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Synonym :

HYDROXYCARBAMIDE

Composition :

HYDROXYUREA-500MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Riborea 500mg Capsule

Riborea 500mg Capsule is an anticancer medicine used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). Head and neck cancer is a disease including abnormal growth of the tissues of the neck and head that may also have the ability to attack or spread to other portions of the body.

In cancer, Riborea 500mg Capsule works by blocking an enzyme that is required for growing cells. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).

You may experience loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Riborea 500mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Take Riborea 500mg Capsule as prescribed by your doctor. You are advised to take Riborea 500mg Capsule for as long as your doctor has prescribed it for you, depending on your medical conditions. Do not chew, break, or crush the medicine. Swallow the medicine as a whole with a glass of water.

Before starting Riborea 500mg Capsule , please inform your doctor if you have any allergies, kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation. Riborea 500mg Capsule may increase the chances of other cancer. Inform your doctor about this risk. Immediately contact your doctor if you are pregnant because this Riborea 500mg Capsule can cause harmful effects on the unborn baby.

Uses of Riborea 500mg Capsule

Riborea 500mg Capsule is used in the treatment of head and neck cancer, blood cancer, and sickle cell anaemia. The detailed uses of Riborea 500mg Capsule are as follows:

  • Treats Head and Neck Cancer:Riborea 500mg Capsule is used alone or in combination with radiotherapy to treat squamous cell carcinoma (skin cancer) of the head and neck by preventing the cancer cells from growing and multiplying.
  • Treats Blood Cancer: Riborea 500mg Capsule helps slow the progression of chronic myeloid leukaemia by reducing the number of abnormal white blood cells in the bone marrow and blood.
  • Manages Ovarian Cancer: Riborea 500mg Capsule is used as part of a chemotherapy treatment to help control the growth and spread of ovarian cancer cells.
  • Manages Sickle Cell Anaemia: Riborea 500mg Capsule increases the level of fetal haemoglobin, which helps reduce the frequency of painful sickle cell attacks, the need for blood transfusion, and complications such as acute chest syndrome.

Have a query?

Directions for Use

  • Take Riborea 500mg Capsule with or without food as advised by your doctor.
  • Riborea 500mg Capsule is generally taken once a day or as directed by the doctor.
  • Swallow Riborea 500mg Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Riborea 500mg Capsule belongs to a group of the class known as an antimetabolite.
  • It is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).
  • In cancer, Riborea 500mg Capsule works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing.
  • In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).
  • This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.

How Riborea 500mg Capsule Works

Riborea 500mg Capsule works by blocking an enzyme required for cell growth. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Riborea 500mg Capsule

Do not take more than the prescribed dose of Riborea 500mg Capsule as it may cause an overdose. The symptoms of overdose include darkening of the skin, sores in the mouth and throat and pain, redness, swelling, and scaling on the hands and feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Before taking Riborea 500mg Capsule inform your doctor if you have any kind of infection because Riborea 500mg Capsule may worsen the infections.
  • Consult your doctor if you experience any allergy symptoms.
  • Inform your doctor if you have any history of kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation.
  • Riborea 500mg Capsule may increase the chances of other cancers. Inform your doctor about this risk.
  • Immediately contact your doctor if you are pregnant because this Riborea 500mg Capsule can cause harmful effects on the unborn baby.
  • Both women and men using this Riborea 500mg Capsule should use birth control to avoid pregnancy. 
  • The use of this Riborea 500mg Capsule by either parent may result in birth defects.
  • You should not take this Riborea 500mg Capsule during breastfeeding; inform your doctor if you take Riborea 500mg Capsule .
  • If any powder from a damaged pill is leaked, wash it up immediately with a wet paper towel and dispose of the towel in a closed plastic bag out of reach of children.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used in conjunction with etanercept may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with etanercept, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used with leflunomide may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with leflunomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Riborea 500mg Capsule:
Taking Bupivacaine and Riborea 500mg Capsule may cause methemoglobinemia (a rare disorder in which the iron in the hemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately).

How to manage the interaction:
Although taking Riborea 500mg Capsule and bupivacaine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Riborea 500mg Capsule:
Prilocaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Riborea 500mg Capsule, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Riborea 500mg Capsule and Prilocaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used with tofacitinib may raise the risk of severe infections, cancers.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with tofacitinib, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used with Adalimumab may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with adalimumab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideVoclosporin
Severe
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used with voclosporin may raise the risk of severe infections, some kinds of cancer, including skin cancer and cancer of the lymph glands (lymphoma).

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with voclosporin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used together with infliximab may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with infliximab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Riborea 500mg Capsule:
Riborea 500mg Capsule when used in conjunction with bacitracin may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Riborea 500mg Capsule with bacitracin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Riborea 500mg Capsule:
Combining Riborea 500mg Capsule with didanosine can have serious consequences on your liver or pancreas. Didanosine may potentially induce lactic acidosis (lactic acid buildup in the body).Lactic acidosis can develop gradually and worsen over time.

How to manage the interaction:
Co-administration of Riborea 500mg Capsule with didanosine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms while taking didanosine: strong discomfort in your upper stomach that spreads to your back, rapid heart rate, nausea and vomiting, diarrhoea, lack of appetite, low fever, dark urine, clay-colored faeces, or jaundice (yellowing of the skin or eyes), unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, stomach pain, and numbness or cold feeling in your arms or legs, contact the doctor immediately.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take Riborea 500mg Capsule at the same time daily, either with or without a meal.
  • It is recommended to remain hydrated and drink a lot of fluids while taking Riborea 500mg Capsule .
  • Do not miss any dose and finish the course as recommended by your doctor.
  • Use an efficient method of birth control to prevent pregnancy while taking this Riborea 500mg Capsule .
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES
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Alcohol

Consult your doctor

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Riborea 500mg Capsule . Taking alcohol in larger amounts causes dizziness.

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Pregnancy

Unsafe

Riborea 500mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.

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Breast Feeding

Consult your doctor

It is unknown whether Riborea 500mg Capsule is excreted in human milk. Please consult a doctor before using Riborea 500mg Capsule while breastfeeding.

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Driving

Caution

Riborea 500mg Capsule may cause dizziness or a severe headache. Therefore, drive only if you are alert after taking Riborea 500mg Capsule .

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Liver

Consult your doctor

If you have any concerns regarding the use of Riborea 500mg Capsule in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Riborea 500mg Capsule in patients with kidney problems, please consult a doctor.

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Children

Unsafe

The safety and efficacy of Riborea 500mg Capsule have not been established in children. Therefore, it is not recommended for children.

FAQs

Riborea 500mg Capsule is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).

Take the Riborea 500mg Capsule as soon as you can, but avoid the missed dose if it is nearly time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of Riborea 500mg Capsule entirely.

Immediately go to the emergency department of your nearest hospital. Be ready to tell or show what was taken, how much, and when it happened.

Riborea 500mg Capsule may cause a risk of skin cancer. Avoid contact with sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outside. Do not handle Riborea 500mg Capsule without the protection of skin.

Riborea 500mg Capsule can cause dizziness and drowsiness during the first limited hours after you take it. These side effects are more expected to happen when you start taking Riborea 500mg Capsule or when your doctor increases your dose.

Do not stop taking Riborea 500mg Capsule without discussing it with your doctor. Your doctor will most likely tell you to take another medicine, folic acid (a vitamin), to reduce some of the side effects of this Riborea 500mg Capsule . Take this Riborea 500mg Capsule exactly as instructed.

Riborea 500mg Capsule is a medication that requires careful monitoring and dosing based on your individual medical condition, weight, and other factors. Please consult your healthcare provider if you have any questions about your hydroxyurea dosage. They can provide personal guidance and ensure you're taking the correct amount.

Riborea 500mg Capsule can cause diarrhoea as a side effect. If you have watery or bloody diarrhoea, call your doctor. Do not use anti-diarrhea medicine unless your paediatrician tells you to.

Yes, it is recommended that you avoid certain foods and drinks while taking Riborea 500mg Capsule . Some substances can interact with the medication, potentially affecting its effectiveness or increasing the risk of side effects. Here are some things to avoid: alcohol, grapefruit, grapefruit juice, Foods high in tyramine (aged cheeses, cured meats, fermented foods, and certain types of beans), and excessive caffeine.

If you're feeling tired and weak while taking hydroxyurea, try these tips: rest when needed, eat healthy foods, drink plenty of water, and get enough sleep. Gentle exercise can also help. Discuss with your healthcare provider if you're experiencing severe fatigue or weakness that interferes with your daily activities. They may be able to adjust your treatment or recommend additional strategies.

Riborea 500mg Capsule is not safe during pregnancy because it may cause harmful effects to the baby.

Riborea 500mg Capsule can make your hair thin or fall out. This is a common side effect, but how much hair you lose can change from person to person. Sometimes, hair loss is temporary, but in rare cases, it can be permanent. If you're worried about hair loss, talk to your doctor. They can help you manage it.

If you notice any changes in your skin while taking Riborea 500mg Capsule , talk to your doctor. It's common to have darker skin or a rash. To protect your skin, use sunscreen, moisturize, and avoid things that might irritate it. If your skin problems are severe, see a dermatologist.

If you are having trouble with constipation while taking Riborea 500mg Capsule , try these tips: eat more fibre, drink plenty of water, exercise regularly, and consider using over-the-counter laxatives after talking to your doctor. Avoid food that can worsen constipation, and try to go to the bathroom at the same time each day. If your constipation is severe, talk to your doctor.

To reduce the risk of infection while taking Riborea 500mg Capsule , wash your hands often, avoid sick people, keep your home clean, get vaccinated, watch for signs of infection, and follow your doctor's instructions.

Common side effects of Riborea 500mg Capsule may include loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Riborea 500mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA
Other Info - RIB0023

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