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  1. Home
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  3. Sambrace 400 Tablet 10's

Prescription drug
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Sambrace 400 Tablet 10's, Pack of 10 TabletS
Sambrace 400 Tablet 10's, Pack of 10 TabletS
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Extra 15% Off with Bank Offers

Composition :

S ADENOSYL L METHIONINE-400MG

Manufacturer/Marketer :

Rebrace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sambrace 400 Tablet

Sambrace 400 Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis, and depression. Alcoholic liver disease occurs due to liver damage caused by excessive alcohol consumption. Osteoarthritis is a condition that affects the joints. Depression is a mood disorder and a psychological, physiological and emotional experience that affects the way we think, the things we do and the way we act.

Sambrace 400 Tablet contains S-Adenosyl-L-Methionine, an essential amino acid required for optimal cellular functioning. Sambrace 400 Tablet is believed to monitor and regulate important physiological functions in living cells. It increases glutathione concentration and enhances liver metabolism. Sambrace 400 Tablet increases chondrocyte proteoglycan synthesis, thereby helping treat osteoarthritis.

Sambrace 400 Tablet may be taken with or without food, but it is better to take it at a designated time. It should be swallowed whole and not crushed or chewed. In some cases, Sambrace 400 Tablet may cause certain common side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform the doctor if you are allergic to any of the components of Sambrace 400 Tablet . Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Exercise caution when taking Sambrace 400 Tablet with any anti-Parkinsonian drugs or anti-depressants. It is not advisable to take alcohol with Sambrace 400 Tablet as there may be an interaction. Discuss your entire surgical history with your treating doctor and keep them informed of any pending surgical procedure.

Uses of Sambrace 400 Tablet

Sambrace 400 Tablet is used to treat various medical conditions. The detailed uses are as follows:

  • Treatment of Alcoholic Liver Disease: Sambrace 400 Tablet helps in managing mild to moderate alcoholic liver disease by enhancing glutathione levels, supporting liver detoxification, and improving overall liver metabolism.
  • Relief from Osteoarthritis Symptoms: Sambrace 400 Tablet supports joint health by promoting the production of proteoglycans in cartilage cells, which helps reduce joint pain and stiffness associated with osteoarthritis.
  • Management of Depression: Sambrace 400 Tablet may be used as an adjunct treatment for mild to moderate depression. It supports the production of neurotransmitters like serotonin and dopamine, which help regulate mood and emotional balance.

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Directions for Use

  • Sambrace 400 Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Sambrace 400 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Sambrace 400 Tablet contains S-Adenosyl-L-Methionine (SAMe), classified as a nutritional and metabolic agent.
  • It works by participating in key biochemical processes such as methylation, antioxidant defence, and neurotransmitter synthesis.
  • It supports liver health by enhancing detoxification, increasing glutathione levels, and promoting healthy liver metabolism.
  • It helps in osteoarthritis by stimulating proteoglycan production in cartilage cells, reducing joint pain and stiffness.
  • It aids in managing mild to moderate depression by supporting the production of mood-related neurotransmitters like serotonin and dopamine.

How Sambrace 400 Tablet Works

Sambrace 400 Tablet contains S-Adenosyl-L-Methionine; an essential amino acid required for optimal cellular functioning. Sambrace 400 Tablet is believed to monitor and regulate important physiological functions in living cells. It increases glutathione concentration and the metabolism of the liver. Sambrace 400 Tablet increases chondrocyte proteoglycan synthesis, thereby helping treat osteoarthritis.

Storage

• Store in a cool and dry place away from sunlight.• Keep Sambrace 400 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Sambrace 400 Tablet
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Swelling of the throat can worsen if there is no proper rest for your throat.
  • Drink plenty of warm fluids and frequently gargle with salt water.
  • Humidify the surrounding air using a humidifier, as dry air may increase dryness and throat pain.
  • Talk to your doctor if the swelling bothers you while swallowing food.
  • Take enough rest and stay in warm places to reduce pain quickly.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Sambrace 400 Tablet

Do not take more than the suggested dose. Using more medication will not improve your symptoms; rather, they may cause poisoning or serious side effects. If you suspect that you may have overdosed of Sambrace 400 Tablet or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

  • Do not take Sambrace 400 Tablet if you are allergic to any of its ingredients.
  • Inform your doctor about your complete medical history, especially if you have liver problems, kidney issues, bipolar disorder, or a weakened immune system.
  • Consult your doctor before using Sambrace 400 Tablet if you are pregnant, planning to become pregnant, or breastfeeding.
  • Use caution if you are taking antidepressants, anti-Parkinson’s medications, or any drugs that affect serotonin levels, as interactions may occur.
  • Avoid alcohol while taking Sambrace 400 Tablet , as it may interfere with liver function and the effectiveness of the supplement.
  • Tell your doctor about all suggested, over-the-counter, or herbal medicines you are taking.
  • Let your doctor know if you are scheduled for any surgery, as Sambrace 400 Tablet may affect anaesthesia or recovery.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Eat a liver-friendly diet: Include leafy greens, cruciferous vegetables (such as broccoli), garlic, and citrus fruits to support liver detoxification and maintain optimal antioxidant levels.
  • Limit alcohol completely: Alcohol worsens liver damage and interferes with the effectiveness of Sambrace 400 Tablet , strictly avoid it.
  • Include anti-inflammatory foods: Add fatty fish (rich in omega-3 fatty acids), turmeric, berries, and nuts to help manage joint pain and inflammation associated with osteoarthritis.
  • Avoid processed and sugary foods: These can worsen liver health, increase inflammation, and negatively impact mood.
  • Ensure adequate protein intake: Moderate intake of lean protein supports muscle strength (important for joint support) and cellular repair.
  • Stay well-hydrated: Proper hydration supports metabolism and the liver's ability to eliminate toxins.
  • Engage in regular physical activity: Low-impact exercises, such as walking, swimming, or yoga, improve joint flexibility and reduce symptoms of depression.
  • Maintain a healthy weight: Excess weight puts pressure on joints and worsens both liver disease and osteoarthritis.
  • Get adequate sunlight or vitamin D: It helps in bone and joint health and may enhance mood.
  • Practice stress-reducing techniques: Meditation, deep breathing, or mindfulness can support mental health and reduce depressive symptoms.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Sambrace 400 Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Sambrace 400 Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Sambrace 400 Tablet should be used with caution in pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

The use of Sambrace 400 Tablet should be exercised with caution in nursing mothers. Please consult a doctor.

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Driving

Caution

Sambrace 400 Tablet may cause drowsiness and dizziness in rare cases. Exercise caution while driving in case of these side effects.

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Liver

Consult your doctor

Sambrace 400 Tablet is possibly safe on the liver. Please consult your doctor if you have any concerns.

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Kidney

Consult your doctor

Sambrace 400 Tablet is possibly safe on the kidney. Please consult your doctor in case of any concerns.

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Children

Caution

It is not established if Sambrace 400 Tablet is safe to use in children. Please consult the treating doctor in case of any concerns.

FAQs

Sambrace 400 Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis‚ and depression.

Please see an orthopaedic doctor if you have had a fracture. Sambrace 400 Tablet is used in the case of arthritis and has limited use in the treatment of fractures, as fractures are more often a surgical concern.

Yes, Sambrace 400 Tablet finds a lot of benefit in treating depression. However, if you are on any antidepressants, keep your doctor informed to avoid any interactions.

In case you miss a dose of Sambrace 400 Tablet , take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.

Sambrace 400 Tablet is probably safe for the kidneys; however, in the case of CKD, it is best to consult your treating doctor before using Sambrace 400 Tablet .

Sambrace 400 Tablet works by synthesising methionine, an essential amino acid required for cellular energy.

Sambrace 400 Tablet may cause side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

Sambrace 400 Tablet should not be used by people who are allergic to any of its components. It is also not recommended for people with bipolar disorder, HIV, pregnant and nursing women.

Sambrace 400 Tablet contains S-Adenosylmethionine, a naturally occurring compound found in almost every tissue and fluid in the body. It is made in the body from methionine, an amino acid found in foods.

It is unknown whether Sambrace 400 Tablet is safe for long-term use. Take Sambrace 400 Tablet for the duration suggested by the doctor.

Country of origin

India
Other Info - SAM0189

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Aug 8, 2025 | 11:57 AM IST

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Reference

  1. https://www.webmd.com/vitamins/ai/ingredientmono-786/same
  2. https://www.drugs.com/npp/same.html
  3. https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth

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