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compositionComposition:ONDANSETRON-4MG+RABEPRAZOLE-20MG
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Prescription Medicine
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Rafron Total Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. It contains Rabeprazole and Ondansetron which inhibit the production of acid in the stomach, protect the ulcers from acid, and block the action of serotonin (chemical messenger) that triggers nausea and vomiting. This medicine may sometimes cause side effects such as constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ONDANSETRON-4MG+RABEPRAZOLE-20MG

Manufacturer/Marketer :

Saffron Therapeutics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Rafron Total Tablet

Rafron Total Tablet is a prescription medication used to treat gastroesophageal reflux disease (GERD) and peptic ulcers when they are accompanied by nausea or vomiting. By combining an acid-reducer with a nausea-preventing agent, it helps manage both sour stomach and the urge to vomit. This combined action provides a highly coordinated approach to upper digestive tract issues.

For the best results, you should take Rafron Total Tablet consistently at the same time every day, typically before your first meal of the day. Taking it on an empty stomach helps the medication absorb properly and prevents symptoms before they start. Making simple dietary changes, such as eating smaller portions and avoiding spicy foods, can also help improve your recovery.

While taking Rafron Total Tablet , you might experience mild side effects like headaches or mild stomach discomfort. If you notice any serious issues, such as severe diarrhoea, muscle weakness, or a fast heartbeat, stop taking it and consult your doctor immediately.

Talk to your doctor before starting Rafron Total Tablet if you have a history of severe liver damage, kidney problems, or low magnesium levels. Do not take this if you are allergic to any of its components or similar acid-reducing medications.

This medication can interact with other drugs like blood thinners, certain antifungals, and heart medications, so let your doctor know everything you take. You should also avoid alcohol and smoking, as they can worsen acid reflux and nausea. If you are pregnant, breastfeeding, or elderly, talk to your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Rafron Total Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Gastroesophageal Reflux Disease (GERD) with nausea: Rafron Total Tablet helps reduce stomach acid irritation while simultaneously controlling the feeling of sickness or vomiting associated with severe acid reflux.
  • Peptic Ulcer Disease: It assists in healing sores in the stomach or intestinal lining by lowering acid levels, while keeping nausea under control during the healing process.
  • Acid-induced Indigestion: It relieves discomfort, bloating, and sour stomach symptoms combined with nausea.

Key Benefits

Rafron Total Tablet provides effective relief from acid-related symptoms and nausea through its dual-action formula. By reducing stomach acid production and controlling nausea and vomiting, it helps improve digestive comfort and supports your daily activities. Key benefits include:

  • Relieves Acid Reflux and Heartburn: This medication reduces the amount of acid produced in the stomach, helping relieve heartburn, acid reflux, and irritation of the food pipe while promoting healing.
  • Controls Nausea and Vomiting: This medication helps reduce nausea and vomiting by blocking serotonin (5-HT3) receptors involved in triggering the vomiting reflex. It works on both the digestive tract nerves and areas of the brain involved in nausea control, helping improve comfort during stomach-related illnesses.
  • Improves Digestive Comfort: By addressing both excess stomach acid and nausea together, this medication provides comprehensive symptom relief, making it easier to enjoy meals, sleep comfortably, and carry out everyday activities.
Side effects of Rafron Total Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Avoid rubbing or scratching the affected area, as this can cause further irritation and discomfort.
  • Consider using a humidifier to add moisture to the air and help reduce the sensation.
  • Seek medical attention if the sensation is severe, persistent, or worsens over time.
  • Avoid extreme temperatures, such as hot or cold showers, that can exacerbate the sensation.
  • Wear light, breathable clothing to help keep the body cool and reduce the sensation.
  • Avoid triggers that can cause the sensation, such as spicy foods or hot drinks.
  • Use cool compresses or fans to help lower body temperature and reduce the sensation.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Rafron Total Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Rafron Total Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Rafron Total Tablet Works

Rafron Total Tablet works through the combined action of two medicines that target acid-related symptoms and nausea. The first component is rabeprazole, a proton pump inhibitor (PPI). It works by blocking the final step of acid production in the stomach. It targets specialised cells in the stomach lining called proton pumps, reducing the amount of acid released into the stomach. This allows irritated tissues in conditions such as GERD and ulcers to heal. The second component is ondansetron, an anti-nausea medicine that works by blocking serotonin (5-HT3) receptors located in the digestive tract and in the brain's chemoreceptor trigger zone (CTZ). Blocking these receptors prevents serotonin from triggering the vomiting reflex through both peripheral and central pathways, helping prevent nausea and vomiting. Together, these components help reduce excess stomach acid while controlling associated nausea and vomiting.
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Alcohol

Unsafe

Alcohol consumption may increase acid production in the stomach. It is advised to avoid alcohol intake to prevent any undesirable side effects of Rafron Total Tablet and further worsening of your disease. Please consult your doctor for more information before using Rafron Total Tablet .

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Pregnancy

Caution

Rafron Total Tablet is not recommended for use in pregnancy since Ondansetron may cause harmful effects on the developing baby. It is advised to consult your doctor if you plan to conceive or already pregnant before starting Rafron Total Tablet .

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Breast Feeding

Caution

It is not known if Rafron Total Tablet passes into breast milk. Please consult your doctor before taking Rafron Total Tablet if you are a nursing mother.

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Driving

Safe if prescribed

Rafron Total Tablet is probably safe to use and doesn’t affect driving. However, please do not drive or operate machines if you experience any side effects that affect your ability to drive.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Rafron Total Tablet .

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Rafron Total Tablet .

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Children

Caution

Ondansetron in Rafron Total Tablet may not be suitable for children below four years of age. Please consult your doctor before giving Rafron Total Tablet to your child. Your doctor will decide the dose and duration based on your child’s age and medical condition.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Rafron Total Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Rafron Total Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Rafron Total Tablet

In case of an accidental overdose, seek immediate medical attention or contact a poison control centre. Symptoms of an overdose may include severe dizziness, rapid heart rate, confusion, or severe stomach pain.

Diet & Lifestyle Advise

  • Eat Smaller, More Frequent Meals: Have smaller meals throughout the day instead of three large ones to reduce pressure on your stomach and support comfortable digestion.
  • Avoid Trigger Foods and Drinks: Stay away from spicy, greasy, acidic foods (such as citrus fruits and tomatoes), as well as caffeinated and carbonated beverages, as they can increase stomach acid and worsen nausea or heartburn.
  • Stay Upright After Eating: Avoid lying down immediately after meals. Wait at least two to three hours before reclining or going to bed to help reduce acid reflux.
  • Elevate Your Head While Sleeping: Raise the head of your bed by 6 to 8 inches to help prevent stomach acid from flowing back into your oesophagus during sleep.
  • Wear Loose-Fitting Clothing: Choose loose clothing around your waist to avoid unnecessary pressure on your abdomen, which can worsen reflux symptoms.
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How Soon It Starts Working

The time required for Rafron Total Tablet to start to work: Rafron Total Tablet ideally shows its action within 30 to 60 minutes of administration. The time for which the effects of Rafron Total Tablet last: Rafron Total Tablet effect lasts for 24 hours.

What if you forget to take Rafron Total Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Rafron Total Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original packaging to protect it from direct light and moisture. Do not store it in the bathroom cabinet.

Drug Warnings

  • Check the capsule before use: Do not take the capsule if the packaging is damaged or if the medicine appears discoloured or unusual.
  • Attend regular health check-ups: If you take this medicine for a long time, your doctor may monitor your magnesium and vitamin B12 levels with periodic blood tests.
  • Be cautious when driving or operating machinery: This medicine may cause dizziness, so avoid hazardous activities until you know how it affects you.
  • Check before taking other acid-reducing medicines: Do not take antacids or other acid-reducing medicines with Rafron Total Tablet unless your doctor advises you to do so.
  • Inform your healthcare provider before procedures: Tell your doctor, surgeon, or dentist that you are taking this medicine before any planned medical or dental procedure.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all the medicines you are taking before taking this, as they may interact with Rafron Total Tablet and affect your treatment.

  • Blood Thinners (such as warfarin): Taking these medicines with Rafron Total Tablet may increase the risk of bleeding.
  • Medicines that require an acidic stomach environment for absorption (such as ketoconazole, itraconazole, atazanavir, and certain other medicines): Rabeprazole, like other proton pump inhibitors (PPIs), reduces stomach acid, which may decrease the absorption and effectiveness of these medicines. Your doctor may recommend an alternative treatment or adjust your therapy if necessary.
  • Heart Medicines (such as digoxin or medicines that prolong the QT interval, including certain antiarrhythmics, some antibiotics, antipsychotics, and antidepressants): Ondansetron may increase the risk of QT prolongation and serious abnormal heart rhythms when used with other QT-prolonging medicines. Digoxin levels may also require monitoring in some patients, and your doctor may recommend ECG or electrolyte monitoring when appropriate.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Caffeine and Carbonated Drinks: These may stimulate stomach acid production and worsen your symptoms, potentially reducing the overall benefit of treatment.
  • High-Fat Meals: High-fat meals may delay the absorption of some acid-reducing medicines and slow the onset of symptom relief.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

FAQs

Rafron Total Tablet is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). It is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.
Rafron Total Tablet works by reducing the amount of acid produced in the stomach and blocks the action of certain chemical messengers that trigger nausea and vomiting. Thus, Rafron Total Tablet relieves stomach ulcers, heartburn, GERD, nausea, vomiting and other gastrointestinal discomforts.
Rafron Total Tablet should be used with caution and only under doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures and autoimmune diseases like lupus.
Antacids do not interfere with the absorption of Rafron Total Tablet . However, it is advised to take antacid and Rafron Total Tablet at different times. Please seek medical advice on how to use other medicines like antacids while using Rafron Total Tablet .
Rabeprazole in Rafron Total Tablet may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of Rafron Total Tablet accordingly and may also suggest Vitamin B12 supplements.
Rafron Total Tablet weakens bones and can increase the risk of fractures in elderly patients if used for long term or if taken in high doses.
Long term usage of the Rafron Total Tablet causes disturbances in liver function, B12 deficiency and changes in electrolyte (magnesium, calcium and sodium) levels. Therefore, if you experience symptoms such as yellow skin and eyes, nausea, dizziness, loss of appetite, fits, headache, itching, tiredness, pale skin, or irritability, consult your doctor immediately. Your doctor may recommend frequent follow-ups and blood tests if Rafron Total Tablet is prescribed for long term use.
You are recommended not to stop taking Rafron Total Tablet on your own without first consulting your doctor as it may worsen your condition. If you experience any difficulty while using Rafron Total Tablet , please consult your doctor.
Rafron Total Tablet is used along with antibiotics for the treatment of H. Pylori infection. It reduces the stomach acid volume and decreases breakdown and washout of antibiotics resulting in increased antibiotic concentration and tissue penetration. Also, it helps in symptomatic relief by reducing associated heartburn, acidity, and reflux.
Yes, you can take Rafron Total Tablet with vitamin D. It is usually advised to take vitamin D as a supplement with Rafron Total Tablet as the long-term use of Rafron Total Tablet reduces calcium absorption and may result in calcium deficiency. This can further lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like wrist, spine and hip fractures. Please discuss with your doctor about ways to prevent this.
Long-term usage of Rafron Total Tablet can decrease magnesium levels in patients taking several daily doses for 3 months or longer. Check your magnesium levels at regular intervals. However, if you experience dizziness, seizures (fits), abnormal or fast heartbeat, jerking movements or shaking (tremors), jitteriness, muscle weakness, spasms of the hands and feet, cramps, or muscle pains, inform your doctor.
It is advised to take Rafron Total Tablet 1 hour before a meal. Avoid spicy and fatty foods while taking Rafron Total Tablet . Also, cut down on caffeinated drinks such as coffee, tea, and cola. Alcohol consumption should also be avoided as it may worsen your symptoms.
Eat healthy and exercise regularly. You can consult a dietician to obtain a diet plan that works best for you. Eat at least 3 hours before going to bed to reduce the chances of worsening of your symptoms at night. Avoid spicy and fatty foods and caffeinated drinks such as coffee, tea, and cola. Also, avoid smoking and alcohol consumption as they may worsen your symptoms.
The side effects of Rafron Total Tablet include headache, nausea, vomiting, constipation, diarrhoea, fatigue, sore throat and stomach pain. If any of these side effects persist or worsen, please consult your doctor.
Yes, it is highly recommended to take Rafron Total Tablet on an empty stomach, usually 30 to 60 minutes before your first meal of the day, to ensure optimal absorption and effectiveness. Talk to your doctor if you have questions about timing.
It is best to avoid alcohol while taking Rafron Total Tablet because alcohol can irritate your stomach lining, trigger acid production, and worsen your nausea. Talk to your doctor for personalised advice.
The safety of Rafron Total Tablet during pregnancy has not been fully established. It should only be used if clearly needed and prescribed by your healthcare provider. Talk to your doctor to discuss safer alternatives.
Taking acid-reducing medications like Rafron Total Tablet for a long period (typically over a year) may increase the risk of bone fractures, especially in older adults or those with existing risk factors. Talk to your doctor about protecting your bone health.
If you develop severe, watery diarrhoea or stomach cramps, stop taking the medication and seek medical help immediately, as this could be a sign of a serious bacterial infection. Talk to your doctor before taking any anti-diarrheal medicine.
No. Swallow the capsule whole with a glass of water. Do not open, crush, chew, or break it because this may damage its protective coating and affect how the medicine works. If you have difficulty swallowing capsules, speak with your doctor about suitable alternatives.
Rafron Total Tablet is usually prescribed for short-term relief. Using it long-term requires careful monitoring by your doctor to watch for potential nutrient deficiencies or bone issues. Talk to your doctor about your treatment duration.

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Country of origin

India

Manufacturer/Marketer address

4603/2, Shanti Estate, Ghanshyam Estate,Aslali, Ta Daskroi ,Ahmedabad -382425.
Other Info - RAF0043

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