Apollo
logo

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
compositionComposition:PERTUZUMAB-420MG
prescription
Prescription Medicine
info
image icons
Best Price

₹65246 with coupons & bank offers*

View

Sigrima 420 mg Injection 14 ml is used in the treatment of Breast cancer. It contains Pertuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in mammalian cells; this causes inhibition of the cancer cell growth and, finally, initiating apoptosis. Sigrima 420 mg Injection 14 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Read more
Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

PERTUZUMAB-420MG

Manufacturer/Marketer :

Zydus Lifesciences Limited

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Sigrima 420 mg Injection 14 ml

Sigrima 420 mg Injection 14 ml is a targeted prescription medicine used to treat specific types of breast cancer, particularly those that are HER2-positive. It is designed to slow down or stop the growth of cancer cells by targeting specific proteins on their surface. This treatment is always used together with other anti-cancer medicines rather than on its own. Depending on your stage of breast cancer, it is commonly given with trastuzumab and chemotherapy such as docetaxel, or with trastuzumab and other chemotherapy medicines chosen by your oncologist to provide the best possible results.

This medicine is injected as an intravenous infusion by a healthcare professional, typically in a hospital or clinic setting. It is given on a consistent, scheduled cycle to maintain its effectiveness in your body. Adopting a nutritious diet, drinking plenty of fluids, and managing stress can help support your overall well-being during this treatment.

While this treatment is highly targeted, some patients may experience common side effects such as diarrhoea, fatigue, or temporary hair loss. It is crucial to monitor how you feel and contact your healthcare provider immediately if you experience serious symptoms like shortness of breath, swelling in your legs, or signs of an infection.

Do not take this if you have had a severe allergic reaction to this medicine or any of its ingredients in the past. Before starting, talk to your doctor if you have a history of heart conditions, liver damage, or if you have previously received radiation therapy to your chest area.

This medicine can interact with other treatments that affect your heart, so it is vital to share a complete list of your medications with your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, you should not use this medicine due to the risk of severe harm to the baby. Older adults should also discuss their specific health risks with their doctor before starting.

Uses of Sigrima 420 mg Injection 14 ml

Your doctor may prescribe Sigrima 420 mg Injection 14 ml to help manage the following conditions:

  • Early-Stage HER2-Positive Breast Cancer (Before Surgery): This medicine is used before surgery (neoadjuvant treatment) alongside other chemotherapy drugs to help shrink tumours, making them easier to remove. It is usually given together with trastuzumab and chemotherapy as part of your treatment plan.
  • Early-Stage HER2-Positive Breast Cancer (After Surgery): It is prescribed after surgery (adjuvant treatment) to target any remaining microscopic cancer cells, significantly lowering the risk of the cancer returning. It is usually continued together with trastuzumab and chemotherapy, depending on your doctor's treatment plan.
  • Metastatic HER2-Positive Breast Cancer: For cancer that has spread to other parts of the body, this medicine is commonly given together with trastuzumab and docetaxel to help control cancer growth and improve survival.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Targeted Cancer Cell Destruction: Unlike traditional chemotherapy, which affects all rapidly dividing cells, this medicine specifically targets HER2-positive cancer cells. This helps spare healthy cells from unnecessary damage.
  • Enhanced Treatment Effectiveness: When used in combination with other anti-HER2 therapies, it provides a dual-blockade effect. This stops cancer cells from growing more effectively than using a single therapy alone.
  • Improved Long-Term Outcomes: Clinical studies show that adding this medicine to standard treatment plans helps keep patients cancer-free for longer and improves overall survival rates in advanced cases.
Side effects of Sigrima 420 mg Injection 14 ml
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Sigrima 420 mg Injection 14 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Sigrima 420 mg Injection 14 ml Works

Pertuzumab is a monoclonal antibody, a type of targeted therapy designed to recognise and bind to specific proteins. In HER2-positive breast cancers, cancer cells have abnormally high amounts of HER2 receptors (proteins) on their surface that signal the cells to grow rapidly. The medicine works by binding to a specific part of the HER2 receptor. This action blocks the receptor from pairing with other HER receptors, effectively shutting down the chemical signals that tell the cancer cell to grow and multiply. Additionally, by attaching to the cancer cells, it acts as a marker that helps your body's own immune system find and destroy the marked cancer cells.
bannner image

Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

bannner image

Pregnancy

Unsafe

Sigrima 420 mg Injection 14 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Sigrima 420 mg Injection 14 ml. Use reliable methods of birth control while on treatment with Sigrima 420 mg Injection 14 ml.

bannner image

Breast Feeding

Caution

It is not known whether Sigrima 420 mg Injection 14 ml is excreted in breast milk. Hence, if you are breastfeeding, inform your doctor before receiving Sigrima 420 mg Injection 14 ml. Your doctor will weigh the benefits and the risks before prescribing this medicine.

bannner image

Driving

Caution

Sigrima 420 mg Injection 14 ml will be administered in the hospital setting. Driving is not recommended while on therapy.

bannner image

Liver

Caution

No clinical trials have assessed the impact of hepatic impairment on the pharmacokinetics of Sigrima 420 mg Injection 14 ml. Hence, if you have a pre-existing or a history of liver disease, inform your doctor.

bannner image

Kidney

Caution

Limited data are available on the effect of Sigrima 420 mg Injection 14 ml in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

bannner image

Children

Unsafe

Sigrima 420 mg Injection 14 ml is not recommended for use in children as the safety and efficacy are not established.

bannner image

Heart

Caution

Sigrima 420 mg Injection 14 ml may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Sigrima 420 mg Injection 14 ml.

bannner image

Geriatrics

Safe if prescribed

Sigrima 420 mg Injection 14 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Sigrima 420 mg Injection 14 ml

Since this medication is prepared and administered by trained medical specialists in a controlled clinical environment, an overdose is highly unlikely. However, if you experience sudden, severe symptoms during or after your infusion, notify your medical team immediately.

Diet & Lifestyle Advise

  • Eat Small Meals: Eat small, frequent meals throughout the day to help manage nausea and maintain your strength.
  • Stay Hydrated: Stay thoroughly hydrated by drinking water, broths, or electrolyte solutions, especially if you experience diarrhoea.
  • Prevent Infections: Wash hands frequently and avoid crowds or contact with sick individuals, as this treatment can lower your white blood cell count and make you more prone to infections.
  • Stay Active: Incorporate gentle physical activities like stretching or short walks into your daily routine to help combat treatment-related fatigue, but always consult your doctor first.
  • Sun Protection: Protect your skin from the sun by wearing protective clothing and applying a broad-spectrum sunscreen, as your skin may become more sensitive during treatment.
health query

Have a query?

How Soon It Starts Working

The time required for Sigrima 420 mg Injection 14 ml to start to work: The time required for Sigrima 420 mg Injection 14 ml to show its action is not clinically established. The time for which the effects of Sigrima 420 mg Injection 14 ml last: The duration of action for Sigrima 420 mg Injection 14 ml is not clinically established.

What if you forget to take Sigrima 420 mg Injection 14 ml

Because this medicine is administered on a strict cycle by a healthcare professional, missing an appointment can disrupt your treatment plan. If you miss or need to reschedule an infusion, contact your doctor's office or clinic immediately to set up a new appointment.

Storage

• It must be kept refrigerated at a temperature between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Verify Your Medicine Before Infusion: Always verify with your nurse that the vial has been checked and matches your prescription before the infusion begins.
  • Check the Infusion Solution: Make sure the liquid solution is clear to slightly pearly and colourless to pale brown; do not receive it if it contains visible particles or is discoloured.
  • Keep Heart Monitoring Appointments: Keep all scheduled appointments for heart monitoring (like echocardiograms or MUGA scans), as this medicine can affect your heart muscle function.
  • Avoid Pregnancy During Treatment: Do not get pregnant while using this medicine and for at least 7 months after your final dose, as it can cause serious birth defects or fetal death.
  • Avoid Live Vaccines: Avoid receiving live vaccines during your treatment period to prevent serious viral complications.
  • Report Infusion Reaction Immediately: If you experience any sudden chills, fever, or breathing difficulties during the injection process, notify the nursing staff immediately.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart Medication Interaction Warning: Taking this medicine alongside other cancer therapies that can harm the heart (such as anthracycline-based chemotherapies) may increase the risk of heart damage. Always inform your doctor of all prescription drugs, over-the-counter medicines, and supplements you are taking.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

Login/Sign Up

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Sigrima 420 mg Injection 14 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Sigrima 420 mg Injection 14 ml is used to treat Breast Cancer.
Sigrima 420 mg Injection 14 ml contains Pertuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.
Inform your doctor whether you have received any other breast cancer treatment containing doxorubicin in your medication list. Sigrima 420 mg Injection 14 ml may cause left ventricular dysfunction, anaphylaxis, hypersensitivity reactions, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Sigrima 420 mg Injection 14 ml.
It is injected as an intravenous (IV) infusion into a vein by a trained healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about the infusion process.
No, you should not receive this medicine if you are pregnant, as it can cause severe harm or death to an unborn baby. Talk to your doctor about effective birth control options.
Yes, hair thinning or hair loss is a common side effect when this medicine is used in combination with other chemotherapy drugs. Talk to your doctor or pharmacist about what to expect.
The infusion is typically given once every three weeks, but your exact schedule will depend on your specific treatment plan. Talk to your doctor to confirm your schedule.
In some countries, including India, biosimilar versions of Sigrima 420 mg Injection 14 ml may be available. Biosimilars are highly similar to the original medicine and are approved only after meeting strict quality, safety, and effectiveness standards. Always receive the exact product prescribed by your oncologist, and do not switch between brands unless your healthcare provider recommends it.
There is no direct interaction, but alcohol can worsen side effects like fatigue, nausea, and dehydration. Talk to your doctor or pharmacist for personalised advice.
Contact your healthcare team immediately if you experience severe or persistent diarrhoea, as they can recommend safe anti-diarrheal medications and help you stay hydrated. Talk to your doctor before taking any over-the-counter remedies.
This medicine can occasionally weaken the heart muscle, leading to a decreased ability to pump blood. Your doctor will perform regular heart scans to monitor your heart function during treatment. Talk to your doctor if you experience shortness of breath or swelling.
You should avoid live vaccines during your treatment, as your immune system may be weakened. Talk to your doctor before receiving any vaccinations.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481
Other Info - SIG0147
whatsapp Floating Button
Buy Now
Add to Cart