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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rapilif-M 25 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

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Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rapilif-M 25 Combipack

Rapilif-M 25 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It is complicated by an overactive bladder and symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.

Rapilif-M 25 Combipack contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Take Rapilif-M 25 Combipack as prescribed. Your doctor will advise you on how often you should take it based on your medical condition. Rapilif-M 25 Combipack may cause common side effects such as abnormal ejaculation, increased heart rate, dizziness, nausea, constipation, urinary tract infections, and runny or blocked nose. Most of these side effects of Rapilif-M 25 Combipack do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Mirabegron, Silodosin, or any other medicines, please tell your doctor. Rapilif-M 25 Combipack is not recommended for children and adolescents under 18 years of age. Drive only if you are alert after taking Rapilif-M 25 Combipack, as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Rapilif-M 25 Combipack, as it may cause complications during the surgery.

Uses of Rapilif-M 25 Combipack

Treatment of Benign prostatic hyperplasia (BPH)

Directions for Use

Take Rapilif-M 25 Combipack as advised by the doctor. Swallow it whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Rapilif-M 25 Combipack contains Mirabegron and Silodosin. Mirabegron is a bladder muscle relaxant which works by reducing the activity of an overactive bladder and treats related symptoms such as frequent urination, urgency incontinence (an uncontrollable urge to urinate) and sudden need to empty the bladder. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms such as incomplete bladder emptying, frequent urination at night and difficulty urinating. Thus, together, they help treat benign prostatic hyperplasia (BPH) symptoms.

How Rapilif-M 25 Combipack Works

Rapilif-M 25 Combipack contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Rapilif-M 25 Combipack

Do not take more than the prescribed dose. Using more medication will not improve symptoms; instead, they may cause serious adverse effects such as Increased pulse rate, systolic blood pressure, and hypotension. If you suspect that you or anyone else who may have overdosed of Rapilif-M 25 Combipack, please go to the emergency department of the closest hospital.

Drug Warnings

If you are allergic to Mirabegron, Silodosin or any other medicines, please tell your doctor. Rapilif-M 25 Combipack is not recommended for children and adolescents below 18 years of age. Drive only if you are alert after taking Rapilif-M 25 Combipack as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Rapilif-M 25 Combipack as it may cause complications during the surgery. Inform your doctor if you take other medicines for overactive bladder treatment. If you get headaches, especially sudden, migraine-like (throbbing) headaches, tell your doctor, as these may be signs of severe high blood pressure.

Drug-Drug Interactions

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MirabegronEliglustat
Critical

Drug-Drug Interactions

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MirabegronEliglustat
Critical
How does the drug interact with Rapilif-M 25 Combipack:
Coadministration of Eliglustat and Rapilif-M 25 Combipack can significantly increase the blood levels of eliglustat. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Rapilif-M 25 Combipack with Eliglustat is not recommended, it should be taken only when advised by a doctor. You should seek immediate medical help if you develop symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, irregular heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Rapilif-M 25 Combipack:
The blood levels and effects of Rapilif-M 25 Combipack may be greatly increased when combined with itraconazole.

How to manage the interaction:
Rapilif-M 25 Combipack and Itraconazole may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
SolifenacinMesoridazine
Critical
How does the drug interact with Rapilif-M 25 Combipack:
Using Mesoridazine together with Rapilif-M 25 Combipack can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Rapilif-M 25 Combipack is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor.
How does the drug interact with Rapilif-M 25 Combipack:
Taking Rapilif-M 25 Combipack and Potassium chloride together can increase the risk of stomach ulcers, bleeding, and stomach injury.

How to manage the interaction:
Taking Rapilif-M 25 Combipack with Potassium chloride is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Rapilif-M 25 Combipack:
Combined use of Rapilif-M 25 Combipack and Pimozide may increase the level of pimozide in the blood. This can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Rapilif-M 25 Combipack and Pimozide may lead to an interaction but they can be taken together if your doctor has prescribed them. However, if you experience drowsiness, blurred vision, dry mouth, constipation, low blood pressure, tremors, trembling of hands, arms, legs, jaw and face, balance and Speech difficulty, or abnormal muscle movements consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rapilif-M 25 Combipack:
Combining Aripiprazole with Rapilif-M 25 Combipack can increase the levels of Aripiprazole in the body. This can lead to increased risk or severity of side effects.

How to manage the interaction:
Although taking Rapilif-M 25 Combipack and Aripiprazole together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs like feeling sleepy, having seizures, unusual muscle movements, low blood pressure, feeling confused, muscle spasms, twitching in your jaw, shaking or jerking in your arms and legs, feeling nervous or restless, dizziness, lightheaded, or fainting contact the doctor right away. Do not stop using any medications without a doctor's advice.
MirabegronBrexpiprazole
Severe
How does the drug interact with Rapilif-M 25 Combipack:
A combined use of Rapilif-M 25 Combipack and Brexpiprazole may increase the level of Brexpiprazole in blood. This can increase the risk or severity of side effects.

How to manage the interaction:
There could be a possible interaction between Rapilif-M 25 Combipack and Brexpipraole, it can be taken together if your doctor has advised them. However, if you experience drowsiness, fatigue, seizure, chest pain or tightness, irregular heart rates, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramp, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rapilif-M 25 Combipack:
Coadministration of Rapilif-M 25 Combipack and Tamoxifen may reduce the effects of tamoxifen.

How to manage the interaction:
Taking Rapilif-M 25 Combipack and Tamoxifen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience painful urination, constipation, dry mouth, headache, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rapilif-M 25 Combipack:
Combine use of Rapilif-M 25 Combipack and thioridazine may raise the blood levels of thioridazine. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Rapilif-M 25 Combipack and thioridazine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience stomach pain, diarrhea, dehydration, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MirabegronVenetoclax
Severe
How does the drug interact with Rapilif-M 25 Combipack:
Coadministration of Rapilif-M 25 Combipack and Venetoclax may significantly increase the blood levels and effects of Venetoclax. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possible interaction between Rapilif-M 25 Combipack and Venetoclax, but they can be taken together if your doctor has prescribed them. However, if you experience nausea, vomiting, diarrhea, fatigue, fever, chills, bleeding problems, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid caffeine and alcohol, especially in the hours after dinner.
  • Urinate as soon as you feel the urge.
  • Go to the washroom even when you don’t feel the urge.
  • Reduce your stress levels, as nervousness may increase urination frequency.
  • Keep yourself warm since being cold may worsen symptoms.
     

Habit Forming

No

Therapeutic Class

BPH AGENTS
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Alcohol

Consult your doctor

The interaction of Rapilif-M 25 Combipack with alcohol is unknown. If you have any concerns, discuss them with your doctor.

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Pregnancy

Not applicable

Rapilif-M 25 Combipack is recommended for use in men.

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Breast Feeding

Not applicable

Rapilif-M 25 Combipack is recommended for use in men.

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Driving

Caution

Rapilif-M 25 Combipack may cause dizziness in some people. Therefore, avoid driving if you feel dizzy after taking Rapilif-M 25 Combipack.

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Liver

Consult your doctor

If you are suffering from liver diseases or conditions, inform your doctor before taking Rapilif-M 25 Combipack. Your doctor may adjust the dose as necessary.

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Kidney

Consult your doctor

If you are suffering from kidney diseases or conditions, inform your doctor before taking Rapilif-M 25 Combipack. Your doctor may adjust the dose as necessary.

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Children

Unsafe

Rapilif-M 25 Combipack is not recommended for children and adolescents below 18 years as there is no relevant use for this age group.

Have a query?

FAQs

Rapilif-M 25 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH) complicated by overactive bladder with symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.

Rapilif-M 25 Combipack contains Mirabegron and Silodosin. Mirabegron reduces the activity of an overactive bladder and treats related symptoms. Silodosin relaxes the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Low blood pressure, especially when starting to take Rapilif-M 25 Combipack, may cause dizziness when standing up suddenly from a sitting or lying position. Therefore, to avoid such effects, it is advised to stand up slowly from a sitting or lying position. Regular blood pressure monitoring is recommended at the beginning of therapy to reduce the possibility of such effects.

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - RAP0177

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