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compositionComposition:ISONIAZID-50MG+RIFAMPICIN-100MG
prescription
Prescription Medicine
info
image icons

RIMACTAZID DISPED 50MG TABLET is used to treat and prevent tuberculosis. It contains Rifampicin, and Isoniazid, which works by killing the bacteria causing TB (tuberculosis). In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ISONIAZID-50MG+RIFAMPICIN-100MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About RIMACTAZID DISPED 50MG TABLET

RIMACTAZID DISPED 50MG TABLET is a prescription oral medicine used to treat active and latent tuberculosis infections. It combines two active antibiotics that work together to eliminate the bacteria causing the infection. Taking this medicine helps cure the infection and prevents it from spreading to others.

To work effectively, you must take RIMACTAZID DISPED 50MG TABLET consistently every day exactly as prescribed, even if you start feeling better. It should be taken on an empty stomach, either one hour before or two hours after a meal, with a full glass of water. Maintaining a balanced diet and getting plenty of rest are helpful lifestyle changes during your recovery.

While taking this medicine, you may notice mild side effects like your urine, sweat, or saliva turning an orange-red colour. However, if you experience more serious symptoms such as severe abdominal pain, persistent nausea, or yellowing of your skin and eyes, you must contact your doctor immediately.

Do not take this if you have severe liver damage, acute liver disease, or have previously had a severe allergic reaction to either of its active components. Talk to your doctor before starting RIMACTAZID DISPED 50MG TABLET if you have a history of liver problems, kidney disease, diabetes, or nerve pain.

This medicine can interact with alcohol, significantly raising the risk of serious liver damage, and can reduce the effectiveness of hormonal birth control. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of RIMACTAZID DISPED 50MG TABLET

RIMACTAZID DISPED 50MG TABLET is used to treat active and latent tuberculosis infections. The detailed uses of RIMACTAZID DISPED 50MG TABLET are as follows:

  • Tuberculosis Treatment: RIMACTAZID DISPED 50MG TABLET is prescribed to treat active tuberculosis infections in the lungs and other parts of the body by killing the disease-causing bacteria.
  • Tuberculosis Prevention: It is used to prevent active tuberculosis from developing in individuals who have a latent (inactive) tuberculosis infection.
     

Key Benefits

RIMACTAZID DISPED 50MG TABLET helps treat tuberculosis by preventing the growth and spread of the bacteria responsible for the infection. By targeting the underlying cause of the disease, it supports recovery and helps improve symptoms over the course of treatment.

  • Helps Relieve Tuberculosis Symptoms: As the infection comes under control, symptoms such as persistent cough, chest discomfort, fever, night sweats, and fatigue gradually improve, helping you regain strength and overall well-being.
  • Supports Effective Tuberculosis Treatment: The combination of two anti-tuberculosis medicines works together to fight the infection more effectively, helping reduce the bacterial load and support successful treatment outcomes.
  • Simplifies Long-Term Treatment: By combining two medicines into a single oral treatment, RIMACTAZID DISPED 50MG TABLET reduces the number of tablets you need to take each day. This convenience can help improve treatment adherence and support completion of the full course of therapy.
     
Side effects of Rimactazid Disped 50mg Tablet

Directions for Use

  • Take RIMACTAZID DISPED 50MG TABLET exactly as prescribed by your doctor. Do not change your dose or stop taking it without consulting them.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine on an empty stomach, either 1 hour before or 2 hours after meals, to ensure the medicine is properly absorbed by your body.
  • Keep taking this medication for the full length of time prescribed by your doctor, even if your symptoms disappear after a few weeks.
     

How RIMACTAZID DISPED 50MG TABLET Works

RIMACTAZID DISPED 50MG TABLET is a combination medicine containing two active ingredients, rifampicin and isoniazid, which target the target bacteria in different ways to ensure the infection is thoroughly cleared. The first active ingredient, rifampicin, works by blocking a specific enzyme known as RNA polymerase, which the bacteria need to make proteins and reproduce. This effectively stops the bacteria from multiplying. The second active ingredient, isoniazid, targets the protective outer cell wall of the bacteria. It prevents the bacteria from building mycolic acid, a crucial component of their cell wall, causing the cell wall to break down and killing the bacteria.
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Alcohol

Unsafe

Avoid alcohol consumption while taking RIMACTAZID DISPED 50MG TABLET as it could lead to increased drowsiness, dizziness and liver damage.

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Pregnancy

Caution

Please consult your doctor if you are pregnant, your doctor will prescribe RIMACTAZID DISPED 50MG TABLET only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

RIMACTAZID DISPED 50MG TABLET passes into breast milk. Do not breastfeed while taking RIMACTAZID DISPED 50MG TABLET.

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Driving

Caution

RIMACTAZID DISPED 50MG TABLET may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking RIMACTAZID DISPED 50MG TABLET if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking RIMACTAZID DISPED 50MG TABLET.

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Children

Consult your doctor

Please consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.

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Heart

Caution

RIMACTAZID DISPED 50MG TABLET can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Unsafe

RIMACTAZID DISPED 50MG TABLET is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of RIMACTAZID DISPED 50MG TABLET

Do not take more than the prescribed dose of RIMACTAZID DISPED 50MG TABLET as it may cause overdose. The symptoms of overdose include stomach pain, nausea, vomiting, headache, itching, tiredness, dizziness, lightheadedness, drowsiness, fainting, blurred vision, or hallucinations. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Drinking alcohol while taking this medicine significantly increases the risk of serious liver damage.
  • Avoid certain foods: Do not eat foods high in tyramine and histamine, such as aged cheeses, red wine, soy sauce, yeast extracts, and certain fish like tuna or mackerel. Combining these foods with this medicine can trigger flushing, sweating, a rapid heartbeat, or headaches.
  • Take Vitamin B6 (pyridoxine) if recommended: Your doctor may advise taking a vitamin B6 supplement daily to help prevent nerve tingling or numbness caused by isoniazid.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys filter the medication safely.
     
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How Soon It Starts Working

The time required for RIMACTAZID DISPED 50MG TABLET to start to work: The time required for RIMACTAZID DISPED 50MG TABLET to show its action is unknown. The time for which the effects of RIMACTAZID DISPED 50MG TABLET last: The duration of action for RIMACTAZID DISPED 50MG TABLET is unknown.

What if you forget to take RIMACTAZID DISPED 50MG TABLET

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store RIMACTAZID DISPED 50MG TABLET at room temperature, ideally between 15°C and 30°C (59°F to 86°F), in a dry place. •Keep the medicine in its original container to protect it from direct light and moisture. Do not store it in the bathroom.

Drug Warnings

  • Expect your body fluids (urine, tears, sweat, saliva) to turn red-orange; this is a harmless side effect of the medicine.
  • Avoid wearing soft contact lenses during treatment, as they may become permanently stained by your tears.
  • Do not stop taking this medicine early, even if you feel completely better, to prevent the bacteria from becoming resistant to antibiotics.
  • Use a non-hormonal method of birth control (such as condoms), as RIMACTAZID DISPED 50MG TABLET can make hormonal contraceptives like birth control pills, patches, or implants less effective.
  • Attend all scheduled appointments for blood tests so your doctor can regularly monitor your liver function throughout your treatment.
     

Drug-Drug Interactions

verifiedApollotooltip

Before using RIMACTAZID DISPED 50MG TABLET, it is important to understand how it may interact with other medicines, foods, or existing health conditions.

Drug-Drug Interactions

  • Hormonal contraceptives: RIMACTAZID DISPED 50MG TABLET may reduce the effectiveness of certain hormonal contraceptives. Discuss appropriate contraceptive options with your doctor, who may recommend additional or alternative methods of birth control during treatment.
  • Blood thinners (e.g., warfarin): This medicine may reduce the effectiveness of anticoagulants, potentially affecting blood clotting control. Your doctor may need to monitor your clotting parameters and adjust treatment if necessary.
  • Anti-seizure medicines (e.g., phenytoin): Taking RIMACTAZID DISPED 50MG TABLET with certain anticonvulsants may alter the levels or effects of either medicine, potentially increasing the risk of side effects or affecting seizure control. Close monitoring may be required.
  • Antifungal medicines (e.g., ketoconazole): RIMACTAZID DISPED 50MG TABLET may reduce the absorption and effectiveness of certain antifungal medications, which could make fungal infections more difficult to treat.

Drug-Food Interactions

  • Foods high in tyramine or histamine (e.g., aged cheese, red wine, tuna): Consuming large amounts of these foods may increase the risk of symptoms such as flushing, itching, headache, palpitations, or a rapid heart rate in susceptible individuals.

Drug-Disease Interactions

  • Liver disease: Use RIMACTAZID DISPED 50MG TABLET with caution if you have liver impairment. The medicine may worsen underlying liver conditions or increase the risk of liver-related side effects. Your doctor may recommend regular liver function monitoring during treatment.
  • Diabetes: RIMACTAZID DISPED 50MG TABLET may affect blood glucose control, making blood sugar levels more difficult to manage. Patients with diabetes should monitor their blood sugar regularly and consult their doctor if significant changes occur.
  • Gout: This medicine may increase uric acid levels in the blood, which can trigger or worsen gout attacks in susceptible individuals. Patients with a history of gout should discuss appropriate monitoring and management with their healthcare provider.
     
Rifampicin + IsoniazidSaquinavir
Critical
Rifampicin + IsoniazidVoriconazole
Critical

Drug-Drug Interactions

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Rifampicin + IsoniazidSaquinavir
Critical
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking saquinavir with Rimactazid Disped 50mg Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidVoriconazole
Critical
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking voriconazole with Rimactazid Disped 50mg Tablet can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between voriconazole and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidRanolazine
Critical
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking ranolazine with Rimactazid Disped 50mg Tablet can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidIndinavir
Critical
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking indinavir with Rimactazid Disped 50mg Tablet can reduce the blood levels and effects of indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidDarunavir
Critical
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking darunavir with Rimactazid Disped 50mg Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidDeflazacort
Severe
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking deflazacort with Rimactazid Disped 50mg Tablet may reduce the blood levels and effects of deflazacort.

How to manage the interaction:
Although there is an interaction between deflazacort and Rimactazid Disped 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidTenofovir alafenamide
Severe
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking tenofovir alafenamide with Rimactazid Disped 50mg Tablet can reduce blood levels of tenofovir and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between Rimactazid Disped 50mg Tablet and tenofovir alafenamide, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidApremilast
Severe
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking apremilast with Rimactazid Disped 50mg Tablet can reduce blood levels and also increase the risk of side effects of Rimactazid Disped 50mg Tablet.

How to manage the interaction:
Although there is an interaction between Rimactazid Disped 50mg Tablet and apremilast, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidBCG vaccine
Severe
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking the BCG vaccine with Rimactazid Disped 50mg Tablet can increase the risk of side effects, which can lead to liver problems.

How to manage the interaction:
Although there is a possible interaction between Rimactazid Disped 50mg Tablet and BCG vaccine, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Rifampicin + IsoniazidTenofovir disoproxil
Severe
How does the drug interact with Rimactazid Disped 50mg Tablet:
Taking tenofovir disoproxil with Rimactazid Disped 50mg Tablet can reduce blood levels of tenofovir disoproxil and also reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between Rimactazid Disped 50mg Tablet and tenofovir disoproxil, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

RIMACTAZID DISPED 50MG TABLET is a combination of two anti-tuberculosis medicines, Rifampicin and Isoniazid, used to treat and prevent tuberculosis (TB). These medicines work together to kill Mycobacterium tuberculosis, the bacteria that causes TB.
RIMACTAZID DISPED 50MG TABLET is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, RIMACTAZID DISPED 50MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).
No. Do not stop taking RIMACTAZID DISPED 50MG TABLET even if your symptoms, such as cough, improve. Stopping treatment early may allow the bacteria to survive, causing the infection to return and increasing the risk of drug-resistant tuberculosis. Complete the full course prescribed by your doctor.
Do not take RIMACTAZID DISPED 50MG TABLET along with antacids as it might decrease the effectiveness of RIMACTAZID DISPED 50MG TABLET. Maintain a minimum gap of 1hour between both.
Consult your doctor before taking RIMACTAZID DISPED 50MG TABLET with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from RIMACTAZID DISPED 50MG TABLET.
RIMACTAZID DISPED 50MG TABLET contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking RIMACTAZID DISPED 50MG TABLET.
Yes. RIMACTAZID DISPED 50MG TABLET may reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, rings, and implants. Use a reliable non-hormonal method of contraception, such as condoms, while taking this medicine. Consult your doctor for advice on suitable contraceptive options.
RIMACTAZID DISPED 50MG TABLET may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking RIMACTAZID DISPED 50MG TABLET. Do not worry as it is a common side-effect of RIMACTAZID DISPED 50MG TABLET.
Yes, RIMACTAZID DISPED 50MG TABLET might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking RIMACTAZID DISPED 50MG TABLET.
RIMACTAZID DISPED 50MG TABLET may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking RIMACTAZID DISPED 50MG TABLET.
Yes, RIMACTAZID DISPED 50MG TABLET may cause liver problems, particularly in adults over 35 years of age. Watch for symptoms such as yellowing of the skin or eyes, dark urine, pale stools, loss of appetite, severe nausea or vomiting, weakness, or persistent pain in the upper right side of the abdomen. Seek medical attention immediately if these symptoms occur. Your doctor may recommend regular liver function tests during treatment.
Before using RIMACTAZID DISPED 50MG TABLET, you should learn about its use, side effects, and limitations.
If you forget a dose of RIMACTAZID DISPED 50MG TABLET, take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
Take RIMACTAZID DISPED 50MG TABLET on an empty stomach, preferably 1 hour before food or 2 hours after food, to ensure optimal absorption and effectiveness.
Store RIMACTAZID DISPED 50MG TABLET in a cool, dry place out of sunlight and children's reach. Check the expiration date regularly. To dispose of it, place it in a plastic bag and throw it away in household trash. Never flush it down the toilet or sink.
You should avoid alcohol while taking RIMACTAZID DISPED 50MG TABLET strictly to ensure safety and efficacy, as it can increase the risk of liver damage when combined with medications like Isoniazid and Rifampicin.
Common side effects of RIMACTAZID DISPED 50MG TABLET may include drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhea, gas, and numbness. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects.
RIMACTAZID DISPED 50MG TABLET is generally considered safe when used as prescribed by a doctor. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
Tingling or numbness in your hands or feet can be a sign of nerve irritation. Your doctor may prescribe a vitamin B6 (pyridoxine) supplement to help prevent or treat this issue. Talk to your doctor right away if you notice these symptoms.
If you are pregnant or planning to become pregnant, you must discuss the benefits and potential risks of this medication with your healthcare provider. Treating tuberculosis is very important during pregnancy, but it requires careful medical supervision. Talk to your doctor for personalised advice.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6124 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Isoniazid And Rifampin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Isoniazid/rifampicin. 1999. [Accessed on 10 Apr. 2019]Check here
  4. Isoniazid Isoniazid. 2015. [Accessed on 10 Apr. 2019]Check here
  5. Lee N, Nguyen H. Ethambutol. StatPearls [Internet]. NIH National Library of Medicine. National Center for Biotechnology Information. [Revised in October 2022] [Accessed on 04th March 2023]Check here
  6. Tuberculosis. National Health Service. [Accessed on 04th March 2023]Check here
  7. Isoniazid and Rifampicin combination for latent tuberculosis. [Accessed on 02 Jun. 2026]Check here

Country of origin

United States

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - RIM0003
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