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compositionComposition:CYCLOSPORINE-50MG
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Sandimmun 50 mg Injection 1 ml is used to prevent rejection of transplanted organs. It contains cyclosporine, which works by suppressing the body’s immune system. This medicine may cause side effects like nausea, vomiting, headache, and abdominal pain. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml belongs to the class of medicines called immunosuppressants, used to prevent organ rejection after a transplant. It may also be indicated in autoimmune conditions like psoriasis and rheumatoid arthritis.

Sandimmun 50 mg Injection 1 ml contains cyclosporine, which works by suppressing the immune response. Thereby, it helps to prevent organ rejection.

Sandimmun 50 mg Injection 1 ml may cause side effects like nausea, vomiting, headache, and abdominal pain. Talk to your doctor if any of the side effects persist or worsen.

Let your doctor know about your medical condition and the medications you are taking to avoid potential interactions. Inform your doctor if you are pregnant or breastfeeding.

Uses of Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml is primarily used to prevent transplant rejection. The detailed uses of Sandimmun 50 mg Injection 1 ml are as follows:

  • Prevention of organ rejection: Sandimmun 50 mg Injection 1 ml prevents graft rejection after transplants, such as kidney, liver, and heart transplants.
  • Manage graft-versus-host disease (GVHD): Used after bone marrow or stem cell transplants to prevent and treat GVHD, a condition where donor cells attack the recipient's tissues.
  • Autoimmune conditions: Treat autoimmune diseases such as rheumatoid arthritis, psoriasis, lupus, and nephrotic syndrome.

Key Benefits

  • Sandimmun 50 mg Injection 1 ml helps prevent graft rejection in patients undergoing solid organ transplants, such as kidney, liver, heart, and lung transplants.
  • It promotes long-term survival and function of the transplanted organ by suppressing the immune system.
  • It is used to manage and reverse cellular rejection episodes in transplant recipients who were previously on other immunosuppressive therapies.
  • Sandimmun 50 mg Injection 1 ml prevents graft rejection in patients receiving allogeneic bone marrow or stem cell transplants.
  • It plays a critical role in preventing and treating graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the recipient’s body.
  • Cyclosporine works by selectively inhibiting the activation of T-lymphocytes, key players in the immune response, thereby reducing the risk of tissue rejection.
  • It ensures a more stable post-transplant period and improves overall transplant success rates.
Side effects of Sandimmun 50 mg Injection 1 ml
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Sandimmun 50 mg Injection 1 ml will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Sandimmun 50 mg Injection 1 ml Works

Sandimmun 50 mg Injection 1 ml contains cyclosporine, which works by blocking the development of specific cells that usually attack the transplanted tissue. Thus, it helps to prevent organ rejection.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sandimmun 50 mg Injection 1 ml. It could lead to an increase in adverse events.

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Pregnancy

Caution

In general, Sandimmun 50 mg Injection 1 ml should not be taken during pregnancy. If it is necessary for you to use this medicine, your doctor will discuss with you the benefits and potential risks of taking it during pregnancy.

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Breast Feeding

Unsafe

Breastfeeding is not recommended while taking Sandimmun 50 mg Injection 1 ml.

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Driving

Caution

Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert.

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Liver

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of liver disease. Your doctor will prescribe it only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of kidney disease. Your doctor will prescribe it only if the benefits outweigh the risks.

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Children

Unsafe

Sandimmun 50 mg Injection 1 ml is not recommended for children as efficacy and safety have not been established.

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Heart

Caution

Sandimmun 50 mg Injection 1 ml should be used with caution in patients with heart problems. Therefore, please inform your doctor if your have any heart problems before prescribing Sandimmun 50 mg Injection 1 ml.

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Geriatrics

Caution

Sandimmun 50 mg Injection 1 ml should be used under medical supervision in geriatric patients due to increased risk of side effects. Therefore, please consult your doctor before using Sandimmun 50 mg Injection 1 ml.

What if I have taken an overdose of Sandimmun 50 mg Injection 1 ml

As Sandimmun 50 mg Injection 1 ml is a parenteral formulation, the chance of overdose may be less. In case of overdose, patients must be closely monitored for signs or symptoms of adverse reactions and appropriate symptomatic treatment instituted.

Diet & Lifestyle Advise

  • Eat a low-sodium diet to help manage high blood pressure.
  • Focus on whole, unprocessed foods like vegetables, fruits, and whole grains.
  • Stay hydrated by drinking plenty of water (at least 8-10 glasses daily).
  • Avoid grapefruit and grapefruit juice as they can interact with Cyclosporine Injection.
  • Exercise regularly, aiming for at least 30 minutes of moderate-intensity exercise per day.
  • Get enough sleep, aiming for 7-8 hours per night.
  • Manage stress through techniques like meditation, deep breathing, or yoga.
  • Avoid smoking and secondhand smoke to reduce the risk of infection.
  • Limit alcohol consumption.
  • Regularly monitor your blood pressure and kidney function with your doctor's guidance.
health query

Have a query?

How Soon It Starts Working

The time required for Sandimmun 50 mg Injection 1 ml to start to work: The time required for Sandimmun 50 mg Injection 1 ml to show its action is unknown. The time for which the effects of Sandimmun 50 mg Injection 1 ml last: The duration of action for Sandimmun 50 mg Injection 1 ml is unknown.

What if you forget to take Sandimmun 50 mg Injection 1 ml

If you miss a dose of Sandimmun 50 mg Injection 1 ml, contact your doctor immediately to schedule a new injection.

Storage

• Store in a cool and dry place away from sunlight.• Keep Sandimmun 50 mg Injection 1 ml out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not receive Sandimmun 50 mg Injection 1 ml if you are allergic to any of its components.
  • Inform your doctor if you have liver or kidney problems, high blood pressure, high lipid levels, low magnesium levels, high potassium levels, high uric acid levels or if you are due to undergo vaccinations.
  • If you are pregnant or breastfeeding, inform your doctor before receiving Sandimmun 50 mg Injection 1 ml.
  • Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert.
  • Let your doctor know about all your medical conditions, sensitivities, and all medications (including herbal and supplement products) you are using.

Drug-Drug Interactions

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Drug-Drug Interactions: Sandimmun 50 mg Injection 1 ml may have interactions with certain Immunosuppressants (mycophenolate mofetil, methotrexate), potassium-sparing diuretics (spironolactone), antibiotics (erythromycin, azithromycin), antifungals (voriconazole, itraconazole), medicines used for heart problems or high blood pressure (diltiazem, amiodarone, nicardipine, verapamil), anti-convulsant medicines (carbamazepine, phenytoine) and pain killers (diclofenac).

Drug-Food Interactions: Avoid alcoholic beverages, grapefruit or grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.

Drug-Disease Interactions: If you have a history of high blood pressure, liver or kidney disease, infections, electrolyte imbalance, or gout, inform your doctor before starting treatment.

CiclosporinBaricitinib
Critical
CiclosporinBosentan
Critical

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of pitavastatin with Sandimmun 50 mg Injection 1 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Sandimmun 50 mg Injection 1 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinSimvastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Combining Sandimmun 50 mg Injection 1 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinFingolimod
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
When fingolimod is taken with cyclosporine, it can increase the risk of infection.

How to manage the interaction:
Although taking fingolimod and Sandimmun 50 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CiclosporinIndinavir
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking indinavir with ciclosporine may increase the blood levels and effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
Co-administration of cyclosporine and indinavir can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, diarrhea, abdominal pain, dizziness, weakness, headache, shaking, fits, and increased or decreased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CiclosporinFosamprenavir
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking fosamprenavir and Sandimmun 50 mg Injection 1 ml may increases the blood levels and effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between fosamprenavir and Sandimmun 50 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms such as diarrhea or stomach pain, feeling dizzy or tired, having a headache or fits, having a fever or sore throat, or bleeding or bruising. Do not stop using any medications without a doctor's advice.
CiclosporinSulfadiazine
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of sulfadiazine with Sandimmun 50 mg Injection 1 ml may increases the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between sulfadiazine and Sandimmun 50 mg Injection 1 ml, they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
CiclosporinCarbamazepine
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking carbamazepine and Sandimmun 50 mg Injection 1 ml may decrease the effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
Although taking carbamazepine and Sandimmun 50 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml can increase the effects of Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Sandimmun 50 mg Injection 1 ml belongs to the class of medicines called immunosuppressants, used to prevent organ rejection after a transplant.
Sandimmun 50 mg Injection 1 ml works by suppressing the body's immune system, preventing it from attacking the transplanted organ. It does this by blocking the production of certain cells that usually attack the transplanted tissue.
The side effects of Sandimmun 50 mg Injection 1 ml include kidney problems, high blood pressure, headaches, tremors, excessive hair growth, and elevated lipid levels.
Sandimmun 50 mg Injection 1 ml may cause high blood pressure. If you experience this side effect, monitoring your blood pressure regularly and following a healthy lifestyle are essential. This includes eating a balanced diet low in sodium and fat, exercising regularly, reducing stress, and taking any prescribed medication as directed. Working closely with your healthcare provider is crucial to managing high blood pressure and adjusting your treatment plan as needed.
If you're already taking blood pressure medication, consult your doctor before starting Cyclosporine Injection, as it may increase blood pressure. Your doctor will advise on safe usage.
Sandimmun 50 mg Injection 1 ml belongs to a class of medications called Immunosuppressants.
Yes, grapefruit and grapefruit juice can interact with Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit or grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.
Yes, in rare cases, Sandimmun 50 mg Injection 1 ml may cause allergic reactions. Seek medical attention immediately if you experience hives, itching, or difficulty breathing.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1036 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% [Internet]. [Accessed on 27 Feb 2025]Check here
  3. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 27 Feb 2025]Check here
  4. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 5280754, Cyclosporine. Retrieved February 27, 2025Check here
  5. DrugBank. Cyclosporine. DrugBank.[Accessed on 27 Feb 2025]Check here
  6. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC) [Revised in May 2022] [ Accessed on 21st November 2022]Check here
  7. Sandimmunneoral Jul2020.Sin App091120. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SAN0075
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