Pregalex-NT Tablet 10's
MRP ₹241
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About Pregalex-NT Tablet
Pregalex-NT Tablet is a combination medicine indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system.
Pregalex-NT Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregalex-NT Tablet helps to treat neuropathic pain.
In some cases, you may experience certain common side-effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Pregalex-NT Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregalex-NT Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregalex-NT Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Uses of Pregalex-NT Tablet
Pregalex-NT Tablet is used in the treatment of neuropathic pain. The detailed uses of Pregalex-NT Tablet are as follows:
- Neuropathic Pain Management: Pregalex-NT Tablet is commonly prescribed to help alleviate pain caused by nerve damage or neuropathy, which can result from conditions such as diabetes or shingles.
- Management of Epilepsy: Pregalex-NT Tablet may be used as part of the treatment plan for patients with epilepsy, specifically for controlling certain types of seizures.
- Anxiety Disorder Treatment: Pregalex-NT Tablet can assist in managing generalized anxiety disorder, providing relief from excessive worry and improving overall emotional well-being.
- Fibromyalgia Treatment: Pregalex-NT Tablet is often utilized to help reduce aches, pain, and discomfort associated with fibromyalgia, enhancing patient’s quality of life.
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Directions for Use
- Take Pregalex-NT Tablet with or without food or as advised by a doctor.
- Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
- Swallow the medicine as a whole with glass of water.
- Do not crush, break, or chew it.
Medicinal Benefits
Pregalex-NT Tablet is a combination of two medicines, namely: Pregabalin and Nortriptyline. Pregalex-NT Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Pregabalin is an anti-convulsant which affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline is an antidepressant which works by increasing the levels of nerve transmitters (serotonin and noradrenaline) in the brain, thereby reduces the pain messages arriving in the brain. Together, Pregalex-NT Tablet helps to treat neuropathic pain (pain due to nerve damage).
How Pregalex-NT Tablet Works
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What if I have taken an overdose of Pregalex-NT Tablet
Drug Warnings
Do not take Pregalex-NT Tablet if you are allergic to any of its contents. Inform your doctor before taking Pregalex-NT Tablet if you have or had heart problems, bipolar syndrome, severe liver disease or if you have taken MAO inhibitors in the last 14 days. Consult your doctor before taking cough-cold medicines containing adrenaline-like drugs such as ephedrine, phenylpropanolamine, isoprenaline, noradrenaline or phenylephrine. Consult your doctor if you are pregnant or breastfeeding. Pregalex-NT Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregalex-NT Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregalex-NT Tablet as it could lead to increased drowsiness and sleepiness.
Drug-Drug Interactions
Drug-Drug Interactions
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Using Pregalex-NT Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).
How to manage the interaction:
Taking Isocarboxazid with Pregalex-NT Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
Coadministration of Pregalex-NT Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.
How to manage the interaction:
Taking Pregalex-NT Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Pregalex-NT Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).
How to manage the interaction:
Taking Pregalex-NT Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Coadministration of Pregalex-NT Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).
How to manage the interaction:
Taking Pregalex-NT Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Coadministration of Pregalex-NT Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).
How to manage the interaction:
Taking Pregalex-NT Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
Coadministration of Pregalex-NT Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.
How to manage the interaction:
Taking Pregalex-NT Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Coadministration of Pregalex-NT Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.
How to manage the interaction:
Taking Pregalex-NT Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
Although it is a rare adverse effect, Coadministration of Pregalex-NT Tablet with Desvenlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.
How to manage the interaction:
Taking Pregalex-NT Tablet with Desvenlafaxine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Pregalex-NT Tablet with Dextromethorphan can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).
How to manage the interaction:
Taking Pregalex-NT Tablet with Dextromethorphan together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Using bepridil together with Pregalex-NT Tablet can increase the risk of an irregular heart rhythm that may be serious.
How to manage the interaction:
There may be a possibility of interaction between Pregalex-NT Tablet and Bepridil, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: your heart beating irregularly, feeling suddenly dizzy or lightheaded, fainting, or having a fast or strong heartbeat. Do not stop using any medications without talking to a doctor.
Drug-Food Interactions
Drug-Food Interactions
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Diet & Lifestyle Advise
- Include food rich in vitamin B and D in your diet.
- Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
- Exercising regularly helps in improving overall health and combating pain.
- Rest well, get plenty of sleep.
- Try taking a warm bath as it can be soothing.
- Avoid smoking and alcohol consumption.
- Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
- Acupuncture can be helpful by stimulating pressure points.
- Using essential oils for massages can help increase circulation.
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Alcohol
Unsafe
Avoid consumption of alcohol while taking Pregalex-NT Tablet as it may cause increased drowsiness and sleepiness.
Pregnancy
Caution
Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
Caution
Consult your doctor before taking Pregalex-NT Tablet ; your doctor will decide whether Pregalex-NT Tablet can be taken by breastfeeding mothers or not.
Driving
Unsafe
Pregalex-NT Tablet may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.
Liver
Caution
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
Caution
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Caution
Pregalex-NT Tablet should not be given to children as safety and efficacy have not been established.
Heart
Consult your doctor
Please inform your doctor if you have any pre-existing heart problems
Geriatrics
Consult your doctor
Limited information available for use of Pregalex-NT Tablet in elderly patients. Please consult your doctor.
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