Sandimmun Neoral 25mg Capsule 5's
MRP ₹147
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Genuine Products
Synonym :
CYCLOSPORIN
Composition :
CYCLOSPORINE-25MG
Manufacturer/Marketer :
Novartis India Ltd
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Sandimmun Neoral 25mg Capsule
Sandimmun Neoral 25mg Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ rejection after a transplant. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis.
Sandimmun Neoral 25mg Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and lowers pain and inflammation in the joints.
Sandimmun Neoral 25mg Capsule may cause side effects like headaches, vomiting, nausea, loss of appetite and diarrhoea. Most of these side effects do not require medical attention and resolve over time. However, consult your doctor if the side effects persist or worsen.
To treat your condition effectually, continue taking Sandimmun Neoral 25mg Capsule for as long as your doctor has prescribed. Inform your doctor about your health condition and any medications you are taking to help rule out any potential/unpleasant side effects.
Uses of Sandimmun Neoral 25mg Capsule
Sandimmun Neoral 25mg Capsule is used to prevent organ rejection and treat psoriasis and rheumatoid arthritis. The detailed uses of Sandimmun Neoral 25mg Capsule are as follows:
- Treatment of Organ Transplant Rejection: Sandimmun Neoral 25mg Capsule is used in the prevention of organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants.
- Treatment of Psoriasis: Sandimmun Neoral 25mg Capsule is used in the treatment of psoriasis. It helps reduce rapid skin cell growth and inflammation caused by psoriasis.
- Treatment of Rheumatoid Arthritis: Sandimmun Neoral 25mg Capsule is used in the treatment of rheumatoid arthritis. It helps reduce pain and inflammation in the joints and slows down joint damage.
Have a query?
Directions for Use
- Sandimmun Neoral 25mg Capsule can be taken with or without food. However, avoid taking it with grapefruit, pineapple, or papaya juice, as they may increase the amount of this medication in your blood.
- It is usually taken 2 times a day or as prescribed by your doctor.
- Swallow the whole capsule with a glass of water.
- Do not crush, chew, or open it.
Medicinal Benefits
- Sandimmun Neoral 25mg Capsule suppresses the immune system to prevent the rejection of transplanted organs (e.g., kidney, liver, heart).
- It is also used in bone marrow and stem cell transplantation to prevent graft rejection.
- Sandimmun Neoral 25mg Capsule helps control immune overactivity in various autoimmune conditions by blocking immune cells that attack the body’s own tissues.
- It reduces rapid skin cell growth and inflammation in severe psoriasis, leading to clearer skin and symptom relief.
- This medicine reduces joint pain, inflammation, and slows down joint damage in patients with active rheumatoid arthritis unresponsive to other therapies.
- It may also be used to treat severe atopic dermatitis, especially in patients who do not respond adequately to topical treatments.
- Helps manage severe inflammatory eye diseases that can threaten vision by reducing immune-mediated damage.
- It is used in certain cases of nephrotic syndrome (a kidney disorder causing excess protein loss in urine), especially when other treatments fail.
How Sandimmun Neoral 25mg Capsule Works
Sandimmun Neoral 25mg Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation). Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.
Storage
• Store in a cool and dry place away from sunlight.• Keep Sandimmun Neoral 25mg Capsule out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Sandimmun Neoral 25mg Capsule
- Limit intake of full-fat dairy products, red meat and processed foods rich in saturated fats.
- Avoid foods with label “partially hydrogenated oils”.
- Eat more vegetables, fruits, oats, whole grains, lentils and beans to increase fiber intake.
- Include foods rich in monounsaturated fats like nuts, avocados, olive oil, and oily fish.
- Limit consumption of egg yolks.
- Exercise for at least 30 minutes 5 days a week.
- Aim for weight loss and maintain healthy weight.
- Quit smoking as smoking raises the risk of heart disease associated with cholesterol.
- Limit alcohol consumption as excessive drinking may raise cholesterol levels.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
- Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
- Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
- Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
- Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
- Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
- Monitor UTI symptoms and report any changes to your doctor.
- If antibiotics are prescribed, take them as directed and complete the full course.
- Rest well; get enough sleep.
- Eat a balanced diet and drink enough water.
- Manage stress with yoga and meditation.
- Limit alcohol and caffeine.
- Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
- Inform your doctor immediately if you experience a fever after starting a new medication.
- Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
- Monitor your body temperature to monitor fever progression.
- Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
- Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
- Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
- If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
- Limit processed foods and eat more vegetables and fruits.
- Exercise at least 30 minutes every day.
- Maintain a healthy weight.
- Quit smoking as it can worsen kidney damage.
- Control your blood pressure and blood glucose.
- Limit salt intake and alcohol consumption.
- Increased creatinine levels must be corrected immediately with the help of a doctor.
- Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
- Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
- Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
- Avoid smoking and drinking alcohol.
- Regular cleansing will help get rid of dead skin cells and stop ingrown hairs.
- Keep your hormones in balance by managing your stress, eating well and exercising regularly.
- Shaving, waxing, and bleaching are ways to get rid of extra hair.
What if I have taken an overdose of Sandimmun Neoral 25mg Capsule
Take Sandimmun Neoral 25mg Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Symptoms of overdose may include headache, drowsiness, vomiting, increased heart rate, and liver and kidney toxicity. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Drug Warnings
- Do not take Sandimmun Neoral 25mg Capsule if you are allergic to any of the components.
- Let your doctor know before using Sandimmun Neoral 25mg Capsule if you have/had liver or kidney problems, epilepsy, high blood pressure, low levels of magnesium, high levels of potassium, cancer, or infection.
- Sandimmun Neoral 25mg Capsule may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.
- Before taking Sandimmun Neoral 25mg Capsule, inform your doctor if you have any type of cancer.
- Consult your doctor before taking Sandimmun Neoral 25mg Capsule if you are pregnant or planning for pregnancy.
- Sandimmun Neoral 25mg Capsule should not be taken by breastfeeding mothers as it passes into breast milk.
- Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.
Drug-Drug Interactions
Critical
Critical
Drug-Drug Interactions
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Critical
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Coadministration of pitavastatin with Sandimmun Neoral 25mg Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Pitavastatin with Sandimmun Neoral 25mg Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
Coadministration of pitavastatin with Sandimmun Neoral 25mg Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Pitavastatin with Sandimmun Neoral 25mg Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
Critical
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
Taking cyclosporine with cidofovir can increase the risk of kidney problems.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
Critical
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Combining Sandimmun Neoral 25mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Combining Sandimmun Neoral 25mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Critical
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Sandimmun Neoral 25mg Capsule:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.
How to manage the interaction:
Taking Sandimmun Neoral 25mg Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Taking cyclosporine and hydroxychloroquine can increases the blood levels of ciclosporine.
How to manage the interaction:
Co-administration of cyclosporine and hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Taking cyclosporine and hydroxychloroquine can increases the blood levels of ciclosporine.
How to manage the interaction:
Co-administration of cyclosporine and hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Severe
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Co-administration of colchicine with Sandimmun Neoral 25mg Capsule may increases the blood levels and effects of both medications.
How to manage the interaction:
Although there is a possible interaction between colchicine and Sandimmun Neoral 25mg Capsule, you can take these medicines together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms such as abdominal pain, diarrhoea, fever, muscle pain, weakness, and numbness or tingling in your hands and feet. Do not discontinue any medications without consulting a doctor.
Co-administration of colchicine with Sandimmun Neoral 25mg Capsule may increases the blood levels and effects of both medications.
How to manage the interaction:
Although there is a possible interaction between colchicine and Sandimmun Neoral 25mg Capsule, you can take these medicines together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms such as abdominal pain, diarrhoea, fever, muscle pain, weakness, and numbness or tingling in your hands and feet. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Using cladribine together with Sandimmun Neoral 25mg Capsule may increase the risk of infections.
How to manage the interaction:
Although taking cladribine and Sandimmun Neoral 25mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
Using cladribine together with Sandimmun Neoral 25mg Capsule may increase the risk of infections.
How to manage the interaction:
Although taking cladribine and Sandimmun Neoral 25mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Using lercanidipine can make cyclosporine more effective at suppressing the immune system.
How to manage the interaction:
Co-administration of Sandimmun Neoral 25mg Capsule with lercanidipine can possibly result in an interaction, but it can be taken if your doctor has advised it. Avoid taking cyclosporine along with other medications that suppress your immune system. It is important to watch out for any signs of infection and contact your doctor immediately if you experience symptoms such as serious infection, anemia, bleeding problems, paleness, fatigue, dizziness, bruising, fever, chills, diarrhea, sore throat, muscle aches, weight loss, or pain during urination. Do not stop using any medications without first talking to your doctor.
Using lercanidipine can make cyclosporine more effective at suppressing the immune system.
How to manage the interaction:
Co-administration of Sandimmun Neoral 25mg Capsule with lercanidipine can possibly result in an interaction, but it can be taken if your doctor has advised it. Avoid taking cyclosporine along with other medications that suppress your immune system. It is important to watch out for any signs of infection and contact your doctor immediately if you experience symptoms such as serious infection, anemia, bleeding problems, paleness, fatigue, dizziness, bruising, fever, chills, diarrhea, sore throat, muscle aches, weight loss, or pain during urination. Do not stop using any medications without first talking to your doctor.
Severe
How does the drug interact with Sandimmun Neoral 25mg Capsule:
Co-administration of pazopanib with Sandimmun Neoral 25mg Capsule can increase the blood levels of pazopanib which increases the risk of side effects.
How to manage the interaction:
Taking pazopanib with Sandimmun Neoral 25mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience notice any symptoms of nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors (shaking), seizures(fits), fever, sore throat, unusual bruising or bleeding, and increased or decreased urination contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Co-administration of pazopanib with Sandimmun Neoral 25mg Capsule can increase the blood levels of pazopanib which increases the risk of side effects.
How to manage the interaction:
Taking pazopanib with Sandimmun Neoral 25mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience notice any symptoms of nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors (shaking), seizures(fits), fever, sore throat, unusual bruising or bleeding, and increased or decreased urination contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities, such as 20-30 minutes of walking or swimming, would be helpful.
- Practising yoga may also help improve joint flexibility and manage pain.
- Maintain a healthy weight by engaging in regular low-impact exercises and eating a balanced diet.
- Get adequate sleep, as rest can help reduce inflammation and swelling.
- Follow heat or cold therapy by applying a cold or hot compress to the joints for 15-20 minutes regularly.
- De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
- Acupuncture, massage, and physical therapy may also be helpful.
- Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
- Foods containing flavonoids can help reduce inflammation. These include soy, berries, broccoli, grapes, and green tea.
- Avoid smoking and alcohol consumption.
Habit Forming
No
Therapeutic Class
IMMUNOSUPPRESSANTS
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Alcohol
Caution
You are recommended to avoid alcohol consumption while taking Sandimmun Neoral 25mg Capsule. It could lead to increased dizziness and drowsiness.
Pregnancy
Caution
It is not known whether Sandimmun Neoral 25mg Capsule will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.
Breast Feeding
Unsafe
It is not recommended to take Sandimmun Neoral 25mg Capsule while you are breastfeeding. Sandimmun Neoral 25mg Capsule passes into breast milk.
Driving
Caution
Drive or operate machinery only if you are alert.
Liver
Caution
Take Sandimmun Neoral 25mg Capsule only if prescribed by the doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.
Kidney
Consult your doctor
Please consult your doctor if you have kidney impairment before taking Sandimmun Neoral 25mg Capsule.
Children
Unsafe
Sandimmun Neoral 25mg Capsule should not be given to children, as the efficacy and safety have not been established.
Heart
Please consult your doctor if you have a history of heart disease before taking Sandimmun Neoral 25mg Capsule. Your doctor will prescribe it only if the benefits outweigh the risks.
Geriatrics
Caution
Sandimmun Neoral 25mg Capsule should be given with caution in elderly patients due to an increased risk of side effects. Talk to your doctor if you have any concerns.
FAQs
Country of origin
Switzerland
Manufacturer/Marketer address
Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SAN0036
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Author Details
Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050715s035,050716s038lbl.pdf
- https://www.mayoclinic.org/drugs-supplements/cyclosporine-oral-route/description/drg-20075815
- https://medlineplus.gov/druginfo/meds/a601207.html
- https://www.drugs.com/disease-interactions/cyclosporine.html
- https://www.medicines.org.uk/emc/files/pil.5300.pdf
- https://www.webmd.com/drugs/2/drug-5645-9108/cyclosporine-oral/cyclosporine-oral/details
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