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compositionComposition:NEOMYCIN-0.5%W/W
prescription
Prescription Medicine
info
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Sofrazen 0.5% Cream 20 gm is used to treat bacterial skin infections. It contains Neomycin,which inhibits the growth of bacteria. Some people may experience side effects such as dry skin, a burning sensation, peeling, itching, and redness. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NEOMYCIN-0.5%W/W

Manufacturer/Marketer :

Zen Labs India Pvt Ltd

Consume Type :

Topical

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Sofrazen 0.5% Cream 20 gm

Sofrazen 0.5% Cream 20 gm is a topical antibiotic used to prevent or treat minor skin infections caused by small cuts, scrapes, or burns. It works by stopping the growth of certain bacteria on the skin's surface. This helps the skin heal safely and reduces the risk of more serious complications.

You typically apply this medication to the affected area one to three times daily, as directed by your healthcare provider. For the best results, it is important to use Sofrazen 0.5% Cream 20 gm consistently at the same times each day. Keeping the wound clean and dry, and eating a balanced diet rich in vitamins C and zinc, can also support your body’s natural skin healing process.

Most people tolerate Sofrazen 0.5% Cream 20 gm well, but you may occasionally experience mild skin redness, itching, or irritation at the application site. If you notice severe burning, swelling, or signs of an allergic reaction like a skin rash, stop using it immediately and consult your doctor.

Talk to your doctor before starting Sofrazen 0.5% Cream 20 gm if you have deep wounds, animal bites, serious burns, or if you are treating a large area of broken skin. You should not use this medicine if you have a known allergy to it or similar antibiotic products.

Although topical treatments have a low risk of interacting with oral medications, alcohol, or smoking, you should still discuss your current medications with your doctor. Always consult your healthcare provider before using this medicine if you are pregnant, breastfeeding, or managing skin conditions in elderly individuals.

Uses of Sofrazen 0.5% Cream 20 gm

Sofrazen 0.5% Cream 20 gm may be prescribed for the following bacterial skin conditions:

  • Minor skin infections: Sofrazen 0.5% Cream 20 gm helps clear up superficial bacterial infections in small cuts, grazes, or scratches.
  • Prevention of wound infections: Applying Sofrazen 0.5% Cream 20 gm to minor wounds helps prevent bacteria from colonising the area and causing an infection.
  • Minor burns: It protects first-degree burns from bacterial contamination while the skin barrier recovers.
     

Key Benefits

Sofrazen 0.5% Cream 20 gm helps treat and prevent bacterial skin infections by eliminating harmful bacteria at the site of application. It supports the skin's natural healing process and helps prevent the infection from worsening.

  • Treats Bacterial Skin Infections: Helps eliminate bacteria that cause or worsen skin infections.
  • Prevents Infection Spread: Helps stop bacteria from spreading to surrounding skin and reduces the risk of more severe infection.
  • Reduces Redness and Swelling: Helps relieve inflammation associated with infected cuts, wounds, and minor skin injuries.
  • Promotes Skin Healing: Supports faster healing by controlling bacterial growth and protecting the affected area.
  • Improves Comfort: Helps reduce pain, tenderness, and discomfort caused by bacterial skin infections, allowing you to resume daily activities more comfortably.
     

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Take a small amount on the fingertip and apply it as a thin layer on the clean and dry affected area as prescribed by your doctor.
  • Sofrazen 0.5% Cream 20 gm is for external use only.
  • Wash your hands before and after use.
  • Avoid contact of Sofrazen 0.5% Cream 20 gm with the nose or eyes. Rinse with water if contact occurs.

How Sofrazen 0.5% Cream 20 gm Works

Sofrazen 0.5% Cream 20 gm contains neomycin, which belongs to a group of medicines known as aminoglycoside antibiotics. When applied to the skin, it targets the bacteria causing the infection by binding to their internal cellular machinery. Specifically, it blocks the bacteria's ability to produce essential proteins that they need to grow and survive. Without these vital proteins, the bacterial cells cannot multiply or repair themselves. This action effectively stops the infection from spreading, allowing your body’s natural immune system to easily clear away the remaining bacteria and heal the tissue.
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Alcohol

Safe if prescribed

No interaction was found. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Unsafe

Sofrazen 0.5% Cream 20 gm is a category D pregnancy drug, which may cause fetal abnormalities if used while pregnant. Its usage during pregnancy may cause hearing problems (ototoxicity) in the fetus. It is advised to consult your doctor if you are pregnant before starting Sofrazen 0.5% Cream 20 gm.

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Breast Feeding

Unsafe

Caution should be exercised. Sofrazen 0.5% Cream 20 gm is not recommended to use in breastfeeding. Consult your doctor if you are breastfeeding before using Sofrazen 0.5% Cream 20 gm.

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Driving

Safe if prescribed

Sofrazen 0.5% Cream 20 gm will not affect your ability to drive or operate machinery.

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Liver

Caution

Consult your doctor if you have any history of liver diseases or hepatic impairment before using Sofrazen 0.5% Cream 20 gm. Your doctor will weigh the benefits and potential risks before prescribing Sofrazen 0.5% Cream 20 gm. However, it is not recommended in patients with severe liver diseases.

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Kidney

Caution

Consult your doctor if you have any history of kidney problems before using Sofrazen 0.5% Cream 20 gm. Your doctor will weigh the benefits and potential risks before prescribing Sofrazen 0.5% Cream 20 gm. However, it is not recommended in patients with severe liver diseases.

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Children

Caution

Sofrazen 0.5% Cream 20 gm is not prescribed for children below the age of 6 years.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Sofrazen 0.5% Cream 20 gm in elderly patients. Please consult your doctor.

What if I have taken an overdose of Sofrazen 0.5% Cream 20 gm

An overdose of a topical medication is unlikely when used as directed. However, if the medication is accidentally swallowed, or if it is applied to very large areas of broken skin over a prolonged period, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Boost your nutrient intake: Consume foods rich in Vitamin C (like citrus fruits and leafy greens) and zinc (like seeds, nuts, and whole grains) to support natural skin repair and collagen synthesis.
  • Keep the wound protected: Avoid picking at scabs or scratching the healing area, as this can reintroduce bacteria and delay recovery.
  • Maintain wound hygiene: Clean the area daily with mild soap and water, ensuring it is dry before reapplying the medication.
  • Stay hydrated: Drink plenty of water to help maintain skin elasticity and overall cellular health during the healing process.
     
health query

Have a query?

How Soon It Starts Working

The time required for Sofrazen 0.5% Cream 20 gm to start to work: The time required for Sofrazen 0.5% Cream 20 gm to show its action is not clinically established. The time for which the effects of Sofrazen 0.5% Cream 20 gm last: The duration of action for Sofrazen 0.5% Cream 20 gm is not clinically established.

What if you forget to take Sofrazen 0.5% Cream 20 gm

If you forget to apply a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply a double amount to make up for the missed application.

Storage

•Store Sofrazen 0.5% Cream 20 gm at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the container tightly closed when not in use to protect the medicine from moisture and direct light. Do not freeze the cream or ointment.

Drug Warnings

  • Check the tube: Do not use the medicine if the protective seal is broken or if the cream or ointment has changed colour or consistency.
  • Avoid sensitive areas: Keep this medication away from your eyes, nose, mouth, and inside the ears unless specifically instructed by your doctor.
  • Limit duration of use: Do not use this product for more than 7 days unless directed by your healthcare provider, as prolonged use can lead to secondary infections.
  • Monitor for sensitisation: Topical antibiotics can sometimes cause skin allergies over time. If your skin condition worsens or does not improve within a few days, consult your doctor.
  • Do not apply to large open wounds: Avoid using this over extensive areas of broken skin, as increased absorption can lead to systemic side effects.
     

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Drug-Drug Interactions

Inform your doctor if you are using any of the following medicines, as they may interact with Sofrazen 0.5% Cream 20 gm:

  • Other aminoglycoside antibiotics: Using Sofrazen 0.5% Cream 20 gm alongside oral or injectable antibiotics from the same class may increase the risk of hearing or kidney problems if significant absorption occurs through the skin.

Drug-Disease Interactions

Inform your doctor if you have any of the following medical conditions before using Sofrazen 0.5% Cream 20 gm, as special precautions may be required:

  • Perforated eardrum: Do not apply this medication near or inside the ear if you have a torn or damaged eardrum, as it may cause hearing damage.
  • Kidney impairment: If you have severe kidney disease, avoid applying this medicine over large areas of broken skin, as absorbed medication can accumulate and worsen kidney function.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Sofrazen 0.5% Cream 20 gm contains neomycin, a topical antibiotic used to treat bacterial skin infections. It works by stopping the growth of bacteria responsible for the infection and helps the affected skin heal. Use it only as directed by your doctor.
Sofrazen 0.5% Cream 20 gm contains neomycin, a topical antibiotic that inhibits the development of key proteins required for bacteria to live, proliferate, and increase in number. As a result, it effectively treats infections of the skin.
Do not use Sofrazen 0.5% Cream 20 gm more frequently than necessary. Neomycin can enter the body through broken skin and cause renal difficulties as well as hearing impairments.
Sofrazen 0.5% Cream 20 gm is not recommended use to treat diaper rash.
You may start to notice improvement within a few days of using Sofrazen 0.5% Cream 20 gm as directed. Continue using it for the full duration recommended by your doctor. If your skin condition does not improve within 5–7 days, or if it worsens at any time, stop using the medicine and consult your doctor, as you may need further evaluation or a different treatment.
Yes, Sofrazen 0.5% Cream 20 gm is effective in the treatment of skin infections. It stops bacterial growth by preventing the synthesis of essential proteins required by bacteria to carry out vital functions.
Take a small amount on the fingertip and apply it as a thin layer on the clean and dry affected area as prescribed by your doctor. Wash your hands before and after using Sofrazen 0.5% Cream 20 gm if your hands are not the affected area to prevent the spread of infection.
Avoid contact with the nose or eyes. In case of accidental contact with these areas, rinse with water thoroughly. Do not use the Sofrazen 0.5% Cream 20 gm on open wounds, blisters, and lesions unless advised by the doctor.
If you miss a dose of Sofrazen 0.5% Cream 20 gm, apply it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and use the next dose at the scheduled time.
Yes, Sofrazen 0.5% Cream 20 gm is safe if used in the dose and duration prescribed by the doctor.
Few studies have found that acne-causing bacteria (P.acnes) are resistant to neomycin. Hence, Sofrazen 0.5% Cream 20 gm may not help with acne. Please consult the doctor for appropriate treatment.
Sofrazen 0.5% Cream 20 gm should be used on an open wound only if advised by the doctor. Do not apply the product more frequently than directed.
Sofrazen 0.5% Cream 20 gm should be used in children only if advised by the doctor. Please consult the doctor if you have any concerns regarding the usage of Sofrazen 0.5% Cream 20 gm in children.
Sofrazen 0.5% Cream 20 gm may cause antibiotic resistance if used for prolonged use. Therefore, use Sofrazen 0.5% Cream 20 gm only as advised by the doctor.
Sofrazen 0.5% Cream 20 gm may cause side effects like dry skin, a burning sensation, peeling, itching, and redness. Most of these side effects are temporary and will go away on their own. However, if the side effects persist or worsen, consult your doctor.
No, Sofrazen 0.5% Cream 20 gm is only intended for minor, superficial cuts, scrapes, and burns. For deep puncture wounds, animal bites, or severe burns, consult a doctor immediately for appropriate treatment.
Yes, you can apply it to minor facial cuts or scrapes, but be extremely careful to avoid getting it near your eyes, nose, or mouth. If you need to treat an area close to these sensitive spots, talk to your doctor first.
Minor redness or irritation can occur occasionally. However, if the redness increases, or if you develop a severe rash or swelling, stop using the product immediately as this could indicate an allergic reaction. Talk to your doctor or pharmacist.
You should consult your healthcare provider before using this medication during pregnancy. While topical absorption is typically low, your doctor will assess whether the benefits outweigh any potential risks. Talk to your doctor.
You should not use human medications on pets without consulting a veterinarian. Animals may lick the ointment off, which can lead to accidental ingestion and adverse effects. Talk to your veterinarian.
Yes, you can cover the treated area with a sterile adhesive bandage to protect it from dirt and further irritation. However, do not use tight, airtight plastic bandages unless specifically instructed to do so. Talk to your doctor.
If the medication gets into your eyes, rinse them immediately and thoroughly with cool, clean water. If you experience persistent irritation, pain, or changes in your vision, talk to your doctor right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A682274 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Neomycin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.6709 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. ScienceDirect ScienceDirect. [Accessed on 31 Mar. 2019]Check here
  5. PubChem PubChem. [Accessed on 31 Mar. 2019]Check here
  6. Dermovate Cream - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 6 July 2021]Check here
  7. Clotrimazole: a medicine used to treat fungal skin infections [Internet]. nhs.uk. 2021 [Accessed on 6 July 2021]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Plot No: 784, Industrial Area, Phase-Ii, Chandigarh Ch 160002 In
Other Info - SOF0207

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