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  3. Prograf 1 mg Capsule 10's

Prograf 1 mg Capsule 10's, Pack of 10 CAPSULES
Prograf 1 mg Capsule 10's, Pack of 10 CAPSULES
Prograf 1 mg Capsule 10's, Pack of 10 CAPSULES
Prograf 1 mg Capsule 10's, Pack of 10 CAPSULES
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Prograf 1 mg Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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Composition :

TACROLIMUS-1MG

Manufacturer/Marketer :

Astellas Pharma India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Prograf 1 mg Capsule

Prograf 1 mg Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Prograf 1 mg Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Take Prograf 1 mg Capsule as prescribed. You are advised to use Prograf 1 mg Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Prograf 1 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Prograf 1 mg Capsule . Avoid alcohol consumption with Prograf 1 mg Capsule . Drive only if you are alert, as Prograf 1 mg Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Prograf 1 mg Capsule . Prograf 1 mg Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Prograf 1 mg Capsule

Prograf 1 mg Capsule is used to treat various medical conditions. The detailed uses are as follows:

  • Prevention of Organ Transplant Rejection: Prograf 1 mg Capsule is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
  • Other Off-Label Uses: In some cases, Prograf 1 mg Capsule may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

Directions for Use

  • Take Prograf 1 mg Capsule at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
  • Strictly follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

Medicinal Benefits

  • Prograf 1 mg Capsule belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
  • It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
  • It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
  • It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
  • It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.

How Prograf 1 mg Capsule Works

Prograf 1 mg Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Storage

• Store in a cool and dry place away from sunlight.• Keep Prograf 1 mg Capsule out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Prograf 1 mg Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Prograf 1 mg Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed of Prograf 1 mg Capsule or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

  • Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Prograf 1 mg Capsule .
  • If you are pregnant or breastfeeding, consult your doctor before using Prograf 1 mg Capsule to ensure it is safe for you and your baby.
  • Avoid alcohol consumption while taking Prograf 1 mg Capsule , as it may increase side effects.
  • Drive or operate machinery only if you feel alert, since Prograf 1 mg Capsule may occasionally cause vision problems, dizziness, or nervous system disturbances.
  • Inform your doctor before receiving any vaccines, as Prograf 1 mg Capsule suppresses the immune system and may reduce the effectiveness of certain vaccines.
  • Prograf 1 mg Capsule can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
  • When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
  • Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.

Drug-Drug Interactions

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TacrolimusZiprasidone
Critical
TacrolimusMifepristone
Critical

Drug-Drug Interactions

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TacrolimusZiprasidone
Critical
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule with Mifepristone may significantly increase the blood levels of Prograf 1 mg Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusThioridazine
Critical
How does the drug interact with Prograf 1 mg Capsule:
Combining Prograf 1 mg Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Prograf 1 mg Capsule:
Taking cidofovir with Prograf 1 mg Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 1 mg Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusDiclofenac
Severe
How does the drug interact with Prograf 1 mg Capsule:
Co-administration of diclofenac with Prograf 1 mg Capsule may cause kidney problems.

How to manage the interaction:
Co-administration of Diclofenac and Prograf 1 mg Capsule can lead to an interaction, it can be taken if advised by your doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without a doctor's advice.
TacrolimusInfliximab
Severe
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule together with infliximab may increase the risk of serious infections.

How to manage the interaction:
Although taking Prograf 1 mg Capsule and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TacrolimusSotalol
Severe
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule together with sotalol can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Prograf 1 mg Capsule and sotalol together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
TacrolimusToremifene
Severe
How does the drug interact with Prograf 1 mg Capsule:
Taking Prograf 1 mg Capsule together with toremifene can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Prograf 1 mg Capsule and toremifene together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Prograf 1 mg Capsule treatment may lead to increased Prograf 1 mg Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Prograf 1 mg Capsule.

Diet & Lifestyle Advise

  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
  • Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
  • Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
  • Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
  • Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
  • Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
  • Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
  • Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
  • Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
  • Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Prograf 1 mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption with Prograf 1 mg Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Prograf 1 mg Capsule .

bannner image

Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Prograf 1 mg Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Prograf 1 mg Capsule .

bannner image

Breast Feeding

Consult your doctor

Prograf 1 mg Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Prograf 1 mg Capsule . You should avoid taking Prograf 1 mg Capsule during breastfeeding or avoid breastfeeding while on treatment with Prograf 1 mg Capsule .

bannner image

Driving

Caution

Prograf 1 mg Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Prograf 1 mg Capsule .

bannner image

Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Prograf 1 mg Capsule .

bannner image

Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Prograf 1 mg Capsule .

bannner image

Children

Safe if prescribed

Prograf 1 mg Capsule should be used in children in doses as advised by a doctor only.

Have a query?

FAQs

Prograf 1 mg Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart.

Prograf 1 mg Capsule contains Tacrolimus, an immunosuppressant that works by inhibiting the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Prograf 1 mg Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as a sore throat or fever.

Prograf 1 mg Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for extended periods or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Prograf 1 mg Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.

Using Prograf 1 mg Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Prograf 1 mg Capsule with other medications.

Prograf 1 mg Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.

Prograf 1 mg Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.

Prograf 1 mg Capsule is a macrolide antibiotic with immunosuppressant properties.

Prograf 1 mg Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.

Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.

Prograf 1 mg Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).

No, Prograf 1 mg Capsule does not have an abuse potential as it is not a controlled substance.

Side effects of Prograf 1 mg Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

Irelend

Manufacturer/Marketer address

Astellas Pharma India Pvt Ltd, 301, 3rd Floor, C and B Square, 127 Andheri Kurla Road, Chakala, Andheri East, Mumbai 400 069.
Other Info - PRO0794

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 31, 2025 | 12:12 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  2. https://www.medsafe.govt.nz/consumers/cmi/t/tacrolimussandozcap.pdf
  3. https://www.astellas.com/us/system/files/prografwpi_3.pdf
  4. https://www.medicines.org.uk/emc/product/461/smpc
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210115s000,050708s047,050709s040lbl.pdf
  6. https://www.drugs.com/cdi/tacrolimus-granules-for-suspension.html
  7. https://www.astellas.com/us/system/files/prografinstructionstouse_2.pdf

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