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compositionComposition:AMBRISENTAN-10MG
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Prescription Medicine
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PULMONEXT 10MG TABLET is used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It contains Ambrisentan, which works by widening the blood vessels and improving blood flow. In some cases, this medicine may cause side effects such as headache, dizziness, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMBRISENTAN-10MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About PULMONEXT 10MG TABLET

PULMONEXT 10MG TABLET is a medication prescribed to treat pulmonary arterial hypertension, which is high blood pressure in the vessels of your lungs. It helps lower blood pressure in these arteries, making it easier for your heart to pump blood and improving your physical stamina. This medicine is designed for long-term management to help you breathe more easily during daily activities.

You should take this medicine once daily, consistently at the same time each day to maintain steady levels in your body. It can be taken with or without food. To get the best results, combine this treatment with doctor-approved lifestyle changes, such as a low-salt diet and light, gentle exercise.

Common side effects of this medicine include a stuffy nose, headache, and swelling in the legs or ankles due to fluid retention. It is important to monitor these symptoms and tell your doctor immediately if you experience rapid weight gain or yellowing of your skin and eyes.

Talk to your doctor before starting this medicine if you have a history of liver problems, kidney disease, or lung scarring. Do not take this medicine if you are pregnant, as it can cause severe, life-threatening birth defects. Women of childbearing potential must use two reliable forms of contraception during treatment and for one month after stopping PULMONEXT 10MG TABLET. A negative pregnancy test is required before starting treatment, followed by regular pregnancy testing during therapy.

This medicine can interact with certain other prescription drugs, such as medications that suppress your immune system. Although no clinically significant interaction has been established between PULMONEXT 10MG TABLET and grapefruit, always inform your doctor or pharmacist about your usual diet and all medicines or supplements you take. Limit or avoid alcohol while taking this medication, as it may increase dizziness or lightheadedness in some people. Pregnant, breastfeeding, or elderly individuals should consult their doctor for personalised safety advice.
 

Uses of PULMONEXT 10MG TABLET

Here are the main conditions where PULMONEXT 10MG TABLET is used to improve blood flow through the lungs and reduce the effects of pulmonary arterial hypertension:

  • Pulmonary Arterial Hypertension (PAH): PULMONEXT 10MG TABLET is used to treat high blood pressure in the lungs (WHO Group 1). It relaxes and widens the narrowed blood vessels, which lowers pressure, reduces heart strain, and slows down the progression of the disease.
  • Exercise Limitation in PAH: By improving blood flow through the lungs, this medicine helps increase your physical stamina, allowing you to walk longer distances and perform daily tasks with less shortness of breath.
     

Key Benefits

PULMONEXT 10MG TABLET offers several important benefits that help improve exercise capacity, reduce symptoms, and slow the progression of pulmonary arterial hypertension:

  • Improved Exercise Capacity: By widening the blood vessels in the lungs, PULMONEXT 10MG TABLET reduces the workload on the heart, making activities such as walking, climbing stairs, and household tasks easier.
  • Reduced Breathlessness and Fatigue: Improved blood flow through the lungs helps relieve shortness of breath and tiredness during everyday activities.
  • Slows Disease Progression: Regular use helps delay the worsening of pulmonary arterial hypertension, reducing the risk of complications and hospitalisation.
  • Protects Heart Function: Lowering pressure within the pulmonary arteries reduces strain on the right side of the heart, supporting better long-term cardiovascular health.

PULMONEXT 10MG TABLET is often prescribed together with other pulmonary arterial hypertension medicines, such as phosphodiesterase-5 (PDE-5) inhibitors, to improve treatment outcomes. Your doctor will decide whether combination therapy is appropriate for your condition. 
 

Side effects of Pulmonext 10mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Take PULMONEXT 10MG TABLET with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to improve effectiveness.
  • Swallow PULMONEXT 10MG TABLET as a whole with a glass of water.
  • Do not crush, chew, or break it.

How PULMONEXT 10MG TABLET Works

PULMONEXT 10MG TABLET contains an active medicine that helps treat pulmonary arterial hypertension by relaxing the blood vessels in the lungs and improving blood flow. Ambrisentan is a selective endothelin-A (ETA) receptor antagonist. It works by blocking the action of endothelin-1, a natural substance that causes the blood vessels in the lungs to tighten and narrow. By preventing endothelin-1 from attaching to ETA receptors, ambrisentan allows these blood vessels to relax and widen, making it easier for blood to flow through the lungs. It continues to preserve the activity of endothelin-B (ETB) receptors, which may contribute to its favourable safety profile. Together, these actions help lower blood pressure in the lungs, reduce the workload on the heart, improve oxygen delivery throughout the body, and enhance exercise capacity.
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Alcohol

Caution

It is advised to limit alcohol intake, since alcohol consumption may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

PULMONEXT 10MG TABLET is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting PULMONEXT 10MG TABLET. You should get a negative pregnancy test for sure before using PULMONEXT 10MG TABLET. Also, please use reliable forms of birth control if you are undergoing treatment with PULMONEXT 10MG TABLET to avoid pregnancy.

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Breast Feeding

Consult your doctor

It is not known if PULMONEXT 10MG TABLET is excreted into the breast milk. Please talk to your doctor for more information before taking PULMONEXT 10MG TABLET if you are a nursing mother.

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Driving

Caution

PULMONEXT 10MG TABLET may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver disease before taking PULMONEXT 10MG TABLET. PULMONEXT 10MG TABLET may cause an increase in liver enzymes. If you are using PULMONEXT 10MG TABLET and experience any nausea, vomiting, loss of appetite, dark-coloured urine and yellowing of the skin, please see your doctor immediately.

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Kidney

Caution

PULMONEXT 10MG TABLET should be used with caution in cases of renal impairment. It is recommended to seek a doctor's advice before starting PULMONEXT 10MG TABLET if you have any kidney problems.

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Children

Unsafe

Safety and effectiveness of PULMONEXT 10MG TABLET have not been established in patients below 18 years of age.

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Heart

Safe if prescribed

PULMONEXT 10MG TABLET can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

PULMONEXT 10MG TABLET should be taken with caution in geriatric patients. Please inform your doctor before using PULMONEXT 10MG TABLET.

What if I have taken an overdose of PULMONEXT 10MG TABLET

If you take more than your prescribed dose, seek emergency medical attention or contact your local poison control centre immediately. An overdose can cause a dangerous drop in blood pressure, leading to severe dizziness, lightheadedness, or fainting.

Diet & Lifestyle Advise

  • Limit your salt intake: Consuming too much sodium can cause your body to retain water, worsening swelling and putting extra strain on your heart and lungs. Avoid processed foods and do not add salt to your meals.
  • Track your daily weight: Weigh yourself every morning at the same time, before eating but after using the restroom. A sudden weight gain of 2 to 3 pounds in a single day, or 5 pounds in a week, can indicate fluid buildup and should be reported to your doctor immediately.
  • Stay active gently: Engage in low-impact, doctor-approved exercises like gentle walking. Avoid heavy lifting, intense workouts, or activities that make you excessively dizzy or short of breath.
  • Manage fluid intake: Talk to your doctor or pharmacist about how much water and other fluids you should drink daily, as fluid restriction is sometimes necessary for patients with heart strain.
     
health query

Have a query?

How Soon It Starts Working

The time required for PULMONEXT 10MG TABLET to start to work: The time required for PULMONEXT 10MG TABLET to show its action is not clinically established.

The time for which the effects of PULMONEXT 10MG TABLET last: The duration of action for PULMONEXT 10MG TABLET is not clinically established.

What if you forget to take PULMONEXT 10MG TABLET

If you miss a dose, take it as soon as you remember on that day. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular daily schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store PULMONEXT 10MG TABLET tablets at room temperature, strictly between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Use Effective Contraception: Women of childbearing potential must use two highly effective forms of birth control during treatment and for one month after stopping PULMONEXT 10MG TABLET.
  • Attend Regular Pregnancy Testing: You must have a negative pregnancy test before starting this medicine and repeat this test every month while taking it.
  • Complete Routine Blood Tests: Your doctor will arrange blood tests before starting treatment and periodically during therapy to monitor your haemoglobin levels. Liver function tests may also be performed when clinically indicated or if you develop symptoms suggestive of liver problems. Attend all scheduled appointments even if you feel well.
  • Stand Up Slowly: Avoid standing up too quickly from a sitting or lying position to reduce the risk of dizziness and falling.
    Consult Your Doctor Before New Medicines: Never start, stop, or change any other medications, herbal re
     

Drug-Drug Interactions

verifiedApollotooltip

Here are the medicines that may interact with PULMONEXT 10MG TABLET and require dose adjustments or closer monitoring:

  • Cyclosporine: May significantly increase the levels of PULMONEXT 10MG TABLET in your body, raising the risk of serious side effects. Your doctor may need to adjust your dose.
  • Other blood pressure medications: Combining these can cause your blood pressure to drop too low, leading to severe dizziness or fainting.
AmbrisentanMipomersen
Severe
AmbrisentanLeflunomide
Severe

Drug-Drug Interactions

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AmbrisentanMipomersen
Severe
How does the drug interact with Pulmonext 10mg Tablet:
Taking Pulmonext 10mg Tablet with Mipomersen can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Pulmonext 10mg Tablet with Mipomersen together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanLeflunomide
Severe
How does the drug interact with Pulmonext 10mg Tablet:
Taking leflunomide and Pulmonext 10mg Tablet can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Pulmonext 10mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanTeriflunomide
Severe
How does the drug interact with Pulmonext 10mg Tablet:
When Pulmonext 10mg Tablet and Teriflunomide are taken together, the risk or severity of developing liver injury increases.

How to manage the interaction:
Although taking Pulmonext 10mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmbrisentanLomitapide
Severe
How does the drug interact with Pulmonext 10mg Tablet:
Taking Pulmonext 10mg Tablet with Lomitapide can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is a possible interaction, Pulmonext 10mg Tablet can be taken with Lomitapide if prescribed by the doctor. Consult the prescriber if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanCiclosporin
Severe
How does the drug interact with Pulmonext 10mg Tablet:
When Pulmonext 10mg Tablet is taken with cyclosporine, this increases the blood levels of Pulmonext 10mg Tablet. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of ciclosporin with Pulmonext 10mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.
AmbrisentanTizanidine
Severe
How does the drug interact with Pulmonext 10mg Tablet:
Coadministration of Tizanidine with Pulmonext 10mg Tablet may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Pulmonext 10mg Tablet and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

Here are the important food and drink considerations while taking PULMONEXT 10MG TABLET:

  • Grapefruit and grapefruit juice: No clinically significant interaction has been established with PULMONEXT 10MG TABLET. This information is provided for completeness. If you are taking multiple medicines or have concerns about your diet, speak with your doctor or pharmacist.  

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

PULMONEXT 10MG TABLET is used to treat Pulmonary arterial hypertension.
PULMONEXT 10MG TABLET consists of Ambrisentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.
Yes, PULMONEXT 10MG TABLET can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.
Do not stop using PULMONEXT 10MG TABLET even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.
PULMONEXT 10MG TABLET should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure).
Store PULMONEXT 10MG TABLET away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.
PULMONEXT 10MG TABLET may rarely cause liver problems. Your doctor will monitor your liver function while you're taking PULMONEXT 10MG TABLET. If you experience symptoms like yellowing skin, dark urine, or abdominal pain, seek medical attention. Discuss any concerns with your doctor.
Take PULMONEXT 10MG TABLET exactly as your doctor tells you to. Typically, it's one tablet once a day. Swallow the tablet whole with water, and take it at the same time each day. Don't crush, chew, or break it.
Don't stop taking PULMONEXT 10MG TABLET without talking to your doctor first. Stopping suddenly can worsen your condition and increase the risk of heart problems. Your doctor will advise you on how to safely stop taking PULMONEXT 10MG TABLET if needed. Follow their instructions carefully.
PULMONEXT 10MG TABLET is used to treat high blood pressure in the lungs, but have risks and limitations. They can cause serious side effects and may not be suitable for everyone, including pregnant women and those with certain medical conditions. Always follow your doctor's instructions and ask questions if needed.
PULMONEXT 10MG TABLET can be effective in treating certain conditions, but in some cases, it can cause serious side effects. Watch out for severe swelling, difficulty breathing or swallowing, and sudden weight gain. Additionally, be aware of extreme tiredness, yellowing of the skin or eyes, dark urine, and severe itching. If you experience any of these symptoms, call your doctor right away or seek emergency medical help. Don't delay; these side effects can be serious and require prompt attention. Discussing the potential risks and benefits with your doctor before starting treatment is essential.
Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Common side effects of PULMONEXT 10MG TABLET may include headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
No, you should not take PULMONEXT 10MG TABLET on your own without consulting a doctor. This medication is prescribed for specific medical conditions and requires a doctor's supervision to ensure safe and effective use.
Safety and effectiveness of PULMONEXT 10MG TABLET have not been established in patients below 18 years of age.
No, you must not take PULMONEXT 10MG TABLET if you are pregnant or planning a pregnancy. This medicine causes severe, life-threatening birth defects. If you can become pregnant, you must use reliable birth control and take monthly pregnancy tests. Talk to your doctor about safe family planning alternatives.
Your doctor will arrange blood tests before starting treatment and periodically during therapy to monitor your haemoglobin levels. Liver function tests may also be recommended if clinically indicated or if you develop symptoms of liver problems. Follow your doctor's recommended testing schedule.
No, you should swallow the tablets whole. Crushing, chewing, or splitting the tablet can alter how the drug is absorbed, which may increase your risk of experiencing side effects. Talk to your doctor or pharmacist if you have difficulty swallowing pills.
It is highly advised to avoid or strictly limit alcohol while taking this medicine. Alcohol may increase dizziness or lightheadedness in some people while taking PULMONEXT 10MG TABLET. Limiting or avoiding alcohol is a sensible precaution. Talk to your doctor for personalised advice.
Yes, PULMONEXT 10MG TABLET can cause your body to hold onto extra fluid, leading to swelling in your ankles and legs, which may result in rapid weight gain. You should monitor your weight daily and report any sudden increases to your doctor. Talk to your doctor if you experience swelling.
Take the missed dose as soon as you remember on that day. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your normal routine. Never double the dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget your doses.
Some heart medications can interact with PULMONEXT 10MG TABLET, potentially causing your blood pressure to drop too low or affecting drug levels in your blood. Always provide your healthcare provider with a complete list of all the prescription and over-the-counter medicines you take. Talk to your doctor to ensure your treatment plan is safe.
If you become pregnant or think you may be pregnant while taking PULMONEXT 10MG TABLET, contact your doctor immediately. Because this medicine may cause serious harm to an unborn baby, your healthcare provider will advise you on the safest next steps and discuss alternative treatment options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - PUL0079
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