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Somagesic NP Tablet is used to treat Neuropathic pain. It contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, it helps to treat neuropathic pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MECOBALAMIN-1500MCG+NORTRIPTYLINE-10MG+PREGABALIN-75MG

Manufacturer/Marketer :

Somatico Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Somagesic NP Tablet

Somagesic NP Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Somagesic NP Tablet combines three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Somagesic NP Tablet helps to treat neuropathic pain.

Take Somagesic NP Tablet as prescribed. Your doctor will decide the dose and duration based on your medical condition. In some cases, Somagesic NP Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. These side effects do not necessitate medical attention and will subside gradually over time. However, you should consult your doctor if you are experiencing these side effects regularly.

Please do not take Somagesic NP Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Somagesic NP Tablet if you are pregnant or breastfeeding. Somagesic NP Tablet may cause drowsiness and dizziness, so drive only if alert. Somagesic NP Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Somagesic NP Tablet as it could increase dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to avoid side effects.

Uses of Somagesic NP Tablet

Somagesic NP Tablet is used in the treatment of Neuropathic pain. The detailed uses of Somagesic NP Tablet are as follows:

  • Neuropathic pain relief: Somagesic NP Tablet is used to treat neuropathic pain relief such as diabetic neuropathy, post-herpetic neuralgia, or sciatica.
  • Peripheral nerve disorders: Somagesic NP Tablet helps in treating peripheral nerve disorders including numbness, tingling, or burning sensations.

Key Benefits

Somagesic NP Tablet is a combination of three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Somagesic NP Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Somagesic NP Tablet helps to treat neuropathic pain.

Side effects of Somagesic NP Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Somagesic NP Tablet can be taken with or without food as directed by your doctor.
  • It is advised to take Somagesic NP Tablet once or twice daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the whole medicine with a glass of water.
  • Do not break, crush or chew Somagesic NP Tablet .

How Somagesic NP Tablet Works

Somagesic NP Tablet combines three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Somagesic NP Tablet helps to treat neuropathic pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Somagesic NP Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take Somagesic NP Tablet unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Somagesic NP Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Somagesic NP Tablet causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Inform your doctor before receiving the Somagesic NP Tablet if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Inform your doctor before receiving the Somagesic NP Tablet if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Children

Unsafe

Somagesic NP Tablet should not be given to children as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Somagesic NP Tablet if you have pre-existing heart problems. Your doctor will prescribe Somagesic NP Tablet if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Somagesic NP Tablet is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Somagesic NP Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Somagesic NP Tablet may include agitation, coma, confusion, irregular heartbeats, severe drowsiness, hallucinations, overactive reflexes, feeling hot or cold, stiff muscles, seizures, vision problems and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.
  • Your diet should include Cayenne pepper because it can help with neuropathic pain.
  • Exercising regularly helps to improve overall health and combat pain.
  • Rest well and get plenty of rest.
  • Taking a warm bath can be very relaxing.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can reduce stress, and pain sensitivity, and improve coping skills.
  • Acupuncture, by stimulating pressure points, can be beneficial.
  • Massages with essential oils can help increase circulation.
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How Soon It Starts Working

The time required for Somagesic NP Tablet to start to work: The time required for Somagesic NP Tablet to show its action is not clinically established. The time for which the effects of Somagesic NP Tablet last: The duration of action for Somagesic NP Tablet is not clinically established.

What if you forget to take Somagesic NP Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep Somagesic NP Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to any of the ingredients in Somagesic NP Tablet , do not consume it. Please do not stop taking Somagesic NP Tablet without consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Somagesic NP Tablet unless your doctor has prescribed it. Somagesic NP Tablet may cause drowsiness and dizziness; therefore, drive only if alert. Somagesic NP Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Somagesic NP Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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Drug-Drug Interactions: Somagesic NP Tablet may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John's wort).

Drug-Food Interactions: Avoid alcohol consumption while taking Somagesic NP Tablet as it might cause increased drowsiness and sleepiness.

Drug-Disease Interactions: Use Somagesic NP Tablet with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.

Mecobalamin + Nortriptyline + PregabalinSafinamide
Critical
Mecobalamin + Nortriptyline + PregabalinLinezolid
Critical

Drug-Drug Interactions

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Mecobalamin + Nortriptyline + PregabalinSafinamide
Critical
How does the drug interact with Somagesic NP Tablet:
Coadministration of Somagesic NP Tablet with safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and safinamide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinLinezolid
Critical
How does the drug interact with Somagesic NP Tablet:
Coadministration of Somagesic NP Tablet with linezolid may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and linezolid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinSelegiline
Critical
How does the drug interact with Somagesic NP Tablet:
Co-administration of Somagesic NP Tablet with selegiline may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between and selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinPotassium citrate
Critical
How does the drug interact with Somagesic NP Tablet:
Coadministration of Somagesic NP Tablet with potassium citrate can increase the risk or severity of gastric bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and potassium citrate, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Nortriptyline + PregabalinTranylcypromine
Critical
How does the drug interact with Somagesic NP Tablet:
Coadministration of Nortriptyline with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between nortriptyline and tranylcypromine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinIsocarboxazid
Critical
How does the drug interact with Somagesic NP Tablet:
Taking Somagesic NP Tablet with isocarboxazid may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and isocarboxazid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinZiprasidone
Critical
How does the drug interact with Somagesic NP Tablet:
Coadministration of nortriptyline with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between nortriptyline and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Nortriptyline + PregabalinEscitalopram
Severe
How does the drug interact with Somagesic NP Tablet:
Coadministration of Somagesic NP Tablet with escitalopram may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and escitalopram, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Mecobalamin + Nortriptyline + PregabalinCeritinib
Severe
How does the drug interact with Somagesic NP Tablet:
Coadministration of nortriptyline with ceritinib can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between nortriptyline and ceritinib they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Nortriptyline + PregabalinNorepinephrine
Severe
How does the drug interact with Somagesic NP Tablet:
Taking Somagesic NP Tablet with norepinephrine can increases the blood pressure.

How to manage the interaction:
Although there is an interaction between Somagesic NP Tablet and norepinephrine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[NEUTRACEUTICAL, MISCELLANEOUS ANALGESICS]

FAQs

Somagesic NP Tablet is used to treat Neuropathic pain.
Somagesic NP Tablet contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Together, Somagesic NP Tablet helps to treat neuropathic pain.
Somagesic NP Tablet contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
Dry mouth could be a side-effect of Somagesic NP Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Somagesic NP Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Somagesic NP Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Somagesic NP Tablet , do not be afraid to speak with your doctor.
Somagesic NP Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Somagesic NP Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
Somagesic NP Tablet is a combination medicine that contains mecobalamin, pregabalin, and nortriptyline. It is effectively used in the treatment of neuropathic pain.
Somagesic NP Tablet may cause sleepiness or drowsiness. To overcome sleepiness or drowsiness, try getting moving, taking a short walk, or stretching, cold shower, and some fresh air. Drink water or other non-caffeinated fluids to stay hydrated. However, consult your doctor if you're consistently struggling with sleepiness.
Taking Somagesic NP Tablet can affect your sexual life. You might experience lower sex drive, erectile dysfunction, or problems with ejaculation or orgasm. If you notice any of these changes, it's important to tell your doctor. They can help you find solutions or adjust your medication to minimize these effects.
The common side effects of Somagesic NP Tablet may include dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. These side effects do not necessitate medical attention and will subside gradually over time. However, you should consult your doctor if you are experiencing these side effects regularly.
The time it takes for Somagesic NP Tablet to take effect can vary from person to person. Some people may start feeling better within a couple of weeks, while others may need 4 to 6 weeks to experience the full benefits. The exact treatment duration will depend on your medical condition, and your doctor will provide personalized guidance on the recommended treatment course.
Focus on nutrient-dense foods, be mindful of your portion sizes, and avoid high-calorie snacks like crisps, cakes, biscuits, and sweets. Instead, opt for fresh fruits and vegetables, low-calorie foods, whole grains, and lean protein sources. Regular exercise will also help stabilize your weight and support overall health and well-being.
If you forget to take Somagesic NP Tablet , take it as soon as you remember if it's within a few hours. If it's almost time for your next dose, skip the missed one and continue as usual. Don't take a double dose to make up for it. If you're unsure or frequently forget doses, consult your doctor or pharmacist for guidance. Taking medication at the same time every day can help make it a habit and reduce the likelihood of forgetting.
Do not take more Somagesic NP Tablet than prescribed. Be aware of serious side effects like abnormal heartbeat, seizures, allergic reactions, and suicidal thoughts. If you experience any of these, tell your doctor right away and get medical help immediately to avoid serious problems.
Taking more than the recommended dose of Somagesic NP Tablet won't improve its effectiveness and can be harmful. Stick to the recommended dosage to minimize risks and maximize benefits. If you have concerns, consult your doctor for personalized guidance.
While taking Somagesic NP Tablet , be aware of potential interactions and risks. Avoid excessive alcohol consumption, driving, and operating heavy machinery until you know how the medication affects you. Also, consult your doctor before taking other medications, or supplements, or changing your diet and exercise routine. Limit grapefruit intake and exercise caution with opioid medications, as they may interact with Somagesic NP Tablet . By following your doctor's guidance, you can minimize risks and ensure the medication works effectively for you.
Regular doctor's visits are important when receiving medical treatment. How often you visit will depend on your situation, but expect more frequent visits during the initial treatment phase to adjust plans and monitor side effects. Even during maintenance, regular check-ins will help track progress and address concerns. This helps ensure you receive the best care and stay on track with your treatment.
Somagesic NP Tablet should be stored in a cool and dry place away from sunlight and keep it out of reach of children. When disposing, check the expiration date, remove the label, and throw it away in a plastic bag in the household trash. Do not flush it down the toilet or sink. Follow these steps to keep the medication safe and effective.

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Reference

  1. National Health Service (NHS). Nortriptyline - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Pregabalin - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Pmc3888748 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Pmc6003018 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Pregabalin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Drugs.com Clinical Review Team. Nortriptyline Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  7. Electronic Medicines Compendium (EMC). Pil.5044 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

C-469, TTC, MIDC Pawane, Navi Mumbai 400703
Other Info - SOM0150

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