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compositionComposition:PRUCALOPRIDE-1MG
prescription
Prescription Medicine
info
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Prucalshil-1 Disintegrating Strips is used to treat chronic idiopathic constipation(long-term constipation with no known cause). It contains prucalopride, which works on the muscles of the gut to increase movement and help restore normal bowel function. In some cases, this medicine may cause side effects, such as headache, diarrhoea, nausea, and abdominal pain. Before using Prucalshil-1 Disintegrating Strips , tell your doctor if you are pregnant, breastfeeding, taking other medications, or have any existing health conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRUCALOPRIDE-1MG

Manufacturer/Marketer :

Shilpa Medicare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prucalshil-1 Disintegrating Strips

Prucalshil-1 Disintegrating Strips is a prescription medication used to treat chronic idiopathic constipation in adults who have not found sufficient relief from other laxatives. It helps restore the natural movement of your bowels, making it easier to pass stool regularly. This medication acts on the gut to help you establish a more consistent and comfortable bathroom routine.

This medication is typically taken once daily, and it is important to take it consistently at the same time each day to maintain its beneficial effects. You can take Prucalshil-1 Disintegrating Strips with or without food, as your daily meals do not change how the medicine is absorbed in your body. Along with taking this medicine, drinking plenty of water and eating a fibre-rich diet can help improve your overall results.

Some people may experience mild, temporary side effects when starting this medication, such as headaches, nausea, or mild stomach pain. These symptoms usually improve after a few days as your body adjusts to the treatment. However, if you develop severe diarrhoea, intense abdominal cramping, or sudden mood changes, you should consult your doctor immediately.

Before taking Prucalshil-1 Disintegrating Strips , talk to your doctor if you have a history of kidney disease, liver damage, or heart problems. Do not take this if you have a blockage in your bowel, a tear in your intestinal wall, or severe inflammatory bowel diseases like Crohn's disease or ulcerative colitis. Your doctor will help determine if this treatment is safe and appropriate for your medical history.

Some medicines can interfere with how this drug works, and drinking alcohol may worsen stomach upset or dizziness during treatment. If you are pregnant, planning to become pregnant, breastfeeding, or are over the age of 65, talk to your doctor or pharmacist to ensure this treatment is safe for your specific situation.

Uses of Prucalshil-1 Disintegrating Strips

Your doctor may prescribe Prucalshil-1 Disintegrating Strips for the following condition:

  • Chronic idiopathic constipation: Prucalshil-1 Disintegrating Strips helps by stimulating the natural muscle contractions in your colon, allowing for more frequent and comfortable bowel movements when standard laxatives have not worked.

Key Benefits

Taking Prucalshil-1 Disintegrating Strips can significantly improve your daily comfort and quality of life by addressing the root cause of chronic constipation. Here are the key benefits of this treatment:

  • Restores natural bowel rhythm: Instead of simply softening stool, it helps your intestines move naturally, encouraging a more predictable and regular bowel schedule.
  • Reduces abdominal discomfort: By promoting regular bowel movements, it helps relieve the painful bloating, straining, and fullness associated with chronic constipation.
  • Provides long-term relief: Unlike some temporary over-the-counter laxatives, this medication is designed to support ongoing bowel function for individuals dealing with long-term, unexplained constipation.
Side effects of Prucalshil-1 Disintegrating Strips
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Prucalshil-1 Disintegrating Strips can be taken with or without food.
  • It is recommended to take Prucalshil-1 Disintegrating Strips once daily or as advised by your doctor.
  • Swallow Prucalshil-1 Disintegrating Strips as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Prucalshil-1 Disintegrating Strips Works

Prucalshil-1 Disintegrating Strips contains prucalopride, which works by targeting specific receptors in the walls of your intestines, known as 5-HT4 receptors. These receptors are responsible for sending signals to the muscles in your digestive tract to contract and move waste through your system. When you take Prucalshil-1 Disintegrating Strips , it activates these receptors, which stimulate the natural squeezing motion of your colon (known as peristalsis). This increased movement helps push stool through your bowels more efficiently, making your bowel movements more regular and decreasing the need to strain.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Prucalshil-1 Disintegrating Strips . Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Prucalshil-1 Disintegrating Strips is not recommended during pregnancy. Use a reliable method of contraception while taking Prucalshil-1 Disintegrating Strips . Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Prucalshil-1 Disintegrating Strips might pass into breastmilk. Avoid breastfeeding while taking Prucalshil-1 Disintegrating Strips .

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Driving

Caution

Prucalshil-1 Disintegrating Strips is unlikely to affect your ability to drive. However, sometimes Prucalshil-1 Disintegrating Strips might cause dizziness and tiredness, so drive only if you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment/kidney disease.

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Children

Unsafe

Prucalshil-1 Disintegrating Strips is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Prucalshil-1 Disintegrating Strips should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Prucalshil-1 Disintegrating Strips .

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Geriatrics

Caution

Prucalshil-1 Disintegrating Strips should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Prucalshil-1 Disintegrating Strips

If you suspect an overdose, seek immediate medical attention or contact a poison control centre. Symptoms of an overdose may include severe diarrhoea, headache, and nausea.

Diet & Lifestyle Advise

  • Increase your fibre intake gradually: Incorporate more whole grains, fruits, vegetables, and beans into your meals to help bulk up your stool and make it easier to pass.
  • Stay well-hydrated: Drink plenty of water throughout the day. Hydration is essential for keeping stool soft and helping Prucalshil-1 Disintegrating Strips work effectively.
  • Engage in regular physical activity: Light exercise, such as walking for 20 to 30 minutes a day, stimulates the natural muscles in your digestive tract and promotes movement.
  • Establish a regular toilet routine: Try to visit the bathroom at the same times each day, especially after meals when your bowel is naturally more active, and do not ignore the urge to go.
health query

Have a query?

How Soon It Starts Working

  • The time required for Prucalshil-1 Disintegrating Strips to start to work: Prucalshil-1 Disintegrating Strips ideally shows its action within 2 to 3 hours of administration.
  • The time for which the effects of Prucalshil-1 Disintegrating Strips last: Prucalshil-1 Disintegrating Strips effect lasts for 24 hours.

What if you forget to take Prucalshil-1 Disintegrating Strips

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Prucalshil-1 Disintegrating Strips tablets in their original packaging at room temperature, ideally between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Monitor for dehydration: If you develop severe diarrhoea, you may lose essential fluids and salts. Drink electrolyte solutions and contact your doctor if the diarrhoea does not stop within a few days.
  • Watch your mood: Pay close attention to any sudden changes in your mood, thoughts, or behaviour. Report any signs of depression or unusual thoughts to your doctor immediately.
  • Check the packaging: Always inspect the tablet blister pack before use. Do not take the medication if the foil is broken or if the tablets appear damaged.
  • Inform all healthcare providers: Make sure your doctors, dentists, and pharmacists know you are taking Prucalshil-1 Disintegrating Strips before you start any new medications or undergo medical procedures.

Drug-Drug Interactions

verifiedApollotooltip

Prucalshil-1 Disintegrating Strips may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.

  • Anticholinergic medications: Taking these medicines alongside Prucalshil-1 Disintegrating Strips may reduce its effectiveness, as they have opposing effects on gut movement.
  • Other laxatives: Using strong laxatives at the same time may increase the risk of severe diarrhoea and dehydration. Talk to your doctor before combining treatments.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • There are no major established food interactions with Prucalshil-1 Disintegrating Strips . It can be safely taken with or without food.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GASTROPROKINETIC AGENTS]

FAQs

Prucalshil-1 Disintegrating Strips is used to treat chronic idiopathic constipation.
Prucalshil-1 Disintegrating Strips acts on the muscle walls of the gut and increases bowel motility. Thereby, helps restore the normal functioning of the bowel and treats constipation.
Diarrhoea might occur if Prucalshil-1 Disintegrating Strips is taken in larger doses. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. Contraceptive pills might become ineffective in case of severe diarrhoea. In such conditions, use an extra method of contraception.
Do not take Prucalshil-1 Disintegrating Strips for longer durations unless advised by the doctor, as it might lead to dependency on Prucalshil-1 Disintegrating Strips for a bowel movement. Consult your doctor if your bowel movement is irregular even after taking Prucalshil-1 Disintegrating Strips for four weeks.
Drink plenty of fluids and consume fibre-rich food, whole-grain bread, unprocessed bran, fruits and vegetables. Try to exercise regularly.
If you miss a dose, try to take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the scheduled dose instead. Avoid taking the double dose as it might cause unpleasant side effects or overdose.
Prucalshil-1 Disintegrating Strips may cause side effects such as vomiting, nausea, diarrhoea, headache, tiredness and stomach cramps/pain. If these side effects persist or worsen, please consult your doctor.
Prucalshil-1 Disintegrating Strips has been shown to act quickly but the effect varies from person to person. This is because each patient reacts differently to particular medication. Generally, Prucalshil-1 Disintegrating Strips causes a bowel movement within 2-3 hours. However, it may take about 4-5 days to show full effect and rapid bowel movements.
Prucalshil-1 Disintegrating Strips is not recommended during pregnancy. Use a reliable method of contraception while taking Prucalshil-1 Disintegrating Strips . Inform your doctor if you are pregnant, think you are pregnant or are planning a pregnancy.
Take Prucalshil-1 Disintegrating Strips as advised by your doctor. It can be taken at any time of the day. It is typically administered once daily orally, with or without food.
Prucalshil-1 Disintegrating Strips has been proven to be beneficial in cases of gastroparesis and constipation. Gastroparesis is a disorder that stops or slows the food movement from stomach to small intestine, even though there is no blockage in the intestines or stomach.
You should avoid taking Prucalshil-1 Disintegrating Strips if you are allergic to it, if you have a tear in your intestinal or stomach wall, a bowel blockage or inflammatory conditions of the intestinal wall like ulcerative colitis or Crohn’s disease. Always consult your doctor before starting Prucalshil-1 Disintegrating Strips .
While it treats constipation, Prucalshil-1 Disintegrating Strips is not a traditional laxative. It is a prokinetic medication, meaning it works by stimulating the natural muscle movements of your intestines to help move waste through. Talk to your doctor.
Alcohol does not directly stop this medication from working, but it can worsen common side effects like headaches, dizziness, or stomach upset. To minimise these risks, limit your alcohol consumption and talk to your doctor.
If you experience severe or persistent diarrhoea, stop taking the medication and drink plenty of fluids to prevent dehydration. You should contact your healthcare provider right away to discuss your symptoms. Talk to your doctor.
Some medications can affect how this medicine works or increase the risk of side effects. Always provide your doctor or pharmacist with a complete list of all prescription and over-the-counter medicines you are taking. Talk to your doctor.
Weight changes are not a common side effect of this medication. However, relieving chronic constipation and bloating may make you feel lighter or less full. If you experience unexpected weight changes, talk to your doctor.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.584 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 210166S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Prucalopride Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A619011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Prucalopride succinate [EMC SmPC]. 2022. [Accessed on 28 Jan. 2019]Check here
  6. Prucalopride [EMC SmPC]. 2022. [Accessed on 28 Mar. 2019]Check here
  7. Information H, Diseases D. Constipation - NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2021 [Accessed on 7 March 2022]Check here

Country of origin

India

Manufacturer/Marketer address

12-6-214/A1, Hyderabad Road, Raichur 584 135, Karnataka, India.
Other Info - PRU0096

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