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  3. Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml, Pack of 1 Injection
Sandimmun 50 mg Injection 1 ml, Pack of 1 Injection
Sandimmun 50 mg Injection 1 ml, Pack of 1 Injection
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Synonym :

CYCLOSPORIN

Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml belongs to the class of medicines called immunosuppressants, which are used to prevent organ rejection after a transplant. Organ rejection occurs when the patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Sandimmun 50 mg Injection 1 ml contains cyclosporine, which blocks the development of specific cells that usually attack the transplanted tissue. Thereby, it helps to prevent organ rejection.

A healthcare expert will administer Sandimmun 50 mg Injection 1 ml in a hospital setting. In some cases, Sandimmun 50 mg Injection 1 ml may cause side effects such as kidney problems, high blood pressure, headaches, uncontrollable shaking of the body, excessive body and facial hair growth, and high levels of lipids in the blood. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Let your doctor know about your medical condition and the medications you are taking to avoid the occurrence of potential interactions. Inform your doctor if you are pregnant, breastfeeding, suspect you are pregnant or plan to have a baby; your doctor will weigh the benefits of Sandimmun 50 mg Injection 1 ml therapy against the risks. Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert.

Uses of Sandimmun 50 mg Injection 1 ml

Sandimmun 50 mg Injection 1 ml is primarily used to:<br/>Prevent organ rejection after transplants, such as kidney, liver, and heart transplants.<br/>Treat autoimmune diseases such as rheumatoid arthritis, psoriasis, lupus, and nephrotic syndrome.<br/>Manage graft-versus-host disease (GVHD) after bone marrow or stem cell transplants.<br/>Control severe inflammatory conditions, like severe eczema or some instances of asthma, when other treatments are ineffective.<br/>It works by suppressing the immune system to prevent the rejection of transplanted organs and to treat conditions where the immune system attacks the body’s tissues.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Sandimmun 50 mg Injection 1 ml will be administered by a doctor or nurse in a healthcare facility.• Do not self-administer.

Medicinal Benefits

Sandimmun 50 mg Injection 1 ml is a potent immunosuppressant that plays a crucial role in controlling the body's immune system following an organ transplant, including stem cell and bone marrow transplants. Its primary function is to prevent the rejection of transplanted organs by effectively blocking the development of certain cells that would normally attack the transplanted tissue, thereby ensuring a successful transplant outcome.

How Sandimmun 50 mg Injection 1 ml Works

Sandimmun 50 mg Injection 1 ml contains cyclosporine, a medication in the class of immunosuppressants. It works by blocking the development of specific cells that usually attack the transplanted tissue. Thus, it helps to prevent organ rejection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Sandimmun 50 mg Injection 1 ml
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

What if I have taken an overdose of Sandimmun 50 mg Injection 1 ml

As Sandimmun 50 mg Injection 1 ml is a parenteral formulation, the chance of overdose may be less. In case of overdose, patients must be closely monitored for signs or symptoms of adverse reactions and appropriate symptomatic treatment instituted.

Drug Warnings

Before taking Sandimmun 50 mg Injection 1 ml, inform your doctor about all your medical conditions, sensitivities, and all medications (including herbal and supplement products) you are using. If you are pregnant or breastfeeding, inform your doctor before taking Sandimmun 50 mg Injection 1 ml. You are recommended to complete the full course of Sandimmun 50 mg Injection 1 ml as prescribed by your doctor for effective results. Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert. Furthermore, avoid consuming alcohol or other substances that may interact with Sandimmun 50 mg Injection 1 ml. Inform your doctor if you experience any changes in your medical condition or if you develop new symptoms. Additionally, note that Sandimmun 50 mg Injection 1 ml suppresses your immune system, increasing your risk of developing certain types of cancer, particularly those of the skin and lymphatic system. Limit your exposure to sunlight and UV light by wearing protective clothing and applying sunscreen with a high protection factor.

Drug-Drug Interactions

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CiclosporinPitavastatin
Critical
CiclosporinSimvastatin
Critical

Drug-Drug Interactions

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CiclosporinPitavastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of pitavastatin with Sandimmun 50 mg Injection 1 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Sandimmun 50 mg Injection 1 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinSimvastatin
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Combining Sandimmun 50 mg Injection 1 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinCidofovir
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinBaricitinib
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Sandimmun 50 mg Injection 1 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinIohexol
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Coadministration of iohexol with Sandimmun 50 mg Injection 1 ml may increases the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between iohexol and Sandimmun 50 mg Injection 1 ml, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
CiclosporinMifepristone
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Co-administration of Sandimmun 50 mg Injection 1 ml with mifepristone may significantly increase the blood levels of Sandimmun 50 mg Injection 1 ml which may increase the risk and/or severity of side effects.

How to manage the interaction:
Although taking Sandimmun 50 mg Injection 1 ml and Mifepristone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you notice nausea, vomiting, diarrhea, abdominal discomfort, exhaustion, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, or increased or decreased urine, consult a doctor. Do not discontinue any medication without consulting a doctor.
CiclosporinGolimumab
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Using Sandimmun 50 mg Injection 1 ml together with golimumab may increase the risk of serious infections.

How to manage the interaction:
Although taking golimumab and Sandimmun 50 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinHydroxychloroquine
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking cyclosporine and hydroxychloroquine can increases the blood levels of ciclosporine.

How to manage the interaction:
Co-administration of cyclosporine and hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
CiclosporinFosamprenavir
Severe
How does the drug interact with Sandimmun 50 mg Injection 1 ml:
Taking fosamprenavir and Sandimmun 50 mg Injection 1 ml may increases the blood levels and effects of Sandimmun 50 mg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between fosamprenavir and Sandimmun 50 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms such as diarrhea or stomach pain, feeling dizzy or tired, having a headache or fits, having a fever or sore throat, or bleeding or bruising. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml can increase the effects of Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit and grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.

Diet & Lifestyle Advise

  • Eat a low-sodium diet to help manage high blood pressure.
  • Focus on whole, unprocessed foods like vegetables, fruits, and whole grains.
  • Stay hydrated by drinking plenty of water (at least 8-10 glasses daily).
  • Avoid grapefruit and grapefruit juice as they can interact with Cyclosporine Injection.
  • Exercise regularly, aiming for at least 30 minutes of moderate-intensity exercise per day.
  • Get enough sleep, aiming for 7-8 hours per night.
  • Manage stress through techniques like meditation, deep breathing, or yoga.
  • Avoid smoking and secondhand smoke to reduce the risk of infection.
  • Limit alcohol consumption to avoid interacting with Cyclosporine Injection.
  • Regularly monitor your blood pressure and kidney function with your doctor's guidance.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sandimmun 50 mg Injection 1 ml. It could lead to an increase in adverse events.

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Pregnancy

Caution

In general, Sandimmun 50 mg Injection 1 ml should not be taken during pregnancy. If it is necessary for you to use this medicine, your doctor will discuss with you the benefits and potential risks of taking it during pregnancy.

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Breast Feeding

Unsafe

Breastfeeding is not recommended while taking Sandimmun 50 mg Injection 1 ml.

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Driving

Caution

Sandimmun 50 mg Injection 1 ml may cause sleepiness, disorientation, or blurred vision. Drive and operate machinery only if you are alert.

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Liver

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of liver disease. Your doctor will prescribe it only if the benefits outweigh the risks.

bannner image

Kidney

Caution

Inform your doctor before receiving Sandimmun 50 mg Injection 1 ml if you have a pre-existing or a history of kidney disease. Your doctor will prescribe it only if the benefits outweigh the risks.

bannner image

Children

Unsafe

Sandimmun 50 mg Injection 1 ml is not recommended for children as efficacy and safety have not been established.

Have a query?

FAQs

Sandimmun 50 mg Injection 1 ml belongs to the class of medicines called immunosuppressants, used to prevent organ rejection after a transplant.

Sandimmun 50 mg Injection 1 ml works by suppressing the body's immune system, preventing it from attacking the transplanted organ. It does this by blocking the production of certain cells that usually attack the transplanted tissue.

The most common side effects of Sandimmun 50 mg Injection 1 ml include kidney problems, high blood pressure, headaches, tremors, excessive hair growth, and elevated lipid levels.

Sandimmun 50 mg Injection 1 ml may cause high blood pressure. If you experience this side effect, monitoring your blood pressure regularly and following a healthy lifestyle are essential. This includes eating a balanced diet low in sodium and fat, exercising regularly, reducing stress, and taking any prescribed medication as directed. Working closely with your healthcare provider is crucial to managing high blood pressure and adjusting your treatment plan as needed.

If you're already taking blood pressure medication, consult your doctor before starting Cyclosporine Injection, as it may increase blood pressure. Your doctor will advise on safe usage.

Sandimmun 50 mg Injection 1 ml belongs to a class of medications called Immunosuppressants.

Yes, grapefruit and grapefruit juice can interact with Sandimmun 50 mg Injection 1 ml. Avoid consuming grapefruit or grapefruit juice while taking Sandimmun 50 mg Injection 1 ml.

Yes, in rare cases, Sandimmun 50 mg Injection 1 ml may cause allergic reactions. Seek medical attention immediately if you experience hives, itching, or difficulty breathing.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SAN0075

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:20 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.1036.pdf
  2. https://www.novartis.com/sg-en/sites/novartis_sg/files/SandimmunNeoral-Jul2020.SIN-app091120.pdf

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