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compositionComposition:CLOBETASOL-0.05%W/W+CLOTRIMAZOLE-1%W/W
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Prescription Medicine
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Propyzole NF Cream is used to treat fungal skin infections. It contains Clobetasol and Clotrimazole, which blocks the production of chemicals that cause skin redness, swelling and itching. Also, it stops the growth of fungi. Thus, it is used to treat athlete's foot (fungal infection between the toes due to sweating) and jock itch (fungal infection in the skin of the genitals, inner thighs and buttocks). It may cause common side effects of such as burning, irritation, itching, redness and thinning of skin at the application site. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CLOBETASOL-0.05%W/W+CLOTRIMAZOLE-1%W/W

Manufacturer/Marketer :

H&H Pharmaceuticals Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Propyzole NF Cream

Propyzole NF Cream is a topical skin medication used to treat fungal skin infections that are accompanied by redness, swelling, and severe itching. It helps clear the underlying fungal infection while rapidly soothing the uncomfortable inflammatory symptoms. This cream is commonly prescribed for skin conditions like infected eczema, ringworm, athlete's foot, or jock itch when inflammation is prominent.

To get the best results, you should apply Propyzole NF Cream consistently at the same times each day as directed by your doctor. It is strictly for external use on the skin and should be applied in a thin layer over the affected area. Keeping the skin clean and dry and wearing loose-fitting cotton clothing can also significantly help speed up your recovery.

While using Propyzole NF Cream, you might experience mild skin irritation, burning, or redness at the application site. These symptoms are usually temporary and go away as your skin adjusts, but if you notice severe skin thinning, stretch marks, or signs of an allergic reaction, stop using it and contact your doctor immediately.

Before starting this medication, tell your doctor if you have skin thinning, tuberculosis of the skin, viral skin infections like herpes, or circulation problems. Do not use this medicine if you are allergic to any of its ingredients or have a history of severe reactions to topical steroids or antifungals.

Although interactions are rare with topical products, inform your healthcare provider about any other skin creams or ointments you are using. If you are pregnant, planning a pregnancy, breastfeeding, or caring for an elderly patient, consult your doctor before applying Propyzole NF Cream to ensure it is safe for your specific situation.
 

Uses of Propyzole NF Cream

Propyzole NF Cream is used to treat fungal skin infections associated with redness, itching, and inflammation. It may be prescribed for the following conditions:

  • Inflamed fungal skin infections: Propyzole NF Cream helps clear fungal overgrowth while rapidly reducing painful swelling, redness, and itching.
  • Infected eczema or dermatitis: It calms severe skin irritation and treats secondary fungal infections that can develop on cracked skin.
  • Resistant ringworm or athlete's foot: It targets stubborn fungal infections that have caused intense localised inflammation and discomfort.
     

Key Benefits

Propyzole NF Cream combines a potent corticosteroid with an antifungal medicine to treat fungal skin infections associated with inflammation. It helps relieve symptoms quickly while treating the underlying fungal infection.

  • Relieves Itching and Inflammation: Helps reduce itching, redness, swelling, and irritation caused by fungal skin infections.
  • Treats Fungal Infections: Eliminates the fungi responsible for the infection, helping prevent it from spreading.
  • Promotes Faster Healing: By controlling both inflammation and infection, it supports quicker healing and restoration of healthy skin.
  • Reduces the Urge to Scratch: Helps minimise scratching, lowering the risk of skin damage and secondary bacterial infections.
  • Provides Convenient Combination Therapy: Combines two complementary medicines in a single cream, simplifying treatment and improving adherence.
     
Side effects of Propyzole Nf Cream 15g
  • Cool the burn by using cool (not cold) running water to reduce tissue damage and pain.
  • Slowly remove any tight clothing or jewellery from the burned area.
  • After cooling, apply a topical ointment like aloevera gel or a mild antibiotic cream to help with healing.
  • Use a clean bandage to protect the burn area from further irritation.
  • Take over-the-counter pain medication if needed.
  • Do not apply butter or other greasy substances, as they can trap bacteria and hinder healing.
  • If the burn covers a large area of skin or if the burn appears to be deeper than the top layer of skin, with blisters or significant redness, consult the doctor and get treated.
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce irritation.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin soothing.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Avoid extreme heat or cold, like hot showers or cold winds, to prevent worsening skin discomfort.
  • Cool compresses: To reduce itch, redness, and swelling.
  • Avoid irritants like harsh chemicals or allergens to prevent worsening skin discomfort.
  • If you have severe itching, burning, or blistering seek medical attention.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
  • Mild hair follicle inflammation often heals on its own without needing treatment.
  • You can apply a warm saltwater or vinegar solution to the affected area with a washcloth, or use over-the-counter antibiotics, oatmeal lotion, or hydrocortisone cream for relief.
  • Avoid making the affected area worse by not shaving, scratching, or wearing tight clothes.
  • Apply a warm compress to the area 3-4 times a day for 15-20 minutes to help speed up healing.
  • Do not scratch, squeeze, or pop any bumps, as this may lead to infection or other problems.
  • If self-care methods fail, consult a doctor for further treatment and advice.
  • Shield your skin from the sun by using sunscreen, seeking shade, and wearing protective clothing.
  • Please don't smoke, as it damages the skin and reduces blood flow.
  • Treat your skin gently by limiting bath time, using mild cleansers, and shaving carefully.
  • Eat a healthy diet of fruits, vegetables, whole grains, and lean proteins.
  • Stay hydrated by drinking plenty of water.
  • Manage stress through sleep, exercise, meditation, and enjoyable activities.
  • Additionally, use moisturizers to coat your skin with a protective barrier, and consider wearing sun-protective clothing.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Take a small amount of Propyzole NF Cream and gently apply it onto clean, dry, unbroken skin affected by the infection.
  • Do not use it on the face and avoid contact with eyes, mouth and nose.
  • Do not put a bandage or a dressing on the affected area while using Propyzole NF Cream unless advised by the doctor.

How Propyzole NF Cream Works

Propyzole NF Cream contains clobetasol and clotrimazole, which work together to treat skin conditions associated with inflammation and fungal infection. Clobetasol is a potent topical corticosteroid that helps block the release of inflammatory substances responsible for redness, swelling, and itching, providing rapid relief from skin irritation. Clotrimazole is an antifungal medicine that works by disrupting the outer protective membrane of fungal cells, causing them to break down and die. This helps eliminate the fungal infection and prevents it from spreading. Together, these actions help control the fungal infection, reduce inflammation, relieve itching, and promote healing of the affected skin.
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Alcohol

Safe if prescribed

No interaction found of Propyzole NF Cream with alcohol.

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Pregnancy

Caution

There is limited data on how the Propyzole NF Cream affects pregnancy. Propyzole NF Cream may be unsafe to use during pregnancy since it affects the baby. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Propyzole NF Cream.

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Breast Feeding

Caution

It is not known if Propyzole NF Cream passes into the breast milk. Please consult your doctor before taking Propyzole NF Cream if you are breastfeeding. If you need to apply the cream or ointment on your breasts, don't do this shortly before giving a feed.

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Driving

Safe if prescribed

There have been no studies to investigate the effect of Propyzole NF Cream on driving performance or the ability to operate machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Propyzole NF Cream.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking Propyzole NF Cream.

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Children

Unsafe

Propyzole NF Cream is not recommended for children less than 12 years of age.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Propyzole NF Cream in elderly patients. Please consult your doctor.

What if I have taken an overdose of Propyzole NF Cream

An overdose of topical Propyzole NF Cream is unlikely when used as directed. However, if the medication is accidentally swallowed, or if it is applied excessively over large areas for an extended period, it can lead to serious health issues. If you suspect an overdose or accidental ingestion, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Keep the Affected Area Clean and Dry: Fungi thrive in warm, moist environments, so gently clean and dry the affected area before applying the medicine.
  • Wear Breathable Clothing: Choose loose-fitting cotton clothing to reduce sweating, friction, and skin irritation.
  • Avoid Sharing Personal Items: Do not share towels, clothing, combs, or other personal items to help prevent the spread of fungal infections.
  • Avoid Scratching: Refrain from scratching the affected skin, as it may worsen irritation, delay healing, and increase the risk of bacterial infection.
  • Wash Clothing and Linen Regularly: Wash towels, clothing, socks, and bed linen frequently in hot water to help prevent reinfection.
     
health query

Have a query?

How Soon It Starts Working

The time required for Propyzole NF Cream to start to work: The time required for Propyzole NF Cream to show its action is not known. The time for which the effects of Propyzole NF Cream last: The duration of action for Propyzole NF Cream is not known.

What if you forget to take Propyzole NF Cream

If you forget to apply Propyzole NF Cream at your regular time, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed one and continue with your normal routine. Do not apply extra cream to make up for a missed application.

Storage

• Store Propyzole NF Cream at room temperature, ideally between 15°C and 30°C (59°F to 86°F). Keep the tube tightly closed when not in use to protect the cream from moisture and air.

Drug Warnings

  • Avoid Contact with Sensitive Areas: Keep the cream away from your eyes, nose, mouth, and other mucous membranes. Rinse thoroughly with water if accidental contact occurs.
  • Use Only on Recommended Areas: Do not apply Propyzole NF Cream to the face, groin, underarms, or skin folds unless specifically directed by your doctor.
  • Review Treatment if Symptoms Persist: Consult your doctor if your condition does not improve after two weeks of treatment or if it worsens.
  • Do Not Reuse or Share the Medicine: Do not use leftover cream for other skin conditions or share it with anyone else, even if their symptoms appear similar.
  • Do Not Apply to Broken Skin: Avoid applying the cream to open wounds, deep cuts, or severely damaged skin unless advised by your doctor.
     

Drug-Drug Interactions

verifiedApollotooltip

Propyzole NF Cream may interact with certain medicines or topical products, which can increase the risk of side effects or affect treatment. Inform your doctor if you are using any of the following:

  • Other Topical Corticosteroids or Skin Products: Using multiple steroid-containing creams or other medicated skin products on the same area may increase the risk of skin thinning, irritation, or excessive steroid absorption.
  • Systemic Antifungal Medicines: Although significant interactions are uncommon with topical use, tell your doctor if you are taking oral antifungal medicines or other prescription medications, especially if large areas of skin are being treated.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Propyzole NF Cream when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS AND ANTIFUNGALS]

FAQs

Propyzole NF Cream is used to treat fungal skin infections.
Propyzole NF Cream contains Clobetasol and Clotrimazole. Clobetasol is a corticosteroid that provides relief from itching and redness of infection. Clotrimazole is an antifungal drug that treats various fungal skin infections by killing and preventing fungi growth.
Propyzole NF Cream is for topical (for skin use) application only. Do not use Propyzole NF Cream on the face and avoid contact with eyes. Do not put a bandage or a dressing on the affected area while using Propyzole NF Cream unless advised by the doctor.
Propyzole NF Cream consists of Clobetasol, a corticosteroid that affects the blood sugar levels. It is advised to consult your doctor before using Propyzole NF Cream and monitor your blood sugar levels regularly.
Propyzole NF Cream should be used with proper caution and doctor consultation if you have any bacterial, fungal, viral and protozoa infections, liver or kidney diseases, glaucoma, cataract, poor blood circulation, immune system problems, diabetes and adrenal gland diseases.
Do not stop using Propyzole NF Cream even if you feel better until the doctor's advised course is finished. Your symptoms may improve, but the infection may not be cured completely.
Clotrimazole in Propyzole NF Cream may cause abnormal liver functions tests in people with liver impairment. Please let your doctor know if you have any history of liver diseases before undergoing any liver function tests.
Clean and dry the affected area and apply Propyzole NF Cream as a thin layer as advised by the doctor.
Propyzole NF Cream should be used for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Common side effects of Propyzole NF Cream include burning, irritation, itching, redness and thinning of skin at the application site. These side effects do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.
No, you should not cover the treated area with bandages, dressings, or tight wraps unless your doctor specifically tells you to do so. Covering the area acts as an occlusive barrier, which can significantly increase how much medicine your skin absorbs, raising the risk of serious side effects.
If your skin symptoms do not start to improve after two weeks of consistent daily application, or if they seem to get worse, stop using the cream and contact your healthcare provider. Talk to your doctor or pharmacist to re-examine the diagnosis.
No, Propyzole NF Cream is not recommended for treating diaper rash in infants. It contains a very strong steroid that can easily be absorbed through an infant's delicate skin, especially under a diaper, potentially causing serious developmental or hormonal side effects. Talk to your doctor for safer paediatric options.
There are no known direct interactions between alcohol and topical Propyzole NF Cream. However, maintaining a healthy lifestyle supports your body's immune system in fighting off infections. If you have concerns about alcohol use, talk to your doctor or pharmacist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Clotrimazole Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Clobetasol Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 020340S007Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.939 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Clobetasol Clobetasol. 1993. [Accessed on 04 Apr. 2019]Check here
  6. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022]Check here
  7. Bethesda (MD). Clotrimazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Office No. 11A - 15, 1St Floor, Free Press House, 215, Nariman Point, Mumbai 400 021.
Other Info - PRO0238

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