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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pylokit Kit is indicated for the eradication of Helicobacter pylori infection associated with peptic ulcer disease. It kills the bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions and damaging their DNA. It also blocks the action of an enzyme called gastric proton pump, which is responsible for acid production, thereby preventing acid-related ulcers.

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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Pylokit Kit

Pylokit Kit is a combination medicine indicated for the eradication of Helicobacter pylori-associated with peptic ulcer disease. Helicobacter pylori weaken the protective lining of the stomach and intestine; this allows the acid to get through the sensitive lining beneath. Both the bacteria and acid irritate the mucosal lining leading to ulcers. Symptoms include burning sensation in the stomach, frequent burping, bloating, and abdominal pain.
 
Pylokit Kit contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin kills the bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production, thereby preventing acid-related ulcers. Tinidazole damages the DNA of bacteria, thereby kills them. Together, Pylokit Kit helps treat peptic ulcer disease.
 
You are advised to take Pylokit Kit for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, stomach pain, constipation, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Pylokit Kit may cause drowsiness, so drive only if you are alert. Pylokit Kit is not recommended for children. Avoid consuming alcohol whilst taking Pylokit Kit and for 3 days after discontinuation. On long-term treatment, Pylokit Kit may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12. 

Uses of Pylokit Kit

Pylokit Kit is used for the treatment of Helicobacter pylori-associated peptic ulcer disease. The detailed uses of Pylokit Kit are as follows:

  • Treating Helicobacter Pylori infections: Pylokit Kit helps to eliminate Helicobacter pylori infections, which can cause stomach ulcers and chronic gastritis, promoting healing and reducing symptoms.
  • Reducing ulcer recurrence: Pylokit Kit helps prevent the recurrence of peptic ulcers by eradicating H. pylori, reducing the risk of future ulcers and related complications.
  • Antibiotic support: Pylokit Kit provides antibiotic support by combining medications that effectively target and eliminate H. pylori bacteria, helping to resolve infections and related gastrointestinal issues.
  • Acid-related ulcers: Pylokit Kit reduces stomach acid and eliminates H. pylori infection, helping to heal ulcers and relieve symptoms like heartburn and acid reflux.
  • Improving gastrointestinal health: Pylokit Kit promotes gastrointestinal health by eradicating H. pylori, healing the stomach lining, and reducing inflammation, which helps restore digestive well-being.

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Directions for Use

  • Pylokit Kit can be taken before a meal or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Pylokit Kit as a whole with a glass of water.
  • Do not break, chew, or crush it.

Key Benefits

Pylokit Kit is a combination of three drugs, namely: Clarithromycin, Lansoprazole, and Tinidazole. Pylokit Kit is indicated for the eradication of Helicobacter pylori-associated peptic ulcer disease. Clarithromycin is an antibiotic that kills bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid, thereby prevents acid-related ulcers. Tinidazole is an antibiotic that damages the DNA of bacteria and infectious microorganisms, thereby kills them. Together, Pylokit Kit helps treat peptic ulcer disease.

How Pylokit Kit Works

Pylokit Kit contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin kills the bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production, thereby preventing acid-related ulcers. Tinidazole damages the DNA of bacteria, thereby kills them. Together, Pylokit Kit helps treat peptic ulcer disease.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Pylokit Kit

Take Pylokit Kit only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Pylokit Kit if you are allergic to any of its contents; if you are taking any proton pump inhibitors, nitroimidazole derivatives, erythromycin or macrolide antibiotics, or rilpivirine; if you have a history of heart problems such as QT prolongation or ventricular cardiac arrhythmia, or if you have both kidney and liver problems. Inform your doctor if you have low magnesium levels, liver or kidney problems. On long-term treatment, Pylokit Kit may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Pylokit Kit may cause drowsiness, so drive only if you are alert. Pylokit Kit is not recommended for children. Avoid consuming alcohol whilst taking Pylokit Kit and for 3 days after discontinuation. 

Drug-Drug Interactions

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ClarithromycinDroperidol
Critical

Drug-Drug Interactions

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ClarithromycinDroperidol
Critical
How does the drug interact with Pylokit Kit:
Co-administration of Droperidol with Pylokit Kit can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Pylokit Kit with Droperidol can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pylokit Kit:
The combination of Alprazolam and Pylokit Kit may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Pylokit Kit, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, memory loss, anxiety, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pylokit Kit:
When Dronedarone is taken with Pylokit Kit, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Pylokit Kit with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Pylokit Kit:
When Quinidine is taken with Pylokit Kit, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Pylokit Kit and Quinidine can lead to an interaction, it can be taken if advised by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. However, if you experience any symptoms like headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Pylokit Kit:
When Naloxegol is taken with Pylokit Kit, the amount of Naloxegol in the blood can go up.

How to manage the interaction:
Co-administration of Pylokit Kit and Naloxegol can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pylokit Kit:
When Tolvaptan and Pylokit Kit are taken together, may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Pylokit Kit, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClarithromycinTerfenadine
Critical
How does the drug interact with Pylokit Kit:
When Terfenadine is taken with Pylokit Kit, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Pylokit Kit and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pylokit Kit:
When Ranolazine and Pylokit Kit are taken together, significantly increases the blood levels and effects of Ranolazine.

How to manage the interaction:
Co-administration of Pylokit Kit and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
ClarithromycinFlibanserin
Critical
How does the drug interact with Pylokit Kit:
When Flibanserin is taken with Pylokit Kit, it can slow down the way Flibanserin is broken down in the body.

How to manage the interaction:
Co-administration of Pylokit Kit and Flibanserin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like excessive drowsiness and decreases in blood pressure that can lead to dizziness, lightheadedness, or fainting, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinAstemizole
Critical
How does the drug interact with Pylokit Kit:
When Astemizole is taken with Pylokit Kit, it can cause a decrease in the metabolism of Astemizole.

How to manage the interaction:
Taking Pylokit Kit with Astemizole is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.

  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

  • Maintain a healthy weight by regular exercising.

  • Avoid lying down after eating to prevent acid reflux.

  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.

  • Practise relaxation techniques and avoid stress by doing yoga or meditation.

  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 

  • Avoid sitting continuously, as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

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Alcohol

Safe if prescribed

Avoid consumption of alcohol while taking Pylokit Kit and for 3 days after discontinuation as it might cause abdominal pain, vomiting, nausea, flushing, and headache.

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Pregnancy

Consult your doctor

Consult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Pylokit Kit contains tinidazole; therefore, breastfeeding should be avoided during treatment and for 72 hours following administration. Consult your doctor if you have any concerns.

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Driving

Safe if prescribed

Pylokit Kit may cause drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed. Consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed. Consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Pylokit Kit is not recommended for children.

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Heart

Pylokit Kit should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Pylokit Kit.

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Geriatrics

Consult your doctor

Pylokit Kit should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

FAQs

Pylokit Kit is indicated for the eradication of Helicobacter pylori associated with peptic ulcer disease.

Pylokit Kit contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin and tinidazole kill the bacteria by interfering with their functioning. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid, thereby prevents acid-related ulcers. Together, Pylokit Kit helps treat ulcers.

Diarrhoea might be a side-effect of Pylokit Kit. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have watery stools and stomach pain.

Pylokit Kit contains lansoprazole which might increase the risk of bone fracture in the hip, spine or wrist. This mainly occurs in people taking higher doses/multiple doses of Pylokit Kit for longer durations. Inform your doctor before taking Pylokit Kit if you have osteoporosis.

To treat your condition effectually, continue taking Pylokit Kit for as long as your doctor has advised. Do not be reluctant to speak with your doctor if you experience any difficulty whilst taking Pylokit Kit.

Avoid taking Pylokit Kit if you have a history of heart conditions such as ventricular cardiac arrhythmia or QT prolongation. Talk to your doctor if you have any concerns.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PYL0003

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