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compositionComposition:TENOFOVIR DISOPROXIL FUMARATE-300MG
prescription
Prescription Medicine
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Samhep-TDF 300 mg Tablet 30's is used to treat HIV and chronic hepatitis B infection. It contains Tenofovir disoproxil fumarate which works by preventing the development of the virus in the human body. In some cases, this medicine may cause side effects such as diarrhoea, rash, nausea, pain, weakness, and stomach pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TENOFOVIR DISOPROXIL FUMARATE-300MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Samhep-TDF 300 mg Tablet 30's

Samhep-TDF 300 mg Tablet 30's is a prescription antiviral medicine used to treat chronic hepatitis B and human immunodeficiency virus type 1 (HIV-1) infection in adults and certain children. It works by slowing the growth of the virus, helping protect the immune system, reduce liver damage, and lower the amount of virus in the body. Although it does not cure HIV or hepatitis B, it plays an important role in their long-term management.

For Samhep-TDF 300 mg Tablet 30's to work effectively, it must be taken exactly as prescribed, usually once daily at the same time each day. Missing doses can make the treatment less effective and increase the risk of the virus becoming resistant to Samhep-TDF 300 mg Tablet 30's. You can take Samhep-TDF 300 mg Tablet 30's with or without food, although taking it with food may help reduce stomach discomfort. Eating a balanced diet, staying well hydrated, avoiding alcohol, and following your doctor's advice can also help support your overall health during treatment.

While taking Samhep-TDF 300 mg Tablet 30's, some people may experience mild side effects such as nausea, diarrhea, headache, or tiredness. These side effects are usually manageable, but seek medical attention immediately if you develop severe muscle pain, unusual weakness, difficulty breathing, persistent vomiting, yellowing of the skin or eyes, or signs of kidney problems such as reduced urination or swelling of the legs.

Before starting Samhep-TDF 300 mg Tablet 30's, tell your doctor if you have kidney disease, liver disease, osteoporosis or other bone problems, or if you have both HIV and hepatitis B infection. Do not stop taking Samhep-TDF 300 mg Tablet 30's without your doctor's advice, especially if you have hepatitis B, as this may cause a serious worsening of your liver disease. Do not take Samhep-TDF 300 mg Tablet 30's if you are allergic to Samhep-TDF 300 mg Tablet 30's or any of its ingredients.

Samhep-TDF 300 mg Tablet 30's can interact with medicines that may affect kidney function, including certain pain relievers, antivirals, and some antibiotics, so always tell your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, discuss the benefits and risks of treatment with your healthcare provider before starting Samhep-TDF 300 mg Tablet 30's.

Uses of Samhep-TDF 300 mg Tablet 30's

Samhep-TDF 300 mg Tablet 30's is used in the treatment of HIV (Human Immunodeficiency Virus) infection and Chronic Hepatitis B. The detailed uses of Samhep-TDF 300 mg Tablet 30's are as follows:

  • HIV-1 Infection: Samhep-TDF 300 mg Tablet 30's helps manage HIV-1 by keeping the virus from multiplying, which protects your immune cells and helps lower the overall amount of virus in your body.
  • Chronic Hepatitis B: Samhep-TDF 300 mg Tablet 30's helps control the hepatitis B virus, preventing it from damaging your liver cells and reducing the risk of long-term liver scarring or liver failure.

Key Benefits

Samhep-TDF 300 mg Tablet 30's helps manage certain viral infections by reducing the amount of virus in the body and supporting long-term immune and liver health. When taken regularly as prescribed, it helps control the infection and improves overall health outcomes.
Benefits may include:

  •  Helps reduce viral activity and supports long-term control of HIV or chronic hepatitis B infection.
  • Supports immune system health by helping keep viral levels low.
  • Helps protect liver health in people with chronic hepatitis B.
  • Reduces the risk of disease progression and virus-related complications.
  • Provides convenient once-daily dosing to support consistent treatment.
  • Promotes long-term health and improved quality of life when taken as prescribed.
Side effects of Samhep-tdf 300mg Tab
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Samhep-TDF 300 mg Tablet 30's can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Samhep-TDF 300 mg Tablet 30's as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Samhep-TDF 300 mg Tablet 30's Works

Samhep-TDF 300 mg Tablet 30's control viral infections by preventing the virus from making copies of itself. This reduces the amount of virus in the body, supports the immune system, and helps protect the liver from further damage.
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Alcohol

Caution

Avoid drinking alcohol. Consuming alcohol while using Samhep-TDF 300 mg Tablet 30's may worsen the condition.

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Pregnancy

Caution

Samhep-TDF 300 mg Tablet 30's is a category B medicine. It should be used with caution in pregnant women because it may cause side effects to the unborn baby.

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Breast Feeding

Unsafe

The active part of Samhep-TDF 300 mg Tablet 30's may pass with breast milk. Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk.

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Driving

Caution

Samhep-TDF 300 mg Tablet 30's may cause dizziness. So, avoid driving or refrain from any activities that require you to alert mentally.

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Liver

Caution

Samhep-TDF 300 mg Tablet 30's should be used with caution in patients with liver diseases. Dose adjustments may be necessary. Patients with liver disease, who are treated with Samhep-TDF 300 mg Tablet 30's, have a higher risk of serious and possibly fatal liver complications.

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Kidney

Unsafe

Samhep-TDF 300 mg Tablet 30's should not be used in adolescents with kidney disease. In other people with severe kidney diseases, Samhep-TDF 300 mg Tablet 30's is given only if clinically needed.

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Children

Unsafe

Samhep-TDF 300 mg Tablet 30's should not be used in children below 12 years of age.

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Heart

Consult your doctor

It is unknown whether Samhep-TDF 300 mg Tablet 30's is safe for use in heart patients or not. Please consult your physician.

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Geriatrics

Caution

Samhep-TDF 300 mg Tablet 30's can be given in elderly patients with extreme caution, due to the cause of adverse effects like liver/kidney problems.

What if I have taken an overdose of Samhep-TDF 300 mg Tablet 30's

If you take more than your prescribed dose, seek emergency medical attention or call a poison control center immediately.

Diet & Lifestyle Advise

  • Drink plenty of water: Stay well-hydrated throughout the day to support your kidney function while your body processes this medication.
  • Avoid alcohol: Do not drink alcohol, as it can put extra stress on your liver and worsen existing liver conditions.
  • Support your bones: Ensure your diet includes adequate calcium and Vitamin D, or speak with your doctor about supplements, as Samhep-TDF 300 mg Tablet 30's can sometimes cause bone thinning.
  • Eat balanced meals: Maintain a nutrient-rich diet to help support your immune system and overall energy levels.
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How Soon It Starts Working

The time required for Samhep-TDF 300 mg Tablet 30's to start to work: Samhep-TDF 300 mg Tablet 30's ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Samhep-TDF 300 mg Tablet 30's last: The effect of Samhep-TDF 300 mg Tablet 30's lasts for 17 hours.

What if you forget to take Samhep-TDF 300 mg Tablet 30's

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose entirely and return to your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Samhep-TDF 300 mg Tablet 30's tablets at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect Samhep-TDF 300 mg Tablet 30's before use: Do not take the tablets if they are discolored, cracked, damaged, or if the packaging shows signs of tampering.
  • Do not stop treatment abruptly: Do not stop taking Samhep-TDF 300 mg Tablet 30's suddenly, especially if you have hepatitis B, as this may cause a severe flare-up of your liver infection. Always consult your doctor before stopping treatment.
  • Attend regular monitoring appointments: Keep all scheduled blood and urine test appointments so your doctor can monitor your kidney function, liver function, and overall response to treatment.
  • Keep an updated medication list: Maintain a current list of all prescription medicines, over-the-counter products, vitamins, and herbal supplements you take, and share it with your doctor, dentist, or any other healthcare professional involved in your care.

Drug-Drug Interactions

verifiedApollotooltip
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, diclofenac): Taking these medicines alongside Samhep-TDF 300 mg Tablet 30's may increase the risk of kidney damage.
  • Other antiviral medicines (for HIV or hepatitis C): Certain antiviral medicines may increase the amount of Samhep-TDF 300 mg Tablet 30's in the body, raising the risk of side effects.
  • Anti-viral medicine (e.g., Adefovir dipivoxil): Do not take Samhep-TDF 300 mg Tablet 30's alongside Samhep-TDF 300 mg Tablet 30's, as using both together may increase the risk of serious side effects.
Tenofovir disoproxilStreptozocin
Critical
Tenofovir disoproxilDidanosine
Critical

Drug-Drug Interactions

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Tenofovir disoproxilStreptozocin
Critical
How does the drug interact with Samhep-tdf 300mg Tab:
Combining Samhep-tdf 300mg Tab and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Samhep-tdf 300mg Tab with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
Tenofovir disoproxilDidanosine
Critical
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Didanosine with Samhep-tdf 300mg Tab can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Samhep-tdf 300mg Tab is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilKetorolac
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Ketorolac with Samhep-tdf 300mg Tab may increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Ketorolac and Samhep-tdf 300mg Tab together can possibly result in an interaction, it can be taken when your doctor has prescribed it. However, if you experience symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, shortness of breath, fatigue, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilTobramycin
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of tobramycin with Samhep-tdf 300mg Tab can increase the risk of kidney problems.

How to manage the interaction:
Taking Samhep-tdf 300mg Tab with Tobramycin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilFosphenytoin
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
When Samhep-tdf 300mg Tab is taken with Fosphenytoin, the amount of Samhep-tdf 300mg Tab in the blood may decrease.

How to manage the interaction:
Taking Fosphenytoin with Samhep-tdf 300mg Tab together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
Tenofovir disoproxilNeomycin
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Neomycin and Samhep-tdf 300mg Tab can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Neomycin and Samhep-tdf 300mg Tab together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Tenofovir disoproxilVancomycin
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Mefenamic acid with Samhep-tdf 300mg Tab can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Samhep-tdf 300mg Tab may result in an interaction, but it can be taken together if a doctor prescribes it. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
Tenofovir disoproxilIopromide
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Iopromide and Samhep-tdf 300mg Tab can increase the risk of kidney problems.

How to manage the interaction:
Taking Iopromide and Samhep-tdf 300mg Tab together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, weakness, and irregular heart rhythm, contact your doctor immediately. You should drink plenty of fluids to keep yourself hydrated, help flush the contrast agent out of your kidneys, and do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilKanamycin
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Kanamycin and Samhep-tdf 300mg Tab can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Kanamycin and Samhep-tdf 300mg Tab together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilSulfasalazine
Severe
How does the drug interact with Samhep-tdf 300mg Tab:
Coadministration of Sulfasalazine and Samhep-tdf 300mg Tab can increase the risk of kidney problems.

How to manage the interaction:
Taking Sulfasalazine and Samhep-tdf 300mg Tab together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Samhep-TDF 300 mg Tablet 30's when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Samhep-TDF 300 mg Tablet 30's is used to treat HIV and chronic hepatitis B infection.
In the case of HIV infection, Samhep-TDF 300 mg Tablet 30's may decrease the risk of spreading the virus to others, but the risks of infecting others still continue. Although, in the case of hepatitis B virus infection, Samhep-TDF 300 mg Tablet 30's has not proven to decrease the risk of transferring the virus to others. Thereby, the patients of both HIV infection and hepatitis B virus (HBV) infection should not share needles and should practice safe sex.
Samhep-TDF 300 mg Tablet 30's is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.
Duration of treatment will depend on the seriousness of hepatitis B virus infection. You will require to take regular blood tests to keep a check on the viral load. Your doctor will then decide the duration of the Samhep-TDF 300 mg Tablet 30's appropriately. In a few cases, treatment is needed lifelong.
Samhep-TDF 300 mg Tablet 30's works by prevents the development of viruses in human cells. This prevents the virus from producing new viruses and cleans up your infection. It can effectively reduce the symptoms associated with HIV and chronic hepatitis B infection.
The main symptoms include yellowing of eyes and skin, flu-like symptoms, pale stools and dark-colored urine.
Samhep-TDF 300 mg Tablet 30's does not prevent the chance of transmission of new virus infection. Therefore, always take necessary precautions as per national guidelines for the prevention of transmission of new virus infection.
If you have Tuberculosis, HIV-1 virus infection or any other medical condition, you are recommended to inform your doctor before taking Samhep-TDF 300 mg Tablet 30's.
You should take Samhep-TDF 300 mg Tablet 30's in the dose and duration prescribed by your doctor. Take Samhep-TDF 300 mg Tablet 30's with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
If you vomit within 1 hour of taking Samhep-TDF 300 mg Tablet 30's, take another one. However, you need not take another tablet if you vomit after more than an hour of taking Samhep-TDF 300 mg Tablet 30's. If you experience vomiting whenever you take Samhep-TDF 300 mg Tablet 30's or if the vomiting persists for a longer duration, consult your doctor.
If you forget to take Samhep-TDF 300 mg Tablet 30's within 12 hours of your usual dosing time, you should take it with food as soon as possible and go back to the normal dosing schedule. If you miss a dose of Samhep-TDF 300 mg Tablet 30's by more than 12 hours and it is almost time for your next dose, you should skip the missed dose and simply resume the regular dosing schedule.
The side effects of Samhep-TDF 300 mg Tablet 30's include nausea, diarrhoea, rash, weakness, and stomach pain. If any of these side effects persist or worsen, please consult your doctor.
Unexplained muscle weakness, especially when accompanied by deep, rapid breathing or extreme tiredness, can be a sign of a serious condition called lactic acidosis. Stop taking Samhep-TDF 300 mg Tablet 30's and seek immediate emergency medical care if you experience these symptoms.
It is highly recommended to avoid or strictly limit alcohol while taking this medication. Alcohol increases stress on your liver, which can worsen liver damage, especially if you are being treated for hepatitis B. Talk to your doctor or pharmacist for personalized advice.
Yes, some people experience a decrease in bone mineral density while taking this medication. Your doctor may monitor your bone health or suggest calcium and vitamin D supplements. Talk to your doctor or pharmacist if you have concerns about your bone health.
You should avoid taking pain relievers known as NSAIDs (like ibuprofen or naproxen) regularly while taking Samhep-TDF 300 mg Tablet 30's, as they can increase the risk of kidney damage. Speak to your doctor or pharmacist to find a safer pain relief alternative.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - SAM0294
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