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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Septasteril Sachet 5 gm is used to treat chronic kidney disease. It contains Alpha Ketoanalogue, which works by lowering urea levels in the blood and improving kidney function. In some cases, this medicine may cause side effects such as increased calcium levels, nausea, vomiting, diarrhoea, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

ALPHA KETOANALOGUE

Manufacturer/Marketer :

Septalyst Lifesciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Septasteril Sachet 5 gm

Septasteril Sachet 5 gm is widely used in the treatment of chronic kidney disease. Chronic kidney disease (CKD) is a long-term condition where the kidneys don't work as they should.

Septasteril Sachet 5 gm contains Alpha Ketoanalogue, which prevents the unnecessary increase in urea levels in the blood due to the intake of non-essential amino acids in patients with kidney failure. Thereby improving renal function.

Not everyone who takes Septasteril Sachet 5 gm will experience these side effects. Common side effects of Septasteril Sachet 5 gm include increased calcium levels, nausea, vomiting, diarrhoea, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time.

Take Septasteril Sachet 5 gm with food orally (by mouth). Depending on your medical condition, your doctor will decide the dose and duration of the medicine. However, it is advised not to take more than the prescribed dose of Septasteril Sachet 5 gm. Do not chew, crush or bite the medicine.

Do not take Septasteril Sachet 5 gm if you are allergic to any components present in Septasteril Sachet 5 gm. Inform your physician if you are pregnant or a breastfeeding mother before using Septasteril Sachet 5 gm. Please do not stop taking Septasteril Sachet 5 gm without consulting your doctor. Avoid consuming alcohol during the treatment to avoid unpleasant side effects.

Uses of Septasteril Sachet 5 gm

Septasteril Sachet 5 gm used in the treatment of chronic kidney disease (CKD). The detailed uses of Septasteril Sachet 5 gm are as follows:

  • Chronic Kidney Disease (CKD): Septasteril Sachet 5 gm helps to manage CKD by reducing the accumulation of nitrogen waste products in the blood, slowing disease progression, and delaying the need for dialysis.
  • Kidney Function Support: Septasteril Sachet 5 gm supports kidney function by reducing uremia and waste accumulation, providing essential amino acids, and reducing the strain on the kidneys.
  • Enhances Nutritional Status: Septasteril Sachet 5 gm enhances nutritional status by providing essential ketoacids, which promote protein synthesis, reduce muscle wasting, and improve overall health.

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Directions for Use

  • Septasteril Sachet 5 gm can be taken with meals to increase absorption.
  • It is advised to take this medication three times daily or as prescribed by your doctor.
  • Swallow Septasteril Sachet 5 gm as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Septasteril Sachet 5 gm is used in the treatment of chronic kidney disease.
  • It is best if taken along with a low-protein diet, as it helps delay the progression of kidney diseases.
  • Make healthy lifestyle changes and ensure that your underlying conditions are well-managed.

How Septasteril Sachet 5 gm Works

Septasteril Sachet 5 gm contains 'Alpha Ketoanalogue', which prevents the unnecessary increase in urea levels in the blood due to the intake of non-essential amino acids in patients with kidney failure. Thereby improving renal function. It is best if taken along with a low-protein diet as it helps delay the progression of kidney diseases.

Storage

• Store in a cool and dry place away from sunlight.• Keep Septasteril Sachet 5 gm out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Septasteril Sachet 5 gm
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Septasteril Sachet 5 gm

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypotension (low blood pressure), fever, rapid pulse, and general symptoms of shock. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Septasteril Sachet 5 gm if you are allergic to any components present in it. 
  • It is advised not to stop taking Septasteril Sachet 5 gm without consulting your doctor.
  • Septasteril Sachet 5 gm should be used in pregnant and breastfeeding women only if clinically needed and the benefits outweigh the risks.
  • Avoid consuming alcohol along with Septasteril Sachet 5 gm as it may lead to unpleasant side effects.
  • People with chronic kidney disease (CKD) may need to closely monitor sodium and phosphorus in foods, especially if their kidney disease is advanced.
  • Septasteril Sachet 5 gm is not recommended for use in children below 18 years of age as the safety has not been established.

Drug-Drug Interactions

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TryptophanTranylcypromine
Critical
TryptophanSafinamide
Critical

Drug-Drug Interactions

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TryptophanTranylcypromine
Critical
How does the drug interact with Septasteril Sachet 5 gm:
Taking tranylcypromine with Septasteril Sachet 5 gm can increase the risk of serotonin syndrome ( high levels of serotonin in body which result in shivering, high fever, diarrhea & muscle stiffness) .

How to manage the interaction:
Taking Tranylcypromine with Septasteril Sachet 5 gm is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
TryptophanSafinamide
Critical
How does the drug interact with Septasteril Sachet 5 gm:
Taking Safinamide with Septasteril Sachet 5 gm can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Septasteril Sachet 5 gm is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
TryptophanRizatriptan
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Taking Rizatriptan with Septasteril Sachet 5 gm can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a possible interaction between Septasteril Sachet 5 gm and Rizatriptan, it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking of hands and legs, incoordination, stomach cramps, nausea, vomiting, and loose stools, contact a doctor. Do not discontinue any medications without consulting a doctor.
TryptophanFluvoxamine
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Using Septasteril Sachet 5 gm together with fluvoxamine can increase the risk of side effects of fluvoxamine.

How to manage the interaction:
Taking Fluvoxamine with Septasteril Sachet 5 gm together can possibly result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health and be aware of any changes. If you notice any of these symptoms - like confusion, sweating, or stomach cramps - it's a good idea to reach out to your doctor right away. They can help figure out what's going on and provide the necessary care. Do not stop using any medications without first talking to your doctor.
TryptophanGranisetron
Severe
How does the drug interact with Septasteril Sachet 5 gm:
When granisetron is taken with Septasteril Sachet 5 gm, can increase the risk of serotonin syndrome (condition in which a chemical called serotonin increase in body).

How to manage the interaction:
There may be a possibility of interaction between Granisetron and Septasteril Sachet 5 gm, but it can be taken if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, consult a doctor. Do not discontinue any medications without consulting a doctor
TryptophanSumatriptan
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Using Septasteril Sachet 5 gm together with Sumatriptan might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Sumatriptan and Septasteril Sachet 5 gm, you can take these medicines together if prescribed by your doctor. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
TryptophanTrazodone
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Using trazodone together with Septasteril Sachet 5 gm can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Trazodone and Septasteril Sachet 5 gm together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
TryptophanVilazodone
Severe
How does the drug interact with Septasteril Sachet 5 gm:
When Vilazodone is taken with Septasteril Sachet 5 gm, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Septasteril Sachet 5 gm, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
TryptophanAmitriptyline
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Combining Septasteril Sachet 5 gm with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Septasteril Sachet 5 gm and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
TryptophanDesvenlafaxine
Severe
How does the drug interact with Septasteril Sachet 5 gm:
Co-administration of Septasteril Sachet 5 gm and Desvenlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Septasteril Sachet 5 gm and Desvenlafaxine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • ​​It is best if taken along with a low-protein diet as it helps delay the progression of kidney diseases.
  • People with kidney problems are advised to limit sodium in their diet, including added salt.
  • Olive oil is a healthy source of fat- and phosphorus-free source, making it an excellent option for people with kidney disease.
  • Bulgur is a whole-grain wheat product that is a terrific, kidney-friendly alternative to other whole grains high in phosphorus and potassium.
  • Blueberries are packed with nutrients and are one of the best sources of antioxidants you can eat.

Habit Forming

No

Therapeutic Class

NUTRITIONAL SUPPLEMENT
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Septasteril Sachet 5 gm to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

Septasteril Sachet 5 gm should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult the doctor; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Caution should be exercised, and it is advisable to consult a doctor before using it. The doctor will prescribe if the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focused. If you experience drowsiness after taking this medication, you should not drive or operate machinery or vehicles.

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Liver

Consult your doctor

Inform your doctor before taking Septasteril Sachet 5 gm if you have a liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Safe if prescribed

Septasteril Sachet 5 gm can be taken safely if prescribed. Usually, it does not affect the kidney.

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Children

Unsafe

The safety and efficacy of Septasteril Sachet 5 gm in children have not been established. Septasteril Sachet 5 gm is not recommended in children.

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Heart

Septasteril Sachet 5 gm is generally safe for heart patients, but they should be taken under medical supervision.

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Geriatrics

Caution

Geriatric patients may take Septasteril Sachet 5 gm with caution, as age-related kidney or calcium metabolism changes require medical supervision. Always consult your doctor to ensure it's suitable for your health status and other medications.

FAQs

Septasteril Sachet 5 gm is used in the treatment of chronic kidney disease.

Septasteril Sachet 5 gm mimics the same catabolic pathways as amino acids and works by improving the body's metabolism, thereby improving renal function.

To treat your condition effectively, continue taking Septasteril Sachet 5 gm for as long as your doctor has prescribed. Please do not stop taking Septasteril Sachet 5 gm without consulting your doctor.

CKD is usually caused by various conditions such as high blood pressure, diabetes, high cholesterol, kidney infections, kidney inflammation, kidney stones that keep coming back, an enlarged prostate, and long-term or regular use of certain medicines such as lithium and non-steroidal anti-inflammatory drugs (NSAIDs).

CKD can be diagnosed using blood and urine tests. These tests look for high levels of certain substances in the blood and urine that show your kidneys are malfunctioning. The results of these tests can be used to determine the stage of your kidney disease.

There are usually no symptoms of kidney disease in the early stages. At a more advanced stage, symptoms can include tiredness, swollen ankles, feet or hands, shortness of breath, feeling sick, and blood in your pee (urine). It may only be diagnosed if you have a blood or urine test for another reason and the results show a possible problem with your kidneys.

Septasteril Sachet 5 gm contains Alpha Ketoanalogue, a nutritional supplement used to treat chronic kidney disease.

No, Septasteril Sachet 5 gm is not same as arginine alpha-ketoglutarate. Septasteril Sachet 5 gm contains alpha ketoanalogue which is a combination of different amino acids, whereas arginine alpha-ketoglutarate is a combination of alpha-ketoglutaric acid &essential amino acid arginine.

Septasteril Sachet 5 gm should be swallowed as a whole with water; do not crush or chew it.

Side effects of Septasteril Sachet 5 gm include increased calcium levels, nausea, vomiting, diarrhoea, and abdominal pain. Talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

P-109, Jai Mata Di Complex, Opp Ranbaxy Laboratories,Kalhar Bhiwandi , Thane Maharashtra -421 302
Other Info - SEP0104

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