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compositionComposition:DOMPERIDONE-30MG+RABEPRAZOLE-20MG
prescription
Prescription Medicine
info
Rabzen-DSR Capsule 10's

Rabzen-DSR Capsule is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. It contains Rabeprazole and Domperidone, which helps reduce stomach acid and increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ). In adults, it may cause common side effects such as headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children, it may cause side effects such as upper respiratory tract infections, headache, fever, diarrhoea, vomiting, rash, and abdominal pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOMPERIDONE-30MG+RABEPRAZOLE-20MG

Manufacturer/Marketer :

Zenix Remedies

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rabzen-DSR Capsule

Rabzen-DSR Capsule is a prescription medication used to treat gastroesophageal reflux disease (GERD), acid reflux, and peptic ulcers. It helps relieve troublesome digestive symptoms such as severe heartburn, sour stomach, and upper abdominal discomfort.

To get the best results, you should take this medicine consistently every day at the same time. It is highly recommended to take Rabzen-DSR Capsule on an empty stomach, typically in the morning before breakfast, to ensure the medicine is properly absorbed. Adopting simple diet and lifestyle adjustments alongside your treatment can also greatly improve your recovery.

While taking Rabzen-DSR Capsule , some people may experience mild and temporary side effects, such as headache, dizziness, stomach discomfort, or mild digestive symptoms. If you notice any severe side effects like an irregular heart rate or signs of a serious allergic reaction, contact your doctor or seek medical care promptly.

Talk to your doctor before starting this medicine if you have liver disease, kidney problems, or heart conditions. Domperidone should generally be avoided in people with known heart rhythm problems, prolonged QT interval (a type of abnormal heart rhythm), low potassium or magnesium levels, or those taking medicines that can affect heart rhythm. Do not take this medicine if you have an allergy to any of its components, a pituitary gland tumour, gastrointestinal bleeding, blockage, or perforation.

This medicine can interact with certain other treatments, such as specific blood thinners, antifungals, or anti-HIV drugs, by altering how they work or are cleared from your body. You should also consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or managing health conditions as an elderly individual.

Uses of Rabzen-DSR Capsule

Your doctor may prescribe Rabzen-DSR Capsule to treat several conditions, including:

  • Gastroesophageal Reflux Disease (GERD): Rabzen-DSR Capsule helps prevent stomach acid from flowing upward into the food pipe, which provides relief from persistent heartburn and acid regurgitation.
  • Peptic Ulcer Disease: It aids in healing painful sores in the stomach and upper intestinal lining by lowering overall stomach acid production.
  • Dyspepsia (Indigestion): Rabzen-DSR Capsule improves muscle movement in the upper digestive tract to help relieve bloating, fullness, and early satiety.
  • Nausea and Vomiting: It helps improve the movement of food through your stomach and digestive tract, which may reduce feelings of nausea and discomfort. 

Key Benefits

Rabzen-DSR Capsule provides effective digestive support by reducing excess stomach acid and improving stomach movement. By controlling acid-related symptoms and protecting the digestive tract, this medicine offers several key health benefits:

  • Relief from Acid Reflux and Digestive Discomfort: Rabzen-DSR Capsule helps reduce excess stomach acid and supports better stomach movement, easing symptoms such as heartburn, acid reflux, and bloating.
  • Improved Nighttime Comfort and Sleep: By helping control acid reflux symptoms that occur at night, Rabzen-DSR Capsule supports more comfortable and uninterrupted sleep.
  • Protection of the Food Pipe and Stomach Lining: By lowering acid levels, Rabzen-DSR Capsule helps protect the oesophagus and stomach lining from irritation and damage, reducing the risk of acid-related complications.
Side effects of Rabzen-DSR Capsule
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Your doctor might suggest giving it some time to see if your sex drive improves after stopping the medication, adjusting the dose, or switching to another medication.
  • Engaging in regular aerobic exercise and strength training can enhance your stamina, improve your mood, and increase your sex drive.
  • Reduce stress by taking a vacation to relax or by practicing yoga.
  • Avoid consuming too much alcohol and smoking.
  • Maintain a healthy weight to support overall health.
  • Consult a sex therapist or counsellor skilled in addressing sexual concerns to help manage your low sex drive.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

To ensure you get the maximum benefit from Rabzen-DSR Capsule , follow these step-by-step instructions:

  • Swallow the capsule or tablet whole with a full glass of water. Do not chew, crush, or break it, as this can damage the special coating that protects the medicine.
  • Take this medication on an empty stomach, ideally 30 to 60 minutes before your first meal or breakfast in the morning.
  • Try to take your dose at the same time every day to keep a steady amount of the medicine in your body.

Always follow your doctor's exact instructions regarding the duration of your treatment, and do not stop taking the medicine early, even if you begin to feel better.
 

How Rabzen-DSR Capsule Works

Rabzen-DSR Capsule works through a combination of two active medicines that target different parts of your digestive system to restore comfort. The first active component is rabeprazole, which belongs to a class of medications called proton pump inhibitors (PPIs). Rabeprazole acts on acid-producing cells in your stomach lining by blocking the tiny 'acid pumps' that release acid. You can think of it like turning down a tap that controls acid production in your stomach, helping reduce acidity and relieve acid-related symptoms. The second active component is domperidone, a medicine that helps reduce nausea and improves the movement of food through your stomach. It works by blocking certain chemical signals in the gut and the vomiting centre that trigger nausea and vomiting. Unlike some other medicines that act on these signals, domperidone has limited entry into the brain, which lowers the risk of effects such as drowsiness or movement-related side effects.
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Alcohol

Unsafe

Drinking alcohol with Rabzen-DSR Capsule may cause dehydration and elevate the level of stomach acid, thereby decreasing its efficiency. So try to avoid, limit alcohol or contact a doctor before intake of Rabzen-DSR Capsule .

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Pregnancy

Consult your doctor

It is not known whether the Rabzen-DSR Capsule affects the baby or not. So, contact a doctor before intake of Rabzen-DSR Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Breast Feeding

Consult your doctor

Domperidone present in Rabzen-DSR Capsule passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Rabzen-DSR Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Driving

Caution

In some cases, Rabzen-DSR Capsule may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.

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Liver

Consult your doctor

If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Unsafe

Rabzen-DSR Capsule is not recommended for use in children due to a lack of data on safety and efficacy. Please consult your doctor.

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Heart

Consult your doctor

Rabzen-DSR Capsule should be taken with caution in patients with heart disease. Please consult your physician.

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Geriatrics

Safe if prescribed

Rabzen-DSR Capsule is safe for use in geriatric patients if prescribed by the physician.

What if I have taken an overdose of Rabzen-DSR Capsule

Do not take more than the prescribed dose of Rabzen-DSR Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid trigger foods and drinks that cause excess acid, such as citrus fruits, tomatoes, onions, garlic, chocolate, caffeine, and highly spicy or fatty dishes.
  • Eat smaller, more frequent meals rather than two or three large, heavy meals to avoid putting excess pressure on your stomach.
  • Stay upright for at least two to three hours after eating; do not lie down immediately after a meal.
  • Elevate the head of your bed by six to nine inches using bed risers or a wedge pillow to prevent stomach acid from travelling up your throat while you sleep.
  • Avoid wearing tight clothing around your waist, as this can compress your stomach and push acid upward.
     

Have a query?

How Soon It Starts Working

The time required for Rabzen-DSR Capsule to start to work: Rabzen-DSR Capsule ideally shows its action within 1 hour after administration. The time for which the effects of Rabzen-DSR Capsule last: The duration of action for Rabzen-DSR Capsule is unknown.

What if you forget to take Rabzen-DSR Capsule

If you miss a dose of Rabzen-DSR Capsule , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store Rabzen-DSR Capsule at room temperature, ideally between 15°C and 30°C, in a cool and dry place. •Keep the medicine in its original blister packaging to protect it from direct light and moisture.

Drug Warnings

  • Take Rabzen-DSR Capsule on an empty stomach in the morning to allow the acid-reducing component to work effectively before your first meal.
  • Do not stop taking this medication suddenly without consulting your doctor, as your acid reflux symptoms can return or worsen.
  • Your doctor may monitor magnesium levels and vitamin B12 levels during long-term use, especially if risk factors are present.
  • Avoid taking over-the-counter pain relievers like ibuprofen or aspirin without checking with your doctor, as these can irritate your stomach lining.
  • Domperidone may increase the risk of a type of abnormal heart rhythm (existing heart rhythm problems, low potassium or magnesium levels) and serious irregular heart rhythms. Inform your doctor if you have heart disease, abnormal ECG findings, low potassium/magnesium levels, or take medicines that affect heart rhythm.
  • Inform your doctor if you are taking clopidogrel or other medicines that rely on the liver's natural way of breaking down medicines, as rabeprazole may affect how these medicines work.
  • If symptoms continue despite treatment, worsen, or return frequently, consult your doctor. Further evaluation may be needed to rule out other causes or adjust treatment 
     

Drug-Drug Interactions

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Drug-Drug Interactions:
Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Medicines that interfere with the liver's natural way of breaking down medicines, such as ketoconazole, clarithromycin, erythromycin, and some antifungal or antiviral medicines, can increase domperidone levels and raise the risk of abnormal heart rhythms. These combinations may need to be avoided.
  • Rabeprazole may affect how some medicines are processed by the liver. It may reduce the activation and effectiveness of clopidogrel, a medicine used to prevent blood clots. Inform your doctor if you are taking clopidogrel, as an alternative acid-reducing medicine, or monitoring may be considered. Rabeprazole may also interact with warfarin in some patients, and your doctor may recommend monitoring when both medicines are used together.
  • May reduce the absorption and effectiveness of certain antifungals (such as ketoconazole) and anti-HIV medications (like atazanavir) that require stomach acid to work.
  • May alter the levels of heart medicines like digoxin in your blood, which may require monitoring by your doctor.

Drug-Food Interactions:

  • Taking this medication with high-fat meals can delay its absorption and reduce its ability to prevent acid reflux effectively.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Rabzen-DSR Capsule , as it may worsen your condition or cause complications.

  • May worsen symptoms or cause complications in patients with a history of severe liver damage or kidney disease.
  • May increase the risk of irregular heartbeats in patients with pre-existing heart rhythm issues or low blood potassium levels. 
Domperidone + RabeprazoleRilpivirine
Critical
Domperidone + RabeprazoleErlotinib
Critical

Drug-Drug Interactions

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Domperidone + RabeprazoleRilpivirine
Critical
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Rilpivirine with Rabzen-DSR Capsule can reduce the levels and effectiveness of Rilpivirine.

How to manage the interaction:
Taking Rilpivirine with Rabzen-DSR Capsule is generally avoided, it can be taken if prescribed by a doctor. Do not discontinue the medications without consulting a doctor.
Domperidone + RabeprazoleErlotinib
Critical
How does the drug interact with Rabzen-DSR Capsule:
Coadministration of Citalopram with Rabzen-DSR Capsule can reduce the levels and effectiveness of Erlotinib

How to manage the interaction:
Taking Citalopram with Rabzen-DSR Capsule is generally avoided as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
Domperidone + RabeprazoleAtazanavir
Severe
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Atazanavir with Rabzen-DSR Capsule can reduce the levels and effectiveness of Atazanavir.

How to manage the interaction:
Although Atazanavir with Rabzen-DSR Capsule can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
Domperidone + RabeprazoleDacomitinib
Severe
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Dacomitinib with Rabzen-DSR Capsule may reduce the levels and effectiveness of Dacomitinib.

How to manage the interaction:
Taking Dacomitinib with Rabzen-DSR Capsule can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Domperidone + RabeprazoleDasatinib
Severe
How does the drug interact with Rabzen-DSR Capsule:
Taking Dasatinib with Rabzen-DSR Capsule can reduce the levels and effectiveness of Dasatinib.

How to manage the interaction:
Although Dasatinib with Rabzen-DSR Capsule can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
Domperidone + RabeprazoleMethadone
Severe
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Domperidone with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domperidone and Methadone together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, or increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
Domperidone + RabeprazoleCisapride
Severe
How does the drug interact with Rabzen-DSR Capsule:
Coadministration of Cisapride with Rabzen-DSR Capsule can increase the levels of Rabzen-DSR Capsule. This can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Cisapride with Rabzen-DSR Capsule can result in an interaction, it can be taken if prescribed by a doctor. Contact a doctor if you experience shortness of breath, palpitations, or chest pain. Do not stop using any medications without talking to a doctor.
Domperidone + RabeprazoleNefazodone
Severe
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Domperidone with Nefazodone can increase the blood levels of Domperidone.

How to manage the interaction:
There may be a possibility of interaction between Domperidone and Nefazodone, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
Domperidone + RabeprazoleMethotrexate
Severe
How does the drug interact with Rabzen-DSR Capsule:
Co-administration of Methotrexate with Rabeprazole can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Rabeprazole and Methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Domperidone + RabeprazoleGefitinib
Severe
How does the drug interact with Rabzen-DSR Capsule:
Taking Gefitinib with Rabzen-DSR Capsule can reduce the levels and effectiveness of Gefitinib.

How to manage the interaction:
Although Gefitinib with Rabzen-DSR Capsule can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

Rabzen-DSR Capsule is used to treat Gastro-Esophagal Reflux Disease (GERD), acid reflux, heartburn, peptic ulcer, stomach ulcers, and dyspepsia (stomach discomfort due to indigestion). It works by blocking the actions of the gastric proton pump, increasing the motility of the upper gastrointestinal tract and blocking the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).
No. Rabzen-DSR Capsule prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.
Yes, Rabzen-DSR Capsule can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.
Diarrhoea might be a side-effect of Rabzen-DSR Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Rabzen-DSR Capsule is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole or any other inactive ingredients of Rabzen-DSR Capsule . Rabzen-DSR Capsule should be used with caution in patients with underlying liver or kidney disease.
Store Rabzen-DSR Capsule at room temperature in a cool and dry place protected from light. Keep it out of reach of children.
It is preferable to take Rabzen-DSR Capsule on an empty stomach, usually 30–60 minutes before the first meal of the day or as directed by your doctor. Taking it before meals helps it work more effectively.
Yes, Rabzen-DSR Capsule may increase the risk of developing irregular heartbeat (serious arrhythmias). Although, it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.
The time taken for Rabzen-DSR Capsule to work may vary depending on the specific formulation prescribed. Domperidone may help improve nausea and stomach discomfort relatively quickly, while rabeprazole usually requires regular daily use for a few days to achieve maximum acid control. If your symptoms do not improve or worsen despite treatment, consult your doctor.
Rabzen-DSR Capsule is generally not recommended during pregnancy or breastfeeding unless your doctor decides that the benefits outweigh the potential risks. The active ingredients can pass into breast milk and may affect your baby. Talk to your doctor to discuss safer alternatives.
Common side effects may include headache, dizziness, stomach discomfort, gas, or mild digestive symptoms. These effects are usually temporary. If symptoms become severe or persistent, talk to your doctor.
It is highly recommended to limit or avoid alcohol while taking this medicine. Alcohol stimulates acid production in the stomach, which can worsen your symptoms and make the medication less effective. Talk to your doctor about safe alcohol limits for your condition.
If you miss a dose, take it as soon as you remember on an empty stomach. If it is almost time for your next scheduled dose, skip the missed dose and continue with your normal routine. Never take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you have concerns.
Yes, taking acid-reducing medications like this one for a year or longer can slightly increase the risk of bone fractures, especially in older adults or those with osteoporosis. Your doctor may recommend calcium or vitamin D supplements to protect your bones. Talk to your doctor if you need to use this medicine long-term.
Some pain relievers, such as ibuprofen, naproxen, or aspirin, can irritate your stomach lining and worsen your reflux or ulcer symptoms. If you need pain relief, it is safer to consult your healthcare provider first. Talk to your doctor about which pain relievers are safe for you to use.

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Reference

  1. CiplaMed Clinical Compendium. Rabicip D Capsules Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026] Check here
  2. CiplaMed CiplaMed. 2020. [Accessed on 13 May 2021] Check here
  3. RABICIP D Capsules [Internet]. CiplaMed. 2021 [Accessed on 7 October 2021] Check here
  4. Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 7 October 2021] Check here
  5. Domperidone 10mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 7 October 2021] Check here
  6. Rabeprazole 20mg Gastro-resistant Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 7 October 2021] Check here
  7. Rabeprazole 20mg Gastro-resistant Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 7 October 2021]Check here

Country of origin

INDIA

Manufacturer/Marketer address

#23, Basement Floor, 8Th 'A' Cross, Kanakanagar, V Nagenahalli,, Sultanpalaya Main Road, Bengaluru, Karnataka 560032
Other Info - RAB0727

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