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  3. REGRACE PLUS TABLET

REGRACE PLUS TABLET, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
REGRACE PLUS TABLET is used to treat schizophrenia. It contains Risperidone and Trihexyphenidyl, which decreases dopaminergic and serotonergic activity in the brain, and reduces the symptoms of schizophrenia and mood disorders. It acts on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and some side effects that arise during antipsychotic treatment. In some cases, it may cause side effects like nausea, constipation, dry mouth, weight gain, sleepiness, orthostatic hypotension (sudden lowering of blood pressure on standing), and nervousness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

RISPERIDONE-3MG + TRIHEXYPHENIDYL-2MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About REGRACE PLUS TABLET

REGRACE PLUS TABLET is used to treat schizophrenia. Schizophrenia is a condition that affects the way your brain processes information. It causes you to lose touch with reality. You might see, hear, or believe things that are not real. Schizophrenia is a symptom, not an illness. A mental or physical illness, substance abuse, or extreme stress or trauma can cause it.

REGRACE PLUS TABLET is a fixed-dose combination composed of two medicines, Risperidone and Trihexyphenidyl. Risperidone belongs to a group of drugs called atypical antipsychotics. Risperidone decreases dopaminergic and serotonergic activity in the brain, which reduces the symptoms of schizophrenia and mood disorders. Trihexyphenidyl is in a category of medicines called antimuscarinic drugs. It acts on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and some side effects that arise during antipsychotic treatment.

REGRACE PLUS TABLET is available in the form of oral tablets. It is dissolved in the mouth with the help of water. It can be taken two times a day, as prescribed by a doctor. Your doctor will decide the dosage based on your medical condition. In some cases, REGRACE PLUS TABLET can cause side effects like nausea, constipation, dry mouth, weight gain, sleepiness, orthostatic hypotension (sudden lowering of blood pressure on standing), and nervousness. Most of these side effects of REGRACE PLUS TABLET do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to REGRACE PLUS TABLET or any other medicines, please inform your doctor. Before taking REGRACE PLUS TABLET, let your doctor know if you have diabetes, heart disease, tardive dyskinesia (movement of face and jaw), or liver and kidney problems. A woman who is pregnant, thinking of being pregnant, breastfeeding, or planning to be pregnant is not allowed to take this medicine, so tell your doctor before taking this medicine. Please do not stop taking REGRACE PLUS TABLET on your own, as it may lead to the recurrence of symptoms or worsen the condition.

Uses of REGRACE PLUS TABLET

Treatment of Schizophrenia (Mental illness)

Directions for Use

• REGRACE PLUS TABLET can be taken with or without food, as advised by your doctor.• It is usually taken twice daily at the same time each day or as prescribed by your doctor.• Swallow REGRACE PLUS TABLET as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

REGRACE PLUS TABLET is used to treat schizophrenia (A mental illness in which a person is confused). REGRACE PLUS TABLET is a fixed-dose combination composed of two different medicines, namely, Risperidone andTrihexyphenidyl. Risperidone is an atypical antipsychotic that acts by regulating the levels of chemical messengers (dopamine and serotonin) to enhance mood, perception and behaviour. Trihexyphenidyl is an anticholinergic agent that works on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and some side effects that arise during antipsychotic treatment.

How REGRACE PLUS TABLET Works

REGRACE PLUS TABLET is a fixed-dose combination composed of two medicines, Risperidone and Trihexyphenidyl. Risperidone belongs to a group of drugs called atypical antipsychotics. Risperidone decreases dopaminergic and serotonergic activity in the brain, which reduces the symptoms of schizophrenia and mood disorders. Trihexyphenidyl is in a category of medicines called antimuscarinic drugs. It acts on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and some side effects that arise during antipsychotic treatment.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Regrace Plus Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.

What if I have taken an overdose of REGRACE PLUS TABLET

Do not take more than the prescribed dose of REGRACE PLUS TABLET as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Before taking REGRACE PLUS TABLET, inform your doctor if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Before using this REGRACE PLUS TABLET, inform your doctor of your medical history like, liver and kidney problems, difficulty in swallowing, family history of diabetes, eye problems, and heart problems. This drug makes you dizzy. Alcohol can make you more dizzy or drowsy. Do not drive or do anything that needs alertness until you can do it safely. A woman who is pregnant or thinking of being pregnant, breastfeeding, or trying to be pregnant is not permitted to take this medication, so inform your doctor before taking this medicine.

Drug-Drug Interactions

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RisperidoneSparfloxacin
Critical
RisperidoneCisapride
Critical

Drug-Drug Interactions

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RisperidoneSparfloxacin
Critical
How does the drug interact with Regrace Plus Tablet:
Coadministration of Regrace Plus Tablet with sparfloxacin can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Sparfloxacin with Regrace Plus Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RisperidoneCisapride
Critical
How does the drug interact with Regrace Plus Tablet:
When Regrace Plus Tablet is taken with Cisapride, it can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking cisapride together with Regrace Plus Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
RisperidoneMetoclopramide
Critical
How does the drug interact with Regrace Plus Tablet:
Co-administration of Metoclopramide with Regrace Plus Tablet can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Regrace Plus Tablet with Metoclopramide is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking, jitteriness, restlessness, pacing, and foot tapping contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
RisperidonePramipexole
Critical
How does the drug interact with Regrace Plus Tablet:
Taking Regrace Plus Tablet with Pramipexole may reduce the effectiveness of Pramipexole.

How to manage the interaction:
Taking Regrace Plus Tablet with Pramipexole is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RisperidoneZiprasidone
Critical
How does the drug interact with Regrace Plus Tablet:
Co-administration of Regrace Plus Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Regrace Plus Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Regrace Plus Tablet:
Co-administration of Regrace Plus Tablet with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Regrace Plus Tablet with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Regrace Plus Tablet:
Co-administration of Regrace Plus Tablet with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Regrace Plus Tablet with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RisperidoneNilotinib
Severe
How does the drug interact with Regrace Plus Tablet:
Taking Regrace Plus Tablet and Nilotinib can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although there is a possible interaction between Nilotinib and Regrace Plus Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
RisperidoneCarbamazepine
Severe
How does the drug interact with Regrace Plus Tablet:
Taking Regrace Plus Tablet with carbamazepine may significantly reduce the blood levels of Regrace Plus Tablet.

How to manage the interaction:
Although taking carbamazepine and Regrace Plus Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RisperidoneTopiramate
Severe
How does the drug interact with Regrace Plus Tablet:
Taking Topiramate with Regrace Plus Tablet can increase the risk of brain related side effects.

How to manage the interaction:
Taking Regrace Plus Tablet and Topiramate together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Monitor your mood. Keep track of your mood regularly, including factors such as sleep, medicine and activities that can impact your mood. Exercise daily.

  • Exercise is nice to relieve tension. It can also avoid the weight gain that can be a side effect of your bipolar medication.

  • You may also practice calming techniques such as meditation and deep breathing exercises.

  • Get some normal sleep. Having enough sleep will help to stabilize your mood.

  • Eat a healthy diet. Certain foods may affect your mood more than others. Consider keeping a food log to track what you eat and how certain foods make you feel. Talk to your doctor or nutritionist about foods that may help stabilize your mood.

  • Stay optimistic. It will take time for your symptoms to improve after you start bipolar therapy, but you will feel relaxed knowing that you will get better and that the worst is most definitely behind you.

  • A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils and low-fat dairy products will help to keep a person in good health.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

REGRACE PLUS TABLET Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

It is unsafe to consume alcohol, since alcohol consumption with REGRACE PLUS TABLET may increase the risk of dizziness, fainting, or headache.

bannner image

Pregnancy

Unsafe

REGRACE PLUS TABLET is not safe in pregnancy because it causes miscarriage and abnormalities in the fetus.

bannner image

Breast Feeding

Caution

There is no evidence on how REGRACE PLUS TABLET affects breastfeeding. Please consult your doctor before taking REGRACE PLUS TABLET if you are breastfeeding.

bannner image

Driving

Caution

REGRACE PLUS TABLET is not safe during the drive because it can make you feel drowsy. So, you should do not do anything that requires concentration and attention.

bannner image

Liver

Caution

REGRACE PLUS TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

REGRACE PLUS TABLET to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

It is not recommended for children below 12 years. REGRACE PLUS TABLET is used to treat only above 12 years of age.

Have a query?

FAQs

REGRACE PLUS TABLET is used to treat schizophrenia.

REGRACE PLUS TABLET is used to treat schizophrenia (A mental illness in which a person is confused). REGRACE PLUS TABLET is composed of two different medicines, namely, Risperidone and, Trihexyphenidyl. Risperidone is an atypical antipsychotic that acts by regulating the levels of chemical messengers (dopamine and serotonin) to enhance mood, perception and behaviour. Trihexyphenidyl is an anticholinergic agent that acts on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and some side effects that arise during antipsychotic treatment.

Yes, REGRACE PLUS TABLET is used to help weight gain and it is not necessary for all people to experience the side effect. It is advisable to follow a regular diet and exercise to maintain a healthy weight.

Do not stop using REGRACE PLUS TABLET even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.

Not safe because REGRACE PLUS TABLET is not safe in pregnancy because it causes miscarriage and abnormalities in the fetus.

There is no evidence on how REGRACE PLUS TABLET affects breastfeeding. Please consult your doctor before taking REGRACE PLUS TABLET if you are breastfeeding.

Stopping the REGRACE PLUS TABLET abruptly can cause withdrawal symptoms, and preventing it too early could make your illness come back. Please consult your doctor if you want to stop taking REGRACE PLUS TABLET.

Country of origin

INDIA

Manufacturer/Marketer address

C-38,Phase-II, Focal Point, Ludhiana-141010 Punjab (India).
Other Info - REG0010

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:38 AM IST

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Reference

  1. https://www.ciplamed.com/content/risnia-plusrisnia-forte-mouth-dissolving-tablets
  2. https://www.webmd.com/drugs/2/drug-6283-2034/risperidone-oral/risperidone-oral/details
  3. https://www.drugs.com/risperidone.html
  4. https://www.webmd.com/drugs/2/drug-8720/trihexyphenidyl-oral/details

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