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Remethyl PN 75 Tablet 10's
Remethyl PN 75 Tablet is a combination medicine used to manage diabetic neuropathy, neuropathic pain, and nutritional deficiencies. This medicine works by altering the nerve signals that cause pain and thereby protects nerve fibres. It helps provide a protective effect on the nerve tissues and the brain. You may experience common side effects like nausea, vomiting, diarrhoea, stomach upset, dizziness, and rash.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

METHYLCOBALAMIN-1500MCG+NORTRIPTYLINE-10MG+PREGABALIN-75MG

Manufacturer/Marketer :

Benz Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Remethyl PN 75 Tablet

Remethyl PN 75 Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Remethyl PN 75 Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Remethyl PN 75 Tablet helps to treat neuropathic pain.

Take Remethyl PN 75 Tablet as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Remethyl PN 75 Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.

Please do not take Remethyl PN 75 Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Remethyl PN 75 Tablet if you are pregnant or breastfeeding. Remethyl PN 75 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Remethyl PN 75 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Remethyl PN 75 Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Remethyl PN 75 Tablet

Remethyl PN 75 Tablet is used in the treatment of Neuropathic pain. The detailed uses of Remethyl PN 75 Tablet are as follows:

  • Neuropathic Pain: Remethyl PN 75 Tablet is used to treat diabetic neuropathy, post-herpetic neuralgia (shingles), sciatica, and spinal cord injuries.
  • Fibromyalgia: Remethyl PN 75 Tablet helps manage widespread pain and fatigue.
  • Peripheral Neuropathy: Remethyl PN 75 Tablet supports nerve repair and reduces tingling, numbness, and burning sensations.
  • Chronic Pain Syndromes: Remethyl PN 75 Tablet is used to treat pain, including lower back pain and migraine prevention.

Key Benefits

Remethyl PN 75 Tablet is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Remethyl PN 75 Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Remethyl PN 75 Tablet helps to treat neuropathic pain.

Side effects of Remethyl PN 75 Tablet

Directions for Use

  • Take Remethyl PN 75 Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Remethyl PN 75 Tablet Works

Remethyl PN 75 Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Remethyl PN 75 Tablet helps to treat neuropathic pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Remethyl PN 75 Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take Remethyl PN 75 Tablet unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Remethyl PN 75 Tablet in breastfeeding/nursing mothers.

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Driving

Unsafe

Remethyl PN 75 Tablet causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Remethyl PN 75 Tablet should not be given to children as the safety and efficacy have not been established.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before using Remethyl PN 75 Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Remethyl PN 75 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Remethyl PN 75 Tablet .

What if I have taken an overdose of Remethyl PN 75 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Remethyl PN 75 Tablet may include irregular heartbeats, severe drowsiness, vision problems, confusion, hallucinations, agitation, stiff muscles, overactive reflexes, vomiting, feeling hot or cold, feeling like you might pass out, seizures, or coma. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.

  • Cayenne pepper should be included in your diet because it can help with neuropathic pain.

  • Exercising regularly helps to improve overall health and combat pain.

  • Rest well and get plenty of rest.

  • Taking a warm bath can be very relaxing.

  • Avoid smoking and drinking alcohol.

  • Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.

  • Acupuncture, by stimulating pressure points, can be beneficial.

  • Massages with essential oils can help increase circulation.

Have a query?

How Soon It Starts Working

The time required for Remethyl PN 75 Tablet to start to work: The time required for Remethyl PN 75 Tablet to show its action is unknown. The time for which the effects of Remethyl PN 75 Tablet last: The duration of action for Remethyl PN 75 Tablet is clinically unknown.

What if you forget to take Remethyl PN 75 Tablet

If you miss a dose of Remethyl PN 75 Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep Remethyl PN 75 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to any of the ingredients in Remethyl PN 75 Tablet , do not consume it. Please do not stop taking Remethyl PN 75 Tablet without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Remethyl PN 75 Tablet unless your doctor has prescribed it. Remethyl PN 75 Tablet may cause drowsiness and dizziness, therefore drive only if you are alert. Remethyl PN 75 Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Remethyl PN 75 Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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Drug-Drug Interactions: Remethyl PN 75 Tablet may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John's wort).

Drug-Food Interactions: Avoid alcohol consumption while taking Remethyl PN 75 Tablet as it might cause increased drowsiness and sleepiness.

Drug-Disease Interactions: Use Remethyl PN 75 Tablet with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.

Mecobalamin + Nortriptyline + PregabalinIsocarboxazid
Critical
Mecobalamin + Nortriptyline + PregabalinSafinamide
Critical

Drug-Drug Interactions

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Mecobalamin + Nortriptyline + PregabalinIsocarboxazid
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Taking Remethyl PN 75 Tablet with isocarboxazid may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and isocarboxazid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinSafinamide
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Remethyl PN 75 Tablet with safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and safinamide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinZiprasidone
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of nortriptyline with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between nortriptyline and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Nortriptyline + PregabalinSelegiline
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Co-administration of Remethyl PN 75 Tablet with selegiline may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between and selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinPotassium citrate
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Remethyl PN 75 Tablet with potassium citrate can increase the risk or severity of gastric bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and potassium citrate, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Nortriptyline + PregabalinTranylcypromine
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Nortriptyline with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between nortriptyline and tranylcypromine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinLinezolid
Critical
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Remethyl PN 75 Tablet with linezolid may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and linezolid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinPimozide
Severe
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Remethyl PN 75 Tablet with pimozide can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and pimozide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Nortriptyline + PregabalinSaquinavir
Severe
How does the drug interact with Remethyl PN 75 Tablet:
Coadministration of Remethyl PN 75 Tablet with saquinavir can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Remethyl PN 75 Tablet and saquinavir, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Nortriptyline + PregabalinDroperidol
Severe
How does the drug interact with Remethyl PN 75 Tablet:
Taking droperidol with Remethyl PN 75 Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between droperidol and Remethyl PN 75 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Remethyl PN 75 Tablet is used to treat neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.
Remethyl PN 75 Tablet contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Remethyl PN 75 Tablet helps to treat neuropathic pain.
Dry mouth could be a side-effect of Remethyl PN 75 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Remethyl PN 75 Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Remethyl PN 75 Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Remethyl PN 75 Tablet , do not be afraid to speak with your doctor.
Remethyl PN 75 Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Remethyl PN 75 Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
Remethyl PN 75 Tablet is not a painkiller. However, it is a combination medicine used to manage neuropathic pain, particularly in conditions like diabetic peripheral neuropathy and postherpetic neuralgia.
The common side effects of Remethyl PN 75 Tablet include sleepiness, dizziness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult the doctor if these symptoms persist or worsen.
Remethyl PN 75 Tablet is a medication combination consisting of Methylcobalamin (Vitamin B12), Nortriptyline (Tricyclic Antidepressant), and Pregabalin (Anticonvulsant), commonly prescribed for managing neuropathic pain and nerve damage.
To manage weight gain associated with Remethyl PN 75 Tablet , maintain a balanced diet rich in fibre and protein while avoiding processed and sugary foods. Engage in regular physical activity, including cardio and strength training, to boost your metabolism. Monitor your weight and consult your doctor if you notice any significant changes.
Yes, Remethyl PN 75 Tablet may cause sleepiness or dizziness as a common side effect. Therefore, avoid driving or operating heavy machinery unless you are fully alert.
Remethyl PN 75 Tablet may affect sexual health in some individuals. It may cause side effects such as reduced libido, erectile dysfunction, or difficulty achieving orgasm, mainly due to Nortriptyline and Pregabalin affecting neurotransmitters and nerve function. Please consult the doctor for guidance or alternative treatment options if you experience any changes in your sexual health.
Remethyl PN 75 Tablet is generally well tolerated, but in very rare cases, it may cause allergic reactions, such as rash, itching, or swelling, and breathing difficulties, especially in individuals with pre-existing lung conditions or when combined with CNS depressants.
Remethyl PN 75 Tablet starts working as soon as you begin taking it. However, it may take a few weeks to show its complete effects. Therefore, continue taking it as prescribed by the doctor, and please consult your doctor if you have any concerns.
If you forget a dose of Remethyl PN 75 Tablet , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose.
If you accidentally overdose on Remethyl PN 75 Tablet , seek immediate medical attention. Overdose symptoms can be severe and include drowsiness, confusion, vision problems, dizziness, irregular heartbeat, low blood pressure, convulsions, and breathing difficulties. In extreme cases, an overdose can lead to coma or even life-threatening complications. Call your doctor or emergency services right away for urgent treatment.
No, taking a higher dose of Remethyl PN 75 Tablet than recommended will not necessarily be more effective and may increase the risk of serious side effects. Always follow the dosage instructions provided by your doctor or pharmacist.
Avoid consuming alcohol while taking Remethyl PN 75 Tablet as it may increase drowsiness or sleepiness. Avoid driving or operating heavy machinery until you know how the medication affects you. Avoid taking other medicines, including herbal supplements and OTC medications, without a doctor’s advice.
While taking Remethyl PN 75 Tablet , your doctor may recommend regular check-ups based on your medical condition to monitor your response, adjust dosages, and manage potential side effects. Please consult your doctor immediately if you experience any changes in your condition.
Remethyl PN 75 Tablet should be stored in a cool and dry place, away from sunlight. Keep it out of sight and reach of children.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Nortriptyline - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. National Health Service (NHS). Pregabalin - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. National Center for Biotechnology Information (NCBI). Pmc3888748 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
  4. National Center for Biotechnology Information (NCBI). Pmc6003018 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Drugs.com Clinical Review Team. Pregabalin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  6. Drugs.com Clinical Review Team. Nortriptyline Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  7. Electronic Medicines Compendium (EMC). Pil.5044 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here

Country of origin

INDIA

Manufacturer/Marketer address

VILLAGE-MANPURA TEHSIL-NALAGARH NALAGARH Solan HP 174101 IN , - , .
Other Info - REM0159

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