stop weight gain. Also, take some measures to control weight such as eating a balanced diet and exercising regularly.

Pregafur-M Tablet 10's may cause drowsiness. So, it is advised to refrain from activities such as driving or operating heavy machinery if you feel sleepy after taking Pregafur-M Tablet 10's.

You may notice pain improvement within 2-3 days after taking Pregafur-M Tablet 10's. However, it may take 2-3 months for your symptoms to improve depending on your health condition.

Pregafur-M Tablet 10's may increase your appetite, which might make you eat more, and thus increases the risk of weight gain. However, it’s easier to prevent weight gain than losing the weight. Try to eat a healthy balanced diet. Avoid consuming high-calorie foods, such as soft drinks, chips, oily food, biscuits, cakes, and sweets. If you feel hungry between meals, do not eat junk food, instead eat vegetables, fruits, and low-calorie foods. Regular exercise helps to prevent weight gain. If you still have any concerns, discuss with your doctor.

Pregafur-M Tablet 10's may rarely cause serious side effects such as allergic reaction, suicidal thoughts or swelling of limbs (legs, hands, or feet). If you experience any signs of these side effects, discontinue Pregafur-M Tablet 10's and consult your doctor. Signs of an allergic reaction include swelling of your face, lips, mouth, tongue, gums, and neck. Allergic reactions can also lead to skin rash, difficulty breathing, hives (raised bumps) or blisters. Watch out for any changes, especially sudden changes in behaviors, mood, thoughts or feelings, or if you have suicidal thoughts.

Pregafur-M Tablet 10's may show an initial benefit after 2 weeks of taking it. However, for full benefits, it may take around 2 to 3 months or more (in some patients).

If you forget to take a dose of Pregafur-M Tablet 10's, take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.

No, taking a higher than the recommended dose may not be more effective, rather it may increase the risk of toxicity and serious side effects. If your symptoms are not relieved or there is an increased severity of your symptoms after using the recommended doses, please consult your doctor.

You are advised to avoid alcohol consumption while taking Pregafur-M Tablet 10's as it may increase the risk of side effects. However, if you have any concerns, please discuss with your doctor.

If you have started taking Pregafur-M Tablet 10's, you may need to see your doctor regularly. However, if the recommended doses does not improve your symptoms or if the side effects persist or worsen which affect your routine activities, consult your doctor.

Store Pregafur-M Tablet 10's at room temperature in a cool place. Protect from light and moisture. Keep it out of reach of children.

The side effects of Pregafur-M Tablet 10's include nausea, vomiting, headache, dizziness, drowsiness, increased appetite, weight gain and vision problems. If these side effects persist or worsen, please consult your doctor.

You are recommended to take Pregafur-M Tablet 10's only if it is advised by your doctor. Therefore, if you are pregnant or planning pregnancy, take your doctor’s advice.

You are recommended to avoid driving or using any tools or machines until you know how Pregafur-M Tablet 10's affects you as it may cause dizziness or drowsiness in some people.

Country of origin

India

Manufacturer/Marketer address

Shop No 1,B Wing, Ruhi Complex,Thane, Maharashtra
Other Info - PRE2109

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Apr 17, 2025 | 10:08 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.7011.pdf
  2. https://www.npra.gov.my/images/reg-and-noti/PI/non-poison/Mecobalamin-Template-oral-Website.pdf
  3. https://medlineplus.gov/druginfo/meds/a605045.html

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