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Pymet 5mg/500mg Tablet is used to treat signs of migraine such as headache, vomiting, and nausea. It contains two medicines, namely Metoclopromide and Paracetamol, which help prevent nausea and vomiting and relieve pain. It may cause common side effects such as dizziness, sleepiness, diarrhoea, irregular periods, weakness, nervousness and breast enlargement in men.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Suzikem Drugs Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Pymet 5mg/500mg Tablet

Pymet 5mg/500mg Tablet is used to treat signs of migraine such as headache, being sick (vomiting), and feeling sick (nausea). Migraine is a neurological condition which is characterised by an intense pulsating, throbbing, pounding, debilitating headache which generally occurs on one side of the head; however, it can occur on both sides or shift.

Pymet 5mg/500mg Tablet is a combination of two drugs: Metoclopramide (anti-emetics) and Paracetamol (analgesics). Metoclopramide works on the part of the brain and prevents the symptoms of nausea and vomiting. It also works on the muscles in the upper part of the digestive system, which helps empty the stomach. Paracetamol works by blocking the effect of a chemical messenger known as prostaglandins, which cause pain. Together, Pymet 5mg/500mg Tablet helps relieve the symptoms of migraine.

Take Pymet 5mg/500mg Tablet as prescribed. You are advised to take Pymet 5mg/500mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, sleepiness, diarrhoea, irregular periods, weakness, nervousness and breast enlargement in men. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Pymet 5mg/500mg Tablet if you are pregnant or breastfeeding. Pymet 5mg/500mg Tablet should not be taken during the first 6 months of pregnancy. Pymet 5mg/500mg Tablet may cause drowsiness and sleepiness, so drive with caution. Pymet 5mg/500mg Tablet is not recommended for children below 18 years as safety and efficacy have not been established. Avoid consuming alcohol with Pymet 5mg/500mg Tablet as it could lead to increased drowsiness and sleepiness. Inform your doctor about your health condition and medicines you are taking to rule out unpleasant side effects.

Uses of Pymet 5mg/500mg Tablet

Here are the main conditions where Pymet 5mg/500mg Tablet is used to relieve migraine symptoms and improve stomach emptying:

  • Migraine headaches with nausea: Pymet 5mg/500mg Tablet targets the severe throbbing head pain while actively stopping the urge to vomit or feel sick during an attack.
  • Delayed stomach emptying during migraines: It helps speed up the rate at which your stomach empties, which allows the pain-relieving medicine to be absorbed much faster into your system.

Key Benefits

Pymet 5mg/500mg Tablet offers several important benefits that help provide faster and more complete relief from migraine attacks:

  • Dual-Action Symptom Relief: It treats both migraine pain and associated nausea in a single medicine, reducing the need for multiple medications.
  • Faster Pain Relief: By improving stomach emptying, it helps the pain-relieving medicine absorb more quickly, allowing faster relief from migraine symptoms.
  • Reduces Nausea and Vomiting: It settles the stomach and helps prevent vomiting, ensuring the medicine remains in your body long enough to work effectively.
  • Shortens Migraine Recovery: By relieving both headache and digestive symptoms at the same time, it helps you recover more quickly and return to your normal activities sooner.

 

Directions for Use

  • Pymet 5mg/500mg Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Pymet 5mg/500mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Pymet 5mg/500mg Tablet Works

Pymet 5mg/500mg Tablet contains two active medicines, metoclopramide and paracetamol, that work together to relieve migraine headaches and the associated symptoms of nausea and vomiting. Paracetamol is a pain reliever that works by blocking the production of chemical messengers in the brain that cause pain. This helps reduce the throbbing headache associated with migraines and provides effective pain relief. Metoclopramide is an antiemetic and stomach-emptying medicine. It works by blocking dopamine receptors in the brain's vomiting centre, helping to prevent nausea and vomiting. It also stimulates the muscles of the upper digestive tract, allowing the stomach to empty more quickly. Since migraines can slow down stomach emptying, this action helps paracetamol reach the small intestine faster, where it is absorbed more efficiently, leading to quicker pain relief. Together, these medicines help relieve migraine pain, reduce nausea and vomiting, and promote faster absorption of the pain reliever for more effective symptom control.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pymet 5mg/500mg Tablet as it may cause increased sleepiness.

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Pregnancy

Unsafe

Pymet 5mg/500mg Tablet should not be taken during the first 6 months of pregnancy. Please consult your doctor before taking Pymet 5mg/500mg Tablet if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Pymet 5mg/500mg Tablet may pass into breastmilk. Please consult your doctor before taking Pymet 5mg/500mg Tablet if you are breastfeeding.

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Driving

Caution

Pymet 5mg/500mg Tablet may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Use Pymet 5mg/500mg Tablet in children only if prescribed by a doctor.

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Heart

Caution

Pymet 5mg/500mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Pymet 5mg/500mg Tablet.

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Geriatrics

Caution

Pymet 5mg/500mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Pymet 5mg/500mg Tablet.

What if I have taken an overdose of Pymet 5mg/500mg Tablet

If you suspect an overdose, seek immediate emergency medical attention or call a poison control centre. An overdose of this medicine can cause severe, life-threatening liver damage and severe neurological issues, including muscle rigidity or spasms.

Diet & Lifestyle Advise

  • Rest in a dark room: At the first sign of a migraine, lie down in a quiet, dark, and cool room to help reduce the intensity of the headache.
  • Stay hydrated: Drink small, frequent sips of water throughout the day. Dehydration is a common trigger for both migraines and nausea.
  • Avoid trigger foods: Keep a food diary to identify and avoid personal dietary triggers, which often include aged cheeses, artificial sweeteners, caffeine, and processed foods.
  • Eat small, frequent meals: If you are prone to delayed stomach emptying, eating smaller portions of easily digestible food can prevent stomach discomfort and support proper digestion.
  • Manage stress levels: Practice relaxation techniques such as deep breathing, meditation, or gentle stretching, as stress is one of the most frequent triggers for migraine attacks.
     
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How Soon It Starts Working

The time required for Pymet 5mg/500mg Tablet to start to work: Pymet 5mg/500mg Tablet ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of Pymet 5mg/500mg Tablet last: The effect of Pymet 5mg/500mg Tablet lasts for 4 to 6 hours.

What if you forget to take Pymet 5mg/500mg Tablet

Since this medicine is usually taken only when you experience a migraine attack, missing a dose is not common. If you are taking it on a scheduled basis and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your normal routine. Do not take a double dose to make up for a missed one.

Storage

• Store Pymet 5mg/500mg Tablet tablets at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check Other Medicines for Paracetamol: Always check the labels of any other cold, flu, cough, or pain relief medications you are taking to ensure they do not contain the same pain-relieving ingredient, as combining them can cause severe liver damage.
  • Avoid Driving Until You Know Its Effects: Do not drive, operate heavy machinery, or perform hazardous activities after taking this medicine until you know how it affects you, as it can cause significant drowsiness.
  • Avoid Alcohol: Limit or completely avoid alcohol consumption while using this medicine, because alcohol increases the risk of liver damage and intensifies drowsiness.
  • Do Not Use for Longer Than Recommended: Avoid using this medicine for more than a few consecutive days without consulting your doctor, as long-term use can increase the risk of serious, involuntary muscle disorders.
  • Inform Healthcare Providers Before Procedures: If you are scheduled for any surgical or dental procedures, tell your healthcare provider that you are currently taking Pymet 5mg/500mg Tablet.
     

Drug-Drug Interactions

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Here are the medicines that may interact with Pymet 5mg/500mg Tablet and increase the risk of side effects or reduce treatment effectiveness:

  • Other pain relievers: Combining this medicine with other products containing the same painkiller can lead to an accidental overdose and severe liver damage.
  • Sedatives and sleep aids: Taking this medicine with tranquillizers, sleeping pills, or opioid pain medications can cause dangerous levels of drowsiness and slowed breathing.
  • Parkinson's medications: Some treatments for Parkinson's disease may become less effective when taken alongside Pymet 5mg/500mg Tablet.
  • Blood thinners: Long-term or regular use of the pain-relieving component in this medicine may increase the risk of bleeding when taken with medications like warfarin.
     

Drug-Drug Interactions

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How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Olanzapine can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Olanzapine with Metoclopramide, you can take these medicines together if prescribed by the doctor. However, if you experience any symptoms like lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Methyldopa and Metoclopramide together can decrease the levels and effects of Methyldopa.

How to manage the interaction:
Taking Metoclopramide with Methyldopa is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Quetiapine can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Quetiapine is generally avoided as it can possibly result in an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms like lip smacking, chewing, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremors, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Tetrabenazine and Metoclopramide can increase the risk of side effects.

How to manage the interaction:
Taking Tetrabenazine and Metoclopramide together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Taking Metoclopramide with Amisulpride may increase the risk or severity of side effects.

How to manage the interaction:
Taking Amisulpride with Metoclopramide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have any symptoms such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Pymet 5mg/500mg Tablet:
Taking Metoclopramide with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience lip-smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Bupropion can increase the levels of Metoclopramide and increase the risk or severity of developing seizures (fits).

How to manage the interaction:
Taking Metoclopramide with Bupropion is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Promethazine can increase the risk of side effects.

How to manage the interaction:
Taking Promethazine with Metoclopramide is generally avoided as it can possibly result in an interaction. They can be taken together However, consult a doctor if you experience such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Amoxapine can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Amoxapine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pymet 5mg/500mg Tablet:
Co-administration of Metoclopramide with Pimozide can increase the risk of side effects.

How to manage the interaction:
Taking Pimozide with Metoclopramide is not recommended, as it can possibly lead to an interaction, but it can be taken if prescribed by the doctor. However, if you experience lip-smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

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Here are the important food and drink considerations while taking Pymet 5mg/500mg Tablet:

  • Alcohol: Drinking alcohol while taking this medicine significantly increases the risk of liver damage and can worsen sleepiness or dizziness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIMIGRAINE AGENTS]

FAQs

Pymet 5mg/500mg Tablet is used to treat signs of migraine such as headache, being sick (vomiting), and feeling sick (nausea).
Pymet 5mg/500mg Tablet contains Metoclopramide and Paracetamol. Metoclopramide works on the part of the brain, thereby prevents the symptoms of nausea and vomiting. It also works on the muscles in the upper part of the digestive system, this helps in emptying the stomach. Paracetamol works by blocking the effect of a chemical messenger known as prostaglandins which cause pain. Thereby, helps in relieving pain.
Consult your doctor before taking oral contraceptive pills along with Pymet 5mg/500mg Tablet as they might decrease the effectiveness of Pymet 5mg/500mg Tablet. Talk to your doctor, he/she may advise you to use an alternate method of contraception.
Pymet 5mg/500mg Tablet contains Paracetamol, an analgesic used to provide relief from pain. Therefore, please consult your doctor before taking any pain killer medicines, fever-reducing medicines, medicines for cold or sleeping problems along with Pymet 5mg/500mg Tablet as they may also contain paracetamol.
If you had an operation on your stomach or intestine, do not take Pymet 5mg/500mg Tablet during the first 3-4days after the surgery. However, please talk to your doctor before taking Pymet 5mg/500mg Tablet if you have had surgery.
Diarrhoea could be a side-effect of Pymet 5mg/500mg Tablet. Drink plenty of liquids to replace the lost fluids if you experience diarrhoea. Consult your doctor if the condition persists or worsens.
Pymet 5mg/500mg Tablet may cause irregular periods or loss of periods. Please consult your doctor if you experience this for longer than a few days.
Pymet 5mg/500mg Tablet contains metoclopramide, which can cause side effects like drowsiness and dizziness. Therefore, avoid giving Pymet 5mg/500mg Tablet before a task that requires mental focus such as running, jogging or cycling, or any other sports activity.
Pymet 5mg/500mg Tablet can enter the brain and can cause serious side effects including unusual mood changes such as anxiety, depression or agitation and uncontrolled and repeated movements of the arms, legs, eyes, mouth, tongue, face and jaw. If you experience any of these side effects, stop taking Pymet 5mg/500mg Tablet and consult your doctor immediately.
Pymet 5mg/500mg Tablet is not recommended for use in patients who are allergic to Pymet 5mg/500mg Tablet, who have stomach or digestive tract bleeding, intestinal blockage, recent stomach or intestine surgery, phaeochromocytoma (a rare tumour of the adrenal gland) or epilepsy.
Children who are malnourished, who are suffering from liver/kidney disease, heart disease, electrolyte disturbances, antipsychotic medications, or atopic allergies, should consult your doctor before taking Pymet 5mg/500mg Tablet.
Overdose of Pymet 5mg/500mg Tablet may make your child feel dizzy, sleepy or drowsy, confused, sweaty, vomit, have pain in the stomach, have convulsions or fits, or experience uncontrolled muscle movements or notice yellowing of the skin. If you notice these symptoms, please consult your doctor immediately.
Store Pymet 5mg/500mg Tablet at temperature not exceeding 25°C, protect from sunlight. Keep out of reach of children.
You are recommended to consult your doctor before taking other medicines with Pymet 5mg/500mg Tablet to avoid possible interactions.
The common side effects of Pymet 5mg/500mg Tablet are dizziness, restlessness, fatigue, drowsiness, diarrhoea, and weakness. If any of these side effects persist or worsen, please consult your doctor.
No, this medicine is not designed to prevent migraines from occurring. It is meant to treat active symptoms once a migraine attack has already started. Talk to your doctor for options on daily preventative treatments.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol significantly increases the risk of severe liver damage and can make the drowsiness caused by the medicine much worse. Talk to your doctor about your alcohol intake.
You should only use this medicine during pregnancy if your doctor has specifically advised you to do so. Some components of this medicine may carry risks to the developing baby depending on the stage of pregnancy. Talk to your doctor to discuss safer alternatives.
If you vomit shortly after taking the tablet, do not immediately take another dose, as you cannot be sure how much of the medicine was already absorbed. Taking another tablet too soon could lead to an accidental overdose. Talk to your doctor or pharmacist for guidance on what to do.
Using this medicine long-term can lead to serious, sometimes permanent, involuntary muscle movements and may also cause medication-overuse headaches. It is strictly meant for short-term, occasional use during active migraine attacks. Talk to your doctor if your migraines are frequent.

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Country of origin

India
Other Info - PY60334
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