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compositionComposition:PROGESTERONE-400MG
prescription
Prescription Medicine
info
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Progivian 400 mg Softgel Capsule is used to treat amenorrhoea (absence of menstrual periods) and prevent endometrial hyperplasia (thickened uterus lining). Also, it is indicated for the maintenance of pregnancy, threatened abortion and prevention of preterm labour. It contains progesterone which works by replacing oestrogen and progesterone hormone levels in the body. This medicine may sometimes cause side effects such as dizziness, drowsiness, headache, mood changes, diarrhoea, vaginal discharge, joint pain, hot flashes or constipation. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PROGESTERONE-400MG

Manufacturer/Marketer :

3M India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Progivian 400 mg Softgel Capsule

Progivian 400 mg Softgel Capsule is an oral prescription medication used to treat absent menstrual periods and to prevent overgrowth of the uterine lining in women undergoing estrogen hormone replacement therapy. It helps restore hormonal balance in the body, ensuring a regular menstrual cycle and protecting uterine health.

For the best results, you must take Progivian 400 mg Softgel Capsule exactly as prescribed by your doctor. Some oral Progivian 400 mg Softgel Capsule formulations are recommended on an empty stomach, while others may be taken with food. Follow the instructions provided with your specific product and use the same method consistently each day, as food can affect how much medicine your body absorbs.

While taking Progivian 400 mg Softgel Capsule , you may experience mild side effects such as drowsiness, dizziness, or mild stomach upset. However, if you experience severe symptoms like chest pain, sudden severe headaches, or breathing difficulties, you must seek immediate medical attention.

Do not take this if you have a history of blood clots, breast cancer, unusual vaginal bleeding, or severe liver damage. Before starting, tell your doctor if you have high blood pressure, asthma, diabetes, or migraine headaches so they can monitor your health closely.

Progivian 400 mg Softgel Capsule can interact with certain medicines that speed up how your liver breaks down drugs (called liver enzyme-inducing medicines), such as carbamazepine or phenytoin. These medicines may reduce how well Progivian 400 mg Softgel Capsule works. Alcohol and smoking may also increase the risk of side effects or affect treatment. If you are pregnant, breastfeeding, or are an elderly individual, consult your healthcare provider to discuss the specific risks and benefits of using this medication.

Uses of Progivian 400 mg Softgel Capsule

Progivian 400 mg Softgel Capsule is used in the treatment of female infertility, female hormonal imbalance, secondary amenorrhea, and hormone replacement therapy. The detailed uses of Progivian 400 mg Softgel Capsule are as follows:

  • Hormone Replacement Therapy (HRT): Helps prevent the overgrowth of the uterine lining in postmenopausal women who are taking estrogen.
  • Secondary Amenorrhea: Helps restore normal menstrual periods in women who have stopped having periods due to a lack of natural progesterone.
  • Luteal Phase Support: Progivian 400 mg Softgel Capsule may be prescribed after fertility treatments or in selected women to help prepare and maintain the uterine lining during early pregnancy when recommended by a fertility specialist.
  • Female Hormonal Imbalance: Helps restore normal progesterone levels, supporting a healthy menstrual cycle and proper reproductive function.
     

Key Benefits

Progivian 400 mg Softgel Capsule helps support hormonal balance and reproductive health by replacing or supplementing the body's natural Progivian 400 mg Softgel Capsule . It plays an important role in regulating the menstrual cycle, supporting pregnancy, and protecting the uterus during hormone therapy.

Benefits may include:

  • Helps regulate menstrual cycles and supports normal reproductive hormone balance.
  • Supports the maintenance of early pregnancy when prescribed for Progivian 400 mg Softgel Capsule deficiency.
  • Helps protect the lining of the uterus during estrogen replacement therapy in postmenopausal women.
  • Supports the management of irregular periods and certain hormone-related conditions.
  • Helps reduce the risk of uterine complications associated with estrogen-only hormone therapy.
  • Promotes overall reproductive health and improves quality of life when used as prescribed.
     
Side effects of Progivian 400 mg Softgel Capsule
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • Progivian 400 mg Softgel Capsule can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Progivian 400 mg Softgel Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Progivian 400 mg Softgel Capsule Works

Progivian 400 mg Softgel Capsule replaces the natural hormone that your body may not be producing in sufficient amounts. After you swallow the capsule, it is processed by the liver before reaching the bloodstream, so the dose and schedule may vary between individuals. Your doctor will prescribe the amount that is most appropriate for your condition.
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Alcohol

Consult your doctor

Interaction of Progivian 400 mg Softgel Capsule with alcohol is unknown. Please consult a doctor before consuming alcohol while using Progivian 400 mg Softgel Capsule .

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Pregnancy

Consult your doctor

Progivian 400 mg Softgel Capsule supports pregnancy and helps in the maintenance of pregnancy. However, please consult a doctor if you are pregnant before taking Progivian 400 mg Softgel Capsule .

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Breast Feeding

Consult your doctor

Progivian 400 mg Softgel Capsule may be excreted in human milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Progivian 400 mg Softgel Capsule may cause dizziness or drowsiness. Therefore, avoid driving if you feel dizzy or drowsy after taking Progivian 400 mg Softgel Capsule .

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Liver

Consult your doctor

Please consult a doctor if you have a history of liver disease. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Progivian 400 mg Softgel Capsule should be given with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Progivian 400 mg Softgel Capsule is not recommended for children.

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Heart

Consult your doctor

Please consult your doctor if you have heart problems before using Progivian 400 mg Softgel Capsule .

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Progivian 400 mg Softgel Capsule in elderly patients.

What if I have taken an overdose of Progivian 400 mg Softgel Capsule

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control center immediately. Symptoms of overdose may include severe dizziness, nausea, or drowsiness.

Diet & Lifestyle Advise

  • Ensure adequate calcium and vitamin D intake: Include calcium- and vitamin D-rich foods in your diet to help support bone health, especially while receiving hormone therapy.
  • Avoid smoking and limit alcohol: Do not smoke and limit alcohol consumption, as both can increase the risk of blood clots and cardiovascular problems during hormone therapy.
  • Engage in weight-bearing exercise: Participate in regular activities such as walking or light strength training to help maintain bone density and support heart health.
  • Attend regular health check-ups: Keep all scheduled follow-up appointments, including breast examinations and mammograms, so your doctor can monitor your health during treatment.
     
health query

Have a query?

How Soon It Starts Working

The time required for Progivian 400 mg Softgel Capsule to start to work: Progivian 400 mg Softgel Capsule ideally shows its action within 2 to 3 hours after administration. 

The time for which the effects of Progivian 400 mg Softgel Capsule last: The effect of Progivian 400 mg Softgel Capsule lasts for 12 hours.

What if you forget to take Progivian 400 mg Softgel Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Store Progivian 400 mg Softgel Capsule at controlled room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Take Progivian 400 mg Softgel Capsule at bedtime: Taking Progivian 400 mg Softgel Capsule at bedtime may help reduce the impact of daytime drowsiness and dizziness.
  • Use caution during activities requiring alertness: Avoid driving, operating machinery, or performing hazardous tasks immediately after taking Progivian 400 mg Softgel Capsule until you know how it affects you.
  • Monitor your breast health: Perform regular breast self-examinations and report any new lumps or unusual breast changes to your doctor promptly.
  • Inform healthcare providers before procedures: Tell your doctor, dentist, surgeon, or other healthcare professionals that you are taking Progivian 400 mg Softgel Capsule before undergoing any medical, surgical, or dental procedure, as temporary interruption of treatment may be necessary.
  • Attend regular monitoring appointments: Keep all scheduled follow-up visits while taking Progivian 400 mg Softgel Capsule . Women receiving long-term hormone replacement therapy may require regular assessment of uterine health, breast health, and overall response to treatment.
  • Seek medical advice if concerning symptoms develop: Contact your doctor promptly if you experience unusual vaginal bleeding, severe headaches, vision changes, symptoms of a blood clot, or persistent side effects during treatment.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., carbamazepine, phenobarbital): These medicines may reduce the effectiveness of Progivian 400 mg Softgel Capsule by increasing its breakdown in the body.
  • Antifungal medicines (e.g., ketoconazole): These medicines may increase the amount of Progivian 400 mg Softgel Capsule in the body, raising the risk of side effects.
ProgesteroneEdoxaban
Severe
ProgesteroneMorphine
Severe

Drug-Drug Interactions

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ProgesteroneEdoxaban
Severe
How does the drug interact with Progivian 400 mg Softgel Capsule:
When Progivian 400 mg Softgel Capsule is taken with Edoxaban, may increase the blood levels of Edoxaban which increases the risk of serious bleeding complications.

How to manage the interaction:
Although taking Progivian 400 mg Softgel Capsule and edoxaban together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
ProgesteroneMorphine
Severe
How does the drug interact with Progivian 400 mg Softgel Capsule:
Co-administration of Progivian 400 mg Softgel Capsule with Morphine may increase the blood levels and side effects of Morphine.

How to manage the interaction:
Co-administration of Morphine with Progivian 400 mg Softgel Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ProgesteroneVenetoclax
Severe
How does the drug interact with Progivian 400 mg Softgel Capsule:
Co-administration of Progivian 400 mg Softgel Capsule with Venetoclax may increase the blood levels of Venetoclax which increases the risk of side effects.

How to manage the interaction:
Although taking Progivian 400 mg Softgel Capsule and Venetoclax together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms such as fatigue, nausea, vomiting, diarrhea, and infections, it is advised to consult a doctor. Without consulting a doctor, never stop taking any drugs.

Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: Taking Progivian 400 mg Softgel Capsule with a high-fat meal may increase its absorption and raise the risk of side effects such as drowsiness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Progivian 400 mg Softgel Capsule is used in combination with oestrogen for hormone replacement therapy. Besides this, Progivian 400 mg Softgel Capsule also treats amenorrhoea (absence of menstrual periods) and prevents endometrial hyperplasia (thickened uterus lining). Also, it is indicated for the maintenance of pregnancy, threatened abortion and prevention of preterm labour.
Progivian 400 mg Softgel Capsule contains Progesterone that works by replacing oestrogen and progesterone hormone levels in the body and helps in providing relief from menopause symptoms.
Progivian 400 mg Softgel Capsule may increase the risk of blood clots especially in patients with a history of blood clots. However, if you experience sudden chest pain, difficulty in breathing or painful swelling and redness of legs, stop taking Progivian 400 mg Softgel Capsule and consult a doctor immediately as these might be signs of blood clot.
If oestrogen is used alone for hormone replacement therapy, it may increase the risk of endometrial hyperplasia (excessive thickening of uterus lining) and endometrial cancer (cancer of the womb). Oestrogen in combination with Progivian 400 mg Softgel Capsule reduces this risk.
You are recommended to inform your doctor that you are taking Progivian 400 mg Softgel Capsule as you may need to stop taking Progivian 400 mg Softgel Capsule 4 to 6 weeks before surgery to decrease the risk of blood clot.
Progivian 400 mg Softgel Capsule may increase the risk of uterine cancer. However, if you experience any unusual vaginal bleeding, please consult a doctor immediately.
Progivian 400 mg Softgel Capsule should be swallowed as a whole with water. Do not crush or chew it.
Progivian 400 mg Softgel Capsule is a hormone extracted from plants and is chemically identical to human progesterone.
Yes, Progivian 400 mg Softgel Capsule can be taken daily. Usually, it is taken once everyday in the evening or at bedtime.
Yes, Progivian 400 mg Softgel Capsule is safe if taken in the dose and duration prescribed by the doctor.
Progesterone plays a vital role in fertility. It improves the chances of becoming and staying pregnant by preparing the uterus lining.
Progivian 400 mg Softgel Capsule may cause side effects like dizziness, drowsiness, headache, mood changes, diarrhoea, vaginal discharge, joint pain, hot flashes (sudden feeling of warmth) or constipation. If the side effects persist or worsen, please consult your doctor.
Progivian 400 mg Softgel Capsule may be prescribed during early pregnancy in certain situations, such as after fertility treatment, for luteal phase support, or in selected women with threatened miscarriage, when your doctor believes it is beneficial. Do not start or stop Progivian 400 mg Softgel Capsule during pregnancy without medical advice.
Taking Progivian 400 mg Softgel Capsule at bedtime helps manage common side effects like drowsiness and dizziness, allowing you to sleep through them. Inform your doctor if these symptoms persist.
Some women may experience mild fluid retention or bloating, which can feel like weight gain. If you notice rapid or significant weight changes, talk to your doctor.
It is best to limit or avoid alcohol while taking Progivian 400 mg Softgel Capsule , as alcohol can increase drowsiness and may interact with how your body processes the hormone.
The time it takes to see results varies depending on the condition being treated; for restoring periods, withdrawal bleeding usually occurs within a few days of finishing a cycle.
Light spotting or bleeding between periods can sometimes occur, especially during the first few months of treatment. However, if the bleeding is heavy or persistent, consult your doctor immediately.
No, this formulation is not a contraceptive and will not prevent pregnancy. Talk to your doctor about safe and effective birth control methods if you wish to avoid pregnancy.
You should not stop taking this medication without consulting your healthcare provider, as stopping abruptly can cause hormonal imbalances or irregular bleeding. Inform your doctor before making any changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

3M India Ltd, Concorde Block, Ub City, #24, Vittal Mallya Road, Bangalore, Karnataka - 560001 India.
Other Info - PRO2527
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