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compositionComposition:PAPAVERINE-30MG
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Prescription Medicine
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Repaverine Injection 2 ml is used to treat circulatory problems, smooth muscle spasms, peripheral vascular disease, and erectile dysfunction (impotence). It contains Papaverine which works by relaxing the blood vessels and smooth muscles and improving blood flow. In some cases, this medicine may cause side effects such as nausea, stomach upset, constipation, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PAPAVERINE-30MG

Manufacturer/Marketer :

Retort Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Repaverine Injection 2 ml

Repaverine Injection 2 ml is a prescription injection used to relax smooth muscles and widen blood vessels. It is primarily prescribed to treat spasms of the blood vessels, particularly in the brain, heart, or limbs, as well as spasms in organs like the stomach, gallbladder, or kidneys. By improving blood flow and relaxing tight muscles, this medicine helps relieve severe pain and cramping.

Since Repaverine Injection 2 ml is given as an injection, it is typically injected as needed for sudden symptoms or on a regular schedule determined by your doctor. It can be injected without regard to meals, but staying well-hydrated is highly recommended during your treatment. Making simple lifestyle adjustments, such as reducing salt intake and avoiding sudden temperature changes, can further support healthy blood flow.

While using Repaverine Injection 2 ml, you may experience mild side effects like flushing, sweating, mild headache, or stomach discomfort. If you experience serious symptoms, such as an irregular heartbeat, yellowing of your skin or eyes, or signs of liver damage, contact your doctor immediately.

Before starting treatment with Repaverine Injection 2 ml, tell your healthcare provider if you have a history of glaucoma, heart block, or liver problems. Do not take this if you have a complete heart block or severe liver damage.

Avoid drinking alcohol while receiving Repaverine Injection 2 ml, as it can increase drowsiness and worsen dizziness. It is also important to talk to your doctor or pharmacist if you are pregnant, breastfeeding, or an older adult, to ensure this injection is safe for your specific situation.

Do not use Repaverine Injection 2 ml if you have complete heart block, severe liver impairment or severe liver disease, or a known hypersensitivity to Repaverine Injection 2 ml or any component of the injection. Use with caution if you have glaucoma and ask your doctor before use. 

Uses of Repaverine Injection 2 ml

Repaverine Injection 2 ml is used to relieve spasms in blood vessels and smooth muscles of internal organs, helping improve blood flow and reduce cramping-related pain.

  • Blood vessel spasms (Vasospasms): Repaverine Injection 2 ml helps relax the walls of blood vessels in the heart, brain, or limbs, improving blood flow and reducing chest pain or numbness.
  • Internal organ cramps (cramping in internal organs like the stomach, gallbladder, or kidneys):  It relieves severe cramps in smooth muscle organs, helping to ease the intense pain associated with gallbladder attacks, kidney stones, or severe stomach spasms.
  • Circulatory complications: It is used to improve blood flow during certain cardiovascular procedures or when managing sudden blockages in the blood vessels.
  • Erectile dysfunction: Repaverine Injection 2 ml may be injected directly into the spongy tissue of the penis to relax smooth muscles and increase blood flow, helping produce an erection. In practice, it is often used with one or two other medicines, such as phentolamine or alprostadil, which also help increase blood flow to the penis, and a urologist or andrologist should guide the choice of formulation. 

Key Benefits

Repaverine Injection 2 ml helps relieve intense cramping and supports healthy blood flow by relaxing smooth muscles and widening narrowed blood vessels.

  • Rapid Relief from Severe Cramping: By directly targeting tight smooth muscles, Repaverine Injection 2 ml helps relieve intense, sharp pain quickly. This rapid action is especially beneficial for managing acute, severe cramping in internal organs like the kidneys or gallbladder.
  • Improved Blood Flow to Vital Tissues: By widening narrowed blood vessels, this medicine restores normal blood flow to vital organs and tissues, preventing tissue damage caused by a lack of oxygen.
  • Support During Medical Procedures: It also supports medical procedures by preventing sudden blood vessel constriction, ensuring safer and more effective outcomes.
Side effects of Repaverine Injection 2 ml
  • Avoid holding and empty the bladder at regular intervals.
  • Apply cold or ice packs for few minutes.
  • Exercise regularly and maintain a healthy lifestyle.
  • Make sure to have an adequate sleep.
  • Maintain healthy diet containing fruits and vegetables.
  • Exercise regularly and maintain a healthy weight.
  • Manage cholesterol and blood pressure.
  • Limit intake of caffeine and alcohol.
  • Avoid vaping and tobacco smoke.
  • Get enough sleep.
  • Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Repaverine Injection 2 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Repaverine Injection 2 ml Works

Repaverine Injection 2 ml belongs to a class of medicines known as vasodilators and smooth muscle relaxants. Papaverine works by helping relax tight muscle walls, so the blood vessels can open up more easily and blood can flow better. These muscles are located in the walls of your blood vessels, stomach, intestines, and other internal organs. When these muscles spasm, they constrict blood vessels, which blocks normal blood flow and causes severe organ pain. This action allows the blood vessels to widen and the organs to relax, restoring normal circulation and relieving painful cramps.
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Alcohol

Caution

You are advised not to consume alcohol while on treatment with Repaverine Injection 2 ml as it might cause increased dizziness and drowsiness.

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Pregnancy

Caution

Consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide if Repaverine Injection 2 ml can be taken by breastfeeding mothers or not.

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Driving

Caution

Repaverine Injection 2 ml may cause dizziness and drowsiness. Therefore you are advised to drive and operate machinery only if you are alert.

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Liver

Caution

Repaverine Injection 2 ml should be used with caution in patients with liver impairment. Please consult your doctor if you have liver impairment/liver disease or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment/kidney disease or any concerns regarding this.

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Children

Unsafe

Repaverine Injection 2 ml should not be given to children as safety and effectiveness have not been established.

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Heart

Caution

Repaverine Injection 2 ml should be administered with caution in patients with heart conditions, as it may increase the risk of side effects. Please inform your doctor of any heart problems before receiving Repaverine Injection 2 ml.

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Geriatrics

Caution

Repaverine Injection 2 ml should be given with caution to elderly patients due to an increased risk of side effects. Please consult your doctor before receiving Repaverine Injection 2 ml.

What if I have taken an overdose of Repaverine Injection 2 ml

In case of an accidental overdose, seek immediate medical attention or call your local poison control centre. Symptoms of an overdose may include extreme drowsiness, rapid heartbeat, severe weakness, or blurred vision.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water to help support healthy circulation and ease the passage of kidney or gallbladder stones if you are using this medicine for organ spasms.
  • Avoid sudden temperature changes: If you suffer from blood vessel spasms in your limbs, avoid sudden exposure to cold air or cold water, which can trigger vessel constriction.
  • Limit sodium intake: Consuming less salt can help maintain healthy blood pressure and reduce the workload on your cardiovascular system.
  • Avoid smoking: Nicotine causes blood vessels to constrict, directly opposing the beneficial widening effects of Repaverine Injection 2 ml.
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How Soon It Starts Working

The time required for Repaverine Injection 2 ml to start to work: Repaverine Injection 2 ml ideally shows its action within 10 minutes after administration. The time for which the effects of Repaverine Injection 2 ml last: The effect of Repaverine Injection 2 ml lasts for 2 to 4 hours..

What if you forget to take Repaverine Injection 2 ml

If you miss a scheduled dose, contact your doctor or pharmacist for guidance. If you are using this medication on an as-needed basis for sudden spasms, you can inject it as soon as you remember, but skip the missed dose if it is almost time for your next scheduled injection. Do not inject a double dose to make up for a missed one.

Storage

• Store Repaverine Injection 2 ml vials at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the medication in its original outer carton to protect it from direct light.

Drug Warnings

  • Check the liquid: Always inspect the vial before drawing up the medicine. If the solution is discoloured, cloudy, or contains visible particles, do not use it.
  • Practice needle safety: Use a new sterile needle and syringe for every injection to prevent infections, and never share injection equipment with anyone.
  • Rotate injection sites: If you self-inject, change the injection spot each time to avoid developing hard lumps, soreness, or skin breakdown.
  • Avoid driving: This medicine can cause drowsiness or dizziness; do not drive, operate heavy machinery, or perform hazardous tasks until you know how it affects you.
  • Monitor liver function: Your doctor may request periodic blood tests to check your liver health while you are using this medicine.
  • Warning for penile injection use:  If Repaverine Injection 2 ml is injected into the penis for erectile dysfunction, seek urgent medical help if an erection lasts longer than 4 hours, as this may be priapism. 

Drug-Drug Interactions

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Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Levodopa: Repaverine Injection 2 ml may decrease the effectiveness of levodopa (a medicine used to help control movement symptoms in Parkinson's disease), leading to a worsening of movement control.
  • Blood Pressure or Drowsy Medicines: Combining Repaverine Injection 2 ml with other blood pressure-lowering drugs or medicines that cause drowsiness, such as sleeping pills, sedatives, or antihistamines, may cause excessive dizziness or a rapid drop in blood pressure. 

Drug-Drug Interactions

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How does the drug interact with Repaverine Injection 2 ml:
Taking leuprolide with Repaverine Injection 2 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking leuprorelin and Repaverine Injection 2 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience dizziness, lightheadedness, fainting, or shortness of breath, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Repaverine Injection 2 ml:
Taking Repaverine Injection 2 ml with Pazopanib can increase the risk of irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Pazopanib and Repaverine Injection 2 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Repaverine Injection 2 ml:
Taking azithromycin with Repaverine Injection 2 ml increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although administration of azithromycin alongside Repaverine Injection 2 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Repaverine Injection 2 ml:
Taking Ceritinib with Repaverine Injection 2 ml can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although there is a interaction between Ceritinib and Repaverine Injection 2 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Repaverine Injection 2 ml:
Combining Clarithromycin with Repaverine Injection 2 ml may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Let the doctor know if you are taking clarithromycin before starting treatment with Repaverine Injection 2 ml. Although there is a possible interaction, clarithromycin can be taken with Repaverine Injection 2 ml if prescribed by the doctor. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. Do not stop using any medications without a doctor's advice.
How does the drug interact with Repaverine Injection 2 ml:
Coadministration of Moxifloxacin with Repaverine Injection 2 ml can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Repaverine Injection 2 ml, you can take these medicines together if prescribed by a doctor. If you experience irregular heart rhythm, dizziness, or difficulty breathing, contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Repaverine Injection 2 ml:
Coadministration of Repaverine Injection 2 ml with Solifenacin can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Repaverine Injection 2 ml with Solifenacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Repaverine Injection 2 ml:
Co-administration of Sertraline and Repaverine Injection 2 ml can increase the risk of irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Sertraline and Repaverine Injection 2 ml, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations , consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Repaverine Injection 2 ml:
The combined use of Repaverine Injection 2 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Repaverine Injection 2 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Repaverine Injection 2 ml:
Combining Mirtazapine with Repaverine Injection 2 ml increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Mirtazapine and Repaverine Injection 2 ml, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like an irregular heart rhythm, complications, sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, make sure to call a doctor right away." Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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  • Alcohol: Consuming alcohol while using Repaverine Injection 2 ml may increase the risk of side effects like extreme drowsiness, dizziness, and rapid heartbeat.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[VASODILATORS]

FAQs

Repaverine Injection 2 ml works by relaxing the blood vessels; this helps the blood to flow easily to the heart and through the body. Thereby, Repaverine Injection 2 ml helps in improving the blood flow in patients with circulatory problems.
Repaverine Injection 2 ml helps treat erectile dysfunction by causing direct smooth muscle relaxation and increasing the blood flow to the penis with blood, resulting in an erection.
Repaverine Injection 2 ml might cause priapism (prolonged erection). Consult a doctor immediately if the erection lasts for more than 4 hours.
Repaverine Injection 2 ml is a non-specific, direct-acting smooth muscle relaxant causing a vasodilating effect on the blood vessels and other smooth muscle systems. Repaverine Injection 2 ml exerts a spasmolytic effect by relaxing the smooth muscles of the gastrointestinal, bronchial, urinary tract, and biliary smooth muscles. Thereby, helps in treating muscle spasms.
Postural hypotension could be a side-effect of Repaverine Injection 2 ml. Postural hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People on treatment with Repaverine Injection 2 ml are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
Yes, but only if you have received proper training from a healthcare professional on how to measure and inject the medicine safely. Do not attempt to self-inject until you are fully confident in the technique. Talk to your doctor or pharmacist for guidance.
You should not use the injection if the solution is cloudy, discolored, or contains small particles. Safely discard the vial in a sharps container and use a new one. Talk to your pharmacist if you notice this issue frequently.
It is highly recommended to avoid alcohol while using this medicine. Alcohol can worsen side effects like dizziness, drowsiness, and flushing, making it unsafe to perform daily tasks. Talk to your doctor for more advice.
In rare cases, this medication can cause liver damage. Your doctor may monitor your liver function through regular blood tests during your treatment. If you notice yellowing of your eyes or skin, contact your healthcare provider immediately.
This medicine should be used with caution if you have narrow-angle (angle-closure) glaucoma. Talk to your doctor to determine if this treatment is safe for you.
The safety of this medication during pregnancy has not been fully established. It should only be used if clearly needed and prescribed by your obstetrician. Talk to your doctor about the risks and benefits.
No, it does not treat Parkinson's disease. In fact, it can reduce the effectiveness of levodopa, which is a common medicine used to manage Parkinson's symptoms. Talk to your doctor if you are taking any medications for movement disorders.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

21, 2, Mc Nichols Rd, Chentarnipet, Chennai, Tamil Nadu 600031
Other Info - REP0070
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