Mirabegron+silodosin
About Mirabegron+silodosin
Mirabegron+silodosin is an oral medicine prescribed to treat lower urinary tract symptoms caused by an enlarged prostate, also known as benign prostatic hyperplasia, combined with an overactive bladder. Mirabegron+silodosin helps ease the discomfort of having a weak urine flow, straining to urinate, and feeling a sudden, uncontrollable urge to go. It is designed to target both the physical blockage and bladder muscle instability to make urination easier.
To get the best results, you must take Mirabegron+silodosin consistently every day at the same time. You should always take Mirabegron+silodosin with food, preferably with the same meal each day, to help your body absorb it properly. Incorporating lifestyle adjustments, such as limiting caffeine and performing pelvic floor exercises, can further improve your urinary symptoms.
While taking Mirabegron+silodosin, some people may experience mild side effects like dizziness, dry mouth, or a harmless condition where semen flows backward into the bladder during ejaculation. However, you should consult your doctor immediately if you experience severe dizziness, fainting, a fast or irregular heartbeat, or a painful erection that lasts for several hours.
Before starting Mirabegron+silodosin, talk to your doctor if you have a history of heart rhythm problems, high blood pressure, or kidney or liver disease. Do not take this if you have severe kidney failure, severe liver damage, or if you are preparing to undergo cataract surgery.
Mirabegron+silodosin can interact with blood pressure medications, certain antifungal drugs, and heart medications, which can increase your risk of severe side effects. Avoid drinking alcohol while taking Mirabegron+silodosin, as it can significantly worsen dizziness and lightheadedness. Elderly individuals should use Mirabegron+silodosin with caution due to an increased risk of falls, and should always consult a doctor before starting treatment.
Uses of Mirabegron+silodosin
Medicinal Benefits
Mirabegron+silodosin helps improve urinary symptoms associated with an enlarged prostate and overactive bladder by relaxing the muscles of the prostate, bladder neck, and bladder. It supports better bladder control and makes urination more comfortable.
Benefits may include:
- Helps improve urine flow and reduces difficulty in passing urine.
- Relieves symptoms such as straining, weak urine stream, and incomplete bladder emptying.
- Helps reduce urinary urgency, frequent urination, and episodes of urge incontinence.
- Decreases nighttime urination, helping promote better sleep.
- Improves bladder control and overall urinary function.
- Enhances comfort and quality of life by effectively managing urinary symptoms when used as prescribed.
Directions for Use
- Mirabegron+silodosin can be taken with or without food, as advised by the doctor.
- Follow your doctor’s instructions on the dosage and timing of this medication.
- Swallow the whole Mirabegron+silodosin with a glass of water.
- Do not chew, crush, or break it.
Storage
Side Effects of Mirabegron+silodosin
Common Side Effects (Usually mild):
- Dizziness or lightheadedness, especially when standing up
- Retrograde ejaculation (a harmless condition where semen enters the bladder instead of leaving the body during orgasm)
- Dry mouth
- Headache or mild nasal congestion
- Mild diarrhea or stomach upset
Serious Side Effects (Call a doctor right away):
- Severe dizziness, spinning sensation, or fainting
- A fast, pounding, or irregular heartbeat (palpitations)
- An erection that is painful or lasts longer than four hours
- Signs of a severe allergic reaction, including swelling of the face, lips, tongue, or throat, severe skin rash, or difficulty breathing
Medicines Containing this Salt
View AllDrug Warnings
- Stand up slowly: Rise gradually from a sitting or lying position, especially when starting Mirabegron+silodosin or after the first few doses, to help reduce the risk of dizziness, lightheadedness, or fainting. If possible, take your first dose when you can rest at home, and sit or lie down if you feel dizzy until the feeling passes.
- Inform healthcare providers before eye surgery: Tell your eye surgeon that you are taking Mirabegron+silodosin before cataract surgery, as silodosin may cause Intraoperative Floppy Iris Syndrome (IFIS) during the procedure.
- Monitor your blood pressure: Check your blood pressure regularly, particularly when starting treatment, as mirabegron may increase blood pressure in some people.
- Use caution during activities requiring alertness: Avoid driving, operating machinery, or performing hazardous tasks until you know how Mirabegron+silodosin affects you, as it may cause dizziness or drowsiness.
- Inspect Mirabegron+silodosin before use: Check the packaging before each use. Do not take the tablets or capsules if the seals are broken or if Mirabegron+silodosin shows signs of moisture damage, discoloration, or other visible changes.
Drug Interactions
- Alpha-blockers or blood pressure medicines (e.g., tamsulosin, amlodipine): Taking these medicines alongside Mirabegron+silodosin may cause an excessive drop in blood pressure, increasing the risk of dizziness or fainting.
- Antifungal medicines (e.g., ketoconazole, itraconazole): These medicines may increase silodosin levels in the body and raise the risk of side effects.
- HIV medicines (e.g., ritonavir): These medicines may increase silodosin levels in the body and increase the risk of side effects.
- Antiarrhythmic medicines (e.g., amiodarone, quinidine): These medicines may interact with the mirabegron component and increase the risk of heart rhythm problems. Your doctor may monitor you more closely.
- P-glycoprotein (P-gp) inhibitors (e.g., cyclosporine): These medicines may increase silodosin levels in the body and raise the risk of side effects. Your doctor may recommend avoiding this combination or adjusting your treatment.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorThe interaction of Mirabegron+silodosin with alcohol is unknown. If you have any concerns, discuss them with your doctor.
Pregnancy
not applicableMirabegron+silodosin is recommended for use in men.
Breast Feeding
not applicableMirabegron+silodosin is recommended for use in men.
Driving
cautionMirabegron+silodosin may cause dizziness in some people. Therefore, avoid driving if you feel dizzy after taking Mirabegron+silodosin.
Liver
consult your doctorIf you are suffering from liver diseases or conditions, inform your doctor before taking Mirabegron+silodosin. Your doctor may adjust the dose as necessary.
Kidney
consult your doctorIf you are suffering from kidney diseases or conditions, inform your doctor before taking Mirabegron+silodosin. Your doctor may adjust the dose as necessary.
Children
unsafeMirabegron+silodosin is not recommended for children and adolescents below 18 years as there is no relevant use for this age group.
Habit Forming
Diet & Lifestyle Advise
- Limit bladder irritants: Reduce your intake of caffeine, alcohol, and artificial sweeteners, as they can irritate the bladder and worsen urinary urgency.
- Manage evening fluid intake: Avoid drinking large amounts of fluids in the evening or close to bedtime to help reduce nighttime urination.
- Practice pelvic floor exercises: Perform pelvic floor muscle exercises (Kegel exercises) regularly to help strengthen the muscles that control urination.
- Increase your fiber intake: Eat a high-fiber diet to help prevent constipation, as a full bowel can put pressure on the bladder and worsen BPH symptoms.
Patients Concern
Disease/Condition Glossary
Benign prostatic hyperplasia (BPH): It is a condition in men in which age-related prostate gland enlargement occurs, which may cause urination difficulty. It occurs when the prostate gland's cells start to multiply. Your prostate gland swells due to these extra cells, which squeeze the urethra and decrease urine flow. The exact cause is unknown, but age-related changes in male sex hormones may be a factor. Any testicular abnormalities or a family history of prostate issues could increase the risk of developing BPH. The symptoms include excessive urination at night, dribbling (to move downwards in a thin flow) after urination, a sense of incomplete bladder emptying, an urge to urinate and leaking, frequent urination and a weak urinary stream.
FAQs
Mirabegron+silodosin is used for the treatment of Benign prostatic hyperplasia (BPH) complicated by overactive bladder with symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.
Mirabegron+silodosin contains Mirabegron and Silodosin. Mirabegron reduces the activity of an overactive bladder and treats related symptoms. Silodosin relaxes the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.
Low blood pressure, especially when starting to take Mirabegron+silodosin, may cause dizziness when standing up suddenly from a sitting or lying position. Therefore, to avoid such effects, it is advised to stand up slowly from a sitting or lying position. Regular blood pressure monitoring is recommended at the beginning of therapy to reduce the possibility of such effects.
The best time to take Mirabegron+silodosin may vary based on the health condition of an individual. However, take Mirabegron+silodosin at the same time each day for best results as advised by the doctor.
Consult the doctor before taking Mirabegron+silodosin if you have any history of kidney disease as dose adjustment may be necessary.
The side effects of Mirabegron+silodosin include constipation, nausea, dizziness, increased heart rate, abnormal ejaculation, urinary tract infections, and runny or blocked nose. Most of these side effects resolve gradually over time on their own. However, consult the doctor if any of these side effects persist or worsen.
Mirabegron+silodosin is primarily intended to treat symptoms of Benign Prostatic Hyperplasia (BPH). While it may have a secondary effect on blood pressure, it is not intended to manage blood pressure. Please check with your doctor for information or to discuss your blood pressure treatment plan.
You should take sildenafil along with Mirabegron+silodosin with caution, as both medications can cause low blood pressure (hypotension), leading to fainting, dizziness, or light-headedness. It’s important to consult your doctor before using them together to avoid potential interactions.
It is best to avoid or strictly limit alcohol while taking Mirabegron+silodosin. Alcohol can worsen side effects like dizziness, lightheadedness, and low blood pressure. Talk to your doctor for advice tailored to your health.
Yes, silodosin in Mirabegron+silodosin can cause retrograde ejaculation, a harmless condition in which semen flows backward into the bladder instead of leaving the body during orgasm. This may result in little or no semen being released during ejaculation. The effect is temporary and usually resolves after Mirabegron+silodosin is stopped. Talk to your doctor if you have any concerns or if it affects your quality of life.
Many people notice an improvement in urine flow within about 1 to 2 weeks of starting Mirabegron+silodosin. However, the full benefits for overactive bladder symptoms, such as urgency and frequent urination, may take several weeks and sometimes up to 4 to 8 weeks of regular treatment. Continue taking Mirabegron+silodosin as prescribed and talk to your doctor if your symptoms do not improve or become worse.
No, Mirabegron+silodosin is specifically formulated and approved for men experiencing symptoms associated with an enlarged prostate. It is not recommended for use in women. Talk to your doctor for appropriate bladder treatments for women.
Inform your eye surgeon (ophthalmologist) well in advance of your cataract surgery that you are taking Mirabegron+silodosin. The silodosin component can cause your pupil to become floppy during surgery, and your surgeon will need to take special precautions. Talk to your doctor about whether to pause Mirabegron+silodosin.
You should not stop taking Mirabegron+silodosin without consulting your doctor first. Stopping Mirabegron+silodosin abruptly can cause your urinary flow issues and bladder urgency to return. Talk to your doctor before making any changes.
The mirabegron component in Mirabegron+silodosin can cause an increase in blood pressure in some patients. It is important to have your blood pressure checked regularly while taking Mirabegron+silodosin. Talk to your doctor if you have a history of high blood pressure.
No, you must swallow Mirabegron+silodosin whole. Crushing, chewing, or breaking Mirabegron+silodosin can affect how it is absorbed in your body and increase the risk of severe side effects. Talk to your doctor or pharmacist if you have trouble swallowing pills.
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