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compositionComposition:SEMAGLUTIDE-14MG
prescription
Prescription Medicine
info
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Rybelsus 14 mg Tablet is an antidiabetic medication used to improve glycaemic control in adult patients with type 2 diabetes mellitus when diet and exercise are not enough or when the other medicines are not enough to control your blood sugar levels. It works by promoting glycemic control via insulin secretion, and reducing postprandial glucagon secretion

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SEMAGLUTIDE-14MG

Manufacturer/Marketer :

Novo Nordisk India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rybelsus 14 mg Tablet

Rybelsus 14 mg Tablet is used to treat Type 2 diabetes in adlts. Type 2 diabetes is a common condition that causes the level of glucose (sugar) in the blood to become too high. It's a lifelong condition that can affect your everyday life. You may need to adjust your diet, take medication, and undergo regular checkups to lead a normal life.

Rybelsus 14 mg Tablet contains semaglutide, which reduces blood sugar (glucose) levels by increasing insulin release while lowering glucagon secretion. Rybelsus 14 mg Tablet resembles a natural hormone, GLP-1, released from the body after eating.

Not everyone who is taking Rybelsus 14 mg Tablet will get these side effects. The most common side effects of Rybelsus 14 mg Tablet are low blood glucose levels, diabetic eye disease (retinopathy), nausea, vomiting, diarrhoea, and upset stomach. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, consult your doctor.

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day. Tell your doctor if your condition does not improve or worsens (if your blood sugar is too high or too low).

It is recommended not to take Rybelsus 14 mg Tablet if you are allergic to any of its components. You should inform your doctor if you get eye problems. If you have significant and ongoing stomach pain, consult a doctor immediately, as this could be a sign of an inflamed pancreas (acute pancreatitis). Avoiding alcohol is recommended to rule out any risk of lactic acidosis or other complications. Rybelsus 14 mg Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Consult the doctor if you are pregnant or breastfeeding. 

It is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, limb loss, and sexual dysfunction. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Uses of Rybelsus 14 mg Tablet

Rybelsus 14 mg Tablet is used in the treatment of Type 2 diabetes mellitus in adults. The detailed uses of Rybelsus 14 mg Tablet are as follows:

  • Type 2 Diabetes Management: Rybelsus 14 mg Tablet is primarily prescribed to help manage blood sugar levels in individuals with type 2 diabetes.
  • Improving Glycemic Control: Rybelsus 14 mg Tablet works by stimulating insulin secretion in response to meals, which helps in maintaining better overall glycemic control for patients with diabetes.
  • Reduced Risk of Hypoglycemia: Unlike some other diabetes medications, Rybelsus 14 mg Tablet is less likely to cause low blood sugar (hypoglycemia) when taken alone, making it a safer option for some patients.

Key Benefits

  • Rybelsus 14 mg Tablet is used to treat type 2 diabetes in people 18 years and older.
  • It is used when diet and exercise are not enough on their own, or when you cannot use another diabetes medicine, or when the other drugs are not enough to control or maintain your blood sugar levels.
  • Rybelsus 14 mg Tablet promotes glycemic control via several mechanisms, including insulin secretion, slowing gastric emptying, and reducing postprandial glucagon secretion.
  • Changes to diet and exercise are often combined with this medication.
Side effects of Rybelsus 14 mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

Directions for Use

  • Take Rybelsus 14 mg Tablet exactly as directed by your doctor, either with or without food. Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the medicine, as this can interfere with how the medication works.
  • Finish the entire course of treatment, even if you start feeling better, to ensure the infection is fully treated.
  • Stopping the medication early or adjusting the dose without consulting your doctor can lead to the infection not being completely cleared and may cause resistance.

How Rybelsus 14 mg Tablet Works

Rybelsus 14 mg Tablet comprises semaglutide. It resembles a natural hormone, GLP-1, released from the body after eating. It reduces blood sugar (glucose) levels by increasing insulin release while lowering glucagon secretion.
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Alcohol

Unsafe

It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

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Pregnancy

Caution

Rybelsus 14 mg Tablet is not recommended during pregnancy, as it is unknown if it affects your unborn baby. Please discuss this with your doctor if you have any concerns regarding this.

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Breast Feeding

Consult your doctor

Rybelsus 14 mg Tablet should not be used if you are breastfeeding because it is unknown whether it goes into breast milk. Please discuss this with your doctor if you have any concerns regarding this.

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Driving

Caution

Caution should be exercised. If your blood sugar is too low or too high, your driving ability may be affected. Do not drive if these symptoms appear.

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Liver

Consult your doctor

Limited information was available for the use of Rybelsus 14 mg Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Rybelsus 14 mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Caution should be exercised in people with kidney impairment while using Rybelsus 14 mg Tablet . Inform your doctor before taking the Rybelsus 14 mg Tablet if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Rybelsus 14 mg Tablet is not indicated for children and adolescents under 18 since the safety and efficacy in this age range have not been verified.

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Heart

Safe if prescribed

Rybelsus 14 mg Tablet is generally considered safe for heart patients. However, please consult your doctor before using Rybelsus 14 mg Tablet .

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Geriatrics

Safe if prescribed

Rybelsus 14 mg Tablet is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Rybelsus 14 mg Tablet

Avoid taking more than the prescribed dose of Rybelsus 14 mg Tablet as it can cause serious side effects. Overdose of Rybelsus 14 mg Tablet include nausea, vomiting, abdominal pain, fainting, headache, migraine, dehydration. Seek immediate medical attention if you observe any of these side effects.

Diet & Lifestyle Advise

  • Eat at regular intervals. Do not take a long gap between meals or snacks.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest in at least 150 min of moderate-intensity physical activity and 15 minutes of exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole-grain foods. Increase fruits, vegetables and other fibre-enriched foods in your diet.
  • Reduce saturated fat foods such as chips, crisps, pastries, biscuits, and samosas.
  • Choose omega-3 fatty acid-containing oils for daily cooking.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Avoid drinking alcohol while on Rybelsus 14 mg Tablet . It increases the risk of hypoglycaemia (a decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).
  • Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar, etc.
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How Soon It Starts Working

The time required for Rybelsus 14 mg Tablet to start to work: Rybelsus 14 mg Tablet ideally shows its action within 1 hour after administration. The time for which the effects of Rybelsus 14 mg Tablet last: The duration of action for Rybelsus 14 mg Tablet is unknown.

What if you forget to take Rybelsus 14 mg Tablet

If you miss a dose, take it as soon as you remember. If it's too close to your next dose, skip the missed dose. Do not take two doses at once. Always consult your doctor if you're unsure.

Storage

• Store in a cool and dry place away from sunlight.• Keep Rybelsus 14 mg Tablet out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • It is recommended not to take Rybelsus 14 mg Tablet if you are allergic to any of its components.
  • You should inform your doctor if you get eye problems, such as changes in vision, during treatment with this medicine, as the Rybelsus 14 mg Tablet may lead to complications of diabetic eye disease (retinopathy).
  • When taking this medication, you may feel nauseous, sick (vomiting), or have diarrhoea. These adverse effects may result in dehydration (loss of fluids). You must consume enough water to avoid dehydration, especially if you have kidney issues. If you have any questions or concerns, consult your doctor.
  • If you have significant and ongoing stomach pain, consult a doctor immediately, as this could be a sign of an inflamed pancreas (acute pancreatitis).
  • Avoiding alcohol is recommended to rule out any risk of lactic acidosis or other complications.
  • Do not take more than the recommended dose of medicine, as it can cause undesirable effects.
  • Be alert for signs of low blood sugar (hypoglycemia), such as sweating, dizziness, dry mouth, dry skin, fast heartbeat, shivering, intense thirst, or frequent urination. If you experience any of these symptoms, take honey or sugar candies right away.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Rybelsus 14 mg Tablet may have interaction with hormonal medications (e.g. levothyroxine), oral anticoagulants (warfarin), certain anti-diabetic medications (e.g. insulin), anti-cancer medications (e.g. bexarotene) and certain antibiotics (e.g. gatifloxacin).

Drug-Food Interactions: No interactions found/established. 

Drug-Disease Interactions: Rybelsus 14 mg Tablet may interact with disease conditions, including suicidal behaviour and ideation, thyroid cancer, GI adverse events, hypoglycaemia, pancreatitis and retinopathy.

SemaglutideGatifloxacin
Critical
SemaglutideBexarotene
Severe

Drug-Drug Interactions

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SemaglutideGatifloxacin
Critical
How does the drug interact with Rybelsus 14 mg Tablet:
Coadministration of Rybelsus 14 mg Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Rybelsus 14 mg Tablet can be taken with Gatifloxacin if prescribed by the doctor. Consult the doctor if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without first consulting your doctor.
SemaglutideBexarotene
Severe
How does the drug interact with Rybelsus 14 mg Tablet:
Co-administration of Bexarotene and Rybelsus 14 mg Tablet can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Bexarotene and Rybelsus 14 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Rybelsus 14 mg Tablet is used to improve glycaemic control in adult patients with type 2 diabetes mellitus when diet and exercise are not enough or when the other medicines are not enough to control your blood sugar levels.
Rybelsus 14 mg Tablet contains semaglutide. Semaglutide is a GLP-1 hormone that enhances glycemic control through various mechanisms, including insulin secretion, slowing gastric emptying, and decreasing postprandial glucagon secretion. This drug is frequently paired with dietary and exercise changes. Altogether Rybelsus 14 mg Tablet reduces sugar levels in the body.
Low blood glucose levels are referred to as hypoglycaemia. Rybelsus 14 mg Tablet may result in hypoglycaemia. Hypoglycaemia can occur if you skip or delay eating, drink alcohol, exercise strenuously, or take other diabetes medications in addition to Rybelsus 14 mg Tablet .
Do not stop taking Rybelsus 14 mg Tablet without first consulting your doctor. Take Rybelsus 14 mg Tablet for as long as the doctor has instructed. Consult a doctor if you have any problems while taking Rybelsus 14 mg Tablet .
Take the missed dose as soon as you remember. If it is time for the next scheduled dose, skip the missing dose and resume your regular dosing regimen. Do not double the dose.
Caution should be exercised if you have severe and ongoing pain in the stomach area. It is recommended to consult a doctor immediately, as this could signify an inflamed pancreas (acute pancreatitis). Your doctor will weigh the benefits and potential risks before prescribing this medication.
Rybelsus 14 mg Tablet is not recommended to treat type 1 diabetes (your body produces no insulin).
Rybelsus 14 mg Tablet should not be used if you have type 1 diabetes or diabetic ketoacidosis or if you are allergic to Semaglutide or any of the other ingredients of this medicine.
No, Rybelsus 14 mg Tablet is not a weight loss pill. It is an anti-diabetic agent used to treat type 2 diabetes mellitus.
Rybelsus 14 mg Tablet contains Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Rybelsus 14 mg Tablet can be taken with other diabetes medications if prescribed by the doctor. However, taking Rybelsus 14 mg Tablet with other diabetes medications may increase the risk of hypoglycaemia (low blood sugar).
Rybelsus 14 mg Tablet may cause serious adverse effects like thyroid C-cell tumours, pancreatitis, diabetic retinopathy complications, acute kidney injury, hypersensitivity, and acute gall bladder disease. Consult the doctor if you notice any unusual symptoms.
Though Rybelsus 14 mg Tablet is not indicated for weight loss, it may help you lose some weight. However, Rybelsus 14 mg Tablet should not be used for weight loss as it is used to treat type 2 diabetes.
Rybelsus 14 mg Tablet is not recommended for use during pregnancy and lactation as it might cause foetal harm and potentially serious adverse reactions in breastfed infants.
Rybelsus 14 mg Tablet should be stored at room temperature (20°C to 25°C) in a dry place away from moisture. Keep it out of sight and reach of children.
Rybelsus 14 mg Tablet may start working within 1-2 weeks of beginning. However, it might take a few weeks to see full benefits.
Consult the doctor if any of the side effects bother you or do not go away. The doctor will guide you appropriately.
Rybelsus 14 mg Tablet should be taken on an empty stomach when you first wake up. It should be swallowed as a whole with water; do not crush, split or chew it. You can eat or drink 30 minutes after taking Rybelsus 14 mg Tablet .
Rybelsus 14 mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, abdominal pain, decreased appetite, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, consult your doctor.
You should inform the doctor if you get eye problems, such as changes in vision, during treatment with this medicine as the Rybelsus 14 mg Tablet may lead to complications of diabetic eye disease (retinopathy). When taking this medication, you may feel nauseous, sick (vomiting), or have diarrhoea. These adverse effects may result in dehydration (loss of fluids). You must consume enough water to avoid dehydration, especially if you have kidney issues.
Concomitant use of Rybelsus 14 mg Tablet with other medicines like sulfonylureas or insulin may cause hypoglycaemia. Also, as Rybelsus 14 mg Tablet can delay gastric emptying, it can impact the absorption of other medicines like levothyroxine. Hence, it is advised to consult the doctor and follow administration instructions if you are taking any other medicines.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.11507 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db13928 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Semaglutide Drug Interactions Database Summary. Auckland, NZ: Drugs.com Clinical Review Team; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Roder ME. Clinical potential of treatment with semaglutide in type 2 diabetes patients. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. December 2019. [Accessed on 25th March 2026]Check here
  5. Novo Nordisk A/S. Electronic Medicines Compendium (EMC). [Revised in January 2026] [Accessed on 25th March 2026]Check here
  6. Semaglutide [Prescribing Information]. 2024. [Accessed on 10 Oct. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No.32, 47-50, Epip Area, Whitefield, Bangalore - 560 066
Other Info - RYB0006
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