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compositionComposition:SULFASALAZINE-1000MG
prescription
Prescription Medicine
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Salazar DS Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. It contains Sulfasalazine, which works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, that control pain and inflammation. Thus, it helps reduce the inflammation of the intestine, skin, and joints. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SULFASALAZINE-1000MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Salazar DS Tablet

Salazar DS Tablet is a prescription medicine used to reduce inflammation and help manage certain chronic inflammatory conditions. It is commonly prescribed for inflammatory bowel diseases such as ulcerative colitis and for inflammatory joint conditions such as rheumatoid arthritis. By helping control inflammation, this medicine can reduce symptoms and support long-term disease management.

Take Salazar DS Tablet exactly as prescribed by your doctor. It is usually taken with food and a full glass of water to help reduce stomach discomfort. Taking the medicine regularly, even when you feel well, helps maintain symptom control and reduce the risk of disease flare-ups.

Some people may experience mild side effects such as nausea, headache, loss of appetite, or stomach discomfort when starting treatment. These effects are often temporary and may improve as your body adjusts to the medicine. However, contact your doctor promptly if you develop severe skin reactions, unusual bruising or bleeding, yellowing of the skin or eyes, persistent fever, or signs of an allergic reaction.

Before taking Salazar DS Tablet , inform your doctor if you have kidney disease, liver disease, asthma, blood disorders, or a history of allergies to sulfonamides or aspirin-containing medicines. This medicine may not be suitable for people with certain intestinal or urinary tract blockages.

Limit alcohol consumption while taking this medicine, as excessive alcohol use may increase the risk of liver-related side effects. Tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or trying to conceive so they can determine whether this medicine is appropriate for you. 

Uses of Salazar DS Tablet

Salazar DS Tablet is used to treat inflammatory bowel diseases and inflammatory joint conditions. The detailed uses of Salazar DS Tablet are as follows:

  • Ulcerative Colitis: Helps reduce inflammation in the lining of the large intestine and supports both symptom control and maintenance of remission.
  • Rheumatoid Arthritis: Helps reduce joint pain, swelling, stiffness, and inflammation in people with rheumatoid arthritis.
  • Crohn's Disease: May be used in selected patients with mild-to-moderate inflammatory bowel disease, particularly when inflammation affects the colon.
  • Other Inflammatory Conditions: In certain situations, doctors may prescribe this medicine for other inflammatory disorders based on individual patient needs.

Key Benefits

Salazar DS Tablet helps control chronic inflammation and supports long-term management of inflammatory conditions. Regular treatment may improve comfort, mobility, and overall quality of life.

  • Improved Joint Comfort: Helps reduce pain, stiffness, and swelling associated with inflammatory arthritis.
  • Better Physical Function: Supports improved movement and daily activities by helping control inflammation.
  • Supports Digestive Health: Helps reduce symptoms such as abdominal discomfort, diarrhoea, and rectal bleeding associated with ulcerative colitis.
  • Helps Prevent Disease Flare-Ups: Consistent use may reduce the frequency and severity of symptom recurrence in chronic inflammatory conditions.
Side effects of Salazar DS Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

To get the full benefit of Salazar DS Tablet and minimise side effects, follow these simple guidelines:

  • Take the tablet orally with food and a full glass of water.
  • Swallow the tablet whole. Do not crush, chew, or break it unless specifically instructed by your doctor.
  • Drink plenty of fluids throughout the day to help support healthy kidney function.
  • Take the medicine at the same time each day to maintain consistent levels in your body.
  • Continue taking the medicine regularly unless your doctor advises otherwise.
  • Always follow your doctor's exact instructions regarding dosage and duration of treatment.
     

How Salazar DS Tablet Works

Salazar DS Tablet contains sulfasalazine. After it reaches the intestine, natural bacteria break the medicine into active components that help reduce inflammation. Reduces Inflammation in the Bowel: One component acts directly within the intestine to help decrease inflammation and tissue irritation. Modulates Immune Activity: The medicine helps regulate inflammatory processes that contribute to joint swelling and stiffness in rheumatoid arthritis. Supports Long-Term Disease Control: By reducing inflammation in affected tissues, the medicine helps improve symptoms and may slow disease progression in certain conditions. Through these actions, Salazar DS Tablet helps manage symptoms and support long-term control of inflammatory diseases.
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Alcohol

Unsafe

It is not recommended to consume alcohol while taking Salazar DS Tablet to avoid unpleasant side-effects.

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Pregnancy

Consult your doctor

Salazar DS Tablet should be recommended in pregnancy only if required. In case, if prescribed to a pregnant woman, it is advised to increase the folate supplementation after consulting your doctor.

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Breast Feeding

Unsafe

Salazar DS Tablet is excreted in breastmilk and is not recommended especially if the baby is premature or is at the risk of jaundice. It might cause kernicterus (excessive levels of bilirubin in the blood) in the new-born.

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Driving

Safe if prescribed

Salazar DS Tablet does not affect the ability to drive. However, if you feel drowsy after taking Salazar DS Tablet , it is advised not to drive.

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Liver

Unsafe

Salazar DS Tablet is not recommended to use in patients with a history of liver diseases. In other people, rarely, it can cause hepatitis (inflammation of the liver).

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Kidney

Unsafe

Salazar DS Tablet is not recommended to use in patients with a history of kidney diseases. In other people, rarely it can cause inflammation of the kidneys.

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Children

Consult your doctor

Salazar DS Tablet should be advised in children only if prescribed by a child specialist.

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Heart

Consult your doctor

Please consult your doctor before using Salazar DS Tablet if you have pre-existing heart problems. Your doctor will prescribe Salazar DS Tablet if the benefits outweigh the risks.

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Geriatrics

Caution

Salazar DS Tablet should be used under caution in geriatric patients as it can lead to serious side effects.

What if I have taken an overdose of Salazar DS Tablet

Do not take more than the prescribed dose of Salazar DS Tablet as it may cause an overdose. The symptoms of overdose include stomach pain, seizures (fits), tiredness, nausea and vomiting. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Drink plenty of water throughout the day to help reduce the risk of kidney-related complications.
  • Follow an Appropriate Diet: If you have inflammatory bowel disease, follow your healthcare provider's dietary recommendations, particularly during flare-ups.
  • Protect Your Skin from Sunlight: This medicine may increase sensitivity to sunlight. Use sunscreen and wear protective clothing when spending time outdoors.
  • Stay Physically Active: Gentle exercise such as walking, swimming, or cycling may help maintain joint flexibility and mobility.
  • Be Aware of Colour Changes: The medicine may cause harmless yellow-orange discoloration of urine, sweat, or tears.
     

Health Queries

I have been suffering from left knee pain for three years. Despite taking sulfasalazine for three months, SAMe 400 for two months, and glucosamine for four months, and continuing with calcium and vitamin D3, my pain persists. What medications or treatment options should I consider next?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Since your pain persists despite trying anti-inflammatory and joint-support medications, I recommend consulting an orthopedic specialist or rheumatologist for a detailed evaluation, possibly including a knee X-ray or MRI. Next treatment steps to discuss with your doctor include: Pain Relief: Topical NSAIDs (like diclofenac gel) or oral NSAIDs (like naproxen) for targeted pain management. Joint Injections: Corticosteroid or hyaluronic acid injections directly into the knee to reduce inflammation and provide lubrication. Physical Therapy: Structured exercises to strengthen the muscles supporting your knee. Prescription Adjustments: If an inflammatory condition is confirmed, your doctor may consider alternative medications like methotrexate.

What medications are recommended for treating knee joint pain associated with polyarthritis?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

To manage knee pain from polyarthritis, treatment typically combines immediate pain relief with long-term disease control. For joint pain and swelling, nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen or ibuprofen, or acetaminophen are commonly used. To target the underlying polyarthritis and prevent joint damage, doctors often prescribe Disease-Modifying Antirheumatic Drugs (DMARDs) such as methotrexate or sulfasalazine. For acute flare-ups, temporary use of oral corticosteroids like prednisone or a direct joint injection can provide rapid relief. Please consult your physician to design a personalised treatment plan, as these medications require professional monitoring to ensure safety and effectiveness.

I have been suffering from ankylosing spondylitis for the last five years. My haemoglobin level is consistently low. I am taking Salazar DS Tablet twice daily. What medicine should I take for my low blood count?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Persistent low haemoglobin may result from haemolytic anaemia, a rare side effect of Salazar DS Tablet (sulfasalazine), or from other causes such as iron, vitamin B12, or folate deficiencies, or anaemia of chronic disease. It is crucial to have a complete blood test and consult your doctor before starting any treatment. Depending on the cause, your doctor may recommend appropriate supplements, adjust your sulfasalazine dosage, or monitor you closely for signs of anaemia. Regular follow-up is essential to prevent complications and ensure safe and effective treatment.
health query

Have a query?

How Soon It Starts Working

The time required for Salazar DS Tablet to start to work: The time required for Salazar DS Tablet to show its action is not clinically established. The time for which the effects of Salazar DS Tablet last: The duration of action for Salazar DS Tablet is not clinically established.

What if you forget to take Salazar DS Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store Salazar DS Tablet at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from moisture and light.

Drug Warnings

  • Attend Regular Blood Tests: Your doctor may monitor your blood counts, liver function, and kidney function during treatment.
  • Monitor for Signs of Infection: Report persistent fever, chills, sore throat, or other symptoms of infection to your healthcare provider.
  • Check for Skin Reactions: Seek medical advice if you develop a rash, blistering, or unusual skin changes.
  • Inform Healthcare Providers: Tell your doctor, dentist, or surgeon that you are taking this medicine before any procedure.
  • Be Aware of Contact Lens Staining: Soft contact lenses may become permanently discoloured due to changes in tear colour.
     

Drug-Drug Interactions

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Drug-Drug Interactions
Inform your doctor if you are taking any of the following medicines, as they may interact with Salazar DS Tablet :

  • Digoxin: Sulfasalazine may reduce the absorption of digoxin, potentially decreasing its effectiveness.
  • Blood Thinners: Medicines such as warfarin may increase the risk of bleeding when used together.
  • Oral Diabetes Medicines: May increase the risk of low blood sugar in some patients.
  • Methotrexate: Concurrent use may increase the risk of certain side effects and may require closer monitoring.
  • Folic Acid Supplements: Sulfasalazine may reduce folic acid absorption, and supplementation may be recommended.

Drug-Food Interactions

  • Iron Supplements: Iron may reduce the absorption of sulfasalazine. Your doctor may recommend separating the timing of these medicines.
  • Alcohol: Excessive alcohol consumption may increase the risk of liver-related side effects.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Salazar DS Tablet , as it may worsen your condition or require additional monitoring:

  • Kidney Disease: May increase the risk of kidney-related complications.
  • Liver Disease: May increase the risk of liver toxicity.
  • Asthma: Some people with asthma may be more likely to experience allergic or sensitivity reactions.
  • Blood Disorders: Sulfasalazine may affect blood cell production and require closer monitoring.
     
SulfasalazineCidofovir
Critical
SulfasalazineWarfarin
Severe

Drug-Drug Interactions

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SulfasalazineCidofovir
Critical
How does the drug interact with Salazar DS Tablet:
Coadministration of Cidofovir with Salazar DS Tablet can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Salazar DS Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SulfasalazineWarfarin
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of warfarin with Salazar DS Tablet can increase the risk of unusual bleeding disorder.

How to manage the interaction:
Although taking Salazar DS Tablet and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache; and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
SulfasalazineBupivacaine
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of bupivacaine and Salazar DS Tablet may result in methemoglobinemia, an uncommon disorder that lowers the blood's ability to carry oxygen, which can induce oxygen deprivation in tissues and essential organs.

How to manage the interaction:
Although taking bupivacaine and Salazar DS Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
SulfasalazineTenofovir disoproxil
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of Salazar DS Tablet and Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking Salazar DS Tablet and Tenofovir disoproxil together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SulfasalazineSirolimus
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of Sirolimus together with Salazar DS Tablet may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Sirolimus with Salazar DS Tablet together can result in an interaction, but it can be taken if a doctor has advised it. Contact a doctor if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without a doctor's advice.
SulfasalazineLeflunomide
Severe
How does the drug interact with Salazar DS Tablet:
Taking Salazar DS Tablet with leflunomide can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between Salazar DS Tablet and leflunomide, it can be taken if prescribed by a doctor. Contact a doctor immediately if you develop paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
SulfasalazineLevobupivacaine
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of Levobupivacaine with Salazar DS Tablet can increase the risk of methemoglobinemia (a rare red blood cell disorder).

How to manage the interaction:
Taking Levobupivacaine with Salazar DS Tablet together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray discoloration, nausea, headache, dizziness, fatigue, or shortness of breath, it's best to contact a doctor right away. They can help determine the cause and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
SulfasalazineProcaine
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of Salazar DS Tablet with Procaine can increase the risk of methemoglobinemia, (a rare red blood cell condition where the oxygen-carrying capacity decreases).

How to manage the interaction:
Although taking Procaine and Salazar DS Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
SulfasalazineDicoumarol
Severe
How does the drug interact with Salazar DS Tablet:
Using Dicoumarol together with Salazar DS Tablet may increase the risk or severity of bleeding. The risk increases in patients with a history of liver or kidney disorders.

How to manage the interaction:
There may be a possibility of interaction between Salazar DS Tablet and Dicoumarol, but it can be taken if prescribed by a doctor. However, if you experience unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness call a doctor. Do not discontinue any medications without consulting a doctor.
SulfasalazinePrilocaine
Severe
How does the drug interact with Salazar DS Tablet:
Coadministration of Salazar DS Tablet with Prilocaine can increase the risk of methemoglobinemia, (a rare red blood cell disorder in which oxygen carrying effectively reduces).

How to manage the interaction:
Although taking Prilocaine and Salazar DS Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Salazar DS Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis).
Yes, Salazar DS Tablet is contraindicated in patients with intestinal or urinary obstruction, patients with porphyria (liver disorders), and patients hypersensitive to sulfasalazine, its metabolites, sulfonamides, or salicylates.
In some men, sulfasalazine may temporarily reduce sperm count. This effect is generally reversible after treatment is stopped. Talk to your doctor or pharmacist if you are planning a family.
Yes, Salazar DS Tablet is safe to use in breastfeeding. However, please inform your doctor if the baby is premature or is at risk of jaundice as this medicine might not be advised in such cases.
Yes, Salazar DS Tablet can rarely affect blood cells and may cause conditions such as leukopenia (low white blood cell count) or, in rare cases, agranulocytosis. Because of this risk, your doctor may recommend regular monitoring with blood counts and other laboratory tests, including kidney and liver function tests. Monitoring is usually more frequent during the first year of treatment. Contact your doctor if you develop symptoms such as fever, sore throat, rash, or signs of infection.
No, Salazar DS Tablet is a disease-modifying anti-rheumatic drug’ (DMARD) and not a painkiller. So, if you are taking a painkiller before starting this medicine, you can continue taking it along with Salazar DS Tablet .
No, Salazar DS Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side-effects. If you think your symptoms are not improving, please consult your doctor.
Salazar DS Tablet may cause central nervous system adverse effects such as serious psychiatric problems including mania, depression, and psychosis, and these symptoms have been reported to occur only infrequently.
The side effects of Salazar DS Tablet include headache, nausea, indigestion and watery diaarhoea. If these side effects persist or worsen, please consult your doctor.
Improvement may take several weeks after starting Salazar DS Tablet . Some patients notice symptom relief within 4–6 weeks, while the full benefits may take 8–12 weeks or longer, especially in rheumatoid arthritis. Continue taking the medicine as prescribed and do not stop treatment without consulting your doctor.
You are recommended to avoid using azathioprine along with Salazar DS Tablet as it may decrease blood cell count, which can be a serious side effect. However, please consult your doctor before taking other medicines with Salazar DS Tablet to avoid drug interactions.
Yes. Salazar DS Tablet may cause harmless yellow-orange discoloration of urine, sweat, saliva, or tears. Because of this, soft contact lenses may become permanently stained and should be used with caution. However, yellowing of the skin or eyes should be reported to your doctor immediately, as it may indicate a liver problem.
No. The tablets should generally be swallowed whole with water unless your doctor specifically advises otherwise. Crushing or chewing them may affect how the medicine works. Talk to your doctor or pharmacist if you have difficulty swallowing tablets.
Your doctor will determine whether this medicine is appropriate during pregnancy based on your individual circumstances. Folic acid supplementation may be recommended. Talk to your doctor or pharmacist if you are pregnant or planning to become pregnant.

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Reference

  1. U.S. Food and Drug Administration (FDA). 007073S124Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Sulphaslazine2 - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Sulfasalazine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Sulfasalazine [EMC Label]. 2010. [Accessed on 23 Jan. 2019]Check here
  5. Sulfasalazine [Patient Information Leaflet]. 2018. [Accessed on 18 Jun. 2019]Check here
  6. Sulfasalazine [Prescribing Information]. 2014. [Accessed on 18 Jun. 2019]Check here
  7. Choi J, Fenando A Sulfasalazine. [Updated 2022 Nov 11]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023Check here

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - SAL0050
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