To manage knee pain from polyarthritis, treatment typically combines immediate pain relief with long-term disease control. For joint pain and swelling, nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen or ibuprofen, or acetaminophen are commonly used. To target the underlying polyarthritis and prevent joint damage, doctors often prescribe Disease-Modifying Antirheumatic Drugs (DMARDs) such as methotrexate or sulfasalazine. For acute flare-ups, temporary use of oral corticosteroids like prednisone or a direct joint injection can provide rapid relief. Please consult your physician to design a personalised treatment plan, as these medications require professional monitoring to ensure safety and effectiveness.