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compositionComposition:RASBURICASE-1.5MG
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Prescription Medicine
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Rasbelon Injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications. It works by breaking down uric acid so that the body can eliminate it. Rasbelon Injection may cause nausea, vomiting, constipation, diarrhoea, abdominal pain, mouth sores, throat pain, headache, anxiety, joint pain and fever.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RASBURICASE-1.5MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rasbelon Injection

Rasbelon Injection is an injectable prescription medicine used to lower high levels of uric acid in the blood of patients undergoing cancer chemotherapy. It is specifically prescribed for those receiving treatment for leukaemia, lymphoma, or solid tumours, where rapid cell destruction can release dangerous amounts of uric acid. By lowering these levels, this medicine prevents kidney damage and severe complications.

This treatment is given as an intravenous infusion once daily for up to 5 days, depending on your chemotherapy schedule. You can receive this medicine with or without having eaten beforehand, as food intake does not alter how the injection works. To support the treatment, it is highly beneficial to drink plenty of fluids to help your kidneys flush out dissolved wastes effectively.

Common side effects of this medicine include fever, headache, nausea, and vomiting. While these symptoms are usually mild, you must seek medical attention immediately if you experience breathing difficulties, a rapid heartbeat, or blue-tinted skin, which can indicate serious allergic or blood-related reactions.

Do not take this if you have a genetic condition known as glucose-6-phosphate dehydrogenase (G6PD) deficiency, as the drug can trigger a dangerous breakdown of your red blood cells. Before starting treatment, tell your doctor if you have a history of severe allergies, asthma, or any other blood disorders.

This medicine can interfere with blood tests for uric acid, so you must inform the lab staff that you are using it. Pregnant or breastfeeding women, as well as elderly individuals, should consult their healthcare provider before treatment, as close monitoring is required to ensure safety.
 

Uses of Rasbelon Injection

Rasbelon Injection is used to lower high uric acid levels in patients undergoing cancer treatment. The detailed uses of Rasbelon Injection are as follows:

  • High uric acid levels during cancer treatment: Rasbelon Injection helps lower and control uric acid levels in the blood for patients undergoing chemotherapy for blood cancers like leukaemia or lymphoma, protecting the kidneys from damage.
     

Key Benefits

Rasbelon Injection provides important support during cancer treatment by rapidly reducing high uric acid levels and helping protect kidney function. The key benefits of Rasbelon Injection include:

  • Rapid Reduction of Uric Acid: This medicine rapidly reduces toxic uric acid levels in the bloodstream, preventing the severe joint pain and kidney strain associated with rapid cancer cell breakdown during chemotherapy.
  • Protection of Kidney Function: By protecting kidney function during intensive chemotherapy cycles, it ensures patients can complete their cancer treatments without dangerous interruptions or the need for emergency kidney dialysis.
     
Side effects of Rasbelon Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Rasbelon Injection will be administered by an oncology doctor.
  • Do not self-administer it

How Rasbelon Injection Works

Rasbelon Injection contains rasburicase, an enzyme that works by breaking down uric acid in the blood into a much more soluble substance called allantoin. Uric acid is a waste product that can build up quickly when cancer cells are destroyed by chemotherapy. If these levels get too high, the uric acid can form crystals in the kidneys, leading to severe damage or kidney failure. Unlike uric acid, allantoin can easily dissolve in water and is safely filtered out of the body through your urine. This direct chemical breakdown provides swift relief to the kidneys.
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Alcohol

Consult your doctor

It is unknown whether Rasbelon Injection interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Rasbelon Injection. You should not become pregnant while on treatment with Rasbelon Injection.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Rasbelon Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Rasbelon Injection is administered as a single dose in a hospital setting. however Rasbelon Injection may cause dizziness; therefore, avoid driving vehicles or operating machinery until you return to normal.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Rasbelon Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Rasbelon Injection as it may lead to kidney failure. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Please consult your doctor. Rasbelon Injection can be used in children if prescribed.

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Heart

Caution

Rasbelon Injection should be used with caution in individuals with heart problems due to potential risks like hypersensitivity reactions, hemolysis, and methemoglobinemia. It’s essential to consult a healthcare provider for cardiac evaluation and close monitoring before administration.

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Geriatrics

Caution

Rasbelon Injection may be used in geriatric patients, as studies have not shown age-specific limitations to its effectiveness. However, older adults should receive it under strict medical supervision due to risks like hypersensitivity, hemolysis, and methemoglobinemia.

What if I have taken an overdose of Rasbelon Injection

Since this medicine is carefully prepared and given by trained medical staff, an overdose is extremely rare. However, if you suspect an issue or experience severe unusual symptoms during or after your infusion, seek immediate medical attention or inform your care team right away.

Diet & Lifestyle Advise

  • Stay Hydrated: Drink plenty of fluids, especially water, as directed by your doctor. Staying exceptionally well-hydrated helps your kidneys flush out the broken-down waste products from your bloodstream.
  • Avoid High-Purine Foods: Avoid consuming foods high in purines, such as red meat, seafood, and organ meats, as these can naturally increase uric acid levels in the body.
  • Limit Alcohol: Limit or avoid alcohol consumption, as alcohol can interfere with how your body processes and eliminates uric acid.
  • Get Adequate Rest: Rest adequately during your treatment cycle to help your body recover from the combined effects of chemotherapy and cellular breakdown.
     
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How Soon It Starts Working

The time required for Rasbelon Injection to start to work: Rasbelon Injection ideally shows its action within 4 hours after administration. The time for which the effects of Rasbelon Injection last: The effect of Rasbelon Injection lasts for 24 hours.

What if you forget to take Rasbelon Injection

Because this medicine is given by healthcare professionals in a clinical setting, it is highly unlikely that you will miss a dose. If you miss an appointment for your infusion, contact your doctor or hospital clinic immediately to reschedule.

Storage

• Rasbelon Injection is stored in a professional healthcare environment. It must be kept in a refrigerator between 2°C and 8°C (36°F to 46°F) and should never be frozen.
icon image

Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the solution: Before injection, the healthcare provider will inspect the vial. Do not use if the solution is discoloured or contains visible floating particles.
  • Screen for G6PD deficiency: Ensure you have been tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency before receiving your first dose, as this medicine can cause severe blood disorders in people with this genetic trait.
  • Monitor for allergic reactions: Inform your nurse immediately if you feel warm, itchy, dizzy, or short of breath during the infusion.
  • Accurate lab testing: Blood samples for uric acid testing must be kept on ice and analysed quickly after collection to prevent false low readings caused by Rasbelon Injection continuing to work in the test tube.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Laboratory Tests: No clinically significant drug-drug interactions have been identified, but this medicine can cause false low readings in laboratory tests for uric acid. Inform your healthcare team before undergoing blood draws.
     
RasburicasePrilocaine
Severe
RasburicaseSodium nitrite
Severe

Drug-Drug Interactions

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RasburicasePrilocaine
Severe
How does the drug interact with Rasbelon Injection:
Combining Rasbelon Injection with Prilocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Rasbelon Injection and Prilocaine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseSodium nitrite
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Sodium nitrite can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.
RasburicaseRopivacaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with ropivacaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Rasbelon Injection and Ropivacaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseEtidocaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Etidocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is a possible interaction between Rasbelon Injection and Etidocaine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakess, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without first talking to your doctor.
RasburicaseLidocaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Lidocaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseTetracaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Tetracaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Rasbelon Injection with Tetracaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseMepivacaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Mepivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Mepivacaine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseBupivacaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Bupivacaine with Rasbelon Injection can increase the risk of methemoglobinemia(blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Bupivacaine with Rasbelon Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
RasburicaseLevobupivacaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Levobupivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Levobupivacaine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
RasburicaseChloroprocaine
Severe
How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is a possible interaction between Rasbelon Injection and Chloroprocaine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Water Intake: No specific drug-food interactions have been established for this medicine. However, maintaining high water intake is recommended.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Rasbelon Injection is used to help remove excess uric acid levels in patients with leukaemia, lymphoma, and solid tumour malignancies.
Rasbelon Injection is known to cause severe hypersensitivity reactions, hemolysis, and methemoglobinemia in some patients. Hence, inform your doctor about your complete medical and medication history before starting the treatment.
Rasbelon Injection is given as an intravenous (IV) infusion into a vein by a trained healthcare professional. The process usually takes about 30 minutes. Talk to your doctor or pharmacist if you have questions about the procedure.
There are no strict food restrictions, but it is highly recommended to avoid high-purine foods like red meat and shellfish, and to drink plenty of water to support your kidneys. Talk to your doctor or pharmacist for personalised dietary advice.
Yes, this medicine is approved for use in both adults and children who are undergoing chemotherapy and are at risk for high uric acid levels. Talk to your doctor or pharmacist for more details.
Rasbelon Injection remains active in blood samples at room temperature, which can cause falsely low uric acid test results. Keeping the blood tubes on ice ensures the laboratory gets an accurate reading. Talk to your doctor if you want to know more about your lab tests.
The safety of this medicine during pregnancy is not fully established. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor or pharmacist if you are pregnant or planning to become pregnant.
Yes, serious allergic reactions, including life-threatening anaphylaxis, can occur during or after the infusion. Your healthcare team will monitor you closely during treatment to manage any sudden reactions. Talk to your doctor if you have a history of allergies.
No, you should not receive this medicine if you have a G6PD deficiency, as it can cause a dangerous and sudden breakdown of red blood cells. Talk to your doctor or pharmacist about alternative treatment options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 103946S5083Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db00049 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A610008 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Rasburicase Rasburicase. 2001. [Accessed on 25 Jan. 2019]Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  6. ELITEK® (rasburicase) IV Infusion. [Accessed on 02 Jun. 2026]Check here
  7. Medscape Clinical Reference. Elitek Rasburicase 342255 Dosage & Guidelines. New York, NY: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - RAS0105
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