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compositionComposition:S ADENOSYL L METHIONINE DISULFATE TOSYLATE-400MG
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Prescription Medicine
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Samford-400 Tablet is an amino acid used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis, and depression. It is a nutritional supplement that helps in optimal cellular functioning, monitors and regulates important physiological functions, and increases glutathione concentration and metabolism of the liver. It may be used to improve joint function and lessen discomfort and inflammation associated with osteoarthritis.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

S ADENOSYL L METHIONINE DISULFATE TOSYLATE-400MG

Manufacturer/Marketer :

Medford Pharmaceuticals

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Samford-400 Tablet

Samford-400 Tablet is a medicine primarily suggested to support liver function and relieve joint discomfort associated with osteoarthritis. It helps restore vital compounds in the body to protect liver cells and maintain healthy cartilage. Doctors often recommend it for managing intrahepatic cholestasis, a condition where bile flow from the liver is reduced.

For best results, this medicine must be taken consistently every day exactly as directed by your healthcare provider. It is typically taken on an empty stomach, at least one hour before or two hours after meals, to ensure optimal absorption. Incorporating a balanced, low-fat diet and staying well-hydrated can significantly enhance your recovery process.

While most people tolerate this medicine well, some may experience mild digestive issues like nausea or stomach discomfort. If you experience unusual mood changes, severe abdominal pain, or signs of a severe allergic reaction such as skin rash or trouble breathing, contact your doctor immediately.

Talk to your doctor before starting this medicine if you have bipolar disorder, as it may trigger manic episodes, or if you have a history of severe anxiety. Do not take this if you are allergic to any of its ingredients or if you have a genetic condition that affects methionine metabolism.

Avoid taking this medicine alongside certain antidepressants like SSRIs, as combining them can cause dangerously high levels of serotonin in your brain. Do not drink alcohol or smoke while on this medication, as they can worsen liver strain and reduce the treatment's effectiveness. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor before starting therapy.

Uses of Samford-400 Tablet

Samford-400 Tablet is used to support liver and joint health by protecting liver cells, improving bile flow, and helping maintain healthy joint function.

  • Intrahepatic cholestasis: Samford-400 Tablet helps improve bile flow from the liver, reducing symptoms like itching and protecting liver cells from damage.
  • Osteoarthritis: This medicine helps reduce joint pain and stiffness by promoting the production of key components that make up joint cartilage.
  • Supportive liver therapy: It helps protect liver cells from toxins by boosting the levels of glutathione, a natural antioxidant in the liver.

Key Benefits

Samford-400 Tablet supports healthy joints and liver function by relieving discomfort and protecting cells from damage. It helps improve mobility, promotes healthy bile flow, and supports overall well-being. Key benefits include:

  • Supports joint comfort: Helps reduce joint pain and stiffness, improving mobility and making daily activities easier.
  • Promotes liver health: Supports healthy liver function and helps protect liver cells from damage.
  • Relieves cholestasis-related symptoms: Helps improve bile flow and reduce itching associated with intrahepatic cholestasis.
  • Supports detoxification and antioxidant defence: Helps boost glutathione levels, protecting cells from oxidative stress and supporting overall energy levels.

Directions for Use

  • Samford-400 Tablet can be taken with or without food as advised by the doctor.
  • Strictly follow your doctor's recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Samford-400 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Samford-400 Tablet Works

Samford-400 Tablet contains S-adenosyl l-methionine (SAMe), a naturally occurring compound that acts as a vital donor of methyl groups, which are small chemical units essential for cellular repair and function. It helps produce glutathione, one of the liver's most powerful natural antioxidants. By increasing glutathione levels, this medicine protects liver cells from damage caused by harmful free radicals and toxins while also improving the flow of bile. In your joints, it plays a key role in the formation of proteoglycans, which are the building blocks of cartilage. By stimulating cartilage production and reducing inflammatory chemical signals, it helps cushion your joints, reducing the wear and tear that contributes to pain and stiffness.
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Alcohol

Consult your doctor

It is not known whether it is safe to consume alcohol with Samford-400 Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Consult your doctor

Please consult your doctor before taking Samford-400 Tablet if you are pregnant.

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Breast Feeding

Consult your doctor

Please consult your doctor before taking Samford-400 Tablet if you are breastfeeding.

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Driving

Caution

Samford-400 Tablet may rarely cause drowsiness and dizziness. Exercise caution while driving in case of these side effects.

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Liver

Consult your doctor

Samford-400 Tablet is possibly safe on the liver. Please consult your doctor if you have any concerns.

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Kidney

Consult your doctor

Samford-400 Tablet is possibly safe on the kidney. Please consult your doctor if you have any concerns.

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Children

Consult your doctor

It is not established whether Samford-400 Tablet is safe for children. Please consult the treating doctor if you have any concerns.

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Heart

Safe if suggested

Samford-400 Tablet is generally considered safe for heart patients when taken at the recommended dose. However, please consult your doctor if you have any concerns.

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Geriatrics

Consult your doctor

Samford-400 Tablet should be given to elderly patients only if recommended by a doctor. Consult your healthcare professional for guidance.

What if I have taken an overdose of Samford-400 Tablet

If you accidentally take too much of this medicine, seek immediate medical attention. Symptoms of an overdose may include severe dizziness, extreme anxiety, or severe stomach pain.

Diet & Lifestyle Advise

  • Follow a liver-friendly diet: Eat plenty of fresh vegetables, fruits, lean proteins, and whole grains while limiting fatty and highly processed foods.
  • Maintain a healthy weight: Reducing excess body weight helps decrease stress on weight-bearing joints, such as the knees and hips.
  • Stay physically active: Engage in low-impact exercises, such as walking, swimming, or cycling, to improve joint flexibility and strengthen supporting muscles.
  • Limit refined sugars: Reduce your intake of refined sugars and processed carbohydrates, as they may contribute to inflammation and worsen joint discomfort.
  • Stay well hydrated: Drink plenty of water throughout the day to support healthy liver function and help maintain joint lubrication.
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How Soon It Starts Working

  • The time required for Samford-400 Tablet to start to work: The effect of Samford-400 Tablet is observed within 30 minutes of administration.
  • The time for which the effects of Samford-400 Tablet last: Samford-400 Tablet effect lasts for 12 hours.

What if you forget to take Samford-400 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store this medicine at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the packaging: Do not use the medicine if the blister pack is torn or damaged, or if the tablets appear discoloured or cracked.
  • Take the last dose earlier in the day: Taking it in the afternoon may help reduce the risk of sleep disturbances or insomnia.
  • Inform your surgeon: Tell your surgeon or dentist that you are taking this medicine before any scheduled surgical procedure, as it may need to be stopped temporarily.
  • Monitor your mood: Contact your doctor immediately if you or your family notice unusual mood changes, irritability, or feelings of extreme sadness.
  • Do not share your medicine: Never give this medicine to anyone else, even if they have symptoms similar to yours.

Drug-Drug Interactions

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  • Antidepressants (such as SSRIs, MAOIs, or tricyclic antidepressants): Combining these with Samford-400 Tablet can lead to high levels of serotonin in the body, which may cause a serious condition called serotonin syndrome.
  • Levodopa (used for Parkinson's disease): Limited evidence suggests this medicine may reduce the effectiveness of levodopa in some individuals. If you are taking levodopa, consult your doctor before starting Samford-400 Tablet , and do not adjust either medicine without medical advice.
  • Cough suppressants (like dextromethorphan): Combining them may increase the risk of serotonin-related side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Samford-400 Tablet when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Samford-400 Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis, and depression.
Samford-400 Tablet works by synthesising methionine, an essential amino acid required for cellular energy.
Please see an orthopaedic doctor if you have had a fracture. Samford-400 Tablet is used in the treatment of arthritis and has limited use in fractures, as fractures are more of a surgical concern.
Samford-400 Tablet finds a lot of benefit in treating depression. However, consult your doctor before starting Samford-400 Tablet , and if you are on any anti-depressants, keep your doctor informed to avoid any interactions.
In case you miss a dose of Samford-400 Tablet , take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.
Samford-400 Tablet is probably safe for the kidneys; however, if you have CKD, it is best to consult your treating doctor before using Samford-400 Tablet .
The active ingredient is S-adenosyl-l-methionine disulfate tosylate, an essential amino acid.
Samford-400 Tablet helps keep your liver healthy. It supports liver function, protects liver cells, and reduces inflammation. Samford-400 Tablet also boosts glutathione production, a powerful antioxidant that protects the liver. Studies have shown that Samford-400 Tablet may be beneficial for various liver conditions, including fatty liver disease, fibrosis, and hepatitis. However, it's crucial to consult a healthcare professional before taking Samford-400 Tablet , especially if you have a pre-existing liver condition or are taking medications. They will determine the right dosage and ensure safe use.
Common side effects of Samford-400 Tablet may include nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.
Informing your doctor about your medical history is crucial for receiving personalised and effective care. Sharing your past illnesses and surgeries, current medications, allergies, and family medical history helps your doctor understand your overall health and make informed decisions. This includes identifying potential drug interactions, avoiding harmful side effects, and developing an adapted treatment plan that addresses your unique needs.
Don't take Samford-400 Tablet without consulting a doctor. They will help you determine if it's right for you, ensure the correct dosage, and monitor potential interactions with other medications or health conditions. Taking medication on your own can be risky and lead to adverse reactions or worsening of underlying conditions. Always consult a healthcare professional before taking any medication, including Samford-400 Tablet , to ensure your safety and well-being.
It is important to exercise caution when driving or riding a bike after taking Samford-400 Tablet . Samford-400 Tablet can cause dizziness, sleepiness, or lightheadedness, impairing your ability to drive safely. For safety, consult your doctor or the medication's label. They might advise you to wait a bit after taking the Samford-400 Tablet or to have someone else drive or ride with you.
The onset of action may vary depending on the individual and the condition being treated.
Consult your doctor before stopping or changing your medication regimen.
It is not established whether Samford-400 Tablet is safe for children. Please consult the treating doctor if you have any concerns.
No, you should not take Samford-400 Tablet with antidepressants unless specifically supervised by your doctor. Doing so can cause a dangerous buildup of serotonin in your brain. Talk to your doctor before combining these medications.
It is best to take Samford-400 Tablet on an empty stomach, at least one hour before or two hours after a meal. This helps your body absorb the medicine more effectively. Talk to your doctor or pharmacist if you experience stomach upset.
The safety of this medicine during pregnancy is not fully established, though it is sometimes used under strict medical supervision in the later stages for certain liver conditions. Always talk to your doctor before taking this medicine if you are pregnant or planning to become pregnant.
Yes, this medicine can cause mild difficulty sleeping or anxiety in some people, especially when taken late in the day. To prevent this, try to take your dose in the morning or early afternoon. Talk to your doctor if sleep issues persist.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can stress your liver and counteract the liver-protective benefits of this medication. Talk to your doctor for more guidance.
Contact your doctor immediately if you experience severe mood swings, unusual excitement, or worsening anxiety while taking this medicine. Do not stop taking the medicine unless your doctor advises you to do so, as they will assess your symptoms and decide whether your treatment needs to be adjusted or discontinued. 
No, Samford-400 Tablet does not cure these chronic conditions, but it helps manage symptoms, protect cells, and improve your overall daily function. Always talk to your doctor about long-term management plans for your health.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Flat No: 302, 3Rd Floor, Nagarjuna Arcade, Sree Colony, Neredmet Cross Roads, Malkajgiri Mandal-500056, Telangana
Other Info - SAM0203

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